Article
Immunology
Liam F. Fitzsimmons, Tina R. Clark, Ted Hackstadt
Summary: NO exerts potent antirickettsial effects by disrupting the energy metabolism of R. rickettsii and restricting its growth inside host cells.
INFECTION AND IMMUNITY
(2021)
Review
Plant Sciences
Dake Zhao, Houping Wang, Suiyun Chen, Diqiu Yu, Russel J. Reiter
Summary: Melatonin plays diverse roles in plant development and stress tolerance, including a beneficial role in plant biotic stress tolerance. It interacts with phytohormone signaling pathways to maximize disease resistance in the early pathogen ingress stage.
TRENDS IN PLANT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Qiqi Zhang, Nini Guo, Yongheng Zhang, Youben Yu, Shuyuan Liu
Summary: PR-1 proteins play an important role in the defense of plants against diseases. In this study, 17 CsPR-1 genes were identified from the tea plant genome and classified into different groups based on their characteristics. Most of the CsPR-1 proteins contain a signal peptide and a conserved PR-1 domain. These genes are closely related to the defense mechanism of the tea plant and are significantly upregulated under tea blister-blight stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Applied
M. Sathiyabama, A. Manikandan
Summary: The study found that the use of Chitosan nanoparticles (ChNPs) can significantly enhance the growth and yield of finger millet, as well as increase the mineral content in the leaves. ChNPs also enhance the innate immune response in finger millet plants by inducing the activity of defense enzymes.
CARBOHYDRATE POLYMERS
(2021)
Article
Plant Sciences
Anik Sarkar, Nilanjan Chakraborty, Krishnendu Acharya
Summary: This study focuses on the protection of emerging Alternaria leaf spot disease of chilli using chi-tosan nanoparticles (CNP). The results show that CNP can enhance the plant's innate immunity and defense responses against the fungus. Additionally, the signaling molecule nitric oxide (NO) plays a significant role in CNP-induced defense responses in chilli plants.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Infectious Diseases
Atul Tyagi, Sudeep Roy, Sanjay Singh, Manoj Semwal, Ajit K. Shasany, Ashok Sharma, Ivo Provaznik
Summary: The study team developed an SVM-based model for designing and predicting plant-derived antifungal peptides. The analysis showed preferences for C, G, K, R, S in amino acid sequences, with G, K, R, A dominating the N-terminal and N, S, C, G preferring the C-terminal. Motif analysis revealed the presence of motifs like NYVF, NYVFP, YVFP, NYVFPA, VFPA.
Article
Biochemistry & Molecular Biology
Yuqi He, Kaixuan Zhang, Shijuan Li, Xiang Lu, Hui Zhao, Chaonan Guan, Xu Huang, Yaliang Shi, Zhen Kang, Yu Fan, Wei Li, Cheng Chen, Guangsheng Li, Ou Long, Yuanyuan Chen, Mang Hu, Jianping Cheng, Bingliang Xu, Mark A. Chapman, Milen Georgiev, Alisdair R. Fernie, Meiliang Zhou
Summary: This study analyzed the Rhizoctonia solani pathogen and identified a strain (AG4-HGI 3) with a broad host range. Several disease-resistant genes were also identified. Additionally, a negative regulator and an antibacterial peptide were found to enhance disease resistance. These findings provide insights for molecular breeding of resistant crop varieties.
Article
Horticulture
Yasemin Bektas
Summary: The study found that the plant defense elicitor FytoSol can effectively prevent early blight, while 2,6-dichloroisonicotinic acid (INA) does not provide protection. FytoSol upregulated the gene expression of PR3 and downregulated the SA-related defense pathway, playing an important role in the control of early blight.
Article
Entomology
Stella Bergmann, Jan-Phillipp Gerhards, Anne Schmitz, Stefanie C. Becker, Michael Stern
Summary: Insects lack adaptive immune system like vertebrates but relies on innate immune system to respond to a broad variety of pathogens. The study evaluated cytotoxic gaseous radical nitric oxide (NO) production in response to immune stimuli in Locusta migratoria, showing an influence on the central nervous system. The findings contribute to understanding neuroimmune interactions in insects.
Article
Microbiology
Yezhou Hu, Yanxia Ding, Boying Cai, Xiaohui Qin, Jingni Wu, Minhang Yuan, Shiwei Wan, Yang Zhao, Xiu-Fang Xin
Summary: This study reveals that phytopathogen Pseudomonas syringae induces water soaking in plant leaf tissue by altering the regulation of abscisic acid (ABA), which leads to ABA signaling and stomatal closure. P. syringae achieves this by binding and inhibiting Arabidopsis type one protein phosphatases (TOPPs) that normally suppress ABA signaling. This hijacking of ABA signaling and stomatal closure are key mechanisms of disease susceptibility.
CELL HOST & MICROBE
(2022)
Review
Biochemistry & Molecular Biology
Guangyuan Xu, Wolfgang Moeder, Keiko Yoshioka, Libo Shan
Summary: Calcium channels play crucial roles in plant immunity by regulating calcium concentration and signaling. Different branches of the plant immune system exhibit specific calcium signatures. Studying diverse types of calcium channels helps to understand the molecular mechanisms of plant immunity.
Article
Agronomy
Jin Chu, Han Xu, Hai Dong, Yuan Hu Xuan
Summary: Through various experiments, it has been confirmed that kinesin-like protein (KLP) interacts with Loose Plant Architecture 1 (LPA1) in the nucleus of rice cells. Further investigations revealed that KLP can promote resistance of rice to sheath blight disease, potentially by activating PIN1a transcriptionally.
Review
Biochemistry & Molecular Biology
Yongxue Zhang, Haodong Tian, Daniel Chen, Heng Zhang, Meihong Sun, Sixue Chen, Zhi Qin, Zhaojun Ding, Shaojun Dai
Summary: Cysteine-rich receptor-like kinases (CRKs), belonging to a large DUF26-containing receptor-like kinase (RLK) family, have important roles in immunity, abiotic stress response, and growth and development. Recent studies have provided insights into the molecular mechanisms underlying CRK functions in Ca2+ influx, reactive oxygen species production, callose deposition, stomatal immunity, and programmed cell death (PCD). This review focuses on the structure-function relationship of CRKs, with an emphasis on their roles in immunity, abiotic stress response, and the tradeoff between growth and stress tolerance. We critically analyze and synthesize how CRKs control intricate regulatory networks that determine diverse phenotypic outputs in plants.
Article
Multidisciplinary Sciences
Samara Mejri, Alina Ghinet, Maryline Magnin-Robert, Beatrice Randoux, Cristina-Maria Abuhaie, Benoit Tisserant, Philippe Gautret, Benoit Rigo, Patrice Halama, Philippe Reignault, Ali Siah
Summary: The current global focus on agroecology and green agriculture requires the discovery of new ecofriendly and sustainable plant protection tools. This study synthesized 30 molecules from pyroglutamic acid, sourced from sugar beet byproducts, and examined their biological activity on wheat-Zymoseptoria tritici. The molecules provided significant disease protection when applied to the leaves, with up to 63% reduction in disease severity. Further investigation revealed that their activity was dependent on the activation of plant defense mechanisms. This study introduces a new family of bio-sourced resistance inducers and contributes to the development of sustainable agriculture.
SCIENTIFIC REPORTS
(2023)
Article
Plant Sciences
Wenyuan Yan, Yinqiao Jian, Shaoguang Duan, Xiao Guo, Jun Hu, Xiaohui Yang, Guangcun Li
Summary: Hormones play a crucial role in plant disease resistance and defense. This study analyzed transcriptome data of a late blight-resistant potato genotype treated with ethylene, jasmonate, salicylic acid, and Phytophthora infestans to assess the ET/JA/SA regulatory network's role in disease resistance and predict resistant genes. The findings suggest that differentially expressed genes overlapped significantly in all treatments, and specific genes for disease interaction were expressed differently in the CN152 treatment. The study reveals the potential for inducing resistance genes through alternative splicing and highlights the synergistic effect of JA and ET pathways.
Article
Environmental Sciences
Sudeshna Nandi, Priyanka Upadhyay, Ayan Roy, Adhiraj Dasgupta, Arnab Sen, Arghya Adhikary, Krishnendu Acharya
Summary: Efforts to treat advanced lung cancer with comprehensive therapies have been inadequate, prompting the search for novel anti-lung cancer drugs. Astrakurkurol, a derivative of wild edible mushroom, has shown promising anticancer efficacy against lung cancer, inducing both apoptosis and autophagy mechanisms. These findings position astrakurkurol as a potent novel anti-cancer agent for further exploration in lung cancer therapies.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sudeshna Nandi, Arghya Adhikary, Krishnendu Acharya
Summary: The study focused on the novel triterpene astrakurkurol isolated from Astraeus hygrometricus and its potential anticancer effects, particularly in HepG2 cells. Astrakurkurol demonstrated significant anti-proliferative, pro-apoptotic, and anti-migratory effects on HepG2, with mechanisms involving apoptosis induction and cell cycle arrest. These findings suggest astrakurkurol as a promising candidate for the development of new treatments against hepatocellular carcinoma.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Plant Sciences
Anamika Paul, Anik Sarkar, Krishnendu Acharya, Nilanjan Chakraborty
Summary: In this study, a fungal elicitor was used to induce defense responses in Catharanthus roseus. Results showed that the fungal elicitor was able to induce defense-related enzymes and the signaling molecule nitric oxide, and also exhibited protective effects against Alternaria leaf blight disease in C. roseus.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Review
Chemistry, Multidisciplinary
Nilanjan Chakraborty, Jishnu Banerjee, Pallab Chakraborty, Anuron Banerjee, Sumeddha Chanda, Kasturi Ray, Krishnendu Acharya, Joy Sarkar
Summary: This review covers the green production techniques of copper/copper oxide nanoparticles and illustrates the exact mechanism of biosynthetic routes. It also discusses the antibacterial, antifungal, antiviral, and anticancer properties of biosynthesized copper/copper oxide nanoparticles, as well as their effects on plant growth, nutrition, and defense mechanism.
GREEN CHEMISTRY LETTERS AND REVIEWS
(2022)
Article
Plant Sciences
Nilanjan Chakraborty, Entaj Tarafder, Anamika Paul, Soumitra Paloi, Krishnendu Acharya
Summary: This paper reports a new species of the genus Trichoglossum - Trichoglossum benghalense, which was found in the lower Gangetic plain of India. The study provides a detailed morphological description, DNA sequence analysis, and comparison with allied accepted species, contributing to a better understanding of this genus.
Review
Food Science & Technology
Jayita De, Sudeshna Nandi, Krishnendu Acharya
Summary: This review highlights the nutritional and medicinal attributes of the genus Lepista, emphasizing its significance as functional food and a source of bioactive components. It provides beneficial guidance and new approaches for the advancement of Lepista as a potent mycomedicine.
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2022)
Article
Biochemistry & Molecular Biology
Ravi Prakash Yadav, Srilagna Chatterjee, Arindam Chatterjee, Dilip Kumar Pal, Sudakshina Ghosh, Krishnendu Acharya, Madhusudan Das
Summary: The study focuses on screening mycocompounds from Astraeus hygrometricus against key cancer signaling proteins in renal cell carcinoma (RCC). Two compounds, astrakurkurone and ergosta-4,6, 8-(14) 22-tetraene-3-one, were found to be potential anticancer drug candidates with satisfactory ADME profiles.
JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION
(2022)
Article
Chemistry, Applied
Naba Kr Mandal, Sudeshna Nandi, Krishnendu Acharya, Jnan Prakash Naskar
Summary: Two novel copper(II) complexes were synthesized and comprehensively characterized. The crystal structures of both complexes were determined by single-crystal X-ray diffraction. Powder X-ray diffraction studies on bulk samples confirmed their solid-phase purity. Cyclic voltammetry experiments showed the redox behavior of the complexes. UV-vis spectra demonstrated the stability of the complexes in solution. Thermal stability and degradation behavior was studied using thermogravimetric analysis. The magnetic moments of the complexes were determined, and their cytotoxic activity against lung cancer cells was screened.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Malini Roy, Oiendrilla Sarkar, Nikhil Ranjan Pramanik, Somanjana Khatua, Krishnendu Acharya, Syamal Chakrabarti
Summary: Two yellow air-stable mononuclear dioxomolybdenum(VI) complexes were synthesized and their binding affinity with BSA was investigated. The complexes show a single binding site per BSA molecule and quench the intrinsic fluorescence of BSA. Molecular docking studies reveal the binding mechanism and fluorescence resonance energy transfer study confirms energy transfer from BSA to the complexes. The complexes also exhibit different antioxidative activities due to halogen substitution.
JOURNAL OF COORDINATION CHEMISTRY
(2023)
Review
Agronomy
Nilanjan Chakraborty, Rusha Mitra, Somrhita Pal, Retwika Ganguly, Krishnendu Acharya, Tatiana Minkina, Anik Sarkar, Chetan Keswani
Summary: Biopesticides are formulations derived from naturally occurring compounds that manage pests through non-toxic and environmentally favorable means. They represent less risk to the environment and human health as they are living organisms or products. They are gaining interest due to their advantages for the environment, target-specificity, efficacy, biodegradability, and applicability in integrated pest management (IPM) programs.
Article
Cell Biology
Rituparna Saha, Arun Kumar Dutta, Anirban Roy, Krishnendu Acharya
Summary: This article reports two species of the genus Tomophagus, including the newly recorded Tomophagus cattienensis in India. The identification of this species was confirmed through morpho-taxonomic and nrDNA ITS-based phylogenetic analyses.
Article
Biology
Mousumi Talukdar, Pinaki Chattopadhyay, Krishnendu Acharya, Arun Kumar Dutta
Summary: This study presents a new record of Lepiota bengalensis, originally described from Bangladesh, for the Indian mycobiota. It distinguishes this taxon from similar looking Lepiotas through nrITS phylogenetic analysis. Detailed taxonomic descriptions, field photographs, and microscopic illustrations for the species are provided.
Review
Plant Sciences
Anamika Paul, Krishnendu Acharya, Nilanjan Chakraborty
Summary: The demand for natural products has led to increased interest in the medicinal plant Catharanthus roseus. This plant is known for its traditional pharmacological applications and its rich phytochemical composition, particularly alkaloids. Among these alkaloids, vinblastine and vincristine are of great importance as expensive anti-cancer compounds. This review provides an overview of the biosynthesis, extraction, detection, mode of action, and limitations of vinblastine and vincristine, aiming to contribute to the understanding of their mechanism of action and potential side effects. The need for increasing the production of these alkaloids using cost-effective biotechnological methods is also highlighted.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Article
Plant Sciences
Nilanjan Chakraborty, Anik Sarkar, Krishnendu Acharya
Summary: The present study evaluates the alleviation of osmotic stress on Lens culinaris seeds by exogenous spermine (SP) application. The results showed that SP can mitigate the negative effects of osmotic stress on plant growth and defense mechanisms.
PHYSIOLOGY AND MOLECULAR BIOLOGY OF PLANTS
(2023)
Article
Chemistry, Multidisciplinary
Sanchari Dasgupta, Suhana Karim, Somanjana Khatua, Amit Adhikary, Krishnendu Acharya, Ennio Zangrando, Suvendu Maity, Debasis Das
Summary: In recent decades, the synthesis of coordination complexes with high catalytic efficiencies has been a topic of interest for bio-inorganic chemists. Two trinuclear mixed-valence manganese complexes have been synthesized and shown to exhibit catecholase-like activity in acetonitrile medium. These complexes have efficient oxidizing activity and can fully oxidize the substrate at a high catalyst-to-substrate ratio. This study is the first to explore the catecholase-like activity of trinuclear species and the second to report pseudo-zero-order kinetics.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Plant Sciences
Wanli You, Jinglin Zhang, Xueyin Ru, Feng Xu, Zhengguo Wu, Peng Jin, Yonghua Zheng, Shifeng Cao
Summary: This study investigated the effect of calcium chloride (CaCl2) treatment on GABA accumulation in fresh-cut cantaloupe and the underlying mechanisms. The results showed that CaCl2 treatment increased GABA content and the activities of GAD and SSADH enzymes, while reducing glutamate content and GABA-T activity. Additionally, CaCl2 treatment upregulated the expressions of CmCML11 and CmCAMTA5, as well as several GABA shunt genes, through the transcriptional activation by CmCAMTA5. Furthermore, the interaction between CmCML11 and CmCAMTA5 enhanced the transcriptional activation of GABA shunt genes. Overall, this study reveals that CaCl2 treatment promotes GABA accumulation in fresh-cut cantaloupe through the combined effect of CmCML11 and CmCAMTA5 in regulating the expressions of GABA shunt genes.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2024)
Article
Plant Sciences
Min Wang, Yupeng Wang, Xiaohui Wang, Guangwei Wei, Huiyi Yang, Xi Yang, Tinghai Shen, Huijie Qu, Sheng Fang, Ziming Wu
Summary: This study identified the high nitrogen use efficiency (NUE) black sesame variety 17-156 and analyzed its underlying physiological and molecular mechanisms. The results showed that 17-156 possesses a sophisticated nitrogen metabolizing machinery to uptake and assimilate higher quantities of inorganic nitrogen, simultaneously improving carbon metabolism and growth. Many important genes were up-regulated in 17-156 under high nitrogen condition. Additionally, 38 potential candidate genes were identified for future studies to improve sesame's NUE. These findings provide valuable resources for understanding the regulatory network of nitrogen metabolism and developing sesame cultivars with improved NUE.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2024)
Article
Plant Sciences
He Dong, Chongmei Xu, Chengtao Zhang, Li Zhang, Yaqin Yao, Suiqi Zhang
Summary: The study found that short cells in maize leaves not only improve leaf mechanical support and photosynthetic performance, enhance drought resistance, but also participate in stomatal regulation.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2024)
Article
Plant Sciences
Na Liu, Wenyan Shang, Mengxin Guan, Jibin Xiao, Guangxiang Tian, Baozhan Ma, Wenjing Shang, Xu Li, Shijia Zhao, Chuang Li, Kun Cheng, Wenming Zheng
Summary: This study cloned the full-length cDNA sequence of TaSPX3 gene in wheat and found that TaSPX3 responds to low phosphorus stress in multiple wheat genotypes. Overexpressing TaSPX3 can alleviate phosphorus deficiency symptoms and promote plant growth in Arabidopsis. The study also revealed the interaction of TaSPX3 with other genes related to the phosphorus starvation signaling pathway.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2024)
Article
Plant Sciences
Kongyuan Wu, Lizhen Wang, Zihan Wu, Ziqing Liu, Zengfei Li, Jun Shen, Shengjie Shi, Hong Liu, Christopher Rensing, Renwei Feng
Summary: Selenium (Se) can reduce uptake and translocation of cadmium (Cd) in plants by regulating root morphology. This study investigated the effects of Se(IV) on root exudates, root morphology, root endogenous hormones, and Cd uptake efficiency in rice under Cd stress. The results showed that Se(IV) significantly reduced Cd concentrations in shoots and roots, and decreased Cd uptake efficiency via root hairs. Se(IV) also affected root morphology, root exudates, and the synthesis of hormones like IAA and JA. However, transcriptome analysis revealed no upregulated differentially expressed genes (DEGs) in IAA synthesis.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2024)
Article
Plant Sciences
Di Wang, Huaifang Zhang, Xuefei Hu, Haizhen Zhang, Shuang Feng, Aimin Zhou
Summary: This study identified a cell number regulator gene called SlCNR8 in willow, which enhances resistance to trace metals in transgenic poplar seedlings. SlCNR8 reduces Cd uptake and accumulation, and can be used as a candidate gene for genetic improvement of phytostabilisation of trace metals.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2024)
