Cysteamine-mediated clearance of antibiotic-resistant pathogens in human cystic fibrosis macrophages

Cysteamine re-establishes the clearance of Pseudomonas aeruginosa by macrophages bearing the cystic fibrosis-relevant F508del-CFTR mutation

(2017) Eleonora Ferrari et al.   Cell Death & Disease

A novel treatment of cystic fibrosis acting on-target: cysteamine plus epigallocatechin gallate for the autophagy-dependent rescue of class II-mutated CFTR

(2016) A Tosco et al.   CELL DEATH AND DIFFERENTIATION

An Open-Label Investigation of the Pharmacokinetics and Tolerability of Oral Cysteamine in Adults with Cystic Fibrosis

(2016) Graham Devereux et al.   CLINICAL DRUG INVESTIGATION

Cystinosis: a review

(2016) Mohamed A. Elmonem et al.   Orphanet Journal of Rare Diseases

Microbial Biofilms: Impact on the Pathogenesis of Periodontitis, Cystic Fibrosis, Chronic Wounds and Medical Device-Related Infections

(2015) Mara Mihai et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Manipulation of Autophagy in Phagocytes Facilitates Staphylococcus aureus Bloodstream Infection

(2015) Kate M. O'Keeffe et al.   INFECTION AND IMMUNITY

The emerging potential of autophagy-based therapies in the treatment of cystic fibrosis lung infections

(2014) Robert D Junkins et al.   Autophagy

Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation

(2014) Daniela De Stefano et al.   Autophagy

Cysteamine (Lynovex®), a novel mucoactive antimicrobial & antibiofilm agent for the treatment of cystic fibrosis

(2014) Cedric Charrier et al.   Orphanet Journal of Rare Diseases

IFN-γ Stimulates Autophagy-Mediated Clearance of Burkholderia cenocepacia in Human Cystic Fibrosis Macrophages

(2014) Kaivon Assani et al.   PLoS One

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Burkholderia cenocepacia J2315 escapes to the cytosol and actively subverts autophagy in human macrophages

(2013) Souhaila Al-Khodor et al.   CELLULAR MICROBIOLOGY

Anti-inflammatory and carbonic anhydrase restoring actions of yam powder (Dioscorea spp) contribute to the prevention of cysteamine-induced duodenal ulcer in a rat model

(2013) Jong-Min Park et al.   NUTRITION RESEARCH

Autophagy Enhances Bacterial Clearance during P. aeruginosa Lung Infection

(2013) Robert D. Junkins et al.   PLoS One

Staphylococcus aureus promotes autophagy by decreasing intracellular cAMP levels

(2012) María Belén Mestre et al.   Autophagy

Targeting autophagy as a novel strategy for facilitating the therapeutic action of potentiators on ΔF508 cystic fibrosis transmembrane conductance regulator

(2012) Alessandro Luciani et al.   Autophagy

Exaggerated inflammatory responses mediated by Burkholderia cenocepacia in human macrophages derived from Cystic fibrosis patients

(2012) Benjamin T. Kopp et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Randomized Controlled Crossover Trial with Delayed-Release Cysteamine Bitartrate in Nephropathic Cystinosis: Effectiveness on White Blood Cell Cystine Levels and Comparison of Safety

(2012) C. B. Langman et al.   Clinical Journal of the American Society of Nephrology

Depletion of the Ubiquitin-binding Adaptor Molecule SQSTM1/p62 from Macrophages HarboringcftrΔF508 Mutation Improves the Delivery ofBurkholderia cenocepaciato the Autophagic Machinery

(2012) Basant A. Abdulrahman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting bacterial integration host factor to disrupt biofilms associated with cystic fibrosis

(2012) Jodi E. Gustave et al.   Journal of Cystic Fibrosis

Autophagy stimulation by rapamycin suppresses lung inflammation and infection byBurkholderia cenocepaciain a model of cystic fibrosis

(2011) Basant A. Abdulrahman et al.   Autophagy

Cystic fibrosis: A disorder with defective autophagy

(2010) Alessandro Luciani et al.   Autophagy

Burkholderia cenocepacia O polysaccharide chain contributes to caspase-1-dependent IL-1β production in macrophages

(2010) Sheetal Kotrange et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition

(2010) Alessandro Luciani et al.   NATURE CELL BIOLOGY

Dynamics of intracellular bacterial replication at the single cell level

(2010) Sophie Helaine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-7 Activation by the Nlrc4/Ipaf Inflammasome Restricts Legionella pneumophila Infection

(2009) Anwari Akhter et al.   PLoS Pathogens