Article
Multidisciplinary Sciences
Nao Hasuzawa, Keita Tatsushima, Lixiang Wang, Masaharu Kabashima, Rie Tokubuchi, Ayako Nagayama, Kenji Ashida, Yoshihiro Ogawa, Yoshinori Moriyama, Masatoshi Nomura
Summary: The VNUT inhibitor clodronate showed beneficial effects in reducing hepatic inflammation and fibrosis, preventing steatohepatitis, and protecting against acute liver injury in mouse models. In vitro experiments demonstrated that clodronate inhibited vesicular ATP release and reduced triglyceride accumulation. These findings suggest that pharmacological inhibition of VNUT may be a potential therapeutic strategy for liver inflammatory disorders.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Yuri Kato, Kengo Ohsugi, Yuto Fukuno, Ken Iwatsuki, Yuika Harada, Takaaki Miyaji
Summary: This study found that EPA and its metabolites can alleviate neuropathic and inflammatory pain by inhibiting VNUT, as well as improve insulin resistance. This suggests that EPA may serve as a unique nutrient-based treatment and prevention strategy for neurological, immunological, and metabolic diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Peng Huang, Qi Cao, Mengnan Xu, Xian-Ping Dong
Summary: SLC17A9 deficiency leads to cell death, which can be rescued by the transcription factor EB. Deficiency of SLC17A9 inhibits the activity of Cathepsin D, while heterologous expression of Cathepsin D can rescue lysosomal dysfunction and cell death. However, SLC17A9 deficiency does not affect the activity of Cathepsin B.
Article
Clinical Neurology
Konrad Platzer, Heinrich Sticht, Caleb Bupp, Mythily Ganapathi, Elaine M. Pereira, Gwenael Le Guyader, Frederic Bilan, Lindsay B. Henderson, Johannes R. Lemke, Holger Taschenberger, Nils Brose, Rami Abou Jamra, Sonja M. Wojcik
Summary: This study identifies de novo missense variants in the SLC32A1 gene as a novel cause of developmental and epileptic encephalopathy. These variants may impair GABAergic neurotransmission through altered synaptic vesicle filling and synaptic short-term plasticity.
ANNALS OF NEUROLOGY
(2022)
Review
Pharmacology & Pharmacy
Nao Hasuzawa, Keita Tatsushima, Rie Tokubuchi, Masaharu Kabashima, Masatoshi Nomura
Summary: ATP, used as an energy source in cells, also functions as an extracellular signaling molecule. Studies on purinergic receptor subtypes have shown its significant roles in different cell types. VNUT, a vital transporter in the SLC17 family, plays a crucial role in storing and releasing ATP in cells, impacting chronic inflammation and metabolic diseases like type 2 diabetes and NAFLD.
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
(2021)
Review
Biology
Catharina van Heusden, Barbara R. Grubb, Brian Button, Eduardo R. Lazarowski
Summary: Mucociliary clearance is crucial for pulmonary health but can be compromised in chronic obstructive lung diseases due to airway surface dehydration and hyperconcentrated mucus production, affecting mucus hydration. Research has shown that molecules such as ATP and adenosine play key roles in this process.
Article
Anatomy & Morphology
Takuya Yokoyama, Hiroki Saito, Nobuaki Nakamuta, Yoshio Yamamoto
Summary: The study found VNUT in SIF cells in the rat superior cervical ganglion, suggesting these cells modulate the excitability of sensory nerve endings and postganglionic neurons through ATP release.
Article
Genetics & Heredity
M. Reza Jabalameli, Fiona M. Fitzpatrick, Roberto Colombo, Sarah A. Howles, Gary Leggatt, Valerie Walker, Akira Wiberg, Edmund R. S. Kunji, Sarah Ennis
Summary: Through whole exome sequencing, a study identified a variant in the SLC25A25 gene (OMIM 608745) that may contribute to calcium kidney stone formation, with incomplete penetrance observed in non-stone formers within the families. Modeling showed that the variant significantly reduces ATP transport activity, potentially increasing the risk of stone formation.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Silas A. Buck, Mary M. Torregrossa, Ryan W. Logan, Zachary Freyberg
Summary: This article summarizes how drugs of abuse, particularly cocaine, opioids, and alcohol, alter DA release in the nucleus accumbens medial shell, examines the potential role of DA/glutamate co-release in mediating these effects, and discusses future directions for further investigating these mechanisms.
Review
Pharmacology & Pharmacy
Mathieu Favier, Nicolas Pietrancosta, Salah El Mestikawy, Giuseppe Gangarossa
Summary: VGLUT3, an atypical vesicular transporter, is expressed in various types of neurons and plays a critical role in modulating brain functions through glutamate co-transmission. Targeting VGLUT3 for therapeutic strategies could lead to breakthroughs in treating conditions such as Parkinson's disease and addiction.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2021)
Article
Anesthesiology
Nobuko Ohashi, Daisuke Uta, Masayuki Ohashi, Hiroshi Baba
Summary: Ivabradine, a blocker of HCN channels, exerts analgesic effects against inflammatory pain by inhibiting spinal responses mediated by HCN channels on primary afferent terminals. It reduces phosphorylated extracellular signal-regulated kinase activation in the spinal dorsal horn and preferentially acts on C-fiber terminals, exhibiting a stronger inhibition of neuronal excitability in inflammatory pain.
Article
Materials Science, Textiles
Neenu Poonia, Vinod Kadam, Neelam M. Rose, Saroj Yadav, N. Shanmugam
Summary: This study investigates the effect of alkali, enzyme, and their sequential combination treatment on the properties of rice straw fibers. The results show that the sequential combination of alkali and enzyme treatment significantly improves the mechanical properties and noise reduction coefficient of rice straw fiber composites.
JOURNAL OF NATURAL FIBERS
(2022)
Article
Chemistry, Analytical
Chunyi Liu, Jie Tang, Yingjiao Xu, Shanshan Cao, Yi Fang, Chao Zhao, Zhengping Chen
Summary: The study aimed to develop a novel chromatographic method for determining the molar activity of [F-18]FP-(+)-DTBZ and investigate the impact of A(m) on the quantitative analysis of VMAT2 autoradiography. The results showed that A(m) and FP-(+)-DTBZ content have a significant effect on the quantitative analysis of VMAT2 autoradiography using [F-18]FP-(+)-DTBZ.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Plant Sciences
Siqi Sun, Axiang Yu, Ruiyang Cheng, Le Wang, Ting He, Xiao Xu, Ruolan Song, Dongjie Shan, Fang Lv, Xiangjian Zhong, Qingyue Deng, Xianxian Li, Yingyu He, Yuan Zheng, Xueyang Ren, Qing Xia, Gaimei She
Summary: This study aimed to investigate the similarities and differences between two specifications (Ziqin and Kuqin) of Scutellaria baicalensis in anti-inflammatory, analgesic, and antioxidant activities. The chemical fingerprints and constituents of Ziqin and Kuqin were analyzed, and it was found that they had similar chemical compositions but different proportions. This study helps to improve the understanding of the different clinical applications of Ziqin and Kuqin and provides a reference for formulation of quality standards and further research.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Neurosciences
Moe Soeda, Seii Ohka, Daisuke Nishizawa, Junko Hasegawa, Kyoko Nakayama, Yuko Ebata, Ken-ichi Fukuda, Kazutaka Ikeda
Summary: Genetic polymorphisms of SLC17A9 and P2RY12 genes are associated with the development of phantom tooth pain, indicating a role of genes in PTP.
Article
Biochemistry & Molecular Biology
Tomoya Takeuchi, Yuika Harada, Satomi Moriyama, Kazuyuki Furuta, Satoshi Tanaka, Takaaki Miyaji, Hiroshi Omote, Yoshinori Moriyama, Miki Hiasa
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Review
Biochemistry & Molecular Biology
Yoshinori Moriyama, Miki Hiasa, Shohei Sakamoto, Hiroshi Omote, Masatoshi Nomura
PURINERGIC SIGNALLING
(2017)
Article
Biochemistry & Molecular Biology
Tatsuya Kawasaki, Takuya Matsumoto, Yuma Iwai, Mamiyo Kawakami, Narinobu Juge, Hiroshi Omote, Tomohiro Nabekura, Yoshinori Moriyama
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2018)
Article
Biochemistry & Molecular Biology
Yuika Harada, Yuri Kato, Takaaki Miyaji, Hiroshi Omote, Yoshinori Moriyama, Miki Hiasa
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Biochemical Research Methods
Mamiyo Kawakami, Narinobu Juge, Yuri Kato, Hiroshi Omote, Yoshinori Moriyama, Takaaki Miyaji
JOURNAL OF PROTEOME RESEARCH
(2018)
Article
Multidisciplinary Sciences
Kumar Nagarathinam, Yoshiko Nakada-Nakura, Christoph Parthier, Tohru Terada, Narinobu Juge, Frank Jaenecke, Kehong Liu, Yunhon Hotta, Takaaki Miyaji, Hiroshi Omote, So Lwata, Norimichi Nomura, Milton T. Stubbs, Mikio Tanabe
NATURE COMMUNICATIONS
(2018)
Article
Biochemistry & Molecular Biology
Yuma Iwai, Setsuko Kamatani, Sawako Moriyama, Hiroshi Omote
JOURNAL OF BIOCHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Shunsuke Matsuo, Miki Hiasa, Hiroshi Omote
JOURNAL OF BIOCHEMISTRY
(2020)
Article
Plant Sciences
Jing Che, Naoki Yamaji, Takaaki Miyaji, Namiki Mitani-Ueno, Yuri Kato, Ren Fang Shen, Jian Feng
PLANT AND CELL PHYSIOLOGY
(2020)
Article
Multidisciplinary Sciences
Yuri Kato, Kengo Ohsugi, Yuto Fukuno, Ken Iwatsuki, Yuika Harada, Takaaki Miyaji
Summary: This study found that EPA and its metabolites can alleviate neuropathic and inflammatory pain by inhibiting VNUT, as well as improve insulin resistance. This suggests that EPA may serve as a unique nutrient-based treatment and prevention strategy for neurological, immunological, and metabolic diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biology
Seiko Nakamura, Aiko Matsui, Shiori Akabane, Yasushi Tamura, Azumi Hatano, Yuriko Miyano, Hiroshi Omote, Mizuho Kajikawa, Katsumi Maenaka, Yoshinori Moriyama, Toshiya Endo, Toshihiko Oka
COMMUNICATIONS BIOLOGY
(2020)