Journal
PROGRESS IN POLYMER SCIENCE
Volume 65, Issue -, Pages 83-126Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.progpolymsci.2016.09.002
Keywords
Biomaterial; Embryonic stem cell; Induced pluripotent stem cell; Differentiation; Hydrogel; Nanofiber
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Funding
- Ministry of Science and Technology, Taiwan [104-2221-E-008-107-MY3]
- LandSeed Hospital project [NCU-LSH-104-A-001, NCU-LSH-105-A-001]
- Cathay General Hospital Project [104CGH-NCU-A3, 105CGH-NCU-A3]
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [15K06591]
- Grants-in-Aid for Scientific Research [15K06591] Funding Source: KAKEN
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Human pluripotent stem cells (hPSCs), including embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs), have the potential to differentiate into many cell types that originate from the three germ layers, such as dopamine-secreting cells and insulin-secreting cells for the treatment of Alzheimer's disease and diabetes, respectively. However, it is challenging to guide hPSC differentiation into desired cell lineages due to their varying differentiation ability. A reasonable strategy is to mimic the stem cell microenvironment for the differentiation of hPSCs into specific cell lineages using optimal polymeric biomaterials for hPSC culture. This review summarizes various methods for differentiating hPSCs cultured on polymeric biomaterials and discusses the optimal methods and cell culture polymeric biomaterials for hPSC differentiation into specific cell lineages. The recent trend in protocols avoids embryoid body (EB, aggregated,cells) formation because EBs contain different types of cells. The combination of appropriate differentiation protocols and cell culture polymeric biomaterials for the differentiation of hPSCs into specific cell lineages will produce a large quantity of highly pure GMP-grade differentiated cells for use in translational medicine. (C) 2016 Elsevier Ltd. All rights reserved.
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