Article
Biochemistry & Molecular Biology
Tsendsuren Tungalag, Kye Won Park, Dong Kwon Yang
Summary: Oxidative stress plays a significant role in the pathogenesis of heart diseases, and butein exhibits potential antioxidant effects in cardiomyocytes, providing protection against oxidative damage and suggesting its therapeutic potential for cardiac diseases.
Article
Cell Biology
Nabeel Abdulrahman, Meram Ibrahim, Jensa Mariam Joseph, Hanan Mahmoud Elkoubatry, Al-Anood Al-Shamasi, Menatallah Rayan, Alain Pierre Gadeau, Rashid Ahmed, Hussein Eldassouki, Anwarul Hasan, Fatima Mraiche
Summary: Diabetes-induced cardiac morbidities are the leading cause of death among diabetic patients. Recent studies have shown that the drug empagliflozin, which is used to treat diabetes, has a cardioprotective effect. In this study, the researchers found that empagliflozin reduces cardiac hypertrophy by inhibiting the expression of certain proteins.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Xiaoliang Yan, Lin Wu, Min Gao, Pengjie Yang, Jinjing Yang, Yongzhi Deng
Summary: The recently discovered adipocytokine omentin has been found to inhibit resistin-induced cardiomyocyte hypertrophy by suppressing the TLR4/MyD88/NF-kappa B signaling pathway. This suggests that omentin may be a potential therapeutic target for preventing and treating resistin-induced cardiac hypertrophy.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Chemistry, Medicinal
Pichamon Kiatwuthinon, Thana Narkthong, Utapin Ngaokrajang, Supeecha Kumkate, Tavan Janvilisri
Summary: Baicalein was found to exhibit cytotoxicity and anti-proliferative activity on nasopharyngeal carcinoma cells, and significantly inhibited metastatic phenotypes. Transcriptome profiling revealed that baicalein inhibited metastatic phenotypes by modulating the expression of integrin beta 8.
Article
Medicine, Research & Experimental
Zhongbai Zhang, Xueting Qin, Zhenghui Wang, Yanchun Li, Fei Chen, Rundu Chen, Chuang Li, Wencheng Zhang, Mei Zhang
Summary: OMT pretreatment showed positive effects on H9c2 cardiomyocytes exposed to H/R injury by reducing oxidative stress, decreasing apoptosis, and modulating the PI3K/Akt signaling pathway. This suggests that OMT may be a potential therapeutic candidate for myocardial ischemia/reperfusion injury.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Medicine, Research & Experimental
Yunchen Yu, Yuying Zhu, Xiaotong Sun, Yongxing Li, Mingling Wang, Bin Dong, Xiaodong Sun, Wenming Hou
Summary: The study demonstrated that DL-3-n-butylphthalide (NBP) protected H9c2 cells from myocardial ischemia-reperfusion injury (MIRI) by regulating heat shock protein 70 (HSP70) expression via PI3K/AKT pathway activation.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Review
Developmental Biology
Naoya Yamaguchi, Holger Knaut
Summary: Cell-extracellular matrix interactions are essential for cell anchoring and migration, with focal adhesions (FAs) playing a key role. However, the role of FAs in vivo is still not well understood.
Article
Biochemistry & Molecular Biology
Lingqin Song, Haifeng Zhang, Min Hu, Chengcheng Liu, Yang Zhao, Shuqun Zhang, Di Liu
Summary: Sinomenine inhibits invasion of breast cancer side population cells under hypoxia through the PI3K/Akt/mTOR pathway.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Plant Sciences
Xiaoyi Qi, Yonglan Chen, Sha Liu, Li Liu, Zehui Yu, Ling Yin, Lu Fu, Mingming Deng, Sicheng Liang, Muhan Lu
Summary: This study revealed the antimetastatic effect of SAG on melanoma and identified the underlying molecular mechanisms through the inhibition of the PI3K-AKT signaling pathway. Results showed that SAG inhibited the proliferation, migration, and invasion of melanoma cells and effectively suppressed tumor growth in a xenograft model. These findings offer a theoretical foundation for the clinical application of SAG in antitumor therapy.
PHARMACEUTICAL BIOLOGY
(2023)
Review
Cell Biology
Yasaswi Gayatri Mishra, Bramanandam Manavathi
Summary: Cell-ECM adhesions, with integrins at their core, serve as a crucial link between the cell cytoskeleton and the extracellular matrix, playing a major role in cell signalling for mechanotransduction, migration, proliferation, and other cellular processes. The diverse integrin adhesion complexes, such as focal adhesions and invadosomes, are not only essential for normal cell survival and development, but also play significant roles in various pathological processes.
CELLULAR SIGNALLING
(2021)
Article
Biology
Yun Qi, Han Liu, Kang Zhang, Yihui Wu, Chenghao Shen, Xinhua Lin
Summary: This study reveals that Ihog proteins play crucial roles in integrin-mediated adhesions and regulate adhesion by interacting with integrins.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Article
Cell Biology
Yi He, Dengwen Zhang, Qingqing Zhang, Yin Cai, Chongfeng Huang, Zhengyuan Xia, Sheng Wang
Summary: miR-17-3p attenuates myocardial ischemia/reperfusion injury by inhibiting PTEN activity and suppressing excessive autophagy via the Akt/mTOR signaling pathway.
CELL BIOLOGY INTERNATIONAL
(2023)
Article
Medicine, Research & Experimental
Jinpeng Hu, Bin Su, Xuewen Li, Yuming Li, Jihong Zhao
Summary: The study demonstrated that klotho could suppress myocardial hypoxia injury-induced cell apoptosis by regulating levels of Hsp70, p-Akt, and p-Bad, suggesting it may be a novel agent for treating coronary disease.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Lingyu Zhu, Zitao Guo, Ji Zhang, Yuliang Yang, Chunyu Liu, Liang Zhang, Zhenghua Gu, Youran Li, Zhongyang Ding, Guiyang Shi
Summary: In this study, human arresten and canstatin were successfully recombinantly expressed in Escherichia coli, and their anti-angiogenesis effects on human umbilical vein endothelial cells (HUVECs) were demonstrated. The results showed that arresten and canstatin could inhibit HUVECs proliferation, migration, and tube formation, as well as downregulate the expression of vascular endothelial growth factor (VEGF) and the phosphorylation levels of PI3K and Akt, suggesting the inhibition of the PI3K/Akt signaling pathway. These findings have important implications for the soluble recombinant expression of human arresten and canstatin, and for cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Supachoke Mangmool, Ei Thet Htar Kyaw, Narawat Nuamnaichati, Sudhir Pandey, Warisara Parichatikanond
Summary: This study demonstrates that stimulation of A(1)Rs can attenuate oxidative stress-induced damage in heart cells, upregulate synthesis of antioxidant enzymes and antiapoptotic proteins, and exert cardioprotective effects through G beta gamma subunit-mediated A(1)R signaling pathway as well as PI3K/Akt and ERK1/2-dependent pathways.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)