Review
Immunology
Zao Ji, Feifei Jiang
Summary: This study systematically evaluated the clinical efficacy and safety of sublingual immunotherapy for allergic rhinitis. The findings showed that sublingual immunotherapy has better efficacy and safety compared to traditional medicine.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Shaobing Xie, Sijie Jiang, Hua Zhang, Fengjun Wang, Yongzhen Liu, Yongchuan She, Qiancheng Jing, Kelei Gao, Ruohao Fan, Shumin Xie, Zhihai Xie, Weihong Jiang
Summary: This study identified several serum biomarkers through metabolomics analysis that can reliably predict the efficacy of ASIT in AR patients, with these biomarkers mainly involving glycolysis, fatty acid metabolism, and other metabolic pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shoko Ueda, Jun Ito, Norihiro Harada, Sonoko Harada, Hitoshi Sasano, Yuuki Sandhu, Yuki Tanabe, Sumiko Abe, Satomi Shiota, Yuzo Kodama, Tetsutaro Nagaoka, Fumihiko Makino, Asako Chiba, Hisaya Akiba, Ryo Atsuta, Sachiko Miyake, Kazuhisa Takahashi
Summary: This study investigated the efficacy of sublingual immunotherapy (SLIT) in asthmatic patients with seasonal allergic rhinitis (SAR-JCP) and found that SLIT not only significantly improved allergic rhinitis and asthma symptoms, but also improved airway resistance. Moreover, the reduction in peripheral blood gamma delta T cells after SLIT was associated with the improvement of asthma symptoms.
Article
Allergy
Wenlong Liu, Qingxiang Zeng, Chunhui He, Rongshan Chen, Yiquan Tang, Shengbao Yan, Xi Luo, Renzhong Luo
Summary: The study compared the efficacy, safety, and compliance of SCIT and SLIT in children with allergic rhinitis. Results indicated that SCIT was more effective than SLIT to a certain degree but had higher occurrence of adverse events. Individuals can choose the appropriate AIT route based on their specific conditions.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Baharudin Abdullah, Ruby Pawankar, Amir Hamzah Abdul Latiff, Kent Chee Keen Woo, Eike Wuestenberg, Mohamad Azizul Fitri Khalid, Yeoh Zhi Xiang, Salina Husain, Nurashikin Mohammad, Norasnieda Md Shukri
Summary: Allergic rhinitis is an inflammatory disease of the upper airway, impacting patients' quality of life and increasing the risk for asthma. Allergen-specific immunotherapy is a treatment that induces tolerance to allergens and has been proven to induce disease-modifying effects. It is recommended as a first-line treatment for moderate to severe allergic rhinitis, and guidelines are important for its appropriate indication and application.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Yanni Zhang, Kang Zhu, Hui Lv, Jingguo Chen, Chao Yu, Tianxi Gao, Jing Yan, Fangli Yang, Lina Fan, Xiaoyong Ren, Cui Xia
Summary: This study found that serum exosome-derived miR-146a-3p may serve as a novel biomarker for predicting the short and long-term efficacies of sublingual immunotherapy (SLIT) in allergic rhinitis (AR) patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Shouming Cao, Haiying Wu, Yan Niu, Lu Wang, Fengjun Wang
Summary: This study found that serum exosome-derived miRNAs have the potential to predict the early effectiveness of SLIT in AR patients. Among them, has-miR-24-3p and has-miR-128-3p showed decreased expression in the effective group, while has-miR-206 showed increased expression, indicating potential as biomarkers for predicting the early efficacy of SLIT.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Otorhinolaryngology
Dijiang Ma, Qiling Zheng, Jianing Sun, Shenjun Tang, Wudan He
Summary: The findings of this meta-analysis indicate that sublingual immunotherapy (SLIT) may be a therapeutic approach to improve symptoms of allergic rhinitis and asthma in patients with asthma. However, further high-quality and well-designed studies are needed to clarify the efficacy of SLIT due to significant heterogeneity in the results.
AMERICAN JOURNAL OF RHINOLOGY & ALLERGY
(2023)
Article
Microbiology
Fabiana Furci, Luisa Ricciardi
Summary: The study observed significant improvement in respiratory and plant food allergies in 15 female patients after undergoing sublingual immunotherapy with a five-grass pollen tablet.
Article
Medicine, General & Internal
Ai-zhi Zhang, Mei-E Liang, Xiao-xue Chen, Yan-fen Wang, Ke Ma, Zhi Lin, Kuan-kuan Xue, Li-ru Cao, Rong Yang, Huan-ping Zhang
Summary: The study demonstrates that patients sensitized to house dust mite with/without other allergens show similar efficacy after 3 years of sublingual immunotherapy. However, patients with three or more allergens show slower initial response during the immunotherapy process.
FRONTIERS IN MEDICINE
(2021)
Review
Otorhinolaryngology
Qian Wang, Ruifang Zhu, Yan Ning, Yaoqing Feng, Yan Feng, Shifan Han
Summary: This study aimed to evaluate the quality of guidelines for sublingual immunotherapy in allergic rhinitis. The findings showed that the current guidelines have an average quality and there is a need for better formulation methods and reporting standards. It is recommended that guideline makers refer to the AGREE II tool to develop high-quality guidelines.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Immunology
Yanni Zhang, Kang Zhu, Cui Xia, Jingguo Chen, Chao Yu, Tianxi Gao, Jing Yan, Huihui Zhang, Xiaoyong Ren
Summary: This study found differences in the levels of multiple cytokines in patients with allergic rhinitis and their association with the efficacy of allergen-specific immunotherapy. IL10 and IL33 may serve as novel biomarkers for early prediction of efficacy and be involved in the therapeutic mechanisms of immunotherapy.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Immunology
Yongquan Zhang, Jian Shui, Lu Wang, Fengjun Wang
Summary: This study identifies serum S100A11 and MMP9 as potential biomarkers for early prediction and monitoring of the effectiveness of sublingual immunotherapy (SLIT) in patients with allergic rhinitis (AR). These findings contribute to guiding treatment and understanding the mechanism of SLIT in AR patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pediatrics
Feng Liao, Shi Chen, Ling Wang, Ying-yu Quan, Li-li Chen, Guo-hua Lin
Summary: This study suggests that house dust mite SLIT is effective and well-tolerated in children with allergic asthma, regardless of the administration time. SLIT dosing in the evening might result in improved asthma control and reduced FeNO levels compared to dosing in the morning.
FRONTIERS IN PEDIATRICS
(2022)
Review
Allergy
Prapasri Kulalert, Phichayut Phinyo, Mongkol Lao-Araya
Summary: HDM-SLIT tablets are an effective treatment for allergic rhinitis, reducing symptom scores and medication use, improving quality of life and conjunctivitis symptoms.
WORLD ALLERGY ORGANIZATION JOURNAL
(2022)
Review
Cell Biology
Heena Khan, Kunal Sharma, Amit Kumar, Amarjot Kaur, Thakur Gurjeet Singh
Summary: This review discusses the role of cyclooxygenase in ischemic injury, focusing on different types of COX and their involvement in various organs, as well as the downstream signaling pathways.
INFLAMMATION RESEARCH
(2022)
Review
Medicine, Research & Experimental
Priyanka Saklani, Heena Khan, Saurabh Gupta, Amarjot Kaur, Thakur Gurjeet Singh
Summary: Neuropeptides play a crucial neuroprotective role in ischemic injury, providing powerful protection by modulating various signaling pathways.
Review
Biochemistry & Molecular Biology
Palak Kalra, Heena Khan, Amarjot Kaur, Thakur Gurjeet Singh
Summary: Cerebral ischemia is a major cause of acquired and persistent disability, and evidence suggests that autophagy plays a significant role in this type of brain injury. This review summarizes the molecular mechanisms and pathobiology related to autophagy in cerebral ischemia and discusses the potential for further pre-clinical studies to be translated into clinical trials.
NEUROCHEMICAL RESEARCH
(2022)
Review
Food Science & Technology
Vivek Rihal, Heena Khan, Amarjot Kaur, Thakur Gurjeet Singh
Summary: Vitamin D deficiency is associated with chronic diseases such as cardiovascular and neurodegenerative diseases, diabetes, and cancer. Therapeutic approaches targeting vitamin D inadequacies and its downstream effects may delay the onset and severity of cerebrovascular disorders such as stroke and neurologic malformations.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Infectious Diseases
James Welker, Juan D. Pulido, Andrew T. Ca Tarizaro, Carlos D. Malvestutto, Zihai Li, Jona Than B. Cohen, Eric D. Whitman, Dana Byrne, Olivia K. Giddings, Jordan E. Lake, Joel Chua, Ella Li, Flan Chen, Xiang Zhou, Kun He, Davis Gates, Amarjot Kaur, Jamie Chen, Hung-Yen Chou, Martin Devenport, Raymond Tommy, Shyamasundaran Kottilil, Yang Liu, Pan Zheng
Summary: CD24Fc is well-tolerated and accelerates clinical improvement in hospitalised adults with COVID-19 receiving oxygen support.
LANCET INFECTIOUS DISEASES
(2022)
Review
Biochemistry & Molecular Biology
Priyanka Saklani, Heena Khan, Thakur Gurjeet Singh, Saurabh Gupta, Amarjot Kaur Grewal
Summary: This review explores the neuroprotective potential of demethyleneberberine in neurodegenerative disorders by attenuating different pathways, such as NF-kappa B, MAPK, and AMPK signaling.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Amarjot Kaur, Thakur Gurjeet Singh, Heena Khan, Manish Kumar, Nirmal Singh, Mohamed M. Abdel-Daim
Summary: The study demonstrates that Piclamilast pPost-trt can effectively reduce the detrimental effects of cerebral ischemia reperfusion injury on biochemical parameters, inflammatory parameters, infarct size, and histopathological changes in mice. It suggests that these neuroprotective effects may be mediated through CREB activation.
NEUROCHEMICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Palak Tiwari, Heena Khan, Thakur Gurjeet Singh, Amarjot Kaur Grewal
Summary: Stroke, a leading cause of morbidity and mortality, can be treated using various mechanistic approaches, including inhibition of poly (ADP-ribose) polymerase (PARP). PARP plays an important role in cerebral stroke, ischemia/reperfusion, and neurotrauma, and its inhibition has shown neuroprotective effects. However, the long-term side effects of PARP inhibitors need further investigation. Despite this, PARP inhibitors have shown promise in clinical trials for the treatment of various disorders.
NEUROCHEMICAL RESEARCH
(2022)
Article
Neurosciences
Heena Khan, Amarjot Kaur Grewal, Manish Kumar, Thakur Gurjeet Singh
Summary: Protocatechuic acid (PCA) postconditioning has a protective effect against the neurological and cognitive abnormalities caused by ischemia/reperfusion (I/R) injury. PCA postconditioning attenuates oxidative stress and inflammation by increasing antioxidants and activating the Nrf2 pathway.
Article
Pharmacology & Pharmacy
Chahat Garg, Heena Khan, Amarjot Kaur, Thakur Gurjeet Singh, Vivek Kumar Sharma, Sachin Kumar Singh
Summary: This article reviews the role of Sonic hedgehog pathway in metabolic control and its interaction with other pathways. The study suggests that pharmacological modulation of the Shh pathway may be beneficial for metabolic disorders. Understanding the importance of these molecular networks provides a rational basis for influencing its activity.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Immunology
Nirbhay Kumar Prabhakar, Heena Khan, Amarjot Kaur Grewal, Thakur Gurjeet Singh
Summary: Traumatic brain injury (TBI) is a leading cause of death and morbidity worldwide. Efforts to find neuroprotective therapeutics for TBI have not yielded beneficial outcomes in human clinical trials. Neuroinflammation and the immune system could be potential targets for TBI treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Komal Thapa, Thakur Gurjeet Singh, Amarjot Kaur
Summary: Renal I/R injury is a severe medical condition with no effective treatment currently available. Ferroptosis, a new type of cell death, plays a significant role in renal I/R injury. Pharmaceutical intervention targeting ferroptosis may help alleviate kidney damage.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)
Review
Psychiatry
Vivek Rihal, Heena Khan, Amarjot Kaur, Thakur Gurjeet Singh, Mohamed M. Abdel-Daim
Summary: Vitamin D deficiency is a hidden pandemic that affects a large percentage of the world's population. It not only impacts bone and calcium homeostasis but also has a connection to brain function and cognitive decline in neuropsychiatric illnesses such as autism, schizophrenia, depression, and ADHD. While existing research highlights the essential role of vitamin D in cognitive function, further studies are needed to determine its specific effects.
PSYCHIATRY RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Veerta Sharma, Thakur Gurjeet Singh, Amarjot Kaur, Ashi Mannan, Sonia Dhiman
Summary: This article reviews the role and function of brain-derived neurotrophic factor (BDNF) and its receptor in the brain. It also highlights the importance of BDNF in various brain-related disorders.
NEUROCHEMICAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Heena Khan, Nikhil Garg, Thakur Gurjeet Singh, Amarjot Kaur, Komal Thapa
Summary: Understanding neuronal cell death mechanisms and finding suitable treatments for neurodegenerative disorders is a significant challenge. Calpain, an important cysteine protease activated in brain disorders, is crucial in the pathophysiology of neurodegeneration. Inhibiting calpain activation may be a promising therapeutic target for managing neurodegenerative diseases.
NEUROCHEMICAL RESEARCH
(2022)