Article
Polymer Science
Jidong Dai, Min Liang, Zhigang Zhang, Katrien Bernaerts, Tianzhu Zhang
Summary: By crosslinking nucleation to prepare crystalline 4arm-PLGA, the degradation rate of PLGA can be effectively controlled, promoting cell growth and potentially having ideal performance in tissue engineering.
Article
Polymer Science
Xiaohua Chang, Dengwen Hu, Liangren Chen, Yaping Wang, Yutian Zhu
Summary: Thermoresponsive block copolymer micelles have potential in biological applications, with studies showing that changes in hydrophobic/hydrophilic block ratio, micelle concentration and addition of salt can alter the cloud point. Increasing the amount of PLGA hydrophobic block significantly decreases the cloud point, while higher micelle concentration and salt addition also lower the cloud point.
Article
Pharmacology & Pharmacy
Nguyen Thi Thu Thao, Surha Lee, Gi Ru Shin, Youngji Kang, Sangdun Choi, Moon Suk Kim
Summary: Small intestine submucosa (SIS) was chosen as a drug carrier and electrospun into nanofiber sheets. Poly(epsilon-caprolactone-ran-l-lactide) (PCLA) copolymers were used to improve the electrospinning performance of SIS, resulting in adjustable S/P-NS with different porosities and tensile strengths. The electrospun S/P-NS successfully delivered dexamethasone (Dex) and silver sulfadiazine (AgS) for sustained release over three weeks, suppressing macrophage infiltration.
Article
Materials Science, Textiles
Min Ho Jee, Song Yeon Choi, Chan sol Kang, Doo Hyun Baik
Summary: In this study, a novel poly(glycolide-co-e-caprolactone-co-l-lactide) block copolymer was synthesized and used to prepare the PGCLA suture. The mechanical and morphological properties of the PGCLA suture during in vitro degradation were systematically investigated. It was found that the simultaneous degradation of glycolide units and l-lactide units in the amorphous region leads to chemical and structural changes, as well as a decrease in the mechanical properties of the suture.
FIBERS AND POLYMERS
(2023)
Article
Polymer Science
Zemei Fang, Zhihua Zhou, Wei Wu, Wenjuan Liu, Hailin Xie, Hongbo Hu, Yan Gan, Jianjun Fang
Summary: A degradable blend scaffold composed of PLLGC and EMPLGA was prepared and characterized for its morphology and biocompatibility. The blend scaffold exhibited a porous structure and high cell proliferation.
JOURNAL OF MACROMOLECULAR SCIENCE PART B-PHYSICS
(2022)
Article
Engineering, Biomedical
Lucy Geddes, Efrosyni Themistou, James F. Burrows, Fraser J. Buchanan, Louise Carson
Summary: This study aimed to develop an in vitro protocol for assessing the long-term cytotoxicity of bioresorbable polymers. Results showed that PDLLGA samples exhibited increasing cytotoxicity at later degradation stages, while PLLGA samples demonstrated significantly less cytotoxic behavior. Additionally, a new dynamic flow culture methodology was developed and validated to test the cytotoxicity of these degradable materials, along with profiling of inflammatory cytokines released by cells in response to degraded PDLLGA and PLLGA.
ACTA BIOMATERIALIA
(2021)
Article
Anatomy & Morphology
Afaf M. Ali, Ali H. Amin
Summary: This study investigates the effects of cold drawing and thermal annealing processes on the properties of surgical suture fibers. The results show that both processes significantly enhance the physical and structural properties of the sutures, providing important improvements for their medical application.
MICROSCOPY RESEARCH AND TECHNIQUE
(2022)
Article
Engineering, Biomedical
Gang Zhong, Yihao Liu, Canpei Liu, Xu Li, Jingwei Lin, Alain Luigi Lanzon, Huagui Zhang, Mingfeng Chen
Summary: Bio-absorbable polymers are desired biomaterials for surgery hemostatic and medical tissue engineering devices. In this study, a blend biomaterial of PPDO/PLGA/PES-b-PGA was prepared using a compatibilizer to enhance compatibility. The biomaterial showed good biocompatibility, slight cytotoxicity, and promoted cell proliferation, making it suitable for potential applications in medical tissue engineering devices.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2021)
Article
Materials Science, Composites
He Cai, Tongrui Zhang, Ruixian Dai, Shiping Song, Rui Han, Yijun Li, Junyu Chen
Summary: In this study, a PLGA/PCL bone fixation plate with enhanced mechanical and cell adhesion properties was produced by micro-injection process. The in-situ fibrillation of PCL at high injection rate constructed unique parent-daughter fibril morphology, promoting the interaction between PLGA and PCL interfaces. The well-oriented PCL fibrils with high crystallinity served as a barrier to prevent slip of PLGA molecular chain and water molecule invasion, playing a key role in promoting cell proliferation.
COMPOSITES SCIENCE AND TECHNOLOGY
(2021)
Article
Polymer Science
Meiling Yi, Zhihua Zhou, Wenjuan Liu, Tianlong Huang, Yanmin Zhao, Ping Chen, Ziwei Zhou, Dan Wang, Chao Zhang, Jianjun Fang
Summary: In this study, PLLGC microspheres with controllable degradation rate were found to have a lower degradation rate compared to PLGA microspheres. This suggests a promising application future in drug delivery field.
JOURNAL OF MACROMOLECULAR SCIENCE PART B-PHYSICS
(2021)
Article
Chemistry, Multidisciplinary
Magda M. Rebanda, Simona Bettini, Laura Blasi, Antonio Gaballo, Andrea Ragusa, Alessandra Quarta, Clara Piccirillo
Summary: Polymeric nanoparticles made of different surfactants were prepared and compared for drug delivery. The results showed that dextran-coated nanoparticles were the most effective carriers for both hydrophilic and hydrophobic drugs, exhibiting cytotoxic activity.
Article
Biotechnology & Applied Microbiology
Bukola A. Oseni, Chukwuemeka P. Azubuike, Omotunde O. Okubanjo, Cecilia I. Igwilo, Jayanth Panyam
Summary: Andrographolide, a potential chemopreventive and chemotherapeutic agent, was encapsulated in PLGA nanoparticles using emulsion solvent evaporation technique to improve its therapeutic efficacy. The optimal formulation, with a polymer ratio of 85:15 lactide to glycolide and ethyl acetate as the organic solvent, demonstrated sustained release of the drug and significantly enhanced in vitro anticancer efficacy compared to free drug in a metastatic breast cancer cell line. Further in-depth efficacy studies are warranted for the nanoparticle formulation of andrographolide.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Xinyu Wang, Zefei Yuan, Xueyi Pan, Jianbo Li, Qinggang Tan, Jie Ren
Summary: Due to the exhaustion of fossil resources and the degradation of the environment, there is a growing interest in using eco-friendly materials as substitutes for petroleum-derived materials. In this study, a series of poly(& epsilon;-caprolactone-co-lacticacid) diols were synthesized with different lactic acid (LA)/& epsilon;-caprolactone (CL) ratios. The resulting eco-friendly diols were used to produce polyurethane reactive hot-melt adhesives (PURHAs), which showed improved properties such as higher glass transition temperature, crystallinity, and strength compared to non-PCL-containing PURHAs. These bio-based PURHAs have potential applications in various industries.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Chemistry, Physical
Andrzej Puszka, Janusz W. Sikora
Summary: New segmented poly(thiourethane-urethane)s (SPTURs) with high molar masses were synthesized by reaction, showing good thermal and mechanical properties as well as adhesion. These SPTURs exhibit high resistance to hydrolysis and are hydrophilic in nature.
Article
Materials Science, Textiles
Min Ho Jee, Ji Hee Park, Song Yeon Choi, Doo Hyun Baik
Summary: By introducing L-lactide as a comonomer in the first step of the polymerization process, significant changes in the microstructure, thermal properties, and in vitro degradation properties of the PGCL block copolymers were observed.
FIBERS AND POLYMERS
(2022)
Article
Engineering, Biomedical
Ali Honarpardaz, Shiva Irani, Mohamad Pezeshki-Modaress, Mojgan Zandi, Amin Sadeghi
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2019)
Article
Chemistry, Applied
Seyed Fakhreddin Hosseini, Zahra Nahvi, Mojgan Zandi
FOOD HYDROCOLLOIDS
(2019)
Article
Materials Science, Multidisciplinary
Atieyh Esmi, Yousef Jahani, Ali Akbar Yousefi, Mojgan Zandi
MATERIALS RESEARCH EXPRESS
(2019)
Article
Nanoscience & Nanotechnology
Mojgan Moghanizadeh-Ashkezari, Parvin Shokrollahi, Mojgan Zandi, Fatemeh Shokrolahi, Morteza J. Daliri, Mozhgan R. Kanavi, Sahar Balaghali
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Polymer Science
Mohadeseh Akbarzadeh, Mohamad Pezeshki-Modaress, Mojgan Zandi
JOURNAL OF APPLIED POLYMER SCIENCE
(2020)
Article
Pharmacology & Pharmacy
Ali Shababdoust, Mojgan Zandi, Morteza Ehsani, Parvin Shokrollahi, Reza Foudazi
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Article
Pharmacology & Pharmacy
Monireh Azizi, Farhid Farahmandghavi, Mohammad Taghi Joghataei, Mojgan Zandi, Mohammad Imani, Mehrdad Bakhtiari, Hamid Omidian
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Article
Polymer Science
Mohammad Kazemi Ashtiani, Mojgan Zandi, Parvin Shokrollahi, Morteza Ehsani, Hossein Baharvand
POLYMERS FOR ADVANCED TECHNOLOGIES
(2020)
Article
Materials Science, Multidisciplinary
Mohammad Vahedi, Fatemeh Shokrolahi, Jalal Barzin, Parvin Shokrollahi, Leila Taghiyar, Mohammad Kazemi Ashtiani
MACROMOLECULAR MATERIALS AND ENGINEERING
(2020)
Article
Polymer Science
Dorfam Hajzamani, Parvin Shokrollahi, Najmeh Najmoddin, Fatemeh Shokrolahi
POLYMERS FOR ADVANCED TECHNOLOGIES
(2020)
Article
Engineering, Biomedical
Maryam Khajavi, Abdolmajid Hajimoradloo, Mojgan Zandi, Mohamad Pezeshki-Modaress, Shahin Bonakdar, Abbas Zamani
Summary: The study successfully engineered a cartilage-like scaffold using ECM from sturgeon fish cartilage to stimulate cartilaginous matrix synthesis in human adipose stem cells. The porous scaffold derived from fish cartilage ECM showed excellent potential for cartilage tissue engineering, supporting cell adhesion, proliferation, and chondrogenic differentiation. The scaffold was demonstrated to facilitate the synthesis of specific cartilage proteins, such as collagen type II and aggrecan, making it a promising option for tissue regeneration.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Polymer Science
Amirhesam Arabsorkhi-Mishabi, Mojgan Zandi, Fahimeh Askari, Mohamad Pezeshki-Modaress
Summary: Different polycaprolactone (PCL) soft blocks were incorporated into poly(glycerol sebacate) (PGS) structure to prepare a series of PGS-based elastomers with varied chemical compositions and mechanical properties. The PGS and PGS-co-PCL elastomers were prepared through thermal curing without any catalysts. The synthesized PGS-co-PCL elastomers exhibited tunable mechanical properties in the range of soft tissues and showed promising potential in biomedical applications and soft tissue engineering.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Engineering, Biomedical
Sogand Safari, Morteza Ehsani, Mojgan Zandi
Summary: A high molecular weight PNVCL-PVAc thermo-responsive copolymer suitable for electrospun nanofiber fabrication was successfully synthesized and demonstrated to have biocompatibility and non-cytotoxicity. The synthesized copolymers showed promising characteristics for biomedical applications, as confirmed by contact angle test and cell proliferation results.
PROGRESS IN BIOMATERIALS
(2021)
Article
Polymer Science
Zhongming Yuan, Hiroko Yamamoto, Shinji Kanehashi, Takeshi Shimomura
Summary: This study reports the synthesis of a flexible light-emitting polymer film using a solution blending method. The selective positioning of MEH-PPV molecules in the PS phase of the film was confirmed. The film exhibited a nanometer-scale luminescent domain with low aggregation quenching and showed good elastomeric characteristics.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2024)