Hybrid approach to structure modeling of the histamine H3 receptor: Multi-level assessment as a tool for model verification

The European Medicines Agency review of pitolisant for treatment of narcolepsy: summary of the scientific assessment by the Committee for Medicinal Products for Human Use

(2017) Marta Kollb-Sielecka et al.   SLEEP MEDICINE

Chlorophenoxy aminoalkyl derivatives as histamine H3R ligands and antiseizure agents

(2016) Kamil Kuder et al.   BIOORGANIC & MEDICINAL CHEMISTRY

GPCRdb: the G protein-coupled receptor database - an introduction

(2016) C Munk et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Hybrid Approach to Structure and Function Modeling of G Protein-Coupled Receptors

(2016) Dorota Latek et al.   Journal of Chemical Information and Modeling

Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region

(2016) A. J. Venkatakrishnan et al.   NATURE

Therapeutic strategies for Alzheimer's disease in clinical trials

(2016) Justyna Godyń et al.   Pharmacological Reports

Assessment of template-based modeling of protein structure in CASP11

(2016) Vivek Modi et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structural insights into µ-opioid receptor activation

(2015) Weijiao Huang et al.   NATURE

The I-TASSER Suite: protein structure and function prediction

(2015) Jianyi Yang et al.   NATURE METHODS

The Extracellular Loop 2 (ECL2) of the Human Histamine H4 Receptor Substantially Contributes to Ligand Binding and Constitutive Activity

(2015) David Wifling et al.   PLoS One

Histamine H3 Receptor Activation Counteracts Adenosine A2A Receptor-Mediated Enhancement of Depolarization-Evoked [3H]-GABA Release from Rat Globus Pallidus Synaptosomes

(2014) Guadalupe-Elide Morales-Figueroa et al.   ACS Chemical Neuroscience

A Randomized, Double-Blind, Placebo-Controlled, 16-Week Study of the H3 Receptor Antagonist, GSK239512 as a Monotherapy in Subjects with Mild-to-Moderate Alzheimer’s Disease

(2014) Richard Grove et al.   Current Alzheimer Research

UniProt: a hub for protein information

(2014)   NUCLEIC ACIDS RESEARCH

Determination of the binding mode and interacting amino-acids for dibasic H3 receptor antagonists

(2013) Nicolas Levoin et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and evaluation of N-alkyl-S-[3-(piperidin-1-yl)propyl]isothioureas: High affinity and human/rat species-selective histamine H3 receptor antagonists

(2013) Shinya Harusawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The expression and function of histamine H3receptors in pancreatic beta cells

(2013) T Nakamura et al.   BRITISH JOURNAL OF PHARMACOLOGY

Efficacy of the histamine 3 receptor (H3R) antagonist pitolisant (formerly known as tiprolisant; BF2.649) in epilepsy: Dose-dependent effects in the human photosensitivity model

(2013) Dorothée Kasteleijn- Nolst Trenité et al.   EPILEPSY & BEHAVIOR

New developments around histamine H3receptor antagonists/inverse agonists: a patent review (2010 – present)

(2013) Dorota Łażewska et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Enhanced Histaminergic Neurotransmission and Sleep-Wake Alterations, a Study in Histamine H3-Receptor Knock-Out Mice

(2013) Elise Gondard et al.   NEUROPSYCHOPHARMACOLOGY

Assessment of template-based protein structure predictions in CASP10

(2013) Yuanpeng J. Huang et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Regulation of CaV2 calcium channels by G protein coupled receptors

(2012) Gerald W. Zamponi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Action of Molecular Switches in GPCRs - Theoretical and Experimental Studies

(2012) B. Trzaskowski et al.   CURRENT MEDICINAL CHEMISTRY

BCL::Score—Knowledge Based Energy Potentials for Ranking Protein Models Represented by Idealized Secondary Structure Elements

(2012) Nils Woetzel et al.   PLoS One

Structural insights into agonist-induced activation of G-protein-coupled receptors

(2011) Xavier Deupi et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Ligand and Decoy Sets for Docking to G Protein-Coupled Receptors

(2011) Edgar A. Gatica et al.   Journal of Chemical Information and Modeling

DSX: A Knowledge-Based Scoring Function for the Assessment of Protein–Ligand Complexes

(2011) Gerd Neudert et al.   Journal of Chemical Information and Modeling

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Structure of the human histamine H1 receptor complex with doxepin

(2011) Tatsuro Shimamura et al.   NATURE

Role of the second and third extracellular loops of the histamine H4 receptor in receptor activation

(2011) Irena Brunskole et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

In-vivo histamine H3 receptor antagonism activates cellular signaling suggestive of symptomatic and disease modifying efficacy in Alzheimer’s disease

(2010) R. Scott Bitner et al.   NEUROPHARMACOLOGY

JNJ-39220675, a novel selective histamine H3 receptor antagonist, reduces the abuse-related effects of alcohol in rats

(2010) Ruggero Galici et al.   PSYCHOPHARMACOLOGY

Importance of the extracellular loops in G protein-coupled receptors for ligand recognition and receptor activation

(2010) M.C. Peeters et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

QMEAN server for protein model quality estimation

(2009) Pascal Benkert et al.   NUCLEIC ACIDS RESEARCH

Refined Docking as a Valuable Tool for Lead Optimization: Application to Histamine H3Receptor Antagonists

(2008) Nicolas Levoin et al.   ARCHIV DER PHARMAZIE

Histamine H3 Receptor Antagonists Go to Clinics

(2008) Kerstin Sander et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Cardioprotective Effect of Histamine H3-Receptor Activation: Pivotal Role of G  -Dependent Inhibition of Voltage-Operated Ca2+ Channels

(2008) C. Morrey et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS