3.9 Article

An Insight on the Swelling, Viscoelastic, Electrical, and Drug Release Properties of Gelatin-Carboxymethyl Chitosan Hydrogels

Journal

POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING
Volume 57, Issue 5, Pages 404-416

Publisher

TAYLOR & FRANCIS INC
DOI: 10.1080/03602559.2016.1260732

Keywords

Carboxymethyl chitosan; gelatin; Peleg's sorption model; Peppas-Sahlin model; Weichert model

Funding

  1. Science and Engineering Research Board (SERB), Govt. of India [SR/FT/LS-171/2009]

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The present study reports the in-depth analysis of the gelatin-carboxymethyl chitosan hydrogels. The composite system formed phase-separated hydrogels, which is confirmed by scanning electron microscopy. The swelling of the carboxymethyl chitosan-containing hydrogels was lower than the gelatin hydrogel. Macroscale deformation study using a static mechanical tester indicated a viscoelastic nature of the hydrogels. A decrease in the impedance of the hydrogels was observed with an increase in the carboxymethyl chitosan content. The drug release from the hydrogels was predominantly Fickian diffusion mediated and was released in its active form. The results suggested the potential use of the hydrogels as drug delivery matrices. [GRAPHICS] .

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