Review
Chemistry, Physical
Jacob Fish, Gregory J. Wagner, Sinan Keten
Summary: Multiscale modelling is a powerful tool for simulating materials behavior across different length and time scales. It aims to simulate continuum-scale behavior using information from computational models of finer scales, rather than relying on empirical constitutive models. Various methods have been developed to bridge multiple length and time scales, including techniques integrating new fields such as machine learning and material design.
Review
Mathematics
Ruben Doste, Alfonso Bueno-Orovio
Summary: Beta-adrenergic receptor stimulation is a physiological mechanism regulating cardiovascular function under stress or exercise. It impacts cardiac pathology by affecting cardiomyocyte electrophysiology and mechanical response. Patient-specific models and multiscale frameworks are important tools for personalized study of cardiac disease, but few studies have incorporated beta-ARS modeling.
Article
Engineering, Chemical
Mario Grassi, Italo Colombo, Davide Manca, Alice Biasin, Lucia Grassi, Gabriele Grassi, Michela Abrami
Summary: Drug activation by grinding or co-grinding has evolved considerably since the 1980s, leading to improved drug bioavailability. This study successfully interpreted and described experimental data by developing a mathematical model to establish the relationship between mill settings and milled drug properties.
CHEMICAL ENGINEERING SCIENCE
(2022)
Article
Biology
James Cushway, Liam Murphy, J. Geoffrey Chase, Geoffrey M. Shaw, Thomas Desaive
Summary: Mechanical ventilation, especially when using high positive end-expiratory pressure, has detrimental effects on the cardiovascular system. Stressed blood volume, which is an index of fluid responsiveness, can potentially be used as a diagnostic tool. Therefore, optimizing both the pulmonary and cardiovascular state is important for guiding the use of positive end-expiratory pressure.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Oncology
George Caddy, Justin Stebbing, Gareth Wakefield, Megan Adair, Xiao Yun Xu
Summary: A multiscale computational model has been developed to assess the distribution of nanoparticles within a realistic tumour, and the results show that negatively charged particles can achieve a more uniform distribution. The choice of injection location also affects the particle distribution.
Article
Multidisciplinary Sciences
Brydon Eastman, Michelle Przedborski, Mohammad Kohandel
Summary: The study shows that chemotherapeutic dosing strategies learned through reinforcement learning methods are more resilient to perturbations in patient-specific parameter values. By training an agent on mean-value parameters and allowing periodic access to a more easily measurable metric, relative bone marrow density, drug dosing schedules that outperform classical optimal control methods can be developed.
SCIENTIFIC REPORTS
(2021)
Article
Materials Science, Multidisciplinary
Shao-Wen Yao, Waqas Ali Faridi, Muhammad Imran Asjad, Adil Jhangeer, Mustafa Inc
Summary: This study focuses on the application of fractional calculus in the mathematical model of atherosclerosis inflammation and proposes a model with memory function in place of initial conditions utilizing the Atangana-Baleanu fractional operator. The obtained solution is discussed to be unique with qualitative analysis carried out on the proposed model. The authors are confident in the effectiveness of the generated mathematical fractional-order atherosclerosis inflammation model and suggest potential new ideas for testing and experiments in the future.
RESULTS IN PHYSICS
(2021)
Article
Polymer Science
Andrey E. Krauklis, Christian W. Karl, Iuri B. C. M. Rocha, Juris Burlakovs, Ruta Ozola-Davidane, Abedin I. Gagani, Olesja Starkova
Summary: This paper summarizes the modelling methods for environmental ageing of polymers and polymer composites, including modular and multiscale approaches. These methods can predict the environmental ageing and degradation of materials, providing a deeper and reliable understanding, and enhancing confidence in the prediction of material's environmental durability.
Article
Multidisciplinary Sciences
Huseyin Tunc, Murat Sari, Seyfullah Kotil
Summary: This article proposes a mathematical modeling framework to study the impact of existing mutations, timing of initiation, and adherence levels of nucleotide reverse transcriptase inhibitors (NRTIs) on the evolutionary dynamics of HIV strains. The results are crucial for optimizing treatment protocols for HIV patients.
Article
Engineering, Geological
Marco Previtali, Matteo Oryem Ciantia, Saverio Spadea, Riccardo Pietro Castellanza, Giovanni Battista Crosta
Summary: In this study, a discrete-element model was used to analyze a full-scale compound mesh barrier, revealing that impact position significantly affects the barrier response, particularly in terms of peak load and different loading modes.
PROCEEDINGS OF THE INSTITUTION OF CIVIL ENGINEERS-GEOTECHNICAL ENGINEERING
(2021)
Article
Engineering, Biomedical
Gustavo Guerrero, Virginie Le Rolle, Corinne Loiodice, Amel Amblard, Jean-Louis Pepin, Alfredo Hernandez
Summary: A model-based approach is proposed to analyze the acute desaturation response to obstructive apneas. By analyzing the data from 107 patients, a dynamic model related to sleep apnea was obtained. The study results have potential applications for personalized diagnosis and treatment.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Biology
N. Ratto, A. Bouchnita, P. Chelle, M. Marion, M. Panteleev, D. Nechipurenko, B. Tardy-Poncet, V. Volpert
Summary: Blood coagulation, a highly studied process in biomedical modelling, faces limitations in clinical applications due to large inter-patient parameter variation and process complexity. This work proposes a patient-specific modelling approach for blood coagulation.
BULLETIN OF MATHEMATICAL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Julia M. Assini, Justin R. Clark, Amer Youssef, Chuce Xing, Alexandria M. Doerfler, So Hyun Park, Lavanya Saxena, Adam B. Yaseen, Jan Boren, Robert Gros, Gang Bao, William R. Lagor, Michael B. Boffa, Marlys L. Koschinsky
Summary: Lp(a) has been shown to contribute to the development of more severe atherosclerotic lesions, especially in female mice. This suggests a potential pro-inflammatory role of Lp(a) in atherosclerosis.
Article
Multidisciplinary Sciences
Karim Kadry, Max L. Olender, David Marlevi, Elazer R. Edelman, Farhad R. Nezami
Summary: This study introduces a semi-automatic computational platform that utilizes clinical optical coherence tomography images to reconstruct a patient-specific multi-material 3D model of atherosclerotic plaques, allowing for mechanical response analysis via structural finite-element simulations. The research demonstrates that including various plaque components significantly affects the mechanical response of lesions, highlighting the importance of multi-material formulations.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2021)
Article
Computer Science, Interdisciplinary Applications
Nicola Ferro, Simona Perotto, Daniele Bianchi, Raffaele Ferrante, Marco Mannisi
Summary: A flexible problem-specific multiscale topology optimization method is proposed to associate different areas of the design domain with diverse microstructures extracted from a dictionary. The dictionary is generated using the micro-SIMPATY algorithm, which promotes free-form layout design. The method is applied to the design of orthotic devices for the treatment of foot diseases and validated in terms of mechanical performances and manufacturability.
STRUCTURAL AND MULTIDISCIPLINARY OPTIMIZATION
(2022)
Article
Physiology
Mona Alimohammadi, Cesar Pichardo-Almarza, Obiekezie Agu, Vanessa Diaz-Zuccarini
FRONTIERS IN PHYSIOLOGY
(2016)
Article
Engineering, Biomedical
Mirko Bonfanti, Stavroula Balabani, Mona Alimohammadi, Obiekezie Agu, Shervanthi Homer-Vanniasinkam, Vanessa Diaz-Zuccarini
MEDICAL ENGINEERING & PHYSICS
(2018)
Article
Engineering, Biomedical
Mona Alimohammadi, Obiekezie Agu, Stavroula Balabani, Vanessa Diaz-Zuccarini
MEDICAL ENGINEERING & PHYSICS
(2014)
Article
Cardiac & Cardiovascular Systems
Iolanda Decorato, Anne-Virginie Salsac, Cecile Legallais, Mona Alimohammadi, Vanessa Diaz-Zuccarini, Zaher Kharboutly
CARDIOVASCULAR ENGINEERING AND TECHNOLOGY
(2014)
Article
Multidisciplinary Sciences
Mohammad Amin Abazari, Deniz Rafieianzab, M. Soltani, Mona Alimohammadi
Summary: The study reconstructed patient-specific geometry of type-B AD and implemented numerical simulation using CFD. Results showed that controlling TAWSS and HOLMES values can prevent lesions and control calcification and plaque formation.
SCIENTIFIC REPORTS
(2021)
Proceedings Paper
Biochemical Research Methods
Mona Alimohammadi, Cesar Pichardo-Almarza, Giulia Di Tomaso, Stavroula Balabani, Obiekezie Agu, Vanessa Diaz-Zuccarini
BIOINFORMATICS AND BIOMEDICAL ENGINEERING (IWBBIO 2015), PT II
(2015)