Article
Multidisciplinary Sciences
Rubens Paula, Nathalia Martins Sonehara, Bruna Victorasso Jardim-Perassi, Akos Pal, Yasmin Asad, Luiz Gustavo Almeida Chuffa, Roger Chammas, Florence I. Raynaud, Debora A. P. C. Zuccari
Summary: Human xenografts are useful models for studying human cancers and therapies. This study compared amino acid concentration in breast cancer cells and non-tumorigenic cells, as well as in plasma of tumor-bearing mice. The results showed significant differences in amino acid levels between cancer and non-tumor cells, as well as in the timing of peak amino acid concentrations in tumor-bearing mice.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
Leonardo Vinicius Monteiro de Assis, Muenevver Demir, Henrik Oster
Summary: Circadian profiling improves the detection of target genes and characterization of pathways in mouse models of nonalcoholic steatohepatitis. Fatty livers show a 3-hour advance in metabolic and clock gene transcript rhythms. Circadian profiling reveals temporal changes in lipid, carbohydrate, and cholesterol metabolic transcripts.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Multidisciplinary Sciences
Guolian Ding, Xin Li, Xinguo Hou, Wenjun Zhou, Yingyun Gong, Fuqiang Liu, Yanlin He, Jia Song, Jing Wang, Paul Basil, Wenbo Li, Sichong Qian, Pradip Saha, Jinbang Wang, Chen Cui, Tingting Yang, Kexin Zou, Younghun Han, Christopher Amos, Yong Xu, Li Chen, Zheng Sun
Summary: The nuclear receptors REV-ERB-alpha and REV-ERB-beta in GABAergic neurons control the diurnal rhythm of insulin-mediated suppression of hepatic glucose production, peaking at waking. This mechanism is crucial for understanding the extended dawn phenomenon in type 2 diabetes.
Article
Multidisciplinary Sciences
Yoshihiko Furuike, Atsushi Mukaiyama, Shin-Ichi Koda, Damien Simon, Dongyan Ouyang, Kumiko Ito-Miwa, Shinji Saito, Eiki Yamashita, Taeko Nishiwaki-Ohkawa, Kazuki Terauchi, Takao Kondo, Shuji Akiyama
Summary: KaiC is a dual ATPase that drives the circadian clock system of cyanobacteria through the coordination of its N-terminal and C-terminal active sites. The activities of these two sites are regulated differently and their delicate interactions drive the assembly and disassembly cycle of KaiA and KaiB.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Xiaojie Bai, Yilie Liao, Fangfang Sun, Xia Xiao, Suneng Fu
Summary: The diurnal organization of biological pathways, especially in relation to energy metabolism and inflammation/proliferation pathways, remains to be fully understood. Perturbing the hepatic transcriptome through nutrient regulators has revealed the enduring properties of pathway organization, with G0s2 and Rgs16 genes identified as potential mediators at the metabolism-inflammation interface. These genes play a role in promoting amino acid oxidation, suppressing mitochondrial respiration, and preventing hepatic inflammation and hepatocyte proliferation under both physiological and pathological conditions, such as obesity.
Article
Multidisciplinary Sciences
Mingxu Fang, Archana G. Chavan, Andy LiWang, Susan S. Golden
Summary: In this study, the researchers used the IVC reactions and massively parallel experiments to study entrainment, the synchronization of the circadian clock with the environment. The results showed that the IVC better explains the in vivo clock-resetting phenotypes of wild-type and mutant strains, and the output components are deeply engaged with the core oscillator, affecting the way input signals entrain the core pacemaker. These findings blur the line between input and output pathways and support the previous demonstration that key output components are fundamental parts of the clock.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biology
Ichiro Chihara, Hiromitsu Negoro, Jin Kono, Yoshiyuki Nagumo, Haruki Tsuchiya, Kosuke Kojo, Masanobu Shiga, Ken Tanaka, Shuya Kandori, Bryan J. J. Mathis, Hiroyuki Nishiyama
Summary: The diurnal rhythm of glucocorticoid signaling is a key regulator of the bladder clock, overcoming other entrainment factors and coordinating the diurnal rhythm of volume voided per micturition. Cortisol treatment resulted in significant shifts in gene expression in a human urothelial cell-line, while corticosterone administration in mice shifted the bladder clock forward by 4 hours. Bilateral adrenalectomy combined with corticosterone administration caused an 8-12 hour shift in the bladder clock. These findings highlight the importance of glucocorticoids in bladder clock regulation.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biology
Leonardo Vinicius Monteiro de Assis, Lisbeth Harder, Jose Thalles Lacerda, Rex Parsons, Meike Kaehler, Ingolf Cascorbi, Inga Nagel, Oliver Rawashdeh, Jens Mittag, Henrik Oster, Matthew A. Quinn
Summary: This study demonstrates that fluctuations in thyroid hormone (TH) levels restructuring the diurnal liver metabolic transcriptome independent of local molecular circadian clocks, which affects energy metabolism processes in the liver.
Article
Multidisciplinary Sciences
Haoran Xin, Fang Deng, Meiyu Zhou, Rongfeng Huang, Xiaogen Ma, He Tian, Yan Tan, Xinghua Chen, Dan Deng, Guanghou Shui, Zhihui Zhang, Min-Dian Li
Summary: This study investigated the impact of inverted feeding on circadian rhythms of metabolism and physiology in peripheral tissues using global profiling of transcripts and metabolites in mice. The results showed that different tissues exhibit distinct kinetics in phase entrainment of diurnal transcriptomes by inverted feeding, with fat tissue being near-completely entrained. Despite the slow kinetics of the heart clock, fatty acid oxidation in the heart fully entrained to inverted feeding, suggesting complex mechanisms underlying circadian regulation in peripheral tissues.
Review
Cell Biology
Zainab Taleb, Phillip Karpowicz
Summary: The circadian clock is a molecular timekeeper that regulates 24-hour rhythms in animals, impacting behavior and physiology, including metabolic and digestive systems. Animal models targeting circadian clock genes have shown their role in regulating liver diseases, inflammatory bowel disease, colorectal cancer, and obesity. Thus, the circadian clock plays a crucial role in maintaining metabolic and digestive health.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Ophthalmology
Jingxin He, Xinwei Jiao, Xin Sun, Yijia Huang, Pengyang Xu, Yunxia Xue, Ting Fu, Jun Liu, Zhijie Li
Summary: The study showed that high fructose intake significantly reprograms the circadian rhythms of the cornea in mice, altering cell cycle, immune function, and neuronal-related pathways. HFI affected the distribution and number of corneal epithelial mitotic cells, and increased the recruitment of immune cells to the limbal region over a circadian cycle.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Rocio A. Barahona, Samuel Morabito, Vivek Swarup, Kim N. Green
Summary: Microglia play a role in the regulation of perineuronal nets (PNNs) but not in the maintenance of diurnal rhythms.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Andreas Psomas, Namrata R. Chowdhury, Benita Middleton, Raphaelle Winsky-Sommerer, Debra J. Skene, Menno P. Gerkema, Daan R. van Der Veen
Summary: This study investigated the metabolic rhythms in the plasma metabolome of voles and found that there were both 24-hour circadian rhythms and faster 2-4 hour ultradian rhythms. These ultradian rhythms were synchronized with the circadian rhythms and were not aligned with meal timing, indicating their importance in metabolic regulation.
Review
Biochemistry & Molecular Biology
Tomoki Sato, Paolo Sassone-Corsi
Summary: Food intake has a profound impact on systemic physiology, and there is a close link between food intake and circadian rhythms. The biological clock controls circadian rhythms through the cyclic expression of genes, and metabolic states also provide feedback to the molecular clock. Nutritional challenges can reprogram the circadian clock, and various factors are involved in the remodeling process.
Article
Multidisciplinary Sciences
Yi Liao, Michael J. Rust
Summary: The study shows that in the cyanobacterium Synechococcus elongatus, the clock generates rhythms in DNA replication to ensure successful completion of genome replication during the night, while providing resources in time to support the process.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Genetics & Heredity
Ryan K. Shultzaberger, Joseph S. Boyd, Spencer Diamond, Ralph J. Greenspan, Susan S. Golden
ANNUAL REVIEW OF GENETICS, VOL 49
(2015)
Article
Multidisciplinary Sciences
Spencer Diamond, Darae Jun, Benjamin E. Rubin, Susan S. Golden
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Multidisciplinary Sciences
Benjamin E. Rubin, Kelly M. Wetmore, Morgan N. Price, Spencer Diamond, Ryan K. Shultzaberger, Laura C. Lowe, Genevieve Curtin, Adam P. Arkin, Adam Deutschbauer, Susan S. Golden
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Biochemistry & Molecular Biology
Inmaculada Couso, Bradley S. Evans, Jia Li, Yu Liu, Fangfang Ma, Spencer Diamond, Doug K. Allen, James G. Umen
Article
Multidisciplinary Sciences
Jared T. Broddrick, Benjamin E. Rubin, David G. Welkie, Niu Du, Nathan Mih, Spencer Diamond, Jenny J. Lee, Susan S. Golden, Bernhard O. Palsson
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Multidisciplinary Sciences
Alexander Crits-Christoph, Spencer Diamond, Cristina N. Butterfield, Brian C. Thomas, Jillian F. Banfield
Article
Multidisciplinary Sciences
David G. Welkie, Benjamin E. Rubin, Yong-Gang Chang, Spencer Diamond, Scott A. Rifkin, Andy LiWang, Susan S. Golden
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Genetics & Heredity
Benjamin E. Rubin, TuAnh Ngoc Huynh, David G. Welkie, Spencer Diamond, Ryan Simkovsky, Emily C. Pierce, Arnaud Taton, Laura C. Lowe, Jenny J. Lee, Scott A. Rifkin, Joshua J. Woodward, Susan S. Golden
Article
Microbiology
Jianping Sun, Chaoguang Tian, Spencer Diamond, N. Louise Glass
Review
Biochemistry & Molecular Biology
David G. Welkie, Benjamin E. Rubin, Spencer Diamond, Rachel D. Hood, David F. Savage, Susan S. Golden
TRENDS IN MICROBIOLOGY
(2019)
Article
Plant Sciences
Young-Saeng Kim, Jin-Ju Kim, Seong-Im Park, Spencer Diamond, Joseph S. Boyd, Arnaud Taton, Il-Sup Kim, James W. Golden, Ho-Sung Yoon
FRONTIERS IN PLANT SCIENCE
(2018)
Article
Microbiology
Spencer Diamond, Peter F. Andeer, Zhou Li, Alexander Crits-Christoph, David Burstein, Karthik Anantharaman, Katherine R. Lane, Brian C. Thomas, Chongle Pan, Trent R. Northen, Jillian F. Banfield
NATURE MICROBIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Richard Baran, Rebecca Lau, Benjamin P. Bowen, Spencer Diamond, Nick Jose, Ferran Garcia-Pichel, Trent R. Northen
ACS CHEMICAL BIOLOGY
(2017)
Meeting Abstract
Plant Sciences
B. E. Rubin, K. M. Wetmore, M. N. Price, S. Diamond, R. K. Shultzaberger, D. G. Welkie, R. Simkovsky, M. Ota, L. C. Lowe, G. Curtin, A. P. Arkin, A. Deutschbauer, S. S. Golden
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-PLANT
(2016)