Histamine H4 receptor knockout mice display reduced inflammation in a chronic model of atopic dermatitis

Phase 2a, randomized, double-blind, placebo-controlled, multicenter, parallel-group study of a H4R-antagonist (JNJ-39758979) in Japanese adults with moderate atopic dermatitis

(2014) Yoko Murata et al.   JOURNAL OF DERMATOLOGY

Delineating the Role of Histamine-1- and -4-Receptors in a Mouse Model of Th2-Dependent Antigen-Specific Skin Inflammation

(2014) Subhashree Mahapatra et al.   PLoS One

Antagonism of the histamine H4 receptor reduces LPS-induced TNF production in vivo

(2013) Jeffery M. Cowden et al.   INFLAMMATION RESEARCH

Histamine induces proliferation in keratinocytes from patients with atopic dermatitis through the histamine 4 receptor

(2013) Franziska Glatzer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Histamine H 4 Receptor Antagonists Ineffective against Itch and Skin Inflammation in Atopic Dermatitis Mouse Model

(2013) Atsuko Kamo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The antagonism of histamine H1 and H4 receptors ameliorates chronic allergic dermatitis via anti-pruritic and anti-inflammatory effects in NC/Nga mice

(2012) Y. Ohsawa et al.   ALLERGY

Langerhans cells are critical in epicutaneous sensitization with protein antigen via thymic stromal lymphopoietin receptor signaling

(2012) Saeko Nakajima et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Lack of preventing effect of systemically and topically administered histamine H1 or H4 receptor antagonists in a dog model of acute atopic dermatitis

(2011) Wolfgang Bäumer et al.   EXPERIMENTAL DERMATOLOGY

Histamine H1, H3 and H4 receptors are involved in pruritus

(2011) K. Rossbach et al.   NEUROSCIENCE

The Role of the Histamine H4 Receptor in Atopic Dermatitis

(2010) Susanne Mommert et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Murine and human Langerhans cells express a functional histamine H4 receptor: modulation of cell migration and function

(2009) M. Gschwandtner et al.   ALLERGY

Histamine H4receptor antagonist ameliorates chronic allergic contact dermatitis induced by repeated challenge

(2009) M. Seike et al.   ALLERGY

In vitro and in vivo characterization of A-940894: a potent histamine H4 receptor antagonist with anti-inflammatory properties

(2009) MI Strakhova et al.   BRITISH JOURNAL OF PHARMACOLOGY

The role of histamine H4 receptor in immune and inflammatory disorders

(2009) E Zampeli et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Histamine H4 Receptor Mediates Inflammation and Pruritus in Th2-Dependent Dermal Inflammation

(2009) Jeffery M. Cowden et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Histamine H4receptors modulate dendritic cell migration through skin - immunomodulatory role of histamine

(2008) W. Bäumer et al.   ALLERGY

Histamine H4receptor antagonism reduces hapten-induced scratching behaviour but not inflammation

(2008) Kristine Roßbach et al.   EXPERIMENTAL DERMATOLOGY

Modification of the Picryl Chloride-Induced Allergic Dermatitis Model in Mouse Ear Lobes by 12-O-Tetradecanoylphorbol 13-Acetate, and Analysis of the Role of Histamine in the Modified Model

(2008) Noriyasu Hirasawa et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY