Journal
PROSTAGLANDINS & OTHER LIPID MEDIATORS
Volume 133, Issue -, Pages 20-28Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.prostaglandins.2017.03.003
Keywords
Human coronary artery; Prostanoid; Coronary artery disease; COX inhibitors; Vascular tone; Vascular remodelling
Categories
Ask authors/readers for more resources
Coronary artery disease is one of the leading causes of death in wordwide. There is growing evidence that prostanoids are involved in the physiology and pathophysiology of the human coronary artery by controlling vascular tone, remodelling of the vascular wall or angiogenesis. In this review, the production of prostanoids and the expression of prostanoid receptors in human coronary artery in health or disease are described. In addition, the interactions between sex hormones and prostanoids, their participations in the development of coronary artery diseases have been addressed. Globally, most of the studies performed in human coronary artery preparations have shown that prostacyclin (PGI(2)) has beneficial effects by inducing vasodilatation and promoting angiogenesis while reverse effects are confirmed by thromboxane A(2) (TxA(2)). More studies are needed to determine the roles of the other prostanoids (PGE(2), PGD(2) and PGF(2).) in vascular functions of the human coronary artery. Finally, in addition to the in vitro data about the human coronary artery, myocardial infarction induced by cyclooxygenase-2 (COX -2) inhibitor and the protective effects of aspirin after coronary artery bypass surgery suggest that prostanoids are key mediators in coronary homeostasis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available