The bottom-up construction of chiral porous organic polymers for heterogeneous asymmetric organocatalysis: MacMillan catalyst built-in nanoporous organic frameworks

Although many porous organic polymers (POPs) embedded with chiral ligand-metal catalytic activities have been examined as heterogeneous asymmetric catalysts, examples of metal-free stereoselective POP catalysts are very scarce. Herein, we report a bottom-up strategy used to construct a MacMillan catalystembedded chiral porous organic polymer, Mac-CPOPs. The porosity of the Mac-CPOPs frameworks could be adjusted by varying the molecular length of the rigid structural monomers. Due to the high Brunauer-Emmett-Teller specific surface area and the built-in character of the covalently linked MacMillan catalyst, the Mac-CPOP-2 polymer can be applied as a highly efficient and recoverable heterogeneous organocatalyst in the asymmetric Diels-Alder reaction, which gives products in good yields and with good enantioselectivity. Moreover, the Mac-CPOP-2 polymer can be reused 6 times for the asymmetric Diels-Alder reaction without any significant loss of catalytic activity and enantioselectivity.