Review
Clinical Neurology
Jia Fu, Junfang Sun, Chao Zhang
Summary: This meta-analysis investigated the association between vitamin D supplementation and the risk of stroke. The results showed that additional vitamin D supplementation did not reduce the risk of stroke. The study suggests that further randomized controlled trials of similar design should not be encouraged to assess any association between vitamin D supplementation and reduced stroke risk.
FRONTIERS IN NEUROLOGY
(2022)
Article
Nutrition & Dietetics
Yoonjung Park, Young-Mi Ah, Yun Mi Yu
Summary: This study conducted a meta-analysis of randomized controlled trials to investigate the effects of vitamin D supplementation on depressive symptom improvement in individuals aged ≥60 years with or without a diagnosis of depression or depressive symptoms. The results showed that vitamin D supplementation was not significantly associated with an improvement in depressive symptoms.
FRONTIERS IN NUTRITION
(2023)
Review
Pediatrics
Sepideh Soltani, Sara Beigrezaei, Shima Abdollahi, Cain C. T. Clark, Marziyeh Ashoori
Summary: This study aims to investigate the relationship between oral vitamin D supplementation and changes in body weight measures in children and adolescents. The results suggest that vitamin D supplementation leads to a significant decrease in body mass index (BMI) in this population. However, there is no significant effect on body weight and other anthropometric indices. Further high-quality randomized controlled trials are needed for more conclusive evidence.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Review
Nutrition & Dietetics
Feitong Wu, Ghada El-Hajj Fuleihan, Guoqi Cai, Christel Lamberg-Allardt, Heli T. Viljakainen, Maya Rahme, Ida M. Gronborg, Rikke Andersen, Anuradha Khadilkar, M. Zulf Mughal, Christian Molgaard, Anni Larnkjaer, Kun Zhu, Richard D. Riley, Tania Winzenberg
Summary: This study, which analyzed data from multiple randomized controlled trials, found that vitamin D supplementation has limited benefits for bone density in healthy children and adolescents, regardless of their baseline vitamin D levels.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Review
Endocrinology & Metabolism
Roger Bouillon, Meryl S. LeBoff, Rachel E. Neale
Summary: Vitamin D plays an important role in calcium homeostasis and cellular processes. However, the benefits of vitamin D supplementation on skeletal and extraskeletal outcomes are conflicting. Large RCTs and MR studies suggest that vitamin D supplementation does not decrease bone loss, fractures, falls, cancer incidence, hypertension, or cardiovascular risk in generally healthy populations. Vitamin D supplementation may have extraskeletal benefits for the immune system, autoimmune diseases, and multiple sclerosis. Accumulating evidence indicates that vitamin D may reduce all-cause mortality. Therefore, the focus of vitamin D supplementation should shift to targeted supplementation in select individuals, good nutritional approaches, and elimination of vitamin D deficiency globally.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Review
Nutrition & Dietetics
Myriam Abboud, Rana Rizk, Fatme AlAnouti, Dimitrios Papandreou, Suzan Haidar, Nadine Mahboub
Summary: Evidence shows that co-supplementation of vitamin D and probiotics yields greater health benefits than its comparators in various diseases, including improved disease severity, mental health, metabolic parameters, inflammation, and antioxidative capacity, and reduced healthcare utilization. Further studies are needed to confirm these findings and determine the optimal form, composition, and frequency of this co-supplementation.
Review
Endocrinology & Metabolism
Xiaoting Zhou, Xiaomei Wu, Xi Luo, Jingyi Shao, Dongqun Guo, Bo Deng, Ze Wu
Summary: This meta-analysis investigated the effects of vitamin D supplementation on in vitro fertilization (IVF) outcomes in infertile women with vitamin D deficiency. The results showed that vitamin D supplementation was associated with improved chemical pregnancy rate, but did not benefit clinical pregnancy rate and other secondary outcomes. Further studies are needed to confirm these findings.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Geriatrics & Gerontology
Jennifer A. Schrack, Yurun Cai, Jacek K. Urbanek, Amal A. Wanigatunga, Christine M. Mitchell, Edgar R. Miller III, Jack M. Guralnik, Stephen P. Juraschek, Erin D. Michos, David L. Roth, Lawrence J. Appel
Summary: This study aimed to assess whether vitamin D-3 supplementation could attenuate the decline in daily physical activity in low-functioning older adults. The results showed that supplementation with 1000 IU/day or higher of vitamin D-3 did not attenuate the decline in physical activity compared to 200 IU/day. Individuals with baseline serum 25(OH)D levels < 20 ng/mL experienced accelerated declines in physical activity.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Food Science & Technology
Folasade A. Adebayo, Suvi T. Itkonen, Taina Ohman, Mairead Kiely, Kevin D. Cashman, Christel Lamberg-Allardt
Summary: Based on data from 20 RCTs and 20 national health surveys, high S-25(OH)D concentrations >125 nmol/L were rare, and no associated adverse effects were observed.
Review
Endocrinology & Metabolism
Jia-Li Zhang, Christina Chui-Wa Poon, Man-Sau Wong, Wen-Xiong Li, Yi-Xun Guo, Yan Zhang
Summary: This systematic review and meta-analysis examines the effects of vitamin D supplementation on muscle strength and mobility in postmenopausal women. The results suggest that vitamin D supplementation improves muscle strength, but has no significant effect on mobility.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Mario Flores-Aldana, Marta Rivera-Pasquel, Armando Garcia-Guerra, Jesus Giovanni Perez-Cortes, Juan E. Barcena-Echegollen
Summary: This study aimed to assess the effect of vitamin D supplementation at different doses on serum 25(OH)D concentrations in preschool children. After three months, there was a significant increase in serum concentrations of 25(OH)D and a decrease in the prevalence of vitamin D deficiency. No adverse effects were observed.
Review
Immunology
Lara S. Kuemmel, Hanna Krumbein, Paraskevi C. Fragkou, Ben L. Huenerbein, Rieke Reiter, Konstantinos A. Papathanasiou, Clemens Thoelken, Scott T. Weiss, Harald Renz, Chrysanthi Skevaki
Summary: Vitamin D supplementation did not improve clinical outcomes in COVID-19 patients, but trends of beneficial effects were observed. Further investigations are required, especially focusing on the daily administration of vitamin D.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Food Science & Technology
Zhangyou Guo, Ming Huang, Dandan Fan, Yuan Hong, Min Zhao, Rong Ding, Yao Cheng, Shigang Duan
Summary: This study conducted a meta-analysis of current randomized clinical trials to assess the association between vitamin D supplementation and cancer incidence and mortality. The results showed that vitamin D supplementation was not associated with a reduction in total cancer incidence, but significantly lowered total cancer mortality.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Nutrition & Dietetics
Dominique Ulrike Glatt, Emeir McSorley, L. Kirsty Pourshahidi, Raquel Revuelta Iniesta, Jane McCluskey, Laura Beggan, Mary Slevin, Nigel Gleeson, Diego F. Cobice, Sara Dobbin, Pamela J. Magee
Summary: This study investigated the vitamin D status and related factors in children in Northern Ireland. The results showed that over half of the children were deficient or insufficient in vitamin D. Additionally, vitamin D intake, outdoor activity time, and muscle strength were positively correlated with vitamin D levels. Therefore, it is recommended to supplement vitamin D, consume foods rich in vitamin D, and increase outdoor activities in winter to prevent vitamin D inadequacy.
Review
Nutrition & Dietetics
Manuel Rupprecht, Stefan Wagenpfeil, Jakob Schoepe, Reinhold Vieth, Thomas Vogt, Joerg Reichrath
Summary: A meta-analysis was conducted to investigate the impact of oral vitamin D supplementation on serum 25-hydroxyvitamin D levels in healthy adults in Europe. The findings suggest that vitamin D supplementation can significantly increase serum 25(OH)D levels, with the effect influenced by dosage and baseline serum levels.
Article
Obstetrics & Gynecology
J. Horn, L. J. Tanz, J. J. Stuart, A. R. Markovitz, G. Skurnik, E. B. Rimm, S. A. Missmer, J. W. Rich-Edwards
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2019)
Article
Public, Environmental & Occupational Health
Lauren J. Tanz, Jennifer J. Stuart, Paige L. Williams, Stacey A. Missmer, Eric B. Rimm, Tamarra M. James-Todd, Janet W. Rich-Edwards
JOURNAL OF WOMENS HEALTH
(2019)
Article
Endocrinology & Metabolism
Simon Timpka, Jennifer J. Stuart, Lauren J. Tanz, Frank B. Hu, Paul W. Franks, Janet W. Rich-Edwards
Article
Cardiac & Cardiovascular Systems
Amanda R. Markovitz, Jennifer J. Stuart, Julie Horn, Paige L. Williams, Eric B. Rimm, Stacey A. Missmer, Lauren J. Tanz, Eirin B. Haug, Abigail Fraser, Simon Timpka, Bjornar Klykken, Havard Dalen, Pal R. Romundstad, Janet W. Rich-Edwards, Bjorn Olav Asvold
EUROPEAN HEART JOURNAL
(2019)
Article
Immunology
James A. McKinnell, Raveena D. Singh, Loren G. Miller, Ken Kleinman, Gabrielle Gussin, Jiayi He, Raheeb Saavedra, Tabitha D. Dutciuc, Marlene Estevez, Justin Chang, Lauren Heim, Stacey Yamaguchi, Harold Custodio, Shruti K. Gohil, Steven Park, Steven Tam, Philip A. Robinson, Thomas Tjoa, Jenny Nguyen, Kaye D. Evans, Cassiana E. Bittencourt, Bruce Y. Lee, Leslie E. Mueller, Sarah M. Bartsch, John A. Jernigan, Rachel B. Slayton, Nimalie D. Stone, Matthew Zahn, Vincent Mor, Kevin McConeghy, Rosa R. Baier, Lynn Janssen, Kathleen O'Donnell, Robert A. Weinstein, Mary K. Hayden, Micaela H. Coady, Megha Bhattarai, Ellena M. Peterson, Susan S. Huang
CLINICAL INFECTIOUS DISEASES
(2019)
Article
Obstetrics & Gynecology
Leslie V. Farland, Jennifer Prescott, Naoko Sasamoto, Deirdre K. Tobias, Audrey J. Gaskins, Jennifer J. Stuart, Daniela A. Carusi, Jorge E. Chavarro, Andrew W. Horne, Janet W. Rich-Edwards, Stacey A. Missmer
OBSTETRICS AND GYNECOLOGY
(2019)
Article
Nutrition & Dietetics
Mariel Arvizu, Jennifer J. Stuart, Janet W. Rich-Edwards, Audrey J. Gaskins, Bernard Rosner, Jorge E. Chavarro
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2020)
Article
Public, Environmental & Occupational Health
Ellen W. Seely, Ann C. Celi, Jaimie Chausmer, Cornelia Graves, Sarah Kilpatrick, Jacinda M. Nicklas, Mary L. Rosser, Kathryn M. Rexrode, Jennifer J. Stuart, Eleni Tsigas, Jennifer Voelker, Carolyn Zelop, Janet W. Rich-Edwards
Summary: There is a lack of awareness and action to prevent cardiovascular disease after preeclampsia, with patients suggesting a clinician checklist, enhanced training, and post-delivery appointments. Clinical programs focus on the first postpartum year, recommending risk modification through regular screenings. Recommendations from national organizations aim to guide management of women with prior preeclampsia.
JOURNAL OF WOMENS HEALTH
(2021)
Article
Medicine, General & Internal
Yi-Xin Wang, Mariel Arvizu, Janet W. Rich-Edwards, Jennifer J. Stuart, JoAnn E. Manson, Stacey A. Missmer, An Pan, Jorge E. Chavarro
BMJ-BRITISH MEDICAL JOURNAL
(2020)
Article
Cardiac & Cardiovascular Systems
Yi-Xin Wang, Mariel Arvizu, Janet W. Rich-Edwards, Liang Wang, Bernard Rosner, Jennifer J. Stuart, Kathryn M. Rexrode, Jorge E. Chavarro
Summary: The study found that experiencing hypertensive disorders of pregnancy (HDPs) such as gestational hypertension or pre-eclampsia is associated with an increased risk of premature mortality, particularly cardiovascular mortality, regardless of developing chronic hypertension later on.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Nisha I. Parikh, Juan M. Gonzalez, Cheryl A. M. Anderson, Suzanne E. Judd, Kathryn M. Rexrode, Mark A. Hlatky, Erica P. Gunderson, Jennifer J. Stuart, Dhananjay Vaidya
Summary: This statement summarizes the impact of adverse pregnancy outcomes on women's risk of cardiovascular disease and highlights the importance of recognizing this impact. Lifestyle interventions such as adopting a heart-healthy diet and increasing physical activity can help reduce CVD risk. Further research on non-White women is needed to address health disparities and inform recommendations for primary CVD prevention.
Article
Public, Environmental & Occupational Health
Lauren J. Tanz, Jennifer J. Stuart, Paige L. Williams, Eric B. Rimm, Stacey A. Missmer, Kenneth J. Mukamal, Kathryn M. Rexrode, Janet W. Rich-Edwards
Summary: The study evaluated the inclusion of preterm delivery and parity in CVD risk scores for improved identification of high-risk women, especially when they are young. The results showed some improvements in CVD risk prediction for women above 30 years old when considering preterm delivery and parity.
JOURNAL OF WOMENS HEALTH
(2021)
Article
Health Care Sciences & Services
Yi-Xin Wang, Raphaelle Varraso, Orianne Dumas, Jennifer J. Stuart, Andrea Florio, Liang Wang, Janet W. Rich-Edwards, Carlos A. Camargo Jr, Jorge E. Chavarro
Summary: This study explored the associations between gestational hypertension and preeclampsia and the risk of asthma and COPD during adulthood, and investigated the mediating role of chronic hypertension. The results showed that nurses with HDPs had a higher risk of incident asthma and COPD. Chronic hypertension explained a significant proportion of the associations between HDPs and asthma and COPD.
LANCET REGIONAL HEALTH-AMERICAS
(2023)
Article
Obstetrics & Gynecology
Mariel Arvizu, Lidia Minguez-Alarcon, Jennifer J. Stuart, Makiko Mitsunami, Bernard Rosner, Janet W. Rich-Edwards, Jorge E. Chavarro
Summary: Prepregnancy physical activity is strongly correlated with hypertensive disorders of pregnancy, and higher levels of physical activity can reduce the risk of gestational hypertension.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2022)
Article
Genetics & Heredity
Altantuya Tsevgee, Khishigjargal Batjargal, Tsolmon Munkhchuluun, Naranchimeg Khurelbaatar, Gerelmaa Nansal, Oyun-Erdene Bulgan, Sumberzul Nyamjav, Gerelmaa Zagd, Erdenetuya Ganbaatar
Summary: The study in Mongolia found that the prevalence of congenital hypothyroidism (CH) confirmed at birth was 1/2091, with a slightly higher incidence in females than males. Most patients were asymptomatic, with thyroid dysgenesis being the most common etiology. The majority of CH-positive children initiated L-thyroxine treatment within 15 days. Further research is needed to expand CH screening coverage in Mongolia.
INTERNATIONAL JOURNAL OF NEONATAL SCREENING
(2021)