Article
Cardiac & Cardiovascular Systems
Joseph Lamelas, Ahmed Alnajar
Summary: This study reviewed the 30-day and 1-year outcomes of 16 patients undergoing MVR-TAVR, showing a 12.5% 30-day mortality rate and a 36.2% 1-year mortality rate, as well as some common postoperative complications. There were no changes in cases of mild paravalvular leak and moderate stenosis during follow-up.
ANNALS OF THORACIC SURGERY
(2021)
Article
Medicine, General & Internal
Raj R. Makkar, Joanna Chikwe, Tarun Chakravarty, Qiudong Chen, Patrick T. O'Gara, Marc Gillinov, Michael J. Mack, Andrew Vekstein, Dhairya Patel, Amanda Lee Stebbins, Annetine C. Gelijns, Moody Makar, Deepak L. Bhatt, Samir Kapadia, Sreekanth Vemulapalli, Martin B. Leon
Summary: A cohort study evaluated the outcomes of transcatheter mitral valve repair for degenerative mitral regurgitation, finding a success rate of 88.9%. Among patients with successful repair, those with mild or less residual regurgitation and low mitral gradients had the lowest mortality.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Denis Berdajs, Jules Miazza, Luca Koechlin, Brigita Gahl, Oliver Reuthebuch, Friedrich Eckstein
Summary: This study evaluated the outcomes of a minimally invasive nonresectional technique for severe mitral valve insufficiency over a 10-year period. The results showed excellent long-term results with high surgical success rate and minimal risk of complications.
CANADIAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Mohamad Alkhouli, Fahad Alqahtani, Akram Kawsara, Mayra Guerrero, Mackram F. Eleid, Vuyisile T. Nkomo, Charanjit S. Rihal, Juan A. Crestanello
Summary: Mitral valve surgery at TMVr centers is associated with improved in-hospital outcomes compared with non-TMVr centers.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Tomas Benito-Gonzalez, Fernando Carrasco-Chinchilla, Rodrigo Estevez-Loureiro, Isaac Pascual, Dabit Arzamendi, Carmen Garrote-Coloma, Luis Nombela-Franco, Manuel Pan, Ana Serrador, Xavier Freixa, Ana Belen Cid Alvarez, Rosa Ana Hernandez Antolin, Leire Andraka, Ignacio Cruz-Gonzalez, Jose Ramon Lopez-Minguez, Jose Luis Diez Gil, Cristobal Urbano-Carrillo, Dario Sanmiguel Cervera, Juan Sanchis, Francisco Bosa, Valeriano Ruiz, Eduardo Molina, Victor Manuel Becerra-Munoz, Javier Gualis, Pablo Avanzas, Chi Hion Li, Jose Antonio Baz, Pilar Jimenez-Quevedo, Dolores Mesa, Ignacio J. Amat-Santos, Ander Regueiro, Ramiro Trillo, Antonio Jesus Dominguez Franco, Juan Horacio Alonso-Briales, Felipe Fernandez-Vazquez
Summary: After TMVR with MitraClip treatment for AFMR patients, there was a significant reduction in the severity of AFMR, which persisted at 12 months. AFMR patients showed a significant improvement in heart function post operation, and had lower rates of readmission and mortality within the first year.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Anita W. Asgar, Anique Ducharme, Michel Pellerin, Patrick Garceau, Arsene Basmadjian, Denis Bouchard, Raoul Bonan
Summary: The prevalence of mitral valve disease has shifted from being primarily rheumatic in origin to affecting the elderly population, encompassing a range of phenotypes including rheumatic mitral stenosis, degenerative mitral regurgitation, degenerative mitral valve calcification, and secondary mitral regurgitation. This review reflects on the history of therapy for mitral valve disease, tracing the development of structural heart intervention from the first percutaneous balloon mitral valvuloplasty to innovative transcatheter mitral valve repair and replacement technologies. It highlights the achievements and contemplates the future direction in this field.
CANADIAN JOURNAL OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Mark Kheifets, Filippo Angelini, Fabrizio D'Ascenzo, Stefano Pidello, Haya Engelstein, Pier Paolo Bocchino, Paolo Boretto, Simone Frea, Amos Levi, Hana Vaknin-Assa, Mordehay Vaturi, Yaron Shapira, Ran Kornowski, Leor Perl
Summary: This study compared the prognosis of patients with degenerative mitral regurgitation (DMR) and functional mitral regurgitation (FMR) after transcatheter edge-to-edge repair (TEER). The results showed higher rates of death and major adverse cardiac events (MACE) in the FMR group. FMR was identified as an independent predictor of MACE rates.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Byomesh Tripathi, Abhishek C. Sawant, Purnima Sharma, Varun Tandon, Toralben Patel, Jason Klein, Ashish Pershad
Summary: The 30-day readmission rate following transcatheter mitral valve repair with the MITRACLIP device is 15%, with half of these readmissions being cardiac in nature. Factors such as female sex, heart failure, atrial fibrillation, and chronic kidney disease are associated with a high risk of readmission, complications, and mortality.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Michael E. Bowdish, Ramsey S. Elsayed, James M. Tatum, Robbin G. Cohen, Wendy J. Mack, Brittany Abt, Victoria Yin, Mark L. Barr, Vaughn A. Starnes
Summary: For degenerative mitral valve disease, minimally invasive and sternotomy mitral valve repair have equivalent outcomes in terms of patient survival and repair durability.
JOURNAL OF CARDIAC SURGERY
(2021)
Article
Medicine, General & Internal
Rebecca H. Maier, Adetayo S. Kasim, Joseph Zacharias, Luke Vale, Richard Graham, Antony Walker, Grzegorz Laskawski, Ranjit Deshpande, Andrew Goodwin, Simon Kendall, Gavin J. Murphy, Vipin Zamvar, Renzo Pessotto, Clinton Lloyd, Malcolm Dalrymple-Hay, Roberto Casula, Hunaid A. Vohra, Franco Ciulli, Massimo Caputo, Serban Stoica, Max Baghai, Gunaratnam Niranjan, Prakash P. Punjabi, Olaf Wendler, Leanne Marsay, Cristina Fernandez-Garcia, Paul Modi, Bilal H. Kirmani, Mark D. Pullan, Andrew D. Muir, Dimitrios Pousios, Helen C. Hancock, Enoch Akowuah
Summary: The number of patients undergoing mitral valve repair surgery for severe mitral regurgitation is increasing, leading to debates on the adoption of minimally invasive surgical approaches. The UK Mini Mitral trial aims to provide definitive evidence on the best surgical approach and outcomes for patients, NHS, and clinical practice, informing the optimization of cost-effective practices and providing a standard for future percutaneous techniques.
Article
Cardiac & Cardiovascular Systems
Mark R. Helmers, Samuel T. Kim, Peter Altshuler, Jason J. Han, Amit Iyengar, John Kelly, Benjamin Smood, W. Clark Hargrove, Pavan Atluri
Summary: The study retrospectively analyzed adult patients undergoing isolated mitral valve surgery between 2002 and 2019, finding that MIMVS is safe in patients with pulmonary hypertension (PH) and provides traditional benefits of minimally invasive surgery, such as shorter initial ventilator times and hospital lengths of stay.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Giovanni Domenico Cresce, Paolo Berretta, Antonio Fiore, Manuel Wilbring, Marc Gerdisch, Antonios Pitsis, Mauro Rinaldi, Nikolaos Bonaros, Jorg Kempfert, Tristan Yan, Frank Van Praet, Hoang Dinh Nguyen, Carlo Savini, Joseph Lamelas, Tom C. Nguyen, Pierluigi Stefano, Gloria Faerber, Loris Salvador, Marco Di Eusanio
Summary: This study aimed to examine the incidence and predictors of stroke after minimally invasive mitral valve surgery (mini-MVS) and assess the role of preoperative CT scan on surgical management and neurological outcomes.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Hidetake Kawajiri, Hartzell Schaff, Joseph A. Dearani, Richard C. Daly, Kevin L. Greason, Arman Arghami, Philip G. Rowse, Jason K. Viehman, Brian D. Lahr, Carlos Gallego-Navarro, Juan A. Crestanello
Summary: This study analyzes the safety and outcomes of mitral valve repair for degenerative mitral valve regurgitation in patients 75 years of age or older. The results show that mitral valve repair in elderly patients can be achieved with low operative mortality and complications. Older age, smoking, and over and underweight are associated with increased risk of mortality, while higher left ventricular ejection fraction and hypertension are associated with reduced risk.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
David W. M. Muller, Paul Sorajja, Alison Duncan, Brian Bethea, Gry Dahle, Paul Grayburn, Vasilis Babaliaros, Mayra Guerrero, Vinod H. Thourani, Francesco Bedogni, Paolo Denti, Nicolas Dumonteil, Thomas Modine, Paul Jansz, Michael L. Chuang, Philipp Blanke, Jonathon Leipsic, Vinay Badhwar
Summary: This study demonstrates the safety and effectiveness of TMVR in patients with severe mitral regurgitation through 2-year follow-up. The highest rates of all-cause mortality and HFH occurred in the first 3 months postprocedure.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Paolo Berretta, Jorg Kempfert, Frank Van Praet, Loris Salvador, Joseph Lamelas, Tom C. Nguyen, Manuel Wilbring, Marc Gerdisch, Mauro Rinaldi, Nikolaos Bonaros, Thierry Folliguet, Torsten Doenst, Dinh Hoang Nguyen, Pierluigi Stefano, Tristan Yan, Carlo Savini, Antonios Pitsis, Marco Di Eusanio
Summary: This study evaluated the operative outcomes of minimally invasive mitral valve surgery across different patient risk profiles. The results showed favorable outcomes in low-, intermediate-, and high-risk patients, but less satisfactory outcomes in extreme-risk patients. The use of the EuroSCORE II model can assist clinicians in making treatment decisions for patients with mitral valve disease.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Luca Paolucci, Fabio Mangiacapra, Michele Mattia Viscusi, Simone Ungaro, Francesca Cocchia, Francesco Piccirillo, Annunziata Nusca, Rosetta Melfi, Elisabetta Ricottini, Paolo Gallo, Nino Cocco, Raffaele Rinaldi, Gian Paolo Ussia, Francesco Grigioni
Summary: This study investigated the clinical outcomes of patients with periprocedural myocardial injury undergoing incomplete revascularization after percutaneous coronary intervention (PCI). The study found that the occurrence of post-procedural myocardial injury is associated with long-term clinical outcomes. Different thresholds of cardiac troponin elevation were used to determine the completeness of revascularization. Patients undergoing incomplete revascularization seem to have an increased risk of major adverse cardiac events.
CARDIOVASCULAR REVASCULARIZATION MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Andrea Scotti, Azeem Latib, Antonio Popolo Rubbio, Luca Testa, Marianna Adamo, Paolo Denti, Francesco Melillo, Maurizio Taramasso, Antonio Sisinni, Federico De Marco, Carmelo Grasso, Arturo Giordano, Antonio L. Bartorelli, Nicola Buzzatti, Rodolfo Citro, Francesco De Felice, Ciro Indolfi, Ida Monteforte, Emmanuel Villa, Cristina Giannini, Anna Sonia Petronio, Gabriele Crimi, Giuseppe Tarantini, Antonio Colombo, Eustachio Agricola, Marco Metra, Alberto Zangrillo, Alberto Margonato, Corrado Tamburino, Francesco Maisano, Francesco Bedogni, Cosmo Godino
Summary: This study aimed to develop and validate a clinical risk score to predict the risk of death or heart failure hospitalization in COAPT-ineligible patients who underwent TEER. The study found that the CITE score is a simple and effective tool for predicting adverse outcomes and can support clinical decision-making.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Benjamin Essayagh, Giovanni Benfari, Clemence Antoine, Francesco Grigioni, Thierry Le Tourneau, Jean-Christian Roussel, Jeroen J. Bax, Victoria Delgado, Nina Ajmone Marsan, Aniek van Wijngaarden, Christophe Tribouilloy, Dan Rusinaru, Aviram Hochstadt, Yan Topilsky, Prabin Thapa, Hector I. Michelena, Maurice Enriquez-Sarano
Summary: This study established a new registry called Mitral Regurgitation International Database Quantitative (MIDA-Q), which showed that the MIDA-Q score is strongly associated with long-term survival in patients diagnosed with MVP. This finding indicates that the MIDA-Q score can serve as an important prognostic tool for clinical management and therapeutic trials.
Editorial Material
Cardiac & Cardiovascular Systems
Valeria Cammalleri, Giuseppe Neri, Myriam Carpenito, Annunziata Nusca, Francesco Grigioni, Gian Paolo Ussia
Summary: Extensive echocardiographic planning is necessary for edge-to-edge tricuspid transcatheter repair as anatomic features may affect the outcome. Tailored strategies are crucial for procedural success. We present a case of massive tricuspid regurgitation treated successfully by clipping the antero-septal commissure, restoring functional coaptation of the valve leaflets at multiple sites.
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Ottavio Alfieri, Michele De Bonis, Elisabetta Lapenna, Francesco Maisano
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Andrea Raffaele Munafo, Andrea Scotti, Rodrigo Estevez-Loureiro, Marianna Adamo, Antonio Portoles Hernandez, Estefania Fernandez Peregrina, Lola Gutierrez, Maurizio Taramasso, Neil P. Fam, Edwin C. Ho, Anita Asgar, Giancarlo Vitrella, Claudia Raineri, Giuliano Chizzola, Elisa Pezzola, Robin Le Ruz, Claudio Montalto, Jacopo A. Oreglia, Chiara Fraccaro, Cristina Giannini, Francesca Fiorelli, Antonio Popolo Rubbio, J. F. Ooms, Miriam Compagnone, Chiara Marcelli, Diego Maffeo, Luca Bettari, Monika Furholz, Dabit Arzamendi, Patrice Guerin, Corrado Tamburino, A. Sonia Petronio, Carmelo Grasso, Eustachio Agricola, Nicolas M. Van Mieghem, Giuseppe Tarantini, Fabien Praz, Isaac Pascual, Luciano Potena, Antonio Colombo, Francesco Maisano, Marco Metra, Alberto Margonato, Gabriele Crimi, Francesco Saia, Cosmo Godino
Summary: After 2 years of follow-up, the use of MitraClip as a bridge-to-transplant has been confirmed as an effective strategy, allowing one-third of patients to receive elective HTx or become eligible for transplantation, and no longer requiring transplantation in 22.5% of cases.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Review
Medicine, General & Internal
Valeria Cammalleri, Giorgio Antonelli, Valeria Maria De Luca, Myriam Carpenito, Annunziata Nusca, Maria Caterina Bono, Simona Mega, Gian Paolo Ussia, Francesco Grigioni
Summary: Functional mitral regurgitation (FMR) and tricuspid regurgitation (FTR) occur due to cardiac remodeling, affecting patients with heart failure (HF) across different left ventricle ejection fraction (LVEF) patterns. Limited data on the management of functional valve regurgitation in HF phenotypes exist. This review summarizes the epidemiology, pathophysiology, and treatment of FMR and FTR within the different patterns of HF defined by LVEF.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Valeria Cammalleri, Edoardo Nobile, Domenico De Stefano, Myriam Carpenito, Simona Mega, Maria Caterina Bono, Aurelio De Filippis, Annunziata Nusca, Carlo Cosimo Quattrocchi, Francesco Grigioni, Gian Paolo Ussia
Summary: In this study, novel CT scan parameters were used to assess the geometrical changes of the tricuspid valve in patients with functional tricuspid regurgitation (TR) and correlate these findings with echocardiography. The results showed that patients with TR >= 3+ had significantly larger tricuspid valve annulus area and perimeter, as well as other dimensions and distances related to the tricuspid valve. These findings provide important insights into the anatomical understanding of the tricuspid valve apparatus in patients with severe functional TR.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Francesco Piccirillo, Paola Liporace, Annunziata Nusca, Vincenzo Nafisio, Andrea Corliano, Francesca Magaro, Raffaele Antonelli Incalzi, Gian Paolo Ussia, Francesco Grigioni
Summary: Patients with CVD and CKD have high rates of cardiorenal outcomes. Activation of the MR induces cardiac and renal injury, and finerenone has shown anti-inflammatory and anti-fibrotic effects in pre-clinical studies. Two large trials investigated the outcomes of finerenone in patients with CKD and type 2 diabetes.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Giulia Nemola, Anita Russi, Gianmarco Cozzani, Giulio Leo, Laura Vetrugno, Francesco Maria Sparasci, Antonio L. M. Parlati, Paolo Della Bella, Matteo Montorfano, Moreno Tresoldi, Anna Salerno, Michela Cera, Paolo Mattiello, Giancarlo Comi, Francesco Maisano, Alberto Zangrillo, Carlo Gaspardone, Francesco Melillo, Alberto Margonato, Cosmo Godino
Summary: Direct oral anticoagulants (DOACs) are the cornerstone therapy for preventing cardioembolic events in patients with nonvalvular atrial fibrillation (NVAF). This study evaluates the clinical features and long-term outcomes of a real-world population treated with DOACs, where the use of the 4 different DOACs is quite equal. The choice of DOAC is influenced by specific patient and drug characteristics.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Benjamin Essayagh, Giovanni Benfari, Clemence Antoine, Francesco Grigioni, Thierry Le Tourneau, Jean-Christian Roussel, Jeroen J. Bax, Nina Ajmone Marsan, Aniek van Wijngaarden, Christophe Tribouilloy, Dan Rusinaru, Aviram Hochstadt, Yan Topilsky, Prabin Thapa, Hector I. Michelena, Maurice Enriquez-Sarano
Article
Cardiac & Cardiovascular Systems
Luigi Biasco, Catherine Klersy, Giovanni Benfari, Patric Biaggi, Roberto Corti, Moreno Curti, Oliver Gaemperli, Raban Jeger, Francesco Maisano, Olivier Mueller, Barbara Naegeli, Stephane Noble, Fabien Praz, Gregorio Tersalvi, Stefan Toggweiler, Marco Valgimigli, Maurice Enriquez-Sarano, Giovanni Pedrazzini
Summary: This study aimed to evaluate the impact of mitral transcatheter edge-to-edge repair (TEER) on postprocedural life expectancy. The results showed that TEER can restore predicted life expectancy in patients aged 80-89, and sustained procedural success can improve survival rates.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Review
Pharmacology & Pharmacy
Federico Bernardini, Annunziata Nusca, Federica Coletti, Ylenia La Porta, Mariagrazia Piscione, Francesca Vespasiano, Fabio Mangiacapra, Elisabetta Ricottini, Rosetta Melfi, Ilaria Cavallari, Gian Paolo Ussia, Francesco Grigioni
Summary: Atherosclerosis is the leading cause of death worldwide, especially in patients with type 2 diabetes mellitus. GLP-1 receptor agonists and DPP-4 inhibitors have been shown to have a protective role in the cardiovascular system beyond their glycemic control. Multiple cardiovascular outcome trials have reported a significant reduction in cardiovascular events with the use of these agents in high-risk patients with type 2 diabetes. Furthermore, recent evidence highlights their favorable benefit/risk profile in myocardial infarction and percutaneous coronary revascularization settings.
Review
Biochemistry & Molecular Biology
Francesco Piccirillo, Sara Mastroberardino, Annunziata Nusca, Lorenzo Frau, Lorenzo Guarino, Nicola Napoli, Gian Paolo Ussia, Francesco Grigioni
Summary: Type-2 diabetes is a major risk factor for cardiovascular diseases, and dyslipidemia is a common metabolic disorder associated with diabetes. This dyslipidemia, characterized by increased triglyceride levels, decreased HDL cholesterol levels, and a shift towards small dense LDL cholesterol, promotes atherosclerosis and increases the risk of cardiovascular morbidity and mortality. Novel antidiabetic agents, such as SGLT2 inhibitors, DPP4 inhibitors, and GLP-1 receptor agonists, have been found to improve cardiovascular outcomes and lipid profiles in diabetic patients. This review summarizes the current knowledge on the effects of these drugs on diabetic dyslipidemia and their overall cardiovascular benefits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Michele Mattia Viscusi, Luca Ambrosio, Danilo Ricciardi, Fabio Mangiacapra, Annunziata Nusca, Luca Paolucci, Gian Paolo Ussia, Francesco Grigioni
Summary: Nasopharyngeal (NP) swab sampling is a common procedure for COVID-19 testing, but can lead to rare complications. We report a case of paroxysmal atrial fibrillation following NP specimen collection. This response may be due to an exaggerated vagal tone triggered by the trigeminocardiac reflex. Less invasive sampling methods, such as saliva testing, may be more suitable for predisposed individuals.
