ZL006, a small molecule inhibitor of PSD-95/nNOS interaction, does not induce antidepressant-like effects in two genetically predisposed rat models of depression and control animals

Source memory in rats is impaired by an NMDA receptor antagonist but not by PSD95-nNOS protein–protein interaction inhibitors

(2016) Alexandra E. Smith et al.   BEHAVIOURAL BRAIN RESEARCH

Pharmacological evidence for the involvement of the NMDA receptor and nitric oxide pathway in the antidepressant-like effect of lamotrigine in the mouse forced swimming test

(2016) Sattar Ostadhadi et al.   BIOMEDICINE & PHARMACOTHERAPY

Metabolic investigation on ZL006 for the discovery of a potent prodrug for the treatment of cerebral ischemia

(2016) Dongyin Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Involvement of NMDA receptors and l-arginine/nitric oxide/cyclic guanosine monophosphate pathway in the antidepressant-like effects of topiramate in mice forced swimming test

(2016) Sattar Ostadhadi et al.   BRAIN RESEARCH BULLETIN

Small molecule inhibitors of PSD95-nNOS protein–protein interactions as novel analgesics

(2015) Wan-Hung Lee et al.   NEUROPHARMACOLOGY

Biochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ/PSD-95-PDZ interactions

(2015) Anders Bach et al.   Scientific Reports

Exploring Female Mice Interstrain Differences Relevant for Models of Depression

(2015) Daniela de Sá-Calçada et al.   Frontiers in Behavioral Neuroscience

Nitric oxide involvement in the antidepressant-like effect of ketamine in the Flinders sensitive line rat model of depression

(2014) Nico Liebenberg et al.   ACTA NEUROPSYCHIATRICA

Interaction of nNOS with PSD-95 Negatively Controls Regenerative Repair after Stroke

(2014) C.-X. Luo et al.   JOURNAL OF NEUROSCIENCE

Small-molecule inhibitors at the PSD-95/nNOS interface attenuate MPP+-induced neuronal injury through Sirt3 mediated inhibition of mitochondrial dysfunction

(2014) Wei Hu et al.   NEUROCHEMISTRY INTERNATIONAL

The nNOS-p38MAPK Pathway Is Mediated by NOS1AP during Neuronal Death

(2013) L.-L. Li et al.   JOURNAL OF NEUROSCIENCE

Abnormalities in White Matter Microstructure Associated with Chronic Ketamine Use

(2013) R Edward Roberts et al.   NEUROPSYCHOPHARMACOLOGY

Small-Molecule Inhibitors at the PSD-95/nNOS Interface have Antidepressant-Like Properties in Mice

(2013) Marika V Doucet et al.   NEUROPSYCHOPHARMACOLOGY

Excitotoxicity and stroke: Identifying novel targets for neuroprotection

(2013) Ted Weita Lai et al.   PROGRESS IN NEUROBIOLOGY

Brain damages in ketamine addicts as revealed by magnetic resonance imaging

(2013) Chunmei Wang et al.   Frontiers in Neuroanatomy

Using the rat forced swim test to assess antidepressant-like activity in rodents

(2012) David A Slattery et al.   Nature Protocols

The role of the NMDA receptors and l-arginine–nitric oxide–cyclic guanosine monophosphate pathway in the antidepressant-like effect of duloxetine in the forced swimming test

(2012) Andréa D.E. Zomkowski et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Inhibition of cytochrome P450 enzymes involved in ketamine metabolism by use of liver microsomes and specific cytochrome P450 enzymes from horses, dogs, and humans

(2011) Lone D. Mössner et al.   AMERICAN JOURNAL OF VETERINARY RESEARCH

Antidepressant-like effect induced by systemic and intra-hippocampal administration of DNA methylation inhibitors

(2011) Amanda J Sales et al.   BRITISH JOURNAL OF PHARMACOLOGY

The economic cost of brain disorders in Europe

(2011) J. Olesen et al.   EUROPEAN JOURNAL OF NEUROLOGY

Cost of disorders of the brain in Europe 2010

(2011) Anders Gustavsson et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Nitric oxide and major depression

(2011) Ashish Dhir et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Involvement of NMDA receptors and l-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effects of escitalopram in the forced swimming test

(2010) Andréa D.E. Zomkowski et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95

(2010) Li Zhou et al.   NATURE MEDICINE

Involvement of serotonin receptor subtypes in the antidepressant-like effect of trim in the rat forced swimming test

(2010) Güner Ulak et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Disruption of nNOS-PSD95 protein-protein interaction inhibits acute thermal hyperalgesia and chronic mechanical allodynia in rodents

(2009) SK Florio et al.   BRITISH JOURNAL OF PHARMACOLOGY

Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders

(2008) Gerard Sanacora et al.   NATURE REVIEWS DRUG DISCOVERY

Effects of neuronal and inducible NOS inhibitor 1-[2-(trifluoromethyl) phenyl] imidazole (TRIM) in unpredictable chronic mild stress procedure in mice

(2008) Oguz Mutlu et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus

(2007) Lêda S.B. Garcia et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY