Journal
PSYCHIATRY AND CLINICAL NEUROSCIENCES
Volume 71, Issue 10, Pages 673-677Publisher
WILEY
DOI: 10.1111/pcn.12539
Keywords
Alzheimer's disease; amyloid beta clearance; glymphatic system; sleep; sleep deprivation
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Sleep is an important factor that plays a key role in Alzheimer's disease pathogenesis. However, it is still unclear whether poor-quality sleep may overlap with sleep disturbances in the underlying dysfunctional mechanisms of amyloid beta (A) clearance metabolism. Here, we aimed to evaluate the current evidence on the role of sleep deprivation in A clearance metabolism. To that end, we discuss possible mechanisms underlying the bidirectional interaction between the sleep deprivation and A clearance pathways.
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