Article
Nutrition & Dietetics
Verena Theiler-Schwetz, Christian Trummer, Martin R. Grubler, Martin H. Keppel, Armin Zittermann, Andreas Tomaschitz, Spyridon N. Karras, Winfried Marz, Stefan Pilz, Stephanie Gangler
Summary: This post hoc analysis investigated the effects of vitamin D on blood pressure and found that vitamin D supplementation did not have an antihypertensive effect in individuals with vitamin D deficiency. However, there was a significant association between achieved 25(OH)D concentrations and blood pressure.
Article
Geriatrics & Gerontology
Jennifer A. Schrack, Yurun Cai, Jacek K. Urbanek, Amal A. Wanigatunga, Christine M. Mitchell, Edgar R. Miller III, Jack M. Guralnik, Stephen P. Juraschek, Erin D. Michos, David L. Roth, Lawrence J. Appel
Summary: This study aimed to assess whether vitamin D-3 supplementation could attenuate the decline in daily physical activity in low-functioning older adults. The results showed that supplementation with 1000 IU/day or higher of vitamin D-3 did not attenuate the decline in physical activity compared to 200 IU/day. Individuals with baseline serum 25(OH)D levels < 20 ng/mL experienced accelerated declines in physical activity.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Review
Medicine, General & Internal
Dominika Guzek, Aleksandra Kolota, Katarzyna Lachowicz, Dominika Skolmowska, Malgorzata Stachon, Dominika Glabska
Summary: Vitamin D supplementation's influence on mental health in healthy adults is inconclusive, with most studies failing to confirm a positive effect. Some studies suggest that supplementation should be combined with physical activity for better results, and that supplementation is less effective than obtaining vitamin D from food sources.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Nutrition & Dietetics
Manuel Rupprecht, Stefan Wagenpfeil, Jakob Schoepe, Reinhold Vieth, Thomas Vogt, Joerg Reichrath
Summary: A meta-analysis was conducted to investigate the impact of oral vitamin D supplementation on serum 25-hydroxyvitamin D levels in healthy adults in Europe. The findings suggest that vitamin D supplementation can significantly increase serum 25(OH)D levels, with the effect influenced by dosage and baseline serum levels.
Article
Medicine, General & Internal
Zsolt Gall, Brigitta Csukor, Melinda Urkon, Lenard Farczadi, Melinda Kolcsar
Summary: This study confirmed that 25(OH)D3 can be detected in human hair, but further investigations are needed to determine its use as a biomarker since no correlation was found between serum 25(OH)D3 concentrations, supplementation, sun exposure, and hair 25(OH)D3 concentrations levels.
Article
Nutrition & Dietetics
Aasiya Bano, Saida Abrar, Elisa Brilli, Germano Tarantino, Ali Akbar Bugti, Marco Fabbrini, Gabriele Conti, Silvia Turroni, Mahroo Bugti, Fauzia Afridi, Shah Mureed, Hakeem Zada, Ikram Din Ujjan, Saadia Ashraf, Aamir Ghafoor, Saeed Khan, Amjad Khan
Summary: This study compared the absorption of an innovative phospholipids-sucrester matrix biodelivery vehicle-based Vit D3 preparation with a reference chewable tablet and soft gel capsule Vit D3 formulations in Vit D-deficient healthy adults. The results showed that the phospholipids-sucrester matrix Vit D3 preparation was efficiently absorbed in the gastrointestinal system, achieving higher and sustained circulatory Vit D levels, and can effectively contribute to the body's protection against Vit D deficiency-associated health conditions.
FRONTIERS IN NUTRITION
(2023)
Article
Nutrition & Dietetics
Riitta J. Sallinen, Olga Dethlefsen, Sanni Ruotsalainen, Robert D. Mills, Timo A. Miettinen, Tuija E. Jaaskelainen, Annamari Lundqvist, Eero Kyllonen, Heikki Kroger, Jaro I. Karppinen, Christel Lamberg-Allardt, Heli Viljakainen, Mari A. Kaunisto, Olli Kallioniemi
Summary: Genetic factors can affect serum 25-hydroxyvitamin D concentration, influencing the optimal intake of vitamin D. By developing a population-matched genetic risk score, personalized vitamin D supplementation was tailored to individuals predisposed to low serum 25(OH)D concentration. Electronic return of individual genetic risk, serum 25(OH)D concentrations, and factors affecting vitamin D status were used to adjust supplementation, showing potential for application in other populations and countries.
JOURNAL OF NUTRITION
(2021)
Article
Environmental Sciences
Jia-Min Li, Han-Yu Yang, Si-Han Wu, Shyamali C. Dharmage, Bin Jalaludin, Luke D. Knibbs, Michael S. Bloom, Yuming Guo, Lidia Morawska, Joachim Heinrich, Yim Steve Hung Lam, Li-Zi Lin, Xiao-Wen Zeng, Bo-Yi Yang, Gong-Bo Chen, Ru-Qing Liu, Guang-Hui Dong, Li-Wen Hu
Summary: This study examined the potential modifying effect of vitamin D levels on the associations between particulate matter (PM) exposure and serum lipids among young healthy individuals. The results showed that vitamin D levels influenced the impact of PM exposure on blood lipids, with significant associations observed in individuals with lower vitamin D levels.
ENVIRONMENTAL POLLUTION
(2023)
Article
Geriatrics & Gerontology
Bistra I. Veleva, Monique A. A. Caljouw, Astrid Muurman, Jenny T. van der Steen, Victor G. M. Chel, Mattijs E. Numans, Rosalinde K. E. Poortvliet
Summary: Observational studies have shown an inverse association between UV radiation and hypertension. This study compared the effects of UV light and vitamin D supplementation on blood pressure changes in dementia patients, finding that UV light had only short-term effects compared to VD use. Future studies in different populations, especially those with hypertension, are needed to further investigate the effects of UV light.
Review
Peripheral Vascular Disease
Songcang Chen, Gio Gemelga, Yerem Yeghiazarians
Summary: Epidemiological studies suggest that vitamin D deficiency may contribute to the development of hypertension. Randomized clinical trials examining the impact of vitamin D supplementation on blood pressure have yielded inconsistent results. Our evaluation of these trials indicates that vitamin D supplementation is ineffective for reducing blood pressure in individuals with sufficient vitamin D levels and normal blood pressure, but may be beneficial for hypertensive patients who are vitamin D deficient when given in daily or weekly doses.
CURRENT HYPERTENSION REPORTS
(2022)
Review
Medicine, General & Internal
Milica Bjelakovic, Dimitrinka Nikolova, Goran Bjelakovic, Christian Gluud
Summary: The review of 27 randomized clinical trials suggests that vitamin D supplementation in adults with chronic liver diseases may have an impact on all-cause mortality, liver-related mortality, and serious adverse events, but the certainty of evidence is very low. There is lack of data on liver-related morbidity and health-related quality of life. Further research is needed to confirm the effects of vitamin D supplementation in this population.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Nutrition & Dietetics
May M. Cheung, Rosemary D. Dall, Patricia A. Shewokis, Asma Altasan, Stella L. Volpe, Renee Amori, Harpreet Singh, Deeptha Sukumar
Summary: This study found that combined magnesium and vitamin D treatment may be more effective in increasing serum 25OHD concentrations compared to vitamin D supplementation alone in overweight and obese individuals, and it also has the potential to lower baseline systolic blood pressure.
Article
Peripheral Vascular Disease
Stephen P. Juraschek, Edgar R. Miller, Amal A. Wanigatunga, Jennifer A. Schrack, Erin D. Michos, Christine M. Mitchell, Rita R. Kalyani, Lawrence J. Appel
Summary: This study analyzed data from the STURDY trial and found that higher doses of vitamin D3 supplementation did not reduce the risk or symptoms of orthostatic hypotension.
AMERICAN JOURNAL OF HYPERTENSION
(2022)
Article
Biochemistry & Molecular Biology
Aislinn F. McCourt, Aifric M. O'Sullivan
Summary: Metabolomics can identify metabolite patterns associated with different nutrition phenotypes and determine changes in metabolism in response to nutrition interventions. This randomised, placebo-controlled trial (RCT) examined the influence of vitamin D status and the effect of vitamin D supplementation on metabolomic profiles in older adults.
Article
Immunology
Ashvin Varadharajan, M. K. Sibin, S. V. Athira, Arijit Kumar Ghosh, Pratibha Misra
Summary: According to this pilot study, there was no significant correlation between CYP2R1 gene methylation levels and 25(OH)D levels in healthy adults in India. Further studies with larger sample sizes including all vitamin D tool genes and different ethnic groups are needed to elucidate the molecular etiology of circulating 25(OH)D deficiency in the Indian population.
INDIAN JOURNAL OF MEDICAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Saifei Liu, Yuliy Y. Chirkov, John D. Horowitz
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Editorial Material
Public, Environmental & Occupational Health
Saad Ezad, Mohammed S. Al-Omary, Allan J. Davies, James Leitch, Aaron L. Sverdlov, Andrew J. Boyle
AUSTRALIAN JOURNAL OF RURAL HEALTH
(2019)
Article
Cardiac & Cardiovascular Systems
Chukwudiebube N. Ajaero, Nathan E. K. Procter, Yuliy Y. Chirkov, Tamila Heresztyn, Margaret A. Arstall, Andrew D. McGavigan, Michael P. Frenneaux, John D. Horowitz
Letter
Medicine, General & Internal
Thanh Ha Nguyen, Yuliy Y. Chirkov, Sai Fei Liu, Irene Stafford, John D. Horowitz
AMERICAN JOURNAL OF MEDICINE
(2020)
Review
Peripheral Vascular Disease
Mohammed S. Al-Omary, Stuart Sugito, Andrew J. Boyle, Aaron L. Sverdlov, Nicholas J. Collins
Article
Cardiac & Cardiovascular Systems
Saifei Liu, Doan Ngo, Yuliy Chirkov, Jeanette Stansborough, Cher-Rin Chong, John D. Horowitz
Article
Medicine, General & Internal
Doan T. M. Ngo, Trent Williams, Sophie Horder, Leonard Kritharides, Janette Vardy, Hiren Mandaliya, Ina I. C. Nordman, James Lynam, Tony Bonaventura, Aaron L. Sverdlov
JOURNAL OF CLINICAL MEDICINE
(2020)
Review
Oncology
P. Ell, J. M. Martin, D. A. Cehic, D. T. M. Ngo, A. L. Sverdlov
Summary: Radiation therapy is crucial in cancer treatment but can elevate cardiovascular risk. Implementing risk mitigation strategies and cardiovascular risk assessment, along with timely cardiac screening, can help reduce the long-term cardiovascular risks for patients undergoing radiotherapy.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Michael J. McGee, Max Ray, Stepehn C. Brienesse, Shanathan Sritharan, Andrew J. Boyle, Nicholas Jackson, James W. Leitch, Aaron L. Sverdlov
Summary: This systematic review investigates the role of remote monitoring (RM) in patients with heart failure (HF) and cardiac implantable electronic devices (CIEDs). While RM did not show benefits in overall mortality or HF readmission rates, it did reduce patient-associated healthcare costs and healthcare presentations.
Review
Peripheral Vascular Disease
Lloyd E. Butel-Simoes, Tatt Jhong Haw, Trent Williams, Shanathan Sritharan, Payal Gadre, Sandra M. Herrmann, Joerg Herrmann, Doan T. M. Ngo, Aaron L. Sverdlov
Summary: Cardiovascular disease and cancer are leading causes of death worldwide, and improvements in cancer therapies have led to increased cardiovascular events, including hypertension. The molecular mechanisms underlying the cardiotoxicity risk of certain cancer therapies and the association between hypertension and cardiovascular disease need further investigation. This review provides current clinical data on hypertension risk with novel anticancer therapies and explores management strategies aimed at improving cardiovascular and cancer-specific outcomes.
Article
Medicine, General & Internal
Dongqing Chen, Rossana Untaru, Glykeria Stavropoulou, Bahador Assadi-Khansari, Conagh Kelly, Amanda J. Croft, Stuart Sugito, Nicholas J. Collins, Aaron L. Sverdlov, Doan T. M. Ngo
Summary: The role of soluble suppression of tumorigenicity (sST2) as a biomarker in predicting clinical outcomes in patients with cardiovascular diseases (CVD) is not fully understood. This study aimed to examine the correlation between sST2 levels and unplanned hospital readmissions due to a major adverse cardiovascular event (MACE) within 1 year of initial admission. The results showed that elevated sST2 levels were associated with higher risks of MACE occurrence, particularly in patients with atrial fibrillation (AF) and heart failure (HF).
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Amanda J. Croft, Conagh Kelly, Dongqing Chen, Tatt Jhong Haw, Aaron L. Sverdlov, Doan T. M. Ngo
Summary: Obesity is associated with various metabolic disorders and cardiovascular diseases, causing increased hospitalizations, morbidity, and mortality. Dysfunction of adipose tissue due to chronic nutrient stress can lead to oxidative stress, mitochondrial dysfunction, inflammation, hypoxia, and insulin resistance. This study aimed to reduce adipose tissue oxidative stress by overexpressing the antioxidant mitochondrial catalase (mCAT) in adipose tissue to improve systemic metabolic function. The results showed that the AdipoQ-mCAT mice were protected from further metabolic impairment under obesogenic dietary conditions compared to obese wild-type mice, highlighting the critical role of physiological H2O2 signaling in metabolism and adipose tissue function.
Article
Cardiac & Cardiovascular Systems
Conagh J. Kelly, Matthew Chu, Rossana Untaru, Bahador Assadi-Khansari, Dongqing Chen, Amanda J. Croft, John D. Horowitz, Andrew J. Boyle, Aaron L. Sverdlov, Doan T. M. Ngo
Summary: SFRP5, an anti-inflammatory adipokine, may have a role in cardiovascular development and disease. This study investigated the potential of SFRP5 as a biomarker for cardiac function. The results showed that low plasma SFRP5 levels were independently associated with heart failure, coronary artery disease, and impaired left ventricular function. These findings suggest that SFRP5 may serve as a biomarker and mediator for cardiac dysfunction, beyond obesity and metabolic regulation.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Hematology
Farrukh T. Awan, Daniel Addison, Feras Alfraih, Sergio J. Baratta, Rodrigo Noronha Campos, Maria Silvana Cugliari, Yeow Tee Goh, Valery Alexandrovich Ionin, Stefanie Mundnich, Aaron L. Sverdlov, Constantine Tam, Loic Ysebaert
Summary: BTKis have revolutionized CLL treatment with effective options, but concerns over CV risks have emerged, necessitating thorough assessment of patients' CV risk levels and tailored treatment strategies. Collaboration with a multidisciplinary team and utilization of newer, more selective BTKis may help optimize therapy outcomes. Additional research is needed to determine the most optimal strategies for managing these drugs.
Review
Geriatrics & Gerontology
Anjalee Thanuja Amarasekera, Dennis Chang, Peter Schwarz, Timothy C. Tan
Summary: The association between vascular endothelial dysfunction (VED) and physical frailty and/or sarcopenia has been supported by evidence from multiple studies, with abnormal levels of disease markers being a key indicator. Inflammation is also considered a significant factor in this association.