Review
Biochemistry & Molecular Biology
Annette Peters, Tim S. Nawrot, Andrea A. Baccarelli
Summary: Environmental insults such as contaminated air, water, and food expose human beings to a plethora of chemicals and stressors, impacting health at all stages of life. The proposed eight hallmarks of environmental insults encompass oxidative stress, genomic alterations, epigenetic changes, and disruptions to various bodily functions, offering insight into the severe health effects induced by complex mixtures of environmental exposures.
Review
Biochemistry & Molecular Biology
Katelyn Cuttler, Maryam Hassan, Jonathan Carr, Ruben Cloete, Soraya Bardien
Summary: Synaptopathies are brain disorders characterized by dysfunctional synapses, which are essential for transmitting information between neurons. Neurexins, a type of synaptic cell adhesion molecule, have gained interest due to their association with neuropsychiatric disorders and neurodegenerative disorders. Both changes in neurexin expression and mutations have been implicated in diseases such as autism spectrum disorder and Parkinson's disease.
Review
Medicine, General & Internal
Ewa Szczepanska-Sadowska, Agnieszka Wsol, Agnieszka Cudnoch-Jedrzejewska, Katarzyna Czarzasta, Tymoteusz Zera
Summary: The cardiovascular system and the central nervous system closely cooperate in regulating vital functions. Several compounds, including the renin-angiotensin system, the vasopressin system, and the oxytocin system, modulate processes in the CNS. Dysfunctions in these systems contribute to neuropsychiatric and neurodegenerative diseases. Understanding their multiple actions can lead to more effective treatments.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Psychiatry
Hiroki Ishiguro, Berhanu Geresu Kibret, Yasue Horiuchi, Emmanuel S. Onaivi
Summary: The endocannabinoid system (ECS) is an important biological system composed of cannabinoid receptors and endocannabinoids, which have diverse physiological effects and potential for treating neuropsychiatric disorders.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Neurosciences
Boby Mathew, M. Shahid Mansuri, Kenneth R. Williams, Angus C. Nairn
Summary: Exosomes are synthesized by various cell types, containing proteins, lipids, metabolites, and RNA that can serve as disease biomarkers. Challenges in isolating exosomes stem from their diverse shapes and variable tissue origins, while analytical techniques for protein detection may struggle with low protein quantities. Despite these obstacles, advancements in proteomics are enhancing exosome research for disease-associated protein biomarkers.
Article
Biochemistry & Molecular Biology
Rachel Schroeder, Preethy Sridharan, Lynn Nguyen, Alexandra Loren, Noelle S. Williams, Kavitha P. Kettimuthu, Coral J. Cintron-Perez, Edwin Vazquez-Rosa, Andrew A. Pieper, Hanna E. Stevens
Summary: Prenatal stress affects embryonic brain development by dysregulating NAD(+) synthesis machinery and GABAergic interneuron development, leading to cognitive deficits and depression-like behavior in adulthood. Maternal administration of the NAD(+) modulator, P7C3-A20, protects offspring from the detrimental effects of prenatal stress.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Neurosciences
Luciana Cristina B. Fernandes, Ianara Mendonca Costa, Marco Aurelio M. Freire, Francisca Overlania V. Lima, Francisca Idalina Neta, Eudes Euler de Souza Lucena, Rodrigo Dias Alves, Jose Rodolfo Lopes P. Cavalcanti, Francisco Irochima Pinheiro, Eduardo Pereira de Azevedo, Carlos Ibere A. Freitas, Fausto Pierdona Guzen
Summary: The study reveals that essential oils have positive effects on neurological disorders such as anxiety, dementia, oxidative stress, cerebral ischemia, and oxidative toxicity, showing potential as alternative agents in the treatment of neurological disorders.
CURRENT NEUROPHARMACOLOGY
(2021)
Review
Cell Biology
Masaru Tanaka, Agnes Szabo, Eleonora Spekker, Helga Polyak, Fanni Toth, Laszlo Vecsei
Summary: The cytoplasmic inheritance of human chloramphenicol resistance, which is mediated by mitochondrial DNA (mtDNA), has been discovered for almost half a century. Mutations in mtDNA have been found to cause severe inheritable metabolic diseases and neurodegenerative diseases. Recent studies have shown that impaired mitochondrial functions and loss of mitochondrial stress resilience can influence animal behaviors. In addition, the activation of the tryptophan-kynurenine metabolic system, which is related to stress and inflammation, has been linked to the development of neurological and psychiatric disorders.
Review
Biochemistry & Molecular Biology
Sen Zhang, Ying-Dan Zhang, Dong-Dong Shi, Zhen Wang
Summary: Oxytocin plays an important role and has therapeutic potential in stress-related neuropsychiatric disorders. This article summarizes the mechanism of oxytocin's anti-stress action, advances in its treatment applications, and methods to increase oxytocin levels in stress-related neuropsychiatric disorders.
CELL AND BIOSCIENCE
(2023)
Article
Neurosciences
Rohan Gupta, Dia Advani, Divya Yadav, Rashmi K. Ambasta, Pravir Kumar
Summary: Neurodegenerative diseases (NDDs) and neuropsychiatric disorders (NPDs) are common causes of death in elderly people, characterized by neuronal cell death and behavioral changes. They share overlapping mechanisms such as post-translational modifications, the microbiota-gut-brain axis, and signaling events. Natural compounds, repurposed drugs, multitarget directed ligands, and RNAs have shown potential as therapeutic agents against NDDs and NPDs.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Psychiatry
Sarah Hartman, Jay Belsky, Michael Pluess
Summary: According to various theories, individuals vary in their sensitivity to environmental influences, with some being more susceptible to both positive and negative contextual conditions. This sensitivity has a genetic basis but is also influenced by environmental factors. This article proposes that prenatal experiences contribute to the development of environmental sensitivity and provides empirical evidence to support this hypothesis. The study explores the biological mechanisms involved in the pathway from prenatal stress exposure to postnatal environmental sensitivity and discusses factors that may moderate the effects of prenatal programming. Additionally, the article highlights unknowns in prenatal programming and their practical implications.
TRANSLATIONAL PSYCHIATRY
(2023)
Review
Endocrinology & Metabolism
Parnian Shobeiri, Amirali Kalantari, Antonio L. Teixeira, Nima Rezaei
Summary: There are gender differences in vulnerability to neuropsychiatric disorders, with genetic factors and sex hormones playing important roles. Recent evidence suggests that interactions between sex-related features and gut microbiota may contribute to the development of these disorders. Understanding the effects of sex differences on the brain and gut microbiota, as well as their interaction, could advance our knowledge of the pathogenesis and treatment of neuropsychiatric disorders.
BIOLOGY OF SEX DIFFERENCES
(2022)
Article
Nutrition & Dietetics
Elena Gonzalez-Burgos, Isabel Urena-Vacas, Marta Sanchez, M. Pilar Gomez-Serranillos
Summary: Moringa oleifera leaf powder methanol extracts possess high phenolic content and antioxidant activity, providing neuroprotective effects against H2O2-induced oxidative stress and safeguarding mitochondrial function.
Review
Biochemistry & Molecular Biology
Yue Jin, Da Song, Yan Yan, Zhenzhen Quan, Hong Qing
Summary: Early-life stress can have long-term effects on physical and mental health by altering the oxytocin system. Oxytocin is a critical hormone that regulates social behaviors and alleviates diseases. Stress-related neuropsychiatric disorders, such as anxiety and depression, can be treated by targeting the oxytocin system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Multidisciplinary
Zikhona Tywabi-Ngeva, Abiodun Olagoke Adeniji, Kunle Okaiyeto
Summary: This study evaluates the research growth on neurotoxicants and their effects on humans and the environment over the past decade. Results show a positive trend of research in this field, contributing to reducing exposure and disorders linked to neurotoxicants.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Georgina Rodriguez de Lores Arnaiz, Marta C. Antonelli
NEUROCHEMICAL RESEARCH
(2016)
Review
Neurosciences
Veronica Pastor, Marta Cristina Antonelli, Maria Eugenia Pallares
NEUROTOXICITY RESEARCH
(2017)
Article
Neurosciences
Cristina E. Gallegos, Mariana Bartos, Cristina Bras, Fernanda Gumilar, Marta C. Antonelli, Alejandra Minetti
Article
Behavioral Sciences
Veronica Pastor, Maria Eugenia Pallares, Marta C. Antonelli
BEHAVIOURAL BRAIN RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Melisa C. Monteleone, Maria Eugenia Pallares, Silvia C. Billi, Marta C. Antonelli, Marcela A. Brocco
JOURNAL OF MOLECULAR NEUROSCIENCE
(2018)
Review
Behavioral Sciences
Martin G. Frasch, Silvia M. Lobmaier, Tamara Stampalija, Paula Desplats, Maria Eugenia Pallares, Veronica Pastor, Marcela A. Brocco, Hau-tieng Wu, Jay Schulkin, Christophe L. Herry, Andrew J. E. Seely, Gerlinde A. S. Metz, Yoram Louzoun, Marta C. Antonelli
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2020)
Article
Immunology
Mingju Cao, James W. MacDonald, Hai L. Liu, Molly Weaver, Marina Cortes, Lucien D. Durosier, Patrick Burns, Gilles Fecteau, Andre Desrochers, Jay Schulkin, Marta C. Antonelli, Raphael A. Bernier, Michael Dorschner, Theo K. Bammler, Martin G. Frasch
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Obstetrics & Gynecology
Silvia M. Lobmaier, A. Mueller, C. Zelgert, C. Shen, P. C. Su, G. Schmidt, B. Haller, G. Berg, B. Fabre, J. Weyrich, H. T. Wu, M. G. Frasch, M. C. Antonelli
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2020)
Review
Behavioral Sciences
Paula Desplats, Ashley M. Gutierrez, Marta C. Antonelli, Martin G. Frasch
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2020)
Review
Neurosciences
Marta C. Antonelli, Martin G. Frasch, Mercedes Rumi, Ritika Sharma, Peter Zimmermann, Maria S. Molinet, Silvia M. Lobmaier
Summary: Exposure to stress during gestation and early childhood may increase the risk of functional developmental impairments. Non-invasively obtainable physiological signals and epigenetic biomarkers can predict neurodevelopmental outcomes and identify children who would benefit from early intervention programs. Early family-centered intervention programs can improve parental attachment and contribute to healthy socio-emotional adulthood. Biomarker-guided early intervention strategies are crucial in preventing future neuropsychiatric problems and reducing their impact.
CURRENT NEUROPHARMACOLOGY
(2022)
Article
Behavioral Sciences
Veronica Pastor, Fernando Castillo Diaz, Valeria C. Sanabria, Juliana F. Dalto, Marta C. Antonelli, Jorge H. Medina
Summary: The activation of ?7 nAChRs in the mPFC is necessary for the acquisition and retrieval of cocaine-associated memories, but not for consolidation. Inhibiting ?7 nAChRs may abolish cocaine-induced sensitization and prevent memory related to drug rewarding effects.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Multidisciplinary Sciences
Pritam Sarkar, Silvia Lobmaier, Bibiana Fabre, Diego Gonzalez, Alexander Mueller, Martin G. Frasch, Marta C. Antonelli, Ali Etemad
Summary: Deep learning models accurately detect chronic stress exposure, emotional stress scores, and FSI values from maternal ECG data, enabling simple and cost-effective early stress detection during pregnancy using regular ECG biosensors.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Peter Zimmermann, Marta C. Antonelli, Ritika Sharma, Alexander Mueller, Camilla Zelgert, Bibiana Fabre, Natasha Wenzel, Hau-Tieng Wu, Martin G. Frasch, Silvia M. Lobmaier
Summary: This study reveals the adverse effects of maternal prenatal stress on fetal iron homeostasis and neurodevelopment. Specifically, the study found lower transferrin saturation and a 15% decrease in fetal ferritin in stressed male neonates. Additionally, the study showed higher fetal stress index in the stressed group compared to the control group, suggesting the potential for early intervention strategies.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Ritika Sharma, Martin G. Frasch, Camila Zelgert, Peter Zimmermann, Bibiana Fabre, Rory Wilson, Melanie Waldenberger, James W. MacDonald, Theo K. Bammler, Silvia M. Lobmaier, Marta C. Antonelli
Summary: Maternal stress before, during and after pregnancy has significant effects on the neurocognitive development of infants. This study aimed to find noninvasive epigenetic biomarkers of prenatal stress (PS) in newborns' saliva. Through DNA methylation analysis, significant associations were found between specific pregnancy worries and cortisol levels, and certain genes involved in secretion, transportation, signaling pathways, and neuronal signaling were identified. Early assessment of these noninvasive biomarkers can help detect at-risk babies and allocate resources for early intervention programs effectively.
CLINICAL EPIGENETICS
(2022)