Article
Biotechnology & Applied Microbiology
Shijia Tang, Lin Wang, Yunyang Zhang, Feimin Zhang
Summary: Repairing bone defects caused by trauma or diseases is a primary focus of prosthodontics. Researchers developed a novel biomimetic hydrogel by combining methacrylated alginate and 4-arm poly (ethylene glycol)-acrylate (4A-PEGAcr). The hydrogel was then incorporated with platelet-rich plasma (PRP) and biomineralized to promote bone tissue regeneration. In vitro and in vivo studies showed that the hydrogel had excellent biocompatibility and osteogenic activities.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Jeffrey L. Van Eps, Joseph S. Fernandez-Moure, Fernando J. Cabrera, Francesca Taraballi, Francesca Paradiso, Silvia Minardi, Xin Wang, Bayan Aghdasi, Ennio Tasciotti, Bradley K. Weiner
Summary: The human bony skeleton undergoes constant remodeling with a turnover of up to 10% bone volume annually. The study evaluated the regenerative ability of a nanostructured MHA/Coll scaffold augmented by autologous PRP in a model of spinal fusion. Both groups showed significantly more new bone formation compared to controls, with Group 2 exhibiting enhanced bone production and successful fusion rates. This study demonstrates the potential of using nanostructured MHA/Coll scaffold and autologous PRP in achieving successful clinical fusion.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Syamsiah Syam, Chun-Wei Chang, Wen-Chien Lan, Keng-Liang Ou, Bai-Hung Huang, Yu-Yeong Lin, Takashi Saito, Hsin-Yu Tsai, Yen-Chun Chuo, Tzu-Sen Yang, Chung-Ming Liu, Ping-Jen Hou
Summary: This study demonstrated that the combination of innovative alpha-CSH with PRP can accelerate bone healing and regeneration in a rabbit model, showing promising results in defect treatment.
APPLIED SCIENCES-BASEL
(2021)
Article
Multidisciplinary Sciences
Jianying Zhang, Feng Li, Tyler Augi, Kelly M. Williamson, Kentaro Onishi, MaCalus Hogan, Matthew D. Neal, James H-C Wang
Summary: Platelet-rich plasma (PRP) containing PLT HMGB1 plays a crucial role in tendon wound healing by reducing inflammation, increasing local HMGB1 levels, and recruiting stem cells to the injured area. The efficacy of PRP treatment for tendon injuries in clinics may be dependent on the presence of PLT HMGB1 in PRP preparations.
Article
Biotechnology & Applied Microbiology
Meral Nadra, Wanting Niu, Motoichi Kurisawa, Dominique Rousson, Myron Spector
Summary: In implant dentistry, the difficulties of reconstructing large defects in the oral cavity and musculoskeletal system using porous blocks have been addressed by developing a gelatin-based gel incorporating platelet-rich plasma lysate. This gel acts as a scaffold for cell migration and a vehicle for sustained release of therapeutic agents, promoting bone reconstruction.
BIOENGINEERING-BASEL
(2022)
Review
Cell Biology
Giuseppina Malcangi, Assunta Patano, Giulia Palmieri, Chiara Di Pede, Giulia Latini, Alessio Danilo Inchingolo, Denisa Hazballa, Elisabetta de Ruvo, Grazia Garofoli, Francesco Inchingolo, Gianna Dipalma, Elio Minetti, Angelo Michele Inchingolo
Summary: This review examines the potentials of concentrated growth factors in maxillary sinus lift technique. The use of platelet concentrates can promote bone remodeling, reduce the amount of autologous bone required during surgery, enhance early vascularization in bone grafts, and stimulate the regeneration of injured tissues. Further studies are still needed, but the use of platelet concentrates can improve clinical results in sinus elevation surgeries by improving bone height, thickness, and vascularization of surgical sites, and promoting post-operative healing.
Article
Dentistry, Oral Surgery & Medicine
Faez Saleh Al-Hamed, Lina Abu-Nada, Rania Rodan, Stylianos Sarrigiannidis, Jose Luis Ramirez-Garcialuna, Hanan Moussa, Osama Elkashty, Qiman Gao, Tayebeh Basiri, Laura Baca, Jesus Torres, Lisa Rancan, Simon D. Tran, Marie Lordkipanidze, Mari Kaartinen, Zahi Badran, Faleh Tamimi
Summary: The study found that double-spin L-PRP showed better efficacy in promoting bone healing by significantly reducing the size of bone defects and decreasing the number of inflammatory cells in the defect area compared to single-spin or filtered L-PRP.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Eduardo Anitua, Mikel Allende, Mohammad Hamdan Alkhraisat
Summary: This systematic review evaluates the efficacy of platelet-rich plasma (PRP) products and composition in regenerating alveolar bone after tooth extraction. The meta-analysis shows significant effects of pure-platelet rich plasma (P-PRP) on new bone formation and bone density, while the effects of leukocyte-rich plasma (L-PRP) are unclear. Despite limitations in the included studies, the data suggests that P-PRP can improve alveolar bone regenerative potential compared to unassisted healing.
BIOENGINEERING-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Dina Saginova, Elyarbek Tashmetov, Yevgeniy Kamyshanskiy, Berik Tuleubayev, Denis Rimashevskiy
Summary: This research aimed to assess the effect of bone allograft combined with platelet-rich plasma (PRP), recombinant human bone morphogenetic protein-2 (rhBMP-2), and zoledronic acid (Zol) on bone formation. The study found that the combination of PRP with bone allograft promoted new bone formation and neovascularization. Additionally, the use of rhBMP-2 induced higher bone formation but also excessive osteoclast activity. The local co-administration of Zol inhibited allograft resorption and new bone formation.
Article
Engineering, Biomedical
Marjan Bahraminasab, Nesa Doostmohammadi, Athar Talebi, Samaneh Arab, Akram Alizadeh, Ali Ghanbari, Amir Salati
Summary: In this study, the properties of 3D-printed PLA scaffolds were improved by infilling them with gelatin-nano-hydroxyapatite (PLA/G-nHA) and subsequent coating with PRP. The scaffolds were evaluated for printing accuracy, structural characterizations, mechanical properties, degradability behavior, cell adhesion, mineralization, systemic effect on liver enzymes, osteocalcin level in blood serum, and in vivo bone regeneration capability. The results showed that PLA/G-nHA/PRP scaffolds had high printing accuracy, superior cell proliferation and adhesion, and better bone regeneration capability compared to bare PLA and PLA/G-nHA scaffolds.
BIOMEDICAL ENGINEERING ONLINE
(2022)
Article
Cell Biology
Peter A. Everts, Albert van Erp, Alfred DeSimone, Dan S. Cohen, Ronald D. Gardner
Summary: There is a growing interest in optimizing post-surgical tissue repair strategies, especially in the use of autologous biological treatments such as platelet-rich plasma (PRP) in orthopedic surgery and sports medicine. However, the lack of consensus on PRP preparation standardization and individualized formulations has led to contradictory outcomes in the literature. There are still many unresolved issues in this field, including addressing the full potential of PRP technology and its therapeutic effects.
Review
Medicine, Research & Experimental
Ming Liu, Yu Liu, Feng Luo
Summary: This review analyzes and summarizes the role and mechanism of platelet-rich fibrin (PRF) in alveolar bone regeneration. PRF promotes bone regeneration through multiple signaling pathways and functions as a scaffold and filler. PRF has extensive applications in the oral field and provides valuable reference for future research.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Nanoscience & Nanotechnology
Shuaiqi Gan, Zheng Zheng, Min Zhang, Li Long, Xu Zhang, Bowen Tan, Zhimin Zhu, Jinfeng Liao, Wenchuan Chen
Summary: A photocrosslinkable composite hydrogel was developed by incorporating lyophilized PRF exudate (LPRFe) into the CMCSMA/GelMA hydrogel, effectively solving the issues of poor storage capabilities, uncontrollable concentration of growth factors, and unstable shape of PRF. The LPRFe-loaded hydrogel improved the adhesion, proliferation, migration, and osteogenic differentiation of BMSCs. Animal experiments showed excellent biocompatibility, biodegradability, and accelerated bone healing process with the introduction of LPRFe in the hydrogel. The combination of LPRFe with CMCSMA/GelMA hydrogel may be a promising therapeutic approach for bone defects.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Francesca Salamanna, Nicolandrea Del Piccolo, Maria Sartori, Gianluca Giavaresi, Lucia Martini, Giuseppe Di Sante, Cesare Stagni, Dante Dallari, Milena Fini
Summary: The study suggests that the combination of autologous activated PRP, as a carrier for BMSCs, is a promising regenerative strategy for bone formation, osseointegration, and mineralization of bone implants.
Review
Biotechnology & Applied Microbiology
Sicong Ren, Hanchi Wang, Sijia Ma, Jing Zhou, Jingjie Zhai, Yuemeng Zhu, Sheng Chen, Siyu Chen, Kewen Jia, Wenzhou Xu, Yanmin Zhou
Summary: Components in blood are crucial for wound healing and tissue regeneration. Autologous platelet concentrates, together with various biomaterials, play a role in each stage of tissue healing and can enhance the process effectively.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Oscar Iglesias-Velazquez, Rosa Maria Lopez-Pintor, Jose Gonzalez-Serrano, Elisabeth Casanas, Jesus Torres, Gonzalo Hernandez
Summary: This study evaluated the increase in salivary lactate dehydrogenase (LDH) levels in patients with oral cancer (OC) or oral potentially malignant disorders (OPMD) compared to a healthy control group (CG). Results showed that LDH levels were higher in the OC group and patients with oral leucoplakia and oral submucous fibrosis also had higher levels. Salivary LDH determination may be a useful method for screening and tracking OC and OPMD, but further studies are needed to establish precise cutoff values.
Letter
Dentistry, Oral Surgery & Medicine
F. Perez-Gonzalez, L. Sanchez-Labrador, P. Molinero-Mourelle, L. M. Saez-Alcaide, J. Cortes-Breton-Brinkmann, J. Torres Garcia-Denche, J. Lopez-Quiles, J. M. Martinez-Gonzalez
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Francisco G. F. Tresguerres, Isabel F. Tresguerres, Oscar Iglesias, Isabel Leco, Faleh Tamimi, Jesus Torres
Summary: This study aimed to evaluate the influence of perforating the cortex of the recipient site on cancellous allogeneic block graft integration and revascularization in the maxilla. The results showed that perforating the cortex of the recipient site did not have a significant effect on angiogenesis and bone formation within the block graft.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2021)
Article
Engineering, Chemical
Zixin He, Qiman Gao, Anna Henley, Zovinar Der Khatchadourian, Wendy Somerville, Michael Wiseman, Luc Mongeau, Faleh Tamimi
Summary: Aerosol particles generated by dental procedures can potentially transmit infectious diseases and contain carcinogens. This study aimed to quantify aerosols produced during drilling and scaling procedures and evaluate measures for aerosol reduction. The results showed that high-volume evacuators (HVEs) and air purifiers effectively reduced aerosol concentration, with the best reduction achieved by using both measures simultaneously.
AEROSOL SCIENCE AND TECHNOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ashwaq A. Al-Hashedi, Nadia Dubreuil, Timothy Schwinghamer, Subad Dorzhiyeva, Lamyia Anweigi, Elham Emami, Faleh Tamimi
Summary: This study tested the efficacy of a cuttlebone-derived aragonite toothpaste in removing dental calculus. The results showed that this toothpaste was effective in removing calculus, preventing calculus formation, and improving gingival health.
CLINICAL AND EXPERIMENTAL DENTAL RESEARCH
(2022)
Article
Anatomy & Morphology
Oscar Iglesias-Velazquez, Rebeca Serrano Zamora, Rosa Maria Lopez-Pintor, Francisco G. F. Tresguerres, Isabel Leco Berrocal, Cristina Meniz Garcia, Isabel Fernandez Tresguerres, Jesus Torres Garcia-Denche
Summary: This study evaluates the clinical and radiographic outcomes of the Periosteal Pocket Flap Technique (PPF) combined with the use of xenogeneic and autologous bone and Plasma Rich in Growth Factors (PRGF) compared to conventional Guided Bone Regeneration (GBR) procedures. The results demonstrate that the combination of autograft/xenograft and PRGF in PPF technique is a simpler, cheaper, and faster technique than GBR technique for achieving moderate lateral bone augmentation in implant treatment.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2022)
Review
Infectious Diseases
Betul Rahman, Anirudh Balakrishna Acharya, Ruqaiyyah Siddiqui, Elise Verron, Zahi Badran
Summary: Peri-implant diseases are inflammatory infections caused by oral bacteria. Mechanical debridement is the standard management approach, and photodynamic therapy is gaining attention as an adjunctive treatment.
Article
Dentistry, Oral Surgery & Medicine
Laura Baca-Gonzalez, Rebeca Serrano Zamora, Lisa Rancan, Francisco Gonzalez Fernandez-Tresguerres, Isabel Fernandez-Tresguerres, Rosa M. Lopez-Pintor, Juan Lopez-Quiles, Isabel Leco, Jesus Torres
Summary: This study compared the release of PDGF, VEGF, IGF-I, and IL-1β in PRGF and L-PRF, and evaluated their biological implications in osteoblasts. The findings showed that PRGF exhibited a slower controlled release at day 14, contributing to a higher synthesis of type I collagen. L-PRF released significantly higher amounts of IL-1β compared to PRGF.
INTERNATIONAL JOURNAL OF IMPLANT DENTISTRY
(2022)
Review
Biology
Mohammad Abusamak, Mohammad Al-Tamimi, Haider Al-Waeli, Kawkab Tahboub, Wenji Cai, Martin Morris, Faleh Tamimi, Belinda Nicolau
Summary: This scoping review systematically maps the evidence supporting chronotherapy in dentistry and identifies knowledge gaps. It found that chrono-radiotherapy and chrono-chemotherapy can reduce treatment side effects and improve therapeutic response in cancer patients, leading to higher survival rates. Animal studies suggest that tooth movement and periodontal tissue response to orthodontic forces follow a diurnal rhythm that may impact bone metabolism. Profound and prolonged local anesthesia can be achieved when injected in the evening. Although the overall quality of the included studies was low, chronotherapy applications in dentistry appear to have favorable outcomes, especially in head and neck cancer treatments.
CHRONOBIOLOGY INTERNATIONAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Leire Virto, Veronica Odeh, Enrique Garcia-Quismondo, David Herrera, Jesus Palma, Faleh Tamimi, Mariano Sanz
Summary: The objective of this study was to investigate the effect of electrochemical treatment on biofilms developed on titanium dental implants. The study found that electrochemical treatment had an impact on the structure and bacterial composition of the biofilms. The reduction in bacterial counts, especially for Fusobacterium nucleatum, demonstrated a bactericidal effect of the treatment.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Alaa Mansour, Maya Romani, Anirudh Balakrishna Acharya, Betul Rahman, Elise Verron, Zahi Badran
Summary: Modern drug discovery methods have led to the development of new drugs with significant potential, but properties like solubility and administration challenges may hinder their benefits. Biotechnology advances have also resulted in the development of molecules with short half-lives, requiring frequent administration. Controlled release systems are necessary to enhance treatment efficacy and improve patient compliance. This review provides an overview of different approaches used for drug delivery.
Review
Dentistry, Oral Surgery & Medicine
Balqees Almufleh, Alexia Arellanob, Faleh Tamimi
Summary: The evidence on patient-reported outcomes and clinical performance of digitally fabricated RPDs compared to conventionally fabricated dentures is limited. Some studies suggest that digitally fabricated RPDs are associated with higher patient satisfaction, while others indicate that conventionally fabricated RPDs have better framework fit accuracy. Overall, both digitally and conventionally fabricated metal RPD frameworks showed clinically acceptable fit.
JOURNAL OF PROSTHODONTICS-IMPLANT ESTHETIC AND RECONSTRUCTIVE DENTISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jose Gonzalez-Serrano, Julia Serrano, Mariano Sanz, Jesus Torres, Gonzalo Hernandez, Rosa Maria Lopez-Pintor
Summary: This study evaluated the efficacy of a gel containing propolis extract, nanovitamin C, and nanovitamin E as adjuvants for the treatment of desquamative gingivitis. The results showed that the gel can alleviate DG and improve quality of life without significant side effects.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Fabian Perez-Gonzalez, Mohammad Abusamak, Luis Miguel Saez-Alcaide, Jesus Torres Garcia-Denche, Faleh Ahmad Tamimi Marino
Summary: The purpose of this study was to evaluate the time-dependent administration of ibuprofen in a lower third molar extraction model. The results showed that there were no significant differences in postoperative swelling and pain perception between the control group, which took ibuprofen every 8 hours, and the experimental group, which took ibuprofen only at breakfast and lunch and replaced dinner intake with a placebo. However, trismus was significantly higher in the experimental group at 72 hours postoperatively.
ORAL AND MAXILLOFACIAL SURGERY-HEIDELBERG
(2022)