Targeting Th17-IL-17 Pathway in Prevention of Micro-Invasive Prostate Cancer in a Mouse Model

Interleukin-17 promotes prostate cancer via MMP7-induced epithelial-to-mesenchymal transition

(2016) Q Zhang et al.   ONCOGENE

Deficiency of IL-17A, but not the prototypical Th17 transcription factor RORγt, decreases murine spontaneous intestinal tumorigenesis

(2015) Mia Shapiro et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Oncogenic Kras Activates a Hematopoietic-to-Epithelial IL-17 Signaling Axis in Preinvasive Pancreatic Neoplasia

(2014) Florencia McAllister et al.   CANCER CELL

Effect of IL-17A on the Migration and Invasion of NPC Cells and Related Mechanisms

(2014) Lixin Wang et al.   PLoS One

Interleukin-17 promotes development of castration-resistant prostate cancer potentially through creating an immunotolerant and pro-angiogenic tumor microenvironment

(2014) Qiuyang Zhang et al.   PROSTATE

The Role and Regulation of Human Th17 Cells in Tumor Immunity

(2012) Jian Ye et al.   AMERICAN JOURNAL OF PATHOLOGY

Interleukin-17 Promotes Formation and Growth of Prostate Adenocarcinoma in Mouse Models

(2012) Q. Zhang et al.   CANCER RESEARCH

Role of IL-17A in the development of colitis-associated cancer

(2012) Y. S. Hyun et al.   CARCINOGENESIS

Interleukin-17 and Prostaglandin E2 Are Involved in Formation of an M2 Macrophage-Dominant Microenvironment in Lung Cancer

(2012) Lunxu Liu et al.   Journal of Thoracic Oncology

Therapeutic potential of targeting IL-17

(2012) Sarah A Jones et al.   NATURE IMMUNOLOGY

Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis

(2012) Kim A. Papp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Anti–Interleukin-17 Monoclonal Antibody Ixekizumab in Chronic Plaque Psoriasis

(2012) Craig Leonardi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypoxia Induced Aggressiveness of Prostate Cancer Cells Is Linked with Deregulated Expression of VEGF, IL-6 and miRNAs That Are Attenuated by CDF

(2012) Bin Bao et al.   PLoS One

Clinical Impact of Different Classes of Infiltrating T Cytotoxic and Helper Cells (Th1, Th2, Treg, Th17) in Patients with Colorectal Cancer

(2011) Marie Tosolini et al.   CANCER RESEARCH

Increased interleukin (IL)-8 and decreased IL-17 production in chronic obstructive pulmonary disease (COPD) provoked by cigarette smoke

(2011) Xiaojun Zhang et al.   CYTOKINE

Prostate cancer and inflammation: the evidence

(2011) Karen S Sfanos et al.   HISTOPATHOLOGY

Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand

(2011) Laura A. Solt et al.   NATURE

Zeb1 is required for TrkB-induced epithelial-mesenchymal transition, anoikis resistance and metastasis

(2011) M A Smit et al.   ONCOGENE

Th17 Cells Are Involved in the Local Control of Tumor Progression in Primary Intraocular Lymphoma

(2011) Claire Galand et al.   PLoS One

TGF-  Receptor II Loss Promotes Mammary Carcinoma Progression by Th17-Dependent Mechanisms

(2011) S. V. Novitskiy et al.   Cancer Discovery

The M1 form of tumor-associated macrophages in non-small cell lung cancer is positively associated with survival time

(2010) Junliang Ma et al.   BMC CANCER

ERβ Impedes Prostate Cancer EMT by Destabilizing HIF-1α and Inhibiting VEGF-Mediated Snail Nuclear Localization: Implications for Gleason Grading

(2010) Paul Mak et al.   CANCER CELL

IL-17 Enhances Tumor Development in Carcinogen-Induced Skin Cancer

(2010) L. Wang et al.   CANCER RESEARCH

Distribution of Th17 cells and FoxP3(+) regulatory T cells in tumor-infiltrating lymphocytes, tumor-draining lymph nodes and peripheral blood lymphocytes in patients with gastric cancer

(2010) Takanori Maruyama et al.   CANCER SCIENCE

IL-17 signaling in host defense and inflammatory diseases

(2010) Youcun Qian et al.   Cellular & Molecular Immunology

Induction of Th17 Cells in the Tumor Microenvironment Improves Survival in a Murine Model of Pancreatic Cancer

(2010) J. L. Gnerlich et al.   JOURNAL OF IMMUNOLOGY

Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis

(2010) W. Hueber et al.   Science Translational Medicine

Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments

(2009) I. Kryczek et al.   BLOOD

IFN  Promotes Papilloma Development by Up-regulating Th17-Associated Inflammation

(2009) M. Xiao et al.   CANCER RESEARCH

The tumor-promoting actions of TNF-α involve TNFR1 and IL-17 in ovarian cancer in mice and humans

(2009) Kellie A. Charles et al.   JOURNAL OF CLINICAL INVESTIGATION

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

(2009) Shaoguang Wu et al.   NATURE MEDICINE

Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myeloma

(2008) K. M. Dhodapkar et al.   BLOOD

Tumor-specific Th17-polarized cells eradicate large established melanoma

(2008) P. Muranski et al.   BLOOD

Phenotypic Analysis of Prostate-Infiltrating Lymphocytes Reveals TH17 and Treg Skewing

(2008) K. S. Sfanos et al.   CLINICAL CANCER RESEARCH

Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis

(2008) Jing Yang et al.   DEVELOPMENTAL CELL