Article
Endocrinology & Metabolism
Min Jin Lee, Ah Reum Khang, Yang Ho Kang, Mi Sook Yun, Dongwon Yi
Summary: Hyperuricemia and abdominal obesity synergistically increase the risk of hypertriglyceridemia and low HDL-C in both sexes.
DIABETES & METABOLISM JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Omar Hahad, Volker H. Schmitt, Natalie Arnold, Karsten Keller, Jurgen H. Prochaska, Philipp S. Wild, Andreas Schulz, Karl J. Lackner, Norbert Pfeiffer, Irene Schmidtmann, Matthias Michal, Jorn M. Schattenberg, Oliver Tuscher, Andreas Daiber, Thomas Munzel
Summary: This study found sex-specific associations between smoking and measures of arterial stiffness, with stronger associations observed in men.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Lili Wu, Meimei Wu, Xuelian Zhang, Shuohua Chen, Guodong Wang, Shouling Wu, Jinqiang Zhuang, Jiang Hong
Summary: This study aimed to analyze the impact of arterial stiffness (AS) on heart failure (HF) in a community-based diabetic population. The results showed that AS was associated with an increased risk of HF in diabetic patients, and there was a dose-response relationship between AS and HF risk.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Review
Nutrition & Dietetics
Akihiro Kuma, Akihiko Kato
Summary: The prevalence of chronic kidney disease (CKD) has been increasing, and younger and middle-aged individuals with lifestyle-related diseases are at a higher risk of CKD. This article summarizes the predictive factors for CKD in the young population and the management of common diseases like hypertension and diabetes in middle-aged patients. As kidney function is mostly normal in the younger and middle-aged population with a lower risk of incident CKD, this review is important for reducing the prevalence of CKD.
Article
Multidisciplinary Sciences
Goh Eun Chung, Hyo Eun Park, Heesun Lee, Su-Yeon Choi
Summary: Increased arterial stiffness is significantly associated with prevalent atrial fibrillation, particularly in individuals with intermediate and high cardiovascular risk.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Kyung Won Lee, Dayeon Shin
Summary: Serum uric acid level and systemic inflammation are associated with an increased risk of type 2 diabetes mellitus (T2DM), and the combination of high levels of serum uric acid and hs-CRP significantly increases the incidence of T2DM.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Oscar Plunde, Anders Franco-Cereceda, Magnus Baeck
Summary: Valvular and arterial function are closely related, with aortic valve disease potentially underestimating arterial stiffness in peripheral segments. Factors such as age, diabetes, low body mass index, and changes in ejection time are independently associated with increased arterial stiffness after aortic valve surgery.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Immunology
Seong Mi Moon, Hayoung Choi, Sang Hyuk Kim, Hyung Koo Kang, Dong Won Park, Jin Hyung Jung, Kyungdo Han, Dong Wook Shin, Hyun Lee
Summary: This study comprehensively evaluated the risk of lung cancer in tuberculosis survivors, considering smoking and chronic obstructive pulmonary disease (COPD). The results showed that tuberculosis survivors had a 1.72-fold higher risk of lung cancer compared to the control group. Current smokers with >= 20 pack-years and tuberculosis survivors with COPD had the highest risks. Risk factors for lung cancer in tuberculosis survivors included pulmonary tuberculosis, age >60 years, smoking, and the presence of COPD or asthma.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Nutrition & Dietetics
Rosaria Del Giorno, Ania Maddalena, Stefano Bassetti, Luca Gabutti
Summary: This systematic literature review examines the association between alcohol use and arterial stiffness. The results suggest a J-shaped relationship, where light-to-moderate alcohol consumption is associated with lower arterial stiffness values, while high doses of alcohol accelerate arterial aging. Gender and age may also influence this association.
Article
Peripheral Vascular Disease
Lidia Cobos-Palacios, Maria Isabel Ruiz-Moreno, Monica Munoz-Ubeda, Almudena Lopez-Sampalo, Alberto Vilches-Perez, Antonio Vargas-Candela, Javier Benitez-Porres, Ana Navarro-Sanz, Luis Miguel Perez-Belmonte, Maria Dolores Lopez-Carmona, Jaime Sanz-Canovas, Ricardo Gomez-Huelgas, Maria Rosa Bernal-Lopez
Summary: This study evaluated the impact of a healthy lifestyle based on the Mediterranean diet and regular physical activity on arterial stiffness in overweight or obese elderly individuals. The findings suggest that a healthy lifestyle is associated with lower levels of arterial stiffness.
JOURNAL OF HYPERTENSION
(2022)
Article
Biochemistry & Molecular Biology
Yuya Fujishima, Hitoshi Nishizawa, Yusuke Kawachi, Takashi Nakamura, Seigo Akari, Yoshiyuki Ono, Shiro Fukuda, Shunbun Kita, Norikazu Maeda, Satoshi Hoshide, Iichiro Shimomura, Kazuomi Kario
Summary: In this study, it was found that topiroxostat, a uric acid-lowering therapy, improved arterial stiffness in hyperuricemic patients with liver dysfunction. This improvement may be attributed to the inhibitory effect of topiroxostat on plasma xanthine oxidoreductase.
Article
Cardiac & Cardiovascular Systems
Lin Lin, Long Wang, Rui Du, Chunyan Hu, Jieli Lu, Tiange Wang, Mian Li, Zhiyun Zhao, Yu Xu, Min Xu, Yufang Bi, Weiqing Wang, Guang Ning, Yuhong Chen
Summary: Arterial stiffness is associated with increased risk of metabolic syndrome and diabetes, with fatty liver partially mediating this association.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cell Biology
Anxin Wang, Yu Wang, Yingting Zuo, Xue Tian, Shuohua Chen, Yihan Ma, Xu Han, Shouling Wu, Xingquan Zhao
Summary: The study found that the risk of arterial stiffness increased significantly for metabolically healthy obese and metabolically unhealthy obese participants compared to metabolically healthy normal-weight controls. Further stratified analysis indicated that metabolic health status was a key factor in the relationship between BMI and arterial stiffness in all study populations.
Article
Cardiac & Cardiovascular Systems
Lin Jin, Mengjiao Zhang, Lei Sha, Mengmeng Cao, Lanyue Tong, Qingqing Chen, Cuiqin Shen, Lianfang Du, Liping Liu, Zhaojun Li
Summary: This study explores the use of the non-invasive arterial stiffness index (API) as a marker for residual stress in the peripheral muscular arteries in clinical settings, and investigates its association with cardiovascular disease (CVD) risk in China. The results show a U-shaped association between API and the China-PAR score, suggesting that API may play an important role in predicting CVD risk in the Chinese population.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Yunkyung Kim, Geun-Tae Kim, Jihun Kang
Summary: The study found that FM patients had a higher risk of central obesity, high triglyceride levels, and impaired fasting glucose. FM group exhibited higher carotid artery beta-index values, possibly correlated with cardiometabolic risk factors and arterial stiffness.
Article
Transplantation
Yu Ho Lee, Ki Pyo Kim, Sun-Hwa Park, Dong-Jin Kim, Yang-Gyun Kim, Ju-Young Moon, Su-Woong Jung, Jin Sug Kim, Kyung-Hwan Jeong, So-Young Lee, Dong-Ho Yang, Sung-Jig Lim, Jeong-Taek Woo, Sang Youl Rhee, Suk Chon, Hoon-Young Choi, Hyeong-Cheon Park, Young-Il Jo, Joo-Hark Yi, Sang-Woong Han, Sang-Ho Lee
Summary: The study identified urinary markers CXCL16 and endostatin as potential biomarkers of IFTA and renal outcome in patients with advanced DKD. Higher levels of these markers were associated with rapid renal progression and poor renal outcome, making them independent risk factors after multivariate adjustments.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Toxicology
S. J. Kim, X. Zhang, S. B. Cho, C. H. Kim, H. C. Park, S. J. Moon
Summary: The study found that uremic solutes can significantly induce the expression of PAR-2 in the skin, and soybean trypsin inhibitor has a pronounced inhibitory effect on it. Additionally, skin from CKD patients and mice exhibited marked upregulation of PAR-2 expression compared to control skin.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2021)
Article
Transplantation
Seung Hwan Song, Hoon Young Choi, Ha Yan Kim, Chung Mo Nam, Hyeon Joo Jeong, Myoung Soo Kim, Soon I. I. Kim, Yu Seun Kim, Kyu Ha Huh, Beom Seok Kim
Summary: The study investigated the effects of bisphosphonates on long-term graft outcomes after kidney transplantation and found that bisphosphonate therapy may improve long-term graft survival in kidney transplant recipients, particularly for those with osteopenia or osteoporosis. The use of bisphosphonates was associated with higher death-censored graft survival and significantly reduced risk of graft failure in the study cohort.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Urology & Nephrology
Anne K. Muehlig, Johanna Steingroever, Hannah S. Heidelbach, Madelaine Wingerath, Wiebke Sachs, Irm Hermans-Borgmeyer, Catherine Meyer-Schwesinger, Hoon Young Choi, Beom Jin Lim, Christian Patry, Georg Friedrich Hoffmann, Nicole Endlich, Katharina Bracke, Mariella Weiss, Andreas H. Guse, Moritz Lasse, Markus M. Rinschen, Fabian Braun, Tobias B. Huber, Victor G. Puelles, Claus Peter Schmitt, Jun Oh
Summary: Activation of podocyte CaSR regulates key podocyte functions and reduces toxin-induced proteinuria and glomerular damage.
KIDNEY INTERNATIONAL
(2022)
Article
Medicine, Research & Experimental
Sung-Eun Choi, Nara Jeon, Hoon Young Choi, Hyeon Joo Jeong, Beom Jin Lim
Summary: LOXL2 inhibition ameliorates renal fibrosis through the TGF-beta/Smad signaling pathway, as demonstrated in both in vivo and in vitro experiments.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Medicine, General & Internal
Eunji Yang, Sang Ho Park, Seoyoung Lee, Donghwan Oh, Hoon Young Choi, Hyeong Cheon Park, Jong Hyun Jhee
Summary: This study aimed to evaluate the association between high pulse pressure (PP) and the increased risk of decline of kidney function (RHF) in healthy young adults. The results showed that high PP was associated with a higher prevalence of RHF, especially in obese young adults.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Jisook Yim, Nak-Hoon Son, Kyoung Min Kim, Dukyong Yoon, Yonggeun Cho, Taeyoung Kyong, Ja-Young Moon, Tae Im Yi, Sang-Guk Lee, Yongjung Park, Jung Joo Lee, Kyung-Ah Kim, Jung Eun Lee, Jeong-Ho Kim
Summary: This study proposed muscle mass-based criteria for the use of cystatin C test in the evaluation of renal function. The results showed significant negative correlation between muscle mass and the difference between eGFRcr and eGFRcys. The study highlights the importance of muscle mass-based selection in renal function evaluation.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Jeongseok Jeon, Da Bin Lee, Sang Joon Shin, Dai Hoon Han, Jee Suk Chang, Yoon Dae Han, Hyunwook Kim, Joon Seok Lim, Han Sang Kim, Joong Bae Ahn
Summary: This study found that high-frequency abdominopelvic computed tomography (AP-CT) testing is associated with a higher proportion of surgery plus chemo- or radiotherapy as postrecurrence treatment, but does not improve the 5-year overall survival rate of patients with stage II-III colon cancer.
CLINICAL COLORECTAL CANCER
(2023)
Article
Biochemistry & Molecular Biology
Yu-Jin Kwon, Mina Kim, Hasung Kim, Jung Eun Lee
Summary: Obesity and recurrent hematuria are known risk factors for chronic kidney disease. This study found that body mass index (BMI) and weight change are associated with recurrent and persistent hematuria in glomerular disease. Maintaining an appropriate weight can help prevent recurrent and persistent hematuria in middle-aged and older Korean adults with glomerular disease.
Article
Endocrinology & Metabolism
Jihyun Yoon, Seok-Jae Heo, Jun-Hyuk Lee, Yu-Jin Kwon, Jung Eun Lee
Summary: The study compared the predictive powers of HOMA-IR and METS-IR for CKD incidence in middle-aged and older adults, finding that METS-IR surpassed HOMA-IR in predicting CKD incidence and was as effective as HOMA-IR in predicting CKD prevalence. This suggests that METS-IR could be a valuable indicator for early detection and prevention of CKD among Korean adults.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Cell & Tissue Engineering
Hoon Young Choi, Tae Yeon Kim, Mirae Lee, Soo Hyun Kim, Jong Hyun Jhee, Yong Kyu Lee, Hyung Jong Kim, Hyeong Cheon Park
Summary: Genetically engineered EVs derived from KMSCs, which are engineered to secrete EPO, significantly improved hemoglobin levels and renal function in mouse models of CKD with renal anemia, suggesting a promising novel strategy for the treatment of this condition.
STEM CELL REVIEWS AND REPORTS
(2022)
Article
Medicine, General & Internal
Eun Jee Kim, Joon Ye Kim, Hoon Young Choi, Hyojung Lee, Juhan Lee, Myoung Soo Kim, Yu Seun Kim, Kyu Ha Huh, Beom Seok Kim
Summary: The study showed that combinatorial treatment with TM/DX significantly increased CTLA-4 expression in both effector T cells and Tregs in vivo. In the TM/DX-treated groups, the expression of ligand molecules for CTLA-4 in splenic dendritic cells also significantly increased. Moreover, splenocytes isolated from TM/DX-treated mice were found to significantly suppress the proliferation of T cells from other strains in MLR experiments.
YONSEI MEDICAL JOURNAL
(2021)