Article
Nutrition & Dietetics
Ling-Jun Li, Ruochen Du, Marion Ouidir, Ruijin Lu, Zhen Chen, Natalie L. Weir, Michael Y. Tsai, Paul S. Albert, Cuilin Zhang
Summary: Saturated fatty acids (SFAs) during pregnancy have an impact on metabolic programming and fetal growth. In this study, plasma phospholipid SFAs were measured in early pregnancy and fetal growth was monitored. It was found that even-chain and very long even-chain SFAs were negatively associated, while odd-chain SFAs were positively associated with fetal weight and size. Pentadecanoic acid (15:0) in the highest tertile showed a greater fetal weight and size compared to the lowest tertile. These findings suggest the potential use of an alternative high-fat diet rich in odd-chain SFAs for optimal fetal growth.
Article
Nutrition & Dietetics
Qixin Wu, Dandan Shi, Ting Dong, Zhuolin Zhang, Qingjian Ou, Yujing Fang, Caixia Zhang
Summary: This study investigated the association between circulating saturated fatty acids (SFAs) including very long-chain SFAs (VLCSFAs) and the risk of colorectal cancer (CRC). The results showed that higher levels of total SFAs were associated with an increased risk of CRC, while higher levels of VLCSFAs were associated with a decreased risk of CRC. Specifically, certain types of SFAs like lauric acid, myristic acid, palmitic acid, heptadecanoic acid, and arachidic acid were positively associated with CRC risk.
Article
Biochemistry & Molecular Biology
Khaled I. Alatibi, Stefan Tholen, Zeinab Wehbe, Judith Hagenbuchner, Daniela Karall, Michael J. Ausserlechner, Oliver Schilling, Sarah C. Gruenert, Jerry Vockley, Sara Tucci
Summary: The study found that treatment with medium-chain fatty acids had limited impact on certain proteomic changes but induced remodeling of complex lipids. Especially, C7 appeared to have a protective effect by improving protein homeostasis in LCHADD under control conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Yiwei Wu, Joram M. Posma, Elaine Holmes, Gary Frost, Edward S. Chambers, Isabel Garcia-Perez
Summary: Two independent studies found that dietary fiber intake did not increase circulating levels of OCFAs, and dose and temporal relations were not observed.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Neurosciences
Yan Liu, Han Xu, Naima Dahir, Ashley Calder, Fangjun Lin, Timothy A. Gilbertson
Summary: Recent studies have identified a new receptor, GPR84, in the gustatory system that responds to medium-chain saturated fatty acids (MCFAs) in male mice. Activation of GPR84 by MCFAs leads to depolarization and an increase in intracellular free calcium in taste cells. Knockout mouse models lacking GPR84 show specific deficits in neural and behavioral responses to oral MCFAs compared to wild-type mice.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Tadashi Takeuchi, Eiji Miyauchi, Takashi Kanaya, Tamotsu Kato, Yumiko Nakanishi, Takashi Watanabe, Toshimori Kitami, Takashi Taida, Takaharu Sasaki, Hiroki Negishi, Shu Shimamoto, Akinobu Matsuyama, Ikuo Kimura, Ifor R. Williams, Osamu Ohara, Hiroshi Ohno
Summary: This study found that the gut microbial metabolite acetate not only increases IgA production in the colon, but also alters the ability of IgA to bind to specific microorganisms. Acetate orchestrates interactions between epithelial and immune cells, induces microbially stimulated CD4 T cells to support T-cell-dependent IgA production, and changes the localization of these bacteria within the colon.
Review
Food Science & Technology
Grzegorz Dabrowski, Iwona Konopka
Summary: This review synthesizes recent data on the food sources and physiological properties of odd-, branched-chain, and cyclic fatty acids, highlighting their impact on human health. The estimated daily intake of these fatty acids from typical Western diets is approximately 1.5g, mainly derived from ruminant fat. In Asian countries, significant sources come from spirulina and fish. For vegans and vegetarians, algae, selected plants, mushrooms, and fermented plants are the best sources. However, there are inconsistencies in specific fatty acid data from different sources.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Food Science & Technology
Ray A. Matulka, Lauren A. Howell, B. Pratyusha Chennupati, J. Teresa Bock
Summary: The study showed that algal oil containing saturated odd-chain fatty acids did not exhibit toxicity or genotoxicity in animals, indicating its safety for use in the food industry.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marina Ushio, Toshiki Ishikawa, Takakazu Matsuura, Izumi C. Mori, Maki Kawai-Yamada, Yoichiro Fukao, Minoru Nagano
Summary: In this study, the functions of MHP1 and MHL in Arabidopsis were investigated. The results showed that MHP1 and MHL are involved in synthesizing OCFAs and regulating immune responses in plants.
Article
Nutrition & Dietetics
Kristina Pigsborg, Goezde Guerdeniz, Oscar Daniel Rangel-Huerta, Kirsten B. Holven, Lars Ove Dragsted, Stine M. Ulven
Summary: This study aimed to investigate the changes in serum metabolome after replacing SFA with PUFA and explore the association between dietary metabolites and cardiometabolic risk markers.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Chemistry, Multidisciplinary
Laura Oliver, Laura Fernandez-de-Castro, Thomas Dietrich, Maria Carmen Villaran, Ramon J. Barrio
Summary: This study demonstrates the potential of using industrial waste-derived volatile fatty acids as a sustainable carbon source for the cultivation of Schizochytrium limacinum. The results showed that acetic and butyric acid resulted in good biomass productivity, while valeric and propionic acid led to higher content of odd-chain fatty acids. The utilization of biowaste derived effluents further validated the use of waste-derived volatile fatty acids as a potential carbon source for industrial applications.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Isaac Ampong, O. John Ikwuobe, James E. P. Brown, Clifford J. Bailey, Dan Gao, Jorge Gutierrez-Merino, Helen R. Griffiths
Summary: High dietary fat intake reduces the levels of odd chain saturated fatty acids, affects gut microbiota and liver lipid metabolism, and is associated with increased risk of metabolic diseases.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Agricultural Engineering
Kun Wu, Weijia Xu, Chun Wang, Jian Lu, Xia He
Summary: The study demonstrates that the formation of calcium palmitate can significantly enhance the efficiency of methane production from LCFAs, primarily due to enhanced bio-aggregation and significant changes in microbial community. Conversely, the formation of calcium oleate decreases the efficiency of methane production from LCFAs, resulting in a small difference in methane recovery.
BIORESOURCE TECHNOLOGY
(2022)
Article
Medicine, General & Internal
Malgorzata Sikorska-Wisniewska, Adriana Mika, Tomasz Sledzinski, Michal Chmielewski
Summary: The serum content of saturated fatty acids (SFA) is significantly associated with mortality in dialysis patients. Patients who consume foods rich in SFA have a higher risk of mortality. Increased SFA content is positively correlated with mortality hazard ratio. The SFA content is significantly higher in patients with diabetes mellitus and cardiovascular disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Agronomy
Tengfei Zhan, Xin Guo, Lu Ma, Shengyong Mao, Dengpan Bu
Summary: This study evaluated the effect of biotin and leucine on the synthesis of odd- and branched-chain fatty acids (OBCFA) in ruminants. The results showed that biotin promoted dry matter degradation, while leucine increased the concentration of branched-chain volatile fatty acids and valerate. In conclusion, biotin and leucine can be effective nutrition strategies to promote OBCFA synthesis.
Article
Biotechnology & Applied Microbiology
Bungo Shirouchi, Shuhei Yanagi, Chinami Okawa, Maiko Koga, Masao Sato
Article
Biotechnology & Applied Microbiology
Akane Kanasaki, Tetsuo Iida, Koji Murao, Bungo Shirouchi, Masao Sato
Article
Biochemistry & Molecular Biology
Shota Hori, Takayuki Abe, Dong Geun Lee, Satoru Fukiya, Atsushi Yokota, Nao Aso, Bungo Shirouchi, Masao Sato, Satoshi Ishizuka
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2020)
Article
Multidisciplinary Sciences
Yasutake Tanaka, Masahiro Ono, Motonori Miyago, Takahisa Suzuki, Yurika Miyazaki, Michio Kawano, Makoto Asahina, Bungo Shirouchi, Katsumi Imaizumi, Masao Sato
Article
Biochemistry & Molecular Biology
Zhe Jiang, Takuya Hayashi, Kentaro Kashima, Kayo Kurotani, Bungo Shirouchi, Tetsuya Mizoue, Masao Sato
Article
Biochemistry & Molecular Biology
Ja-Young Lee, Hidehisa Shimizu, Masahito Hagio, Satoru Fukiya, Masamichi Watanabe, Yasutake Tanaka, Ga-Hyun Joe, Hitoshi Iwaya, Reika Yoshitsugu, Keidai Kikuchi, Misaki Tsuji, Nanako Baba, Takuma Nose, Koji Tada, Taketo Hanai, Shota Hori, Akari Takeuchi, Yumiko Furukawa, Bungo Shirouchi, Masao Sato, Tadasuke Ooka, Yoshitoshi Ogura, Tetsuya Hayashi, Atsushi Yokota, Satoshi Ishizuka
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2020)
Article
Food Science & Technology
Wei-Ting Tsai, Yuki Nakamura, Taiki Akasaka, Yoshinori Katakura, Yasutake Tanaka, Bungo Shirouchi, Zhe Jiang, Xingyu Yuan, Masao Sato
Summary: Soyasaponins, triterpenoid glycosides found in soybean, show anti-obesity effects by suppressing adipocyte differentiation and lipogenesis, reducing body weight, adipose tissue weight, and hepatic triacylglycerol accumulation.
JOURNAL OF FOOD SCIENCE
(2021)
Article
Agriculture, Multidisciplinary
Xingyu Yuan, Yutaro Minobe, Yasutake Tanaka, Yumi Fukuda, Yumiko Furukawa, Motonori Miyago, Takuya Mizokami, Wei-Ting Tsai, Zhe Jiang, Li-Tao Tong, Taiki Akasaka, Bungo Shirouchi, Yoshiko Toyosawa, Toshihiro Kumamaru, Masao Sato
Summary: The study showed that dietary LGC-1, which is rich in alpha-globulin, significantly reduced serum cholesterol levels in ExHC rats, possibly by partially inhibiting bile acid and cholesterol synthesis in the liver.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Biochemistry & Molecular Biology
Zhe Jiang, Yuki Kimura, Bungo Shirouchi, Yasutake Tanaka, Wei-ting Tsai, Xingyu Yuan, Masao Sato
Summary: The study revealed that egg white protein hydrolysates (EWH) have a significant improvement on nonalcoholic fatty liver (NAFL) in rats, with EWH reducing liver triacylglycerol (TAG) levels more effectively and rapidly compared to egg white protein (EWP). EWH also promoted hepatic TAG secretion, showing a potential therapeutic effect on NAFL induced by orotic acid (OA).
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ai Takeyama, Asami Teramoto, Tianyu Wang, Takuya Hayashi, Yasutake Tanaka, Masao Sato, Bungo Shirouchi
Summary: This study found that dietary LysoPL affects lymphatic fat transport, especially in reducing cholesterol transport significantly. Compared to a phospholipid diet, both sn-1 and sn-2 LysoPL diets decreased the lymphatic transport of cholesterol, but had no effect on PL and TAG transport; in addition, LysoPL also affected the solubility of cholesterol in bile acid micelles.
Article
Biochemistry & Molecular Biology
Bungo Shirouchi, Ayano Fukuda, Taiki Akasaka
Summary: Choline, betaine, and L-carnitine can be converted into trimethylamine (TMA) by gut microbiota and further oxidized into trimethylamine-N-oxide (TMAO). Elevated TMAO levels can have negative effects on human health. This study investigated the effects of different choline compounds on plasma TMAO levels and gut microbiota in rats. The results showed that dietary phosphatidylcholine (PC) did not increase plasma TMAO levels, while glycerophosphocholine (GPC) and choline chloride (CC) significantly increased TMAO levels. In terms of gut microbiota, certain species were found to be positively or negatively correlated with plasma TMAO levels. This study suggests that dietary PC, unlike GPC or CC, does not contribute to the increase in plasma TMAO levels in rats.
Article
Biochemistry & Molecular Biology
Bungo Shirouchi, Yuri Kawahara, Yuka Kutsuna, Mina Higuchi, Mai Okumura, Sarasa Mitsuta, Norio Nagao, Kazunari Tanaka
Summary: This study investigated the effects of marine microalga Chaetoceros gracilis on lipid abnormalities in rats fed a high-sucrose cholesterol-containing diet. The results showed that C. gracilis could alleviate hepatic lipid accumulation, increase muscle weight, and improve serum HDL cholesterol levels, suggesting its potential use as a food resource.
Article
Chemistry, Applied
Satoshi Wanezaki, Shintaro Saito, Nao Inoue, Nobuhiko Tachibana, Bungo Shirouchi, Masao Sato, Teruyoshi Yanagita, Koji Nagao
JOURNAL OF OLEO SCIENCE
(2020)
Review
Chemistry, Applied
Bungo Shirouchi, Ryosuke Matsuoka
JOURNAL OF OLEO SCIENCE
(2019)
Correction
Nutrition & Dietetics
Bungo Shirouchi, Rikako Yamanaka, Shoji Tanaka, Fagyun Kawatou, Takuya Hayashi, Ai Takeyama, Akiko Nakao, Ryoko Goromaru, Masako Iwamoto, Masao Sato
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
(2021)