The histone variant macroH2A confers functional robustness to the intestinal stem cell compartment

Intestinal cancer stem cells marked by Bmi1 or Lgr5 expression contribute to tumor propagation via clonal expansion

(2017) Hirotsugu Yanai et al.   Scientific Reports

Mouse Label-Retaining Cells Are Molecularly and Functionally Distinct From Reserve Intestinal Stem Cells

(2016) Ning Li et al.   GASTROENTEROLOGY

Msi RNA-binding proteins control reserve intestinal stem cell quiescence

(2016) Maryam Yousefi et al.   JOURNAL OF CELL BIOLOGY

Krt19+/Lgr5− Cells Are Radioresistant Cancer-Initiating Stem Cells in the Colon and Intestine

(2015) Samuel Asfaha et al.   Cell Stem Cell

Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage

(2015) S. Tao et al.   EMBO JOURNAL

Composite macroH2A/NRF-1 Nucleosomes Suppress Noise and Generate Robustness in Gene Expression

(2015) Matthieu D. Lavigne et al.   Cell Reports

Mice without MacroH2A Histone Variants

(2014) J. R. Pehrson et al.   MOLECULAR AND CELLULAR BIOLOGY

MacroH2A1.1 and PARP-1 cooperate to regulate transcription by promoting CBP-mediated H2B acetylation

(2014) Hongshan Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Macrohistone Variant Links Dynamic Chromatin Compaction to BRCA1-Dependent Genome Maintenance

(2014) Simran Khurana et al.   Cell Reports

A System for Genome-Wide Histone Variant Dynamics In ES Cells Reveals Dynamic MacroH2A2 Replacement at Promoters

(2014) Ozlem Yildirim et al.   PLoS Genetics

Single-Cell Analysis of Proxy Reporter Allele-Marked Epithelial Cells Establishes Intestinal Stem Cell Hierarchy

(2014) Ning Li et al.   Stem Cell Reports

MacroH2A – An epigenetic regulator of cancer

(2013) Neus Cantariño et al.   CANCER LETTERS

Lgr5+ Stem Cells Are Indispensable for Radiation-Induced Intestinal Regeneration

(2013) Ciara Metcalfe et al.   Cell Stem Cell

MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency

(2013) Alexandre Gaspar-Maia et al.   Nature Communications

Differential Regulation and Predictive Potential of MacroH2A1 Isoforms in Colon Cancer

(2012) Judith C. Sporn et al.   AMERICAN JOURNAL OF PATHOLOGY

The Pan-ErbB Negative Regulator Lrig1 Is an Intestinal Stem Cell Marker that Functions as a Tumor Suppressor

(2012) Anne E. Powell et al.   CELL

The histone variant macroH2A1.1 is recruited to DSBs through a mechanism involving PARP1

(2012) Chang Xu et al.   FEBS LETTERS

Crypt Base Columnar Stem Cells in Small Intestines of Mice Are Radioresistant

(2012) Guoqiang Hua et al.   GASTROENTEROLOGY

Histone variant macroH2A marks embryonic differentiation in vivo and acts as an epigenetic barrier to induced pluripotency

(2012) V. Pasque et al.   JOURNAL OF CELL SCIENCE

MacroH2A1 Regulates the Balance between Self-Renewal and Differentiation Commitment in Embryonic and Adult Stem Cells

(2012) C. Creppe et al.   MOLECULAR AND CELLULAR BIOLOGY

The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse

(2011) Anna Merlos-Suárez et al.   Cell Stem Cell

Histone variant macroH2A confers resistance to nuclear reprogramming

(2011) Vincent Pasque et al.   EMBO JOURNAL

QKI-Mediated Alternative Splicing of the Histone Variant MacroH2A1 Regulates Cancer Cell Proliferation

(2011) L. Novikov et al.   MOLECULAR AND CELLULAR BIOLOGY

A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable

(2011) Hua Tian et al.   NATURE

The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations

(2011) K. S. Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interconversion Between Intestinal Stem Cell Populations in Distinct Niches

(2011) N. Takeda et al.   SCIENCE

Age-associated increase in heterochromatic marks in murine and primate tissues

(2010) Jill A. Kreiling et al.   AGING CELL

The histone variant macroH2A suppresses melanoma progression through regulation of CDK8

(2010) Avnish Kapoor et al.   NATURE

Synergism between DNA methylation and macroH2A1 occupancy in epigenetic silencing of the tumor suppressor gene p16(CDKN2A)

(2010) Michal Barzily-Rokni et al.   NUCLEIC ACIDS RESEARCH

Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells

(2010) R. K. Montgomery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coexistence of Quiescent and Active Adult Stem Cells in Mammals

(2010) L. Li et al.   SCIENCE

The histone variant macroH2A1 marks repressed autosomal chromatin, but protects a subset of its target genes from silencing

(2009) M. J. Gamble et al.   GENES & DEVELOPMENT

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation

(2009) Gyula Timinszky et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The histone variant macroH2A is an epigenetic regulator of key developmental genes

(2009) Marcus Buschbeck et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Histone macroH2A isoforms predict the risk of lung cancer recurrence

(2009) J C Sporn et al.   ONCOGENE

MacroH2A Allows ATP-Dependent Chromatin Remodeling by SWI/SNF and ACF Complexes but Specifically Reduces Recruitment of SWI/SNF†

(2008) Evelyn Y. Chang et al.   BIOCHEMISTRY

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE

Bmi1 is expressed in vivo in intestinal stem cells

(2008) Eugenio Sangiorgi et al.   NATURE GENETICS