Article
Biochemistry & Molecular Biology
Syed Benazir Alam, Ashley Wagner, Steven Willows, Marianna Kulka
Summary: Quercetin and resveratrol have differential inhibitory effects on mast cells, potentially through modulation of FcεRI expression, signaling, and mediator release.
Article
Cell Biology
Young-Ae Choi, Hima Dhakal, Soyoung Lee, Namkyung Kim, Byungheon Lee, Taeg Kyu Kwon, Dongwoo Khang, Sang-Hyun Kim
Summary: This study elucidated the non-transcriptional role of IRF3 in mast cell activation and allergic inflammation. In vitro and in vivo experiments showed that IRF3 played a significant role in mast cell-mediated allergic inflammation. The activation of IRF3 was observed during mast cell activation process, and it affected the production of granule contents and the anaphylaxis responses. Overall, IRF3 is an important factor inducing mast cell activation and regulating HDC activity.
Article
Allergy
Ying Wang, Mang Yu, Kazufumi Matsushita, Chen Liu, Naotada Ishihara, Masatoshi Nomura, Mindy Tsai, Stephen J. Galli
Summary: This study reveals that the protein Drp1 can differentially regulate the activation of mast cells by different stimuli. Promoting or inhibiting Drp1 activation might represent novel approaches for treating IgE-dependent mast cell activation or mitigating other substance P-induced mast cell-dependent responses.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Oncology
Elnaz Ahani, Mohammad Fereydouni, Mona Motaghed, Christopher L. Kepley
Summary: This study reveals a novel mechanism of communication between mast cells (MCs) and tumor cells, involving tunneling nanotubes (TnT) and other membrane structures. The communication is dependent on MC receptors interacting with tumor antigens and results in the entry of tumor-killing mediators from MC into the tumor cells, leading to apoptosis. These findings have important implications for understanding the role of MCs in cancer pathogenesis.
Review
Physiology
Tamara Rosenbaum, Leon D. Islas
Summary: The ability to detect environmental stimuli is crucial for survival, and ion channels, such as TRP proteins, play a key role in this process. The TRPV subfamily, which belongs to the TRP family, responds to various chemical and physical changes. Despite intensive research in the past two decades, controversies still exist regarding the function of these proteins due to their complexity. In this article, we discuss important features of their regulation and highlight efforts to advance the field.
ANNUAL REVIEW OF PHYSIOLOGY
(2023)
Article
Cell Biology
Li-Na Wang, Xue-Zhi Wang, Yu-Jia Li, Bing-Rong Li, Meng Huang, Xiao-Yu Wang, Ryszard Grygorczyk, Guang-Hong Ding, Wolfgang Schwarz
Summary: This review provides experimental evidence that subcutaneous mast cells play a role in the analgesic effects of acupuncture. The manipulation of acupuncture needles activates mast cells, leading to the release of various mediators that reduce the electrical activities of sensory neurons, resulting in analgesia. This finding is of great significance in further understanding the mechanisms of acupuncture.
Article
Immunology
Jessy Elst, Leander P. De Puysseleyr, Didier G. Ebo, Margaretha A. Faber, Athina L. Van Gasse, Marie-Line M. van der Poorten, Ine I. Decuyper, Chris H. Bridts, Christel Mertens, Michel Van Houdt, Margo M. Hagendorens, Luc S. De Clerck, Anke Verlinden, Katrien Vermeulen, Marie-Berthe Maes, Zwi N. Berneman, Peter Valent, Vito Sabato
Summary: This study compares the burden, phenotype, and behavior of mast cells and basophils in patients with clonal mast cell disorders (CMCD) and other related disorders. The study found that CMCD patients have an elevated burden of aberrant activated mast cells, particularly in patients with wasp venom anaphylaxis. Basophils show similar characteristics and functions across different patient populations.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yutaro Kuwashima, Masataka Yanagawa, Mitsuhiro Abe, Michio Hiroshima, Masahiro Ueda, Makoto Arita, Yasushi Sako
Summary: TRPV1 and TRPV4, as members of the transient receptor potential vanilloid family, exhibit differences in their cellular dynamics, with TRPV1 forming higher-order oligomers more readily and TRPV4 undergoing rapid internalization upon stimulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Fan Ye, Yucui Jiang, Yingxin Zong, Jian Zhang, Chan Zhu, Yan Yang, Zongxiang Tang
Summary: The activation of MRGPRB2 leads to an increase in intracellular calcium concentration and voltage-dependent current, which is correlated with extracellular calcium concentration. The activation of MRGPRB2 in mast cells involves the PLC-IP3-ORAI signaling pathway and CACCS.
IMMUNOLOGY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Kazuki Nagata, Sanae Araumi, Daisuke Ando, Naoto Ito, Miki Ando, Yuki Ikeda, Miki Takahashi, Sakura Noguchi, Yayoi Yasuda, Nobuhiro Nakano, Tomoaki Ando, Mutsuko Hara, Takuya Yashiro, Masakazu Hachisu, Chiharu Nishiyama
Summary: In this study, the effects of kaempferol on bone marrow-derived mast cells (BMMCs) were evaluated. Kaempferol treatment significantly and dose-dependently inhibited IgE-induced degranulation, and cytokine production of BMMCs while maintaining cell viability. Furthermore, kaempferol downregulated the surface expression levels of Fc epsilon RI on BMMCs and upregulated the expression of SHIP1, leading to the suppression of various signaling-mediated stimulations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Magda Babina, Zhao Wang, Saptarshi Roy, Sven Guhl, Kristin Franke, Metin Artuc, Hydar Ali, Torsten Zuberbier
Summary: Codeine activates dermal mast cells through MRGPRX2 as its dominant receptor, with activation displaying individual variability and being subject to desensitization. Codeine-induced activation of MRGPRX2 leads to rapid internalization and E3-arrestin activation, suggesting a potential mechanism for refractoriness. Pre-stimulation with MRGPRX2 agonists results in cross desensitization, indicating a possible strategy to prevent severe pseudoallergic reactions.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Shuai Zhang, Xinpei Zhang, Haolin Zhong, Xuanyi Li, Yujie Wu, Jun Ju, Bo Liu, Zhenyu Zhang, Hai Yan, Yizheng Wang, Kun Song, Sheng-Tao Hou
Summary: Therapeutic hypothermia at 32-34 degrees C during or after cerebral ischaemia is neuroprotective, but peripheral cold sensor-triggered hypothermia is ineffective. Deep brain stimulation of warm-sensitive neurones in the medial preoptic nucleus can produce tolerable hypothermia in mice, which confers significant brain protection. Activation of WSNs contributes to DBS-evoked hypothermia, while inhibition of WSNs prevents it.
NATURE COMMUNICATIONS
(2022)
Article
Audiology & Speech-Language Pathology
Ajmal A. Azees, Alex C. Thompson, Ross Thomas, Jenny Zhou, Patrick Ruther, Andrew K. Wise, Elise A. Ajay, David J. Garrett, Anita Quigley, James B. Fallon, Rachael T. Richardson
Summary: This study compares the spread of neural activity in the auditory midbrain during electrical and optical stimulation in the cochlea of mice with opsin-modified spiral ganglion neurons. Optogenetic stimulation results in reduced channel interaction and higher spatial precision compared to electrical stimulation, potentially increasing the number of independent channels in a cochlear implant and improving speech perception for recipients.
Article
Immunology
Md Abdul Alim, Mirjana Grujic, Paul W. Ackerman, Per Kristiansson, Pernilla Eliasson, Magnus Peterson, Gunnar Pejler
Summary: Mast cells play a role in communication between peripheral nerves and immune cells, expressing glutamate receptors and being sensitive to glutamate signaling. Glutamate induces upregulation of various glutamate receptors and gene expression in mast cells, including pro-inflammatory components and transcription factors. The presence of a functional glutamate-glutamate receptor axis in mast cells is supported by in vitro and in vivo evidence, revealing a novel principle of communication between immune cells and nerve cells.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Allergy
Erika Mendez-Enriquez, Maya Salomonsson, Jens Eriksson, Christer Janson, Andrei Malinovschi, Mikael E. Sellin, Jenny Hallgren
Summary: It has been found that mast cell progenitors can be activated by IgE cross-linking, which may contribute to the development of acute allergic airway inflammation.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)