BKM120 induces apoptosis and inhibits tumor growth in medulloblastoma
Published 2017 View Full Article
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Title
BKM120 induces apoptosis and inhibits tumor growth in medulloblastoma
Authors
Keywords
Medulloblastoma, Cancer treatment, Apoptosis, Cell metabolism, Cell viability testing, Cytotoxicity, Malignant tumors, Gene expression
Journal
PLoS One
Volume 12, Issue 6, Pages e0179948
Publisher
Public Library of Science (PLoS)
Online
2017-06-30
DOI
10.1371/journal.pone.0179948
References
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Note: Only part of the references are listed.- Inhibitor of pan class-I PI3K induces differentially apoptotic pathways in acute leukemia cells: Shedding new light on NVP-BKM120 mechanism of action
- (2016) Davood Bashash et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Treatment with the PI3K inhibitor buparlisib (NVP-BKM120) suppresses the growth of established patient-derived GBM xenografts and prolongs survival in nude rats
- (2016) I. A. Netland et al. JOURNAL OF NEURO-ONCOLOGY
- PI-3K Inhibitors Preferentially Target CD15+ Cancer Stem Cell Population in SHH Driven Medulloblastoma
- (2016) Alok R. Singh et al. PLoS One
- PI3K inhibitors as new cancer therapeutics: implications for clinical trial design
- (2016) Cristian Massacesi et al. OncoTargets and Therapy
- Targeting the PI3K/AKT/mTOR Signaling Pathway in Medulloblastoma
- (2015) V. Dimitrova et al. CURRENT MOLECULAR MEDICINE
- Buparlisib, an oral pan-PI3K inhibitor for the treatment of breast cancer
- (2015) Elena Geuna et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Safety and Efficacy of Buparlisib (BKM120) in Patients with PI3K Pathway-Activated Non-Small Cell Lung Cancer
- (2015) Johan F. Vansteenkiste et al. Journal of Thoracic Oncology
- Inhibition of PI3K Signalling Selectively Affects Medulloblastoma Cancer Stem Cells
- (2015) Chiara Frasson et al. Biomed Research International
- Evaluation of In Vitro Activity of the Class I PI3K Inhibitor Buparlisib (BKM120) in Pediatric Bone and Soft Tissue Sarcomas
- (2015) Jennifer L. Anderson et al. PLoS One
- Targeting Phosphatidylinositide3-Kinase/Akt pathway by BKM120 for radiosensitization in hepatocellular carcinoma
- (2015) Wei-Lin Liu et al. Oncotarget
- Hsp90 inhibition enhances PI-3 kinase inhibition and radiosensitivity in glioblastoma
- (2014) Phyllis R. Wachsberger et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Stand Up to Cancer Phase Ib Study of Pan-Phosphoinositide-3-Kinase Inhibitor Buparlisib With Letrozole in Estrogen Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer
- (2014) Ingrid A. Mayer et al. JOURNAL OF CLINICAL ONCOLOGY
- Cognitive disorders in pediatric medulloblastoma: what neuroimaging has to offer
- (2014) Duc Ha Hoang et al. Journal of Neurosurgery-Pediatrics
- PI3K and cancer: lessons, challenges and opportunities
- (2014) David A. Fruman et al. NATURE REVIEWS DRUG DISCOVERY
- Tandem high-dose chemotherapy and autologous stem cell rescue in children with newly diagnosed high-risk medulloblastoma or supratentorial primitive neuro-ectodermic tumors
- (2014) Christelle Dufour et al. PEDIATRIC BLOOD & CANCER
- Rationally designed treatment for metastatic colorectal cancer: Current drug development strategies
- (2014) Pavlina Spiliopoulou WORLD JOURNAL OF GASTROENTEROLOGY
- Overcoming multiple drug resistance mechanisms in medulloblastoma
- (2014) Ramadhan T Othman et al. Acta Neuropathologica Communications
- Novel Therapies for the Treatment of Advanced Prostate Cancer
- (2013) J. M. Clarke et al. CURRENT TREATMENT OPTIONS IN ONCOLOGY
- Phosphatidylinositol 3-kinase (PI3K) inhibitors as cancer therapeutics
- (2013) Akintunde Akinleye et al. Journal of Hematology & Oncology
- The Clinical Relevance of Cancer Cell Lines
- (2013) J.-P. Gillet et al. JNCI-Journal of the National Cancer Institute
- The rationale for targeted therapies in medulloblastoma
- (2013) Tobey J. MacDonald et al. NEURO-ONCOLOGY
- An Animal Model of MYC-Driven Medulloblastoma
- (2012) Yanxin Pei et al. CANCER CELL
- Homeostasis and the Importance for a Balance Between AKT/mTOR Activity and Intracellular Signaling
- (2012) D. A. Altomare et al. CURRENT MEDICINAL CHEMISTRY
- HD-MB03 is a novel Group 3 medulloblastoma model demonstrating sensitivity to histone deacetylase inhibitor treatment
- (2012) Till Milde et al. JOURNAL OF NEURO-ONCOLOGY
- Subgroup-specific structural variation across 1,000 medulloblastoma genomes
- (2012) Paul A. Northcott et al. NATURE
- Current clinical development of PI3K pathway inhibitors in glioblastoma
- (2012) P. Y. Wen et al. NEURO-ONCOLOGY
- Antitumor Activity of NVP-BKM120--A Selective Pan Class I PI3 Kinase Inhibitor Showed Differential Forms of Cell Death Based on p53 Status of Glioma Cells
- (2011) D. Koul et al. CLINICAL CANCER RESEARCH
- Phase I, Dose-Escalation Study of BKM120, an Oral Pan-Class I PI3K Inhibitor, in Patients With Advanced Solid Tumors
- (2011) Johanna C. Bendell et al. JOURNAL OF CLINICAL ONCOLOGY
- Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor
- (2011) S.-M. Maira et al. MOLECULAR CANCER THERAPEUTICS
- Challenging issues in pediatric oncology
- (2011) Ching-Hon Pui et al. Nature Reviews Clinical Oncology
- Predictive biomarkers for the activity of mammalian target of rapamycin (mTOR) inhibitors
- (2011) Catherine Delbaldo et al. Targeted Oncology
- Mouse models of medulloblastoma
- (2011) Xiaochong Wu et al. Chinese Journal of Cancer
- Childhood medulloblastoma: novel approaches to the classification of a heterogeneous disease
- (2010) David W. Ellison ACTA NEUROPATHOLOGICA
- Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma
- (2010) S. Buonamici et al. Science Translational Medicine
- Small-Molecule Inhibitors of Phosphatidylinositol 3-Kinase/Akt Signaling Inhibit Wnt/ -Catenin Pathway Cross-Talk and Suppress Medulloblastoma Growth
- (2009) N. Baryawno et al. CANCER RESEARCH
- Targeting the PI3K p110 Isoform Inhibits Medulloblastoma Proliferation, Chemoresistance, and Migration
- (2008) A. S. Guerreiro et al. CLINICAL CANCER RESEARCH
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