A guide to the effects of a large portion of the residues of triosephosphate isomerase on catalysis, stability, druggability, and human disease

The effect of specific proline residues on the kinetic stability of the triosephosphate isomerases of two trypanosomes

(2017) Valeria Guzmán-Luna et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Interplay between Protein Thermal Flexibility and Kinetic Stability

(2017) Andrea G. Quezada et al.   STRUCTURE

Structure–Function Studies of Hydrophobic Residues That Clamp a Basic Glutamate Side Chain during Catalysis by Triosephosphate Isomerase

(2016) John P. Richard et al.   BIOCHEMISTRY

Proton pump inhibitors drastically modify triosephosphate isomerase from Giardia lamblia at functional and structural levels, providing molecular leads in the design of new antigiardiasic drugs

(2016) Itzhel García-Torres et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Structural insights from a novel invertebrate triosephosphate isomerase from Litopenaeus vannamei

(2016) Alonso A. Lopez-Zavala et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Connecting Active-Site Loop Conformations and Catalysis in Triosephosphate Isomerase: Insights from a Rare Variation at Residue 96 in the Plasmodial Enzyme

(2016) Vidhi Pareek et al.   CHEMBIOCHEM

Identification of the critical residues responsible for differential reactivation of the triosephosphate isomerases of two trypanosomes

(2016) Monica Rodríguez-Bolaños et al.   Open Biology

Structural and Genetic Studies Demonstrate Neurologic Dysfunction in Triosephosphate Isomerase Deficiency Is Associated with Impaired Synaptic Vesicle Dynamics

(2016) Bartholomew P. Roland et al.   PLoS Genetics

Structural Basis for Redox Regulation of Cytoplasmic and Chloroplastic Triosephosphate Isomerases from Arabidopsis thaliana

(2016) Laura M. López-Castillo et al.   Frontiers in Plant Science

Cytosolic Triosephosphate Isomerase from Arabidopsis thaliana Is Reversibly Modified by Glutathione on Cysteines 127 and 218

(2016) Sébastien Dumont et al.   Frontiers in Plant Science

Triosephosphate isomerase I170V alters catalytic site, enhances stability and induces pathology in a Drosophila model of TPI deficiency

(2015) Bartholomew P. Roland et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Probing the role of highly conserved residues in triosephosphate isomerase - analysis of site specific mutants at positions 64 and 75 in thePlasmodialenzyme

(2015) Debarati Bandyopadhyay et al.   FEBS Journal

Substrate-Induced Dimerization of Engineered Monomeric Variants of Triosephosphate Isomerase from Trichomonas vaginalis

(2015) Samuel Lara-Gonzalez et al.   PLoS One

Structural Effects of Protein Aging: Terminal Marking by Deamidation in Human Triosephosphate Isomerase

(2015) Ignacio de la Mora-de la Mora et al.   PLoS One

Giardial Triosephosphate Isomerase as Possible Target of the Cytotoxic Effect of Omeprazole in Giardia lamblia

(2014) Horacio Reyes-Vivas et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Enzyme Architecture: The Effect of Replacement and Deletion Mutations of Loop 6 on Catalysis by Triosephosphate Isomerase

(2014) Xiang Zhai et al.   BIOCHEMISTRY

Reflections on the catalytic power of a TIM-barrel

(2014) John P. Richard et al.   BIOORGANIC CHEMISTRY

Hemolytic Anemia and Progressive Neurologic Impairment: Think About Triosephosphate Isomerase Deficiency

(2014) Khaoula Aissa et al.   Fetal and Pediatric Pathology

A redesigned Escherichia coli triosephosphate isomerase restores growth properties in a bacterial strain useful for Immobilized Metal Affinity Chromatography (IMAC)

(2014) R. Haley et al.   JOURNAL OF BIOTECHNOLOGY

The E104D mutation increases the susceptibility of human triosephosphate isomerase to proteolysis. Asymmetric cleavage of the two monomers of the homodimeric enzyme

(2013) Ignacio De La Mora-De La Mora et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Introduction of a thermophile-sourced ion pair network in the fourth beta/alpha unit of a psychophile-derived triosephosphate isomerase from Methanococcoides burtonii significantly increases its kinetic thermal stability

(2013) Neeraj Dhaunta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

MMDB and VAST+: tracking structural similarities between macromolecular complexes

(2013) Thomas Madej et al.   NUCLEIC ACIDS RESEARCH

Structural and Functional Perturbation of Giardia lamblia Triosephosphate Isomerase by Modification of a Non-Catalytic, Non-Conserved Region

(2013) Gloria Hernández-Alcántara et al.   PLoS One

Different contribution of conserved amino acids to the global properties of triosephosphate isomerases

(2013) Yolanda Aguirre et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Mechanism for Activation of Triosephosphate Isomerase by Phosphite Dianion: The Role of a Hydrophobic Clamp

(2012) M. Merced Malabanan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural insights into the editing of germ-line-encoded interactions between T-cell receptor and MHC class II by V  CDR3

(2012) L. Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The folding pathway of glycosomal triosephosphate isomerase: Structural insights into equilibrium intermediates

(2012) Valeria Guzman-Luna et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Energy metabolism and ageing regulation: Metabolically driven deamidation of triosephosphate isomerase may contribute to proteostatic dysfunction

(2011) Alan R. Hipkiss   AGEING RESEARCH REVIEWS

Probing the role of the fully conserved Cys126 in triosephosphate isomerase by site-specific mutagenesis - distal effects on dimer stability

(2011) Moumita Samanta et al.   FEBS Journal

Evolutionary Walk between (β/α)8 Barrels: Catalytic Migration from Triosephosphate Isomerase to Thiamin Phosphate Synthase

(2011) Gloria Saab-Rincón et al.   JOURNAL OF MOLECULAR BIOLOGY

The adaptive evolution divergence of triosephosphate isomerases between parasitic and free-living flatworms and the discovery of a potential universal target against flatworm parasites

(2011) Bing Chen et al.   PARASITOLOGY RESEARCH

Triosephosphate Isomerase Deficiency: A Patient With Val231Met Mutation

(2011) Gul Serdaroglu et al.   PEDIATRIC NEUROLOGY

Identification of Amino Acids that Account for Long-Range Interactions in Two Triosephosphate Isomerases from Pathogenic Trypanosomes

(2011) Itzhel García-Torres et al.   PLoS One

A Ribosomal Misincorporation of Lys for Arg in Human Triosephosphate Isomerase Expressed in Escherichia coli Gives Rise to Two Protein Populations

(2011) Beatriz Aguirre et al.   PLoS One

Engineered dimer interface mutants of triosephosphate isomerase: the role of inter-subunit interactions in enzyme function and stability

(2011) M. Banerjee et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Determining the molecular mechanism of inactivation by chemical modification of triosephosphate isomerase from the human parasite Giardia lamblia: A study for antiparasitic drug design

(2011) Sergio Enríquez-Flores et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Mass spectrometric identification of an intramolecular disulfide bond in thermally inactivated triosephosphate isomerase from a thermophilic organism Methanocaldococcus jannaschii

(2011) Mousumi Banerjee et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Role of Lys-12 in Catalysis by Triosephosphate Isomerase: A Two-Part Substrate Approach

(2010) Maybelle K. Go et al.   BIOCHEMISTRY

Triosephosphate isomerase: a highly evolved biocatalyst

(2010) R. K. Wierenga et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Homodimeric Enzymes as Drug Targets

(2010) D. Cardinale et al.   CURRENT MEDICINAL CHEMISTRY

A role for flexible loops in enzyme catalysis

(2010) M Merced Malabanan et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Analysis of nucleotide variation within the triose-phosphate isomerase gene ofGiardia duodenalisfrom sheep and its zoonotic implications

(2010) Matthew J. Nolan et al.   ELECTROPHORESIS

An internal sequence targets Trypanosoma brucei triosephosphate isomerase to glycosomes

(2010) Nathalie Galland et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

A theoretical study to establish the relationship between the three-dimensional structure of triose-phosphate isomerase of Giardia duodenalis and point mutations in the respective gene

(2010) Matthew J. Nolan et al.   MOLECULAR AND CELLULAR PROBES

Theoretical analysis of intermolecular interactions of selected residues of triosephosphate isomerase from Trypanosoma cruzi with its inhibitor 3-(2-benzothiazolylthio)-1-propanesulfonic acid

(2010) Rodrigo Chávez-Calvillo et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Crystal structure of recombinant human triosephosphate isomerase at 2.8 Å resolution. Triosephosphate isomerase-related human genetic disorders and comparison with the trypanosomal enzyme

(2010) Shekhar C. Mande et al.   PROTEIN SCIENCE

Biochemical and structural characterization of residue 96 mutants ofPlasmodium falciparumtriosephosphate isomerase: active-site loop conformation, hydration and identification of a dimer-interface ligand-binding site

(2009) P. Gayathri et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Tyr74 is essential for the formation, stability and function of Plasmodium falciparum triosephosphate isomerase dimer

(2009) L. Michel Espinoza-Fonseca et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Role of Loop−Loop Interactions in Coordinating Motions and Enzymatic Function in Triosephosphate Isomerase

(2009) Yan Wang et al.   BIOCHEMISTRY

Triosephosphate isomerase deficiency: New insights into an enigmatic disease

(2009) Ferenc Orosz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Attenuation of ionic interactions profoundly lowers the kinetic thermal stability of Pyrococcus furiosus triosephosphate isomerase

(2009) Sanjeev Kumar Chandrayan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Selective inactivation of triosephosphate isomerase from Trypanosoma cruzi by brevifolin carboxylate derivatives isolated from Geranium bellum Rose

(2009) Juan Gayosso-De-Lucio et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation

(2009) Francesc X. Guix et al.   BRAIN

Structural effects of a dimer interface mutation on catalytic activity of triosephosphate isomerase

(2009) Mousumi Banerjee et al.   FEBS Journal

Triosephosphate isomerase activity-deficient mice show haemolytic anaemia in homozygous condition

(2009) WALTER PRETSCH   Genetics Research

Interaction of triosephosphate isomerase from the cell surface of Staphylococcus aureus and  -(1->3)-mannooligosaccharides derived from glucuronoxylomannan of Cryptococcus neoformans

(2009) H. Furuya et al.   MICROBIOLOGY-SGM

The role of quaternary structure in (β/α)8-barrel proteins: evolutionary happenstance or a higher level of structure-function relationships?

(2009) Sean R A Devenish et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Structural studies show that the A178L mutation in the C-terminal hinge of the catalytic loop-6 of triosephosphate isomerase (TIM) induces a closed-like conformation in dimeric and monomeric TIM

(2008) Markus Alahuhta et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Hydrophobic Repacking of the Dimer Interface of Triosephosphate Isomerase by in Silico Design and Directed Evolution†‡

(2008) Mariana Peimbert et al.   BIOCHEMISTRY

Key Residues of Loop 3 in the Interaction with the Interface Residue at Position 14 in Triosephosphate Isomerase fromTrypanosoma brucei†

(2008) Nallely Cabrera et al.   BIOCHEMISTRY

Unraveling the mechanisms of tryptophan fluorescence quenching in the triosephosphate isomerase from Giardia lamblia

(2008) Gloria Hernández-Alcántara et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Degradation of Functional Triose Phosphate Isomerase Protein Underlies sugarkill Pathology

(2008) Jacquelyn L. Seigle et al.   GENETICS

Structural Basis of Human Triosephosphate Isomerase Deficiency

(2008) Claudia Rodríguez-Almazán et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Triosephosphate Isomerase Genes in Two Trophic Modes of Euglenoids (Euglenophyceae) and Their Phylogenetic Analysis

(2008) GUI-LING SUN et al.   JOURNAL OF EUKARYOTIC MICROBIOLOGY

The conserved salt bridge linking two C-terminal β/α units in homodimeric triosephosphate isomerase determines the folding rate of the monomer

(2008) César A. Reyes-López et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Species-specific inhibition of Giardia lamblia triosephosphate isomerase by localized perturbation of the homodimer

(2007) Sergio Enriquez-Flores et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Kinetic and structural properties of triosephosphate isomerase fromHelicobacter pylori

(2007) Chen-Hsi Chu et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS