Journal
POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING
Volume 57, Issue 5, Pages 459-470Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/03602559.2017.1320722
Keywords
Acrylic acid; perindopril erbumin; xanthan gum
Categories
Ask authors/readers for more resources
A novel xanthan gum-co-acrylic acid superabsorbent hydrogel composite was formulated by free radical polymerization reaction of acrylic acid on xanthan gum. Effect of variables like dynamic swelling ratio, equilibrium swelling ratio, drug loading and drug release was investigated. Swelling ratio increases with decrease in crosslinker concentration. Drug release studies were conducted in pH 7.4 and 0.1N HCl. In acidic environment, drug release was low whereas it was sustained release in alkaline. XG4 showed significant swelling and drug release up to 24 hr. Physicochemical evaluation also confirmed it was optimized formulation. Hence XG4-co-AA was optimized for once daily dose of Perindopril Erbumine. [GRAPHICS] .
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available