NGF-TrkA signaling in sensory nerves is required for skeletal adaptation to mechanical loads in mice

NGF-TrkA Signaling by Sensory Nerves Coordinates the Vascularization and Ossification of Developing Endochondral Bone

(2016) Ryan E. Tomlinson et al.   Cell Reports

HIF-1α regulates bone formation after osteogenic mechanical loading

(2015) Ryan E. Tomlinson et al.   BONE

In vivo mechanical loading rapidly activates β-catenin signaling in osteocytes through a prostaglandin mediated mechanism

(2015) N. Lara-Castillo et al.   BONE

Serious joint-related adverse events in randomized controlled trials of anti-nerve growth factor monoclonal antibodies

(2015) M.C. Hochberg   OSTEOARTHRITIS AND CARTILAGE

Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone

(2015) Jinhu Xiong et al.   PLoS One

The neurobiology of skeletal pain

(2014) Patrick W. Mantyh   EUROPEAN JOURNAL OF NEUROSCIENCE

Antagonizing the αvβ3Integrin Inhibits Angiogenesis and Impairs Woven but Not Lamellar Bone Formation Induced by Mechanical Loading

(2014) Ryan E Tomlinson et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Role of Calcitonin Gene-Related Peptide in Functional Adaptation of the Skeleton

(2014) Susannah J. Sample et al.   PLoS One

Induction of nerve growth factor expression and release by mechanical and inflammatory stimuli in chondrocytes: possible involvement in osteoarthritis pain

(2014) Emilie Pecchi et al.   ARTHRITIS RESEARCH & THERAPY

Tactile sensory system: encoding from the periphery to the cortex

(2014) Lynette A. Jones et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Osteocytes: Master Orchestrators of Bone

(2013) Mitchell B. Schaffler et al.   CALCIFIED TISSUE INTERNATIONAL

SeeDB: a simple and morphology-preserving optical clearing agent for neuronal circuit reconstruction

(2013) Meng-Tsen Ke et al.   NATURE NEUROSCIENCE

Bone Modeling and Remodeling

(2012) Ego Seeman   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee

(2012) David W Dempster et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

The Proprioceptive Senses: Their Roles in Signaling Body Shape, Body Position and Movement, and Muscle Force

(2012) Uwe Proske et al.   PHYSIOLOGICAL REVIEWS

Antagonism of Nerve Growth Factor-TrkA Signaling and the Relief of Pain

(2011) Patrick W. Mantyh et al.   ANESTHESIOLOGY

Mechanical stretch of sympathetic neurons induces VEGF expression via a NGF and CNTF signaling pathway

(2011) Erol Saygili et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nerve growth factor promoter activity revealed in mice expressing enhanced green fluorescent protein

(2011) Michael D. Kawaja et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The majority of myelinated and unmyelinated sensory nerve fibers that innervate bone express the tropomyosin receptor kinase A

(2011) G. Castañeda-Corral et al.   NEUROSCIENCE

Mechanical loading-related changes in osteocyte sclerostin expression in mice are more closely associated with the subsequent osteogenic response than the peak strains engendered

(2011) A. Moustafa et al.   OSTEOPOROSIS INTERNATIONAL

Neuropeptide Y innervation during fracture healing and remodeling

(2010) Hua Long et al.   Acta Orthopaedica

Mechanical stretch induces nerve sprouting in rat sympathetic neurocytes

(2010) Obaida R. Rana et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition

(2010) Keertik Fulzele et al.   CELL

The amazing osteocyte

(2010) Lynda F Bonewald   JOURNAL OF BONE AND MINERAL RESEARCH

Tanezumab for the Treatment of Pain from Osteoarthritis of the Knee

(2010) Nancy E. Lane et al.   NEW ENGLAND JOURNAL OF MEDICINE

A phenotypically restricted set of primary afferent nerve fibers innervate the bone versus skin: Therapeutic opportunity for treating skeletal pain

(2009) Juan Miguel Jimenez-Andrade et al.   BONE

Emerging roles of Wnts in the adult nervous system

(2009) Nibaldo C. Inestrosa et al.   NATURE REVIEWS NEUROSCIENCE

Osteocytes, mechanosensing and Wnt signaling

(2008) Lynda F. Bonewald et al.   BONE