Article
Chemistry, Multidisciplinary
Siddharth S. Matikonda, Dominic A. Helmerich, Mara Meub, Gerti Beliu, Philip Kollmannsberger, Alexander Greer, Markus Sauer, Martin J. Schnermann
Summary: The study investigates the light-promoted conversion of cyanine dyes and their application in improving spatial resolution in super-resolution single-molecule localization microscopy. By optimizing conditions, the yield of photoconversion can be significantly increased, demonstrating the potential of this common chemical transformation to be utilized as a valuable optical tool.
ACS CENTRAL SCIENCE
(2021)
Article
Polymer Science
Jiayan Shi, Chunhua Wei, Min Shen, Tingting Pan, Yanqing Tian
Summary: Two new block copolymers (P1 and P2) containing platinum porphyrin-based phosphorescent probes with different molar ratios of polydimethylsiloxane (PDMS) and isobutyl methacrylate (IBM) were successfully synthesized via atom transfer radical polymerization (ATRP) with narrow polydispersity smaller than 1.21. The polymer with higher PDMS content exhibited better oxygen sensitivity, pressure sensitivity, and faster response time. The pressure sensitivity of the polymer was significantly influenced by temperature, with P1 having a high pressure sensitivity of 0.82%/kPa at 50 wt% PDMS content.
Editorial Material
Cardiac & Cardiovascular Systems
Kenneth R. Olson
Summary: Cardiovascular regulation is mainly an anti-rise process, aiming to downregulate oxygen delivery and maintain a reduced intracellular environment. This hypothesis is supported by the properties of hemoglobin, oxygen-sensitive vasoconstrictors, and the effects of Fahraeus and Fahraeus-Lindqvist.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Engineering, Electrical & Electronic
Deepak Mishra, Arijit Baral, Sivaji Chakravorti
Summary: This study proposes a noninvasive and effective method to predict the activation energy of insulation materials by recording the dielectric response. The method requires a few seconds of polarization current data and can quickly sense the value of activation energy with high accuracy.
IEEE SENSORS JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Laura Zarnitz, Benedict M. Doorschodt, Lisa Ernst, Aisa Hosseinnejad, Eileen Edgworth, Tamara Fechter, Alexander Theissen, Sonja Djudjaj, Peter Boor, Rolf Rossaint, Rene H. Tolba, Christian Bleilevens
Summary: Donor organ shortage has led to the use of marginal grafts, but normothermic machine perfusion (NMP) can assess and restore the viability of these grafts before transplantation. An alternative to autologous packed red blood cell (pRBC)-based perfusates is the cell- and oxygen carrier-free solution Ecosol, supplemented with taurine, which may prevent adverse effects. This study compared the effects of 6 h NMP using pRBC and Ecosol on porcine kidneys, and found that despite some tissue damage in the Ecosol group, functional parameters and oxygenation were similar to the pRBC group, and taurine improved antioxidant capacity in the Ecosol group.
Article
Medicine, General & Internal
Eberhard Grambow, Niels Arne Sandkuehler, Justus Gross, Daniel G. E. Thiem, Michael Dau, Matthias Leuchter, Malte Weinrich
Summary: This study investigated the feasibility of using hyperspectral imaging (HSI) to monitor skin oxygenation in patients with peripheral artery disease (PAD). The results showed that HSI can be used as an additional technique to assess tissue oxygen saturation in PAD patients, and it is robust to external confounders such as temperature and physical activity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Developmental Biology
Yida Jiang, Li-Juan Duan, Guo-Hua Fong
Summary: This article discusses the molecular mechanisms of the oxygen-sensing pathway and the regulation of HIFα under normoxia and hypoxia conditions. Through mouse models, it investigates loss-of-function phenotypes and emphasizes the clinical relevance of HIF in angiogenesis and tissue repair.
Article
Biochemical Research Methods
Neil T. Clancy, Antonio S. Soares, Sophia Bano, Laurence B. Lovat, Manish Chand, Danail Stoyanov
Summary: This study utilizes multispectral imaging laparoscope technology to achieve quantitative measurement of tissue oxygen saturation, demonstrating its potential application in clinical surgeries. The results indicate that this technique can provide surgical guidance by assessing perfusion, helping surgeons in choosing anastomosis points and ensuring the use of well-perfused tissue during surgery.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Medicine, General & Internal
Przemyslaw Dyrla, Arkadiusz Lubas, Jerzy Gil, Marek Saracyn, Maciej Gonciarz
Summary: The study found significant differences in dynamic tissue perfusion measurement (DTPM) and single vessel flow measurement (SVFM) in differentiating between inflammatory and malignant lesions of the pancreas, with parameters such as TFV and TPI showing slightly better discriminatory properties. Evaluating these parameters can help better differentiate between these two types of lesions. Tissue perfusion has better discriminatory properties in differentiating solid pancreatic lesions than the Doppler blood flow examination in a single vessel within the tumor.
Article
Engineering, Biomedical
Mahboubeh Sadat Mousavi, Ghassem Amoabediny, Seyed Hossein Mahfouzi, Seyed Hamid Safiabadi Tali
Summary: The study introduced a novel perfusion-based bioreactor (PBB) method for efficient decellularization of bovine articular cartilages, resulting in better preservation of the tissue structure and essential components while reducing harmful physical and chemical steps and process duration. The PBB method showed a 90% reduction in DNA content, significantly higher than the control method, and maintained around 50% of sulfated glycosaminoglycan (sGAG) content and 92% of compression properties, demonstrating efficient preservation of scaffold structure and components. Additionally, the PBB specimens supported cell adherence and proliferation effectively, showing promise for producing close-to-natural scaffolds for cartilage tissue engineering.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Critical Care Medicine
Ravindran Visagan, Florence R. A. Hogg, Mathew J. Gallagher, Siobhan Kearney, Argyro Zoumprouli, Marios C. Papadopoulos, Samira Saadoun
Summary: This study examines the feasibility of monitoring tissue oxygen tension in patients with acute, severe traumatic spinal cord injuries. The results show that tissue oxygen tension is influenced by various factors, including intraspinal pressure, spinal cord perfusion pressure, tissue glucose levels, lactate/pyruvate ratio, and fever. In patients with motor-incomplete injuries, fluctuations in tissue oxygen tension correlate with fluctuations in limb motor score.
CRITICAL CARE MEDICINE
(2022)
Article
Computer Science, Information Systems
Sheng Miao, Yukun Dang, Qixiu Zhu, Sudong Li, Mohammad Shorfuzzaman, Haibin Lv
Summary: This study presents a novel approach using multimodal sensing data and deep learning algorithms to assess upper limb functionality, which shows better accuracy compared to traditional training methods.
Article
Chemistry, Physical
Mandeep Singh, Navpreet Kaur, Andrea Casotto, Luigi Sangaletti, Nicola Poli, Elisabetta Comini
Summary: This study demonstrates the importance of tailoring metal oxide nanowires with suitable self-assembled monolayers for developing highly efficient and selective chemical sensors with low power consumption. The functionalization strategy of SAMs on ZnO nanowires enhances sensor performance towards acetone and improves the ability to discriminate acetone molecules. TEOS functionalized sensors show superior performance at lower operating temperatures compared to other sensor structures. This SAM functionalization strategy has great potential in developing high performance chemical sensor devices for various analytes including acetone and environmental pollutants.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Article
Chemistry, Analytical
Bin Hu, Jiawei Zhu, Jianjun Shen, Liang Yang, Changlong Jiang
Summary: A portable sensing platform using an upconversion-based nano-sensor has been developed for real-time visual quantitative monitoring of the regional antidote Mesna in chemotherapy patients, providing a new strategy for point-of-care drug testing in clinical settings.
ANALYTICAL CHEMISTRY
(2022)
Review
Gastroenterology & Hepatology
Jiahao Li, Haoyang Lu, Jian Zhang, Yixuan Li, Qiang Zhao
Summary: This review summarizes the criteria, indicators, and methods used to evaluate liver viability during normothermic machine perfusion (NMP) in liver transplantation. It discusses the analysis of liver shape, appearance, and hemodynamics at a macroscopic level and biochemical analysis of liver injury markers, liver and bile duct function indicators, and other relevant indicators. It also introduces novel methods for assessing liver viability and provides suggestions for future clinical practice considering the limitations of evaluating liver viability during NMP.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Letter
Surgery
Marek Paul, Michal Barwijuk, Adrianna Jurkiewicz, Piotr Kolczewski, Iwona Gabriel
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2018)
Article
Materials Science, Biomaterials
Manos Gkikas, Thomas Peponis, Tomaz Mesar, Celestine Hong, Reginald K. Avery, Emmanuel Roussakis, Hyung-Jin Yoo, Anushri Parakh, Manuel Patino, Dushyant Sahani, Michael T. Watkins, Rahmi Oklu, Conor L. Evans, Hassan Albadawi, George Velmahos, Bradley D. Olsen
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2019)
Article
Surgery
Marek A. Paul, Jakub Opyrchal, Jan Witowski, Ahmed M. S. Ibrahim, Michal Knakiewicz, Pawel Jaremkow
JOURNAL OF CRANIOFACIAL SURGERY
(2019)
Article
Engineering, Biomedical
Emmanuel Roussakis, Roger V. Ortines, Bret L. Pinsker, Cavin T. Mooers, Conor L. Evans, Lloyd S. Miller, Xiomara Calderon-Colon
Article
Biochemistry & Molecular Biology
Emmanuel Roussakis, Juan Pedro Cascales, Haley L. Marks, Xiaolei Li, Mark Grinstaff, Conor L. Evans
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2020)
Article
Multidisciplinary Sciences
Marek A. Paul, Jakub Opyrchal, Michal Knakiewicz, Pawel Jaremkow, Lukasz Duda-Barcik, Ahmed M. S. Ibrahim, Samuel J. Lin
Review
Surgery
Marek A. Paul, Jakub Opyrchal, Michal Knakiewicz, Pawel Jaremkow, Jan Bajtek, Anna Chrapusta
JOURNAL OF CRANIOFACIAL SURGERY
(2020)
Article
Neurosciences
Matthew T. Flavin, Marek A. Paul, Alexander S. Lim, Senan Abdulhamed, Charles A. Lissandrello, Robert Ajemian, Samuel J. Lin, Jongyoon Han
Summary: The article introduces a fast, low-cost fabrication process for patterning electrode contacts in an implantable peripheral nerve cuff, using a laser cutter to ensure precise contact geometries. This method shows favorable electrical characteristics and expected electrophysiological behaviors in acute implantation on the rat sciatic nerve, making it suitable for rapid manufacturing with consistent and precise electrode geometries.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Thomas Huang, Edward O'Leary, Mark E. Alexander, Laura Bevilacqua, Francis Fynn-Thompson, Elizabeth S. DeWitt, Vassilios J. Bezzerides, Douglas Y. Mah
Summary: This study explores the use of permanent pacemakers to treat syncope in children and young adults, with a 24% complication rate. Post-implant, 14% of patients had complete resolution of symptoms, while 8% continued to experience syncope.
CARDIOLOGY IN THE YOUNG
(2022)
Article
Surgery
Adriana M. Paskal, Pawel Jaremkow, Paulina Malyszczak, Wiktor Paskal, Korneliusz Wojcik, Jakub Opyrchal, Marek A. Paul
Summary: The study assessed the changes in plastic surgery training in Europe during the COVID-19 pandemic, finding alterations in courses, workshops, and conferences for all respondents, significant reduction in admissions, and negative impact on training and health.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2022)
Article
Engineering, Biomedical
Haley L. Marks, Katherine Cook, Emmanuel Roussakis, Juan Pedro Cascales, Jeremy T. Korunes-Miller, Mark W. Grinstaff, Conor L. Evans
Summary: Sensor-integrated wound dressings provide quantitative insights into tissue characteristics and enable easy monitoring of wound healing. This study presents a cost-effective method to quantify oxygen and pH in a hydrogel dressing using a single photograph. The luminescence of a dendritic polyamine Pt-porphyrin and fluorescein conjugate responds to oxygen and pH, respectively, and can be captured using a modified DSLR camera for image analysis.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Computer Science, Information Systems
Juan Pedro Cascales, Daniel A. Greenfield, Emmanuel Roussakis, Lilian Witthauer, Xiaolei Li, Avery Goss, Conor L. Evans
Summary: This research presents a wireless prototype designed to detect changes in tissue oxygenation using off-the-shelf electronic components and 3D printing technology. The accuracy of oxygenation measurements has been improved through a machine learning approach, which can potentially be integrated into device firmware and software for stable and accurate readings.
IEEE INTERNET OF THINGS JOURNAL
(2021)
Article
Multidisciplinary Sciences
Matthew T. Flavin, Marek A. Paul, Alexander S. Lim, Charles A. Lissandrello, Robert Ajemian, Samuel J. Lin, Jongyoon Han
Summary: In this study, the researchers developed an implantable device that combines ion-selective membrane with electrical stimulation to achieve selective control of peripheral nerves. They demonstrated that calcium depletion increased the sensitivity of the nerve to electrical stimulation, and the ion modulation selectively influenced functional components of the nerve, enabling selective activation by electrical current.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Analytical
Juan Pedro Cascales, Xiaolei Li, Emmanuel Roussakis, Conor L. Evans
Summary: This study reports on the creation of a wearable prototype device for transcutaneous CO2 monitoring based on quantifying the fluorescence of a highly breathable CO2-sensing film. The device can monitor the changes in transcutaneous CO2 partial pressure in real-time and is insensitive to humidity.
Article
Medicine, General & Internal
Thomas Huang, Clayton W. Armstrong, Geoffrey D. Panjeton
Summary: Early diagnosis of brachial plexus injuries is crucial to prevent long-term morbidity and improve outcomes. This case report highlights a unique case of delayed onset of brachial plexus compression following a traumatic gunshot injury. The patient experienced significant pain and progressive neurological changes during follow-up visits, leading to the discovery of a left subclavian artery pseudoaneurysm. Management through operative intervention was successful.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)