Structural basis for ligand binding to an enzyme by a conformational selection pathway

Human CD4 Metastability Is a Function of the Allosteric Disulfide Bond in Domain 2

(2016) Gavin R. Owen et al.   BIOCHEMISTRY

13C-NMR studies on disulfide bond isomerization in bovine pancreatic trypsin inhibitor (BPTI)

(2016) Mitsuhiro Takeda et al.   JOURNAL OF BIOMOLECULAR NMR

Conformational Selection in a Protein-Protein Interaction Revealed by Dynamic Pathway Analysis

(2016) Kalyan S. Chakrabarti et al.   Cell Reports

Contact between the β1 and β2 Segments of α-Synuclein that Inhibits Amyloid Formation

(2015) Hamed Shaykhalishahi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural basis for catalytically restrictive dynamics of a high-energy enzyme state

(2015) Michael Kovermann et al.   Nature Communications

Pathways of allosteric regulation in Hsp70 chaperones

(2015) Roman Kityk et al.   Nature Communications

A Hexameric Peptide Barrel as Building Block of Amyloid-β Protofibrils

(2014) Christofer Lendel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Distinguishing induced fit from conformational selection

(2014) Stefano Gianni et al.   BIOPHYSICAL CHEMISTRY

Occurrence of protein disulfide bonds in different domains of life: a comparison of proteins from the Protein Data Bank

(2014) I. Bosnjak et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Structural Topology and Activation of an Initial Adenylate Kinase–Substrate Complex

(2013) Jörgen Ådén et al.   BIOCHEMISTRY

Conformational Motions Regulate Phosphoryl Transfer in Related Protein Tyrosine Phosphatases

(2013) S. K. Whittier et al.   SCIENCE

Essential cysteine residues for human RNase κ catalytic activity

(2012) Marianna N. Kiritsi et al.   FEBS Journal

A strong 13C chemical shift signature provides the coordination mode of histidines in zinc-binding proteins

(2012) Pierre Barraud et al.   JOURNAL OF BIOMOLECULAR NMR

Modulation of a Pre-existing Conformational Equilibrium Tunes Adenylate Kinase Activity

(2012) Jörgen Ådén et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein frustratometer: a tool to localize energetic frustration in protein molecules

(2012) M. Jenik et al.   NUCLEIC ACIDS RESEARCH

Conformational Plasticity and Dynamics in the Generic Protein Folding Catalyst SlyD Unraveled by Single-Molecule FRET

(2011) Dana Kahra et al.   JOURNAL OF MOLECULAR BIOLOGY

On the Roles of Substrate Binding and Hinge Unfolding in Conformational Changes of Adenylate Kinase

(2010) Jason B. Brokaw et al.   BIOPHYSICAL JOURNAL

Protein Flexibility and Conformational Entropy in Ligand Design Targeting the Carbohydrate Recognition Domain of Galectin-3

(2010) Carl Diehl et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Overlap between folding and functional energy landscapes for adenylate kinase conformational change

(2010) Ulrika Olsson et al.   Nature Communications

NMR chemical shift data and ab initio shielding calculations: emerging tools for protein structure determination

(2009) Frans A. A. Mulder et al.   CHEMICAL SOCIETY REVIEWS

TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts

(2009) Yang Shen et al.   JOURNAL OF BIOMOLECULAR NMR

Conformational selection or induced fit: A flux description of reaction mechanism

(2009) G. G. Hammes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rational modulation of conformational fluctuations in adenylate kinase reveals a local unfolding mechanism for allostery and functional adaptation in proteins

(2009) T. P. Schrank et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enzymes with lid-gated active sites must operate by an induced fit mechanism instead of conformational selection

(2008) S. M. Sullivan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recognition Dynamics Up to Microseconds Revealed from an RDC-Derived Ubiquitin Ensemble in Solution

(2008) O. F. Lange et al.   SCIENCE