Article
Nutrition & Dietetics
Yildirim Kayacan, Aybike Zeynep Kola, Stefano Guandalini, Hayrullah Yazar, Mehtap Unlu Sogut
Summary: This study found that the combination of probiotics and exercise can decrease dynamic disulfide levels and significantly reduce oxidative damage. The use of probiotics alone had no effect on thiol/disulfide homeostasis. The results suggest that probiotics may be beneficial in reducing oxidative stress in sports involving intense exercise.
Article
Medicine, General & Internal
Simona Roxana Georgescu, Cristina Iulia Mitran, Madalina Irina Mitran, Clara Matei, Gabriela Loredana Popa, Ozcan Erel, Mircea Tampa
Summary: This article reviews the role of thiol-disulfide homeostasis (TDH) in various skin diseases. The results indicate that the changes in TDH may shift towards disulfides or thiols, depending on the extent of oxidative damage.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Clinical Neurology
Merve Ergin Tuncay, Murat Ilhan Atagun, Ozcan Erel
Summary: The thiol-disulfide couple is important for maintaining intracellular redox status and plays crucial roles in metabolic processes, signal mechanisms, inflammation, and antioxidant defense. Imbalances in thiol-disulfide homeostasis have been implicated in numerous diseases. This comprehensive review identifies studies on thiol-disulfide homeostasis in psychiatric disorders, which reveal alterations in the thiol-disulfide balance, usually shifting towards the oxidative side. The use of N-acetylcysteine, a thiol-containing compound, as a potential treatment and the role of glutathione, the most abundant thiol in the brain, highlight the importance of evaluating thiol-disulfide balance in psychiatric disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Environmental Sciences
Osman Gokhan Ozakinci, Meside Gunduzoz, Murat Buyuksekerci, Mevlut Karatas, Ahmet Rifat Balik, Salim Neselioglu, Ozcan Erel
Summary: This study used a novel and automated colorimetric measurement method to determine thiol-disulfide homeostasis as indices of oxidative stress in painters. The results showed that the levels of disulfide/native thiol and disulfide/total thiol were significantly higher in painters with longer duration of work. There was a positive correlation between urinary phenol and thiol-disulfide homeostasis, ischemia-modified albumin levels, disulfide levels, and duration of work. The newly developed automated colorimetric method proposed in this study can be a promising and practical test for evaluating the oxidative status of painters.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2022)
Article
Andrology
Medeni Arpa, Bayram Sen, Huseyin Eren, Hakki Uzun, Oguzhan Okcu, Ozcan Erel
Summary: The study assessed the distinctiveness of serum levels of different sulfur compounds in prostate cancer patients and created a new parameter, the prostate thiol index (PTI), to aid in diagnosis. PTI showed the best performance in distinguishing between prostate cancer and benign prostatic hyperplasia (BPH), with TT, tPSA, fPSA, PSA-AV, PSAD, and PTI demonstrating significant diagnostic capabilities. PTI, tPSA, and PSAD were positively correlated with cancer severity grades, while PSA-AV had a negative correlation.
Article
Dermatology
Ayse Akbas, Fadime Kilinc, Sertac Sener, Cemile Bicer, Funda Eren, Yildiz Hayran, Akin Aktas
Summary: This study explored the presence of oxidative stress in male patients with Androgenetic Alopecia (AGA) and found that thiol disulfide homeostasis is generally balanced in these patients, but may shift towards oxidative stress in individuals with emotional stress and vitamin D deficiency.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Obstetrics & Gynecology
Burak Sezgin, Fatih Pirincci, Aysun Camuzcuoglu, E. Adeviye Sahin, Ozcan Erel, Salim Neselioglu, Hakan Camuzcuoglu
Summary: The study showed that patients with high-grade squamous intraepithelial lesion have significantly lower levels of native thiol and total thiol, and significantly higher levels of disulfide, indicating more severe oxidative stress damage in these patients.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Pediatrics
Mehmet Semih Demirtas, Huseyin Erdal
Summary: This study explores the association between vitamin B12 deficiency and dynamic thiol/disulfide homeostasis in adolescent patients. The study consists of 45 adolescent patients with vitamin B12 deficiency and a control group of 45 healthy adolescents. The results show that vitamin B12 level is significantly lower in the deficiency group, and oxidative stress may play a vital role in vitamin B12 deficiency in adolescence.
ITALIAN JOURNAL OF PEDIATRICS
(2023)
Article
Psychiatry
Yekta Ozkan, Hasan Kandemir, Sermin Yalin Sapmaz, Fatma Taneli, Habib Ozdemir, Ozge Gozacanlar Ozkan
Summary: The study found that the onset of pediatric OCD is associated with oxidative stress, and thiol/disulfide homeostasis may affect the etiopathogenesis of the disorder.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Psychiatry
Gianluca Pandolfo, Giovanni Genovese, Antonio Bruno, Domenica Campolo, Valeria Tigano, Mariateresa Cristani, Marco Casciaro, Giovanni Pioggia, Sebastiano Gangemi
Summary: The pathophysiology of schizophrenia is still not well understood. Genetic factors and oxidative stress play key roles in its development and progression. Oxidative stress leads to the continuous production of oxidation products, such as AGEs and AOPPs, which interact with their receptors, amplifying the production of reactive oxygen species (ROS) and pro-inflammatory cytokines. In this study, plasma levels of AGEs and AOPPs were found to be significantly higher in schizophrenia patients compared to controls, confirming their involvement in mental disorders. Antioxidant nutraceuticals and a healthy lifestyle could reduce oxidative stress and alleviate schizophrenia symptoms.
PSYCHIATRY RESEARCH
(2022)
Article
Oncology
Pinar Akyol, Didem Sener Dede, Burak Bilgin, Arife Ulas, Mehmet Ali Nahit Sendur, Muhammed Bulent Akinci, Salih Baser, Cihan Erol, Mutlu Hizal, Bulent Yalcin
Summary: This study aimed to investigate the changes of thiol compounds during cancer chemotherapy. The results showed that the thiol disulfide balance shifted towards disulfide direction in cancer patients before chemotherapy, and repetitive chemotherapy sessions may lead to an increase in oxidative stress levels.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2022)
Article
Dermatology
Zeynep Busra Balik, Ahmet Rifat Balik, Cigdem Yucel, Yildiz Hayran, Ercan Caliskan, Ozcan Erel
Summary: This study investigates the relationship between thiol-disulfide homeostasis and ischemia-modified albumin in Hidradenitis suppurativa (HS). The results show an increase in disulfide levels and a significant increase in IMA levels in patients with HS, suggesting the importance of oxidation status in the etiopathogenesis of HS.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hamza Ayaydin, Fethiye Kilicaslan, Ismail Koyuncu, Hakim Celik, Mustafa Calik, Ahmet Guzelcicek, Adnan Kirmit
Summary: This study found that impaired dynamic thiol/disulfide homeostasis in the serum of children with ASD may have diagnostic value for autism. Various thiol/disulfide parameters showed significant differences between the ASD group and the control group, indicating potential as diagnostic markers for autism.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2021)
Article
Toxicology
F. Kar, I Sogut, C. Hacioglu, Y. Goncu, H. Senturk, A. Senat, O. Erel, N. Ay, G. Kanbak
Summary: The study found that higher doses of hBN NPs caused oxidative stress in rat serum dose-dependently, but did not affect the thiol/disulfide balance in kidney, liver, spleen, pancreas, and heart tissues of rats. Additionally, hBN NPs increased serum disulfide formation by disrupting the thiol/disulfide balance in rats, leading to an increase in LOOH and MPO levels at high doses and a statistically significant decrease in CAT levels.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2021)
Article
Medicine, General & Internal
Mehmet Semih Demirtas, Huseyin Erdal
Summary: The aim of this study was to evaluate oxidative stress and thiol-disulfide homeostasis in term newborns receiving phototherapy for hyperbilirubinemia. Blood samples were taken before and after phototherapy from 28 term newborns, and levels of total and native thiol, total antioxidant status (TAS) and total oxidant status (TOS), and oxidative stress index (OSI) were measured. The results showed that phototherapy caused a decrease in thiol levels and an increase in oxidative stress markers. The study concluded that thiol-disulfide homeostasis can be used as a marker of oxidative stress in neonates with hyperbilirubinemia.
JOURNAL OF INVESTIGATIVE MEDICINE
(2023)
Article
Veterinary Sciences
Osman Safa Terzi, Erdal Kara, Yasin Senel, Ebubekir Ceylan, Salim Neselioglu, Ozcan Erel
Summary: The study investigates the TDH parameters and IMA levels in calves with neonatal diarrhea compared to healthy controls. The results show that calves with neonatal diarrhea have significantly decreased levels of native thiol and total thiol compared to healthy controls. The study also finds that IMA levels are increased in calves with neonatal diarrhea due to oxidative stress.
ANKARA UNIVERSITESI VETERINER FAKULTESI DERGISI
(2023)
Article
Obstetrics & Gynecology
Burak Sezgin, Fatih Pirincci, Aysun Camuzcuoglu, E. Adeviye Sahin, Ozcan Erel, Salim Neselioglu, Hakan Camuzcuoglu
Summary: The study showed that patients with high-grade squamous intraepithelial lesion have significantly lower levels of native thiol and total thiol, and significantly higher levels of disulfide, indicating more severe oxidative stress damage in these patients.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Medicine, Research & Experimental
Ceylan Bal, Canan Topcuoglu, Ahmet Rifat Balik, Fatma Meric Yilmaz, Ozcan Erel, Gulsen Yilmaz
Summary: Twenty-four-hour urine measurements are crucial for diagnosing, monitoring, and treating various diseases. Different collection methods can affect the results of certain tests, such as chloride, microalbumin, amylase, and protein. The measurement of adrenaline, noradrenaline, and dopamine should be done in acid-added urine.
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
(2022)
Article
Medical Laboratory Technology
Elif Guler Kazanci, Muhammet Furkan Korkmaz, Funda Eren, Ozcan Erel
Summary: This study aimed to evaluate the oxidant/antioxidant balance in individuals with beta-thalassemia major (beta-TM) and healthy children, and found that thiol/disulfide homeostasis was weakened in beta-TM patients. The study also revealed that the oxidant imbalance worsened when beta-TM patients did not receive regular chelation therapy.
LABORATORY MEDICINE
(2023)
Article
Medical Laboratory Technology
Yunus H. Polat, Sukran Erten, Ahmet Kor, Ismail Dogan, Yuksel Maras, Orhan Kucuksahin, Guniz Y. Ustuner, Ozcan Erel
Summary: This study aimed to evaluate the thiol/disulfide balance in patients with rheumatoid arthritis (RA) compared to healthy controls, and to examine its relationship with Disease Activity Score-28 (DAS28). The results showed that RA patients had lower thiol levels and higher disulfide levels compared to controls. Additionally, the group in remission had higher thiol levels and lower disulfide levels compared to other DAS28 groups. These findings suggest that the antioxidant defense system is impaired in RA patients, leading to oxidative stress and imbalance.
CLINICAL BIOCHEMISTRY
(2023)
Article
Neurosciences
Birsen Can Demirdogen, Osman Oguzhan Kilic, Ata Ayhan Yilmaz, Semra Mungan, Salim Neselioglu, Ozcan Erel
Summary: This study aimed to investigate the association between cognitive impairment and oxidative stress biomarkers TDH and IMA in multiple sclerosis patients. The results showed that plasma native thiol and total thiol levels were significantly decreased in patients with SPMS. The study also found significant correlations between TDH, BICAMS scores, clinical indices of disease severity, and MRI parameters.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Pathology
Ilknur Surucu Kara, Cuma Mertoglu, Guelsah Siranli, Yusuf Kemal Arslan, Gamze Gok, Ozcan Erel
Summary: The aim of the study is to examine the relationship between obesity, Vitamin-D deficiency, and protein oxidation. The results showed that obese children had lower vitamin-D levels than pre-obese and normal-weight children. Thiol-disulfide homeostasis was negatively affected by low vitamin D levels, pubertal period, and high triglyceride levels.
FETAL AND PEDIATRIC PATHOLOGY
(2023)
Article
Pharmacology & Pharmacy
Selin Ozkan-Kotiloglu, Dilek Kaya-Akyuzlu, Safak Yalcin-Sahiner, Nagihan Ayaz
Summary: The aim of this study was to evaluate the association between OPRK1 rs963549 and rs997917 and opioid use disorder (OUD) and related phenotypes. A total of 208 individuals with (n = 100) and without (n = 108) OUD participated in the study. OPRK1 rs963549 and rs997917 were analyzed using PCR-RFLP. Craving, opioid withdrawal, and the intensity of depressive and anxiety symptoms were measured using appropriate scales. The results showed a trend of association between OPRK1 rs963549 variation and decreased opioid withdrawal. There were no significant associations between OPRK1 rs963549 and rs997917 polymorphisms and craving, depression, or anxiety symptoms. Neither single OPRK1 SNPs nor OPRK1 haplotypes were associated with OUD.
Article
Medicine, General & Internal
Kadriye Erdogan, Nazli Tunca Sanlier, Emine Utlu Ozen, Sueleyman Erol, Inci Kahyaoglu, Salim Neselioglu, Ozcan Erel, Serra Akar, Yaprak Engin Ustun
Summary: This study evaluates the role of oxidative stress in unexplained infertility (UEI) by assessing dysfunctional high-density lipoprotein (HDL) through the myeloperoxidase (MPO) and paraoxonase (PON) ratio. The results show that patients with UEI have higher total dosages of gonadotropin, lower number of Grade 1 embryos and quality of blastocysts, and higher serum MPO/PON ratio. Serum MPO/PON ratio can significantly predict the duration of infertility.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Sukru Alperen Korkmaz, Sadice Kizgin, Esra Firat Oguz, Salim Neselioglu, Ozcan Erel
Summary: This study found significant differences in levels of thiol-disulphide parameters, ischemia-modified albumin (IMA), and C-reactive protein (CRP) between bipolar disorder (BD) patients in acute mania and early remission compared to healthy controls. Additionally, during the manic phase, markers such as neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammatory index (SII), platelet-to-albumin ratio (PAR), and CRP levels were significantly higher. These findings highlight the importance of inflammation in bipolar disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Cetin Turan, Guliz Senormanci, Salim Neselioglu, Yasemin Budak, Ozcan Erel, Omer Senormanci
Summary: This study aimed to investigate the differences in oxidative stress and systemic inflammation biomarkers between methamphetamine users and the control group. Serum thiol/disulfide balance and ischemia-modified albumin levels were used to assess oxidative stress, while serum interleukin-6 (IL-6) levels and complete blood count (CBC) were used to evaluate inflammation.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2023)
Article
Neurosciences
Almila Senat, Esra Kabadayi-Sahin, Ibrahim Sogut, Tomris Duymaz, Ozcan Erel
Summary: This study aimed to evaluate oxidative contributors of atherosclerotic risk factors in patients with Alcohol Use Disorder (AUD). The results showed significantly elevated oxidative markers in AUD patients and decreased antioxidant capacity. Atherosclerotic markers were also higher and correlated with alcohol intake. Thus, oxidative markers may serve as indicators for atherosclerotic risk and therapeutic interventions targeting oxidative load may help prevent clinical manifestation of atherosclerotic diseases.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Yasemin Dogan, Yucel Yilmaz, Saban Kelesoglu, Bekir Calapkorur, Salim Neselioglu, Ozcan Erel, Nihat Kalay
Summary: The aim of this study was to investigate the relationship between thiol, the main component of the antioxidant system, and coronary collateral circulation (CCC). The results showed that patients with stable coronary artery disease (sCAD) who developed poor CCC had lower levels of native thiol, total thiol, and disulfide compared to those with good CCC. Additionally, DM, total thiol, and disulfide were identified as independent predictors of poor CCC.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Gamze Yilmaz, Salim Neselioglu, Fatma Nur Ceylan, Burak Elmas, Fatmanur Ece Aydogdu, Ozcan Erel, Ozlem Uzunlar, Esma Sarikaya, Ozlem Moraloglu Tekin
Summary: This study reveals that the highest level of antioxidant status can be observed in full-term pregnancies, and it is correlated with better APGAR scores in newborns. However, no significant difference in maternal oxidant balance was found between different gestational stages.
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2023)
Article
Medicine, General & Internal
Ozgul Ozgan Celikel, Gamze Gok, Ozcan Erel, Filiz Yildirim
Summary: The aim of the study was to evaluate the potential changes in thiol-disulfide levels according to the type of anesthesia in patients who underwent cesarean section. The analysis of blood samples showed significant differences in thiol and disulfide measurements before and after anesthesia. The results indicate that anesthesia is safe in terms of its potential to cause oxidant damage.
ANNALS OF CLINICAL AND ANALYTICAL MEDICINE
(2022)
