Overexpression of a type-I isopentenyl pyrophosphate isomerase of Artemisia annua in the cytosol leads to high arteannuin B production and artemisinin increase

Overexpression and Suppression of Artemisia annua 4-Hydroxy-3-Methylbut-2-enyl Diphosphate Reductase 1 Gene (AaHDR1) Differentially Regulate Artemisinin and Terpenoid Biosynthesis

(2017) Dongming Ma et al.   Frontiers in Plant Science

Synthetic biology’s first malaria drug meets market resistance

(2016) Mark Peplow   NATURE

Metabolic engineering of anthocyanins in dark tobacco varieties

(2016) Xianzhi He et al.   PHYSIOLOGIA PLANTARUM

Overexpression of a synthetic insect–plant geranyl pyrophosphate synthase gene in Camelina sativa alters plant growth and terpene biosynthesis

(2016) Jing Xi et al.   PLANTA

Artemisia annua glandular secretory trichomes: the biofactory of antimalarial agent artemisinin

(2016) Ling Xiao et al.   Science Bulletin

Application of a Fast Isoprene Sensor (FIS) for measuring isoprene production from marine samples

(2016) Dan A. Exton et al.   LIMNOLOGY AND OCEANOGRAPHY-METHODS

Breaking new ground in the regulation of the early steps of plant isoprenoid biosynthesis

(2015) Manuel Rodríguez-Concepción et al.   CURRENT OPINION IN PLANT BIOLOGY

A Genome-Wide Scenario of Terpene Pathways in Self-pollinated Artemisia annua

(2015) Dong-Ming Ma et al.   Molecular Plant

Expression of β-glucosidase increases trichome density and artemisinin content in transgenicArtemisia annuaplants

(2015) Nameirakpam Dolendro Singh et al.   PLANT BIOTECHNOLOGY JOURNAL

Breeding strategy for genetic improvement up to four generations in relation to artemisinin with canopy and other secondary metabolites in Artemisia annua L

(2014) Shilpi Paul et al.   INDUSTRIAL CROPS AND PRODUCTS

Changes in key constituents of clonally propagated Artemisia annua L. during preparation of compressed leaf tablets for possible therapeutic use

(2014) Pamela J. Weathers et al.   INDUSTRIAL CROPS AND PRODUCTS

Pharmacokinetics of artemisinin delivered by oral consumption of Artemisia annua dried leaves in healthy vs. Plasmodium chabaudi-infected mice

(2014) Pamela J. Weathers et al.   JOURNAL OF ETHNOPHARMACOLOGY

Semisynthetic Artemisinin, the Chemical Path to Industrial Production

(2014) Joël Turconi et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Isopentenyl diphosphate and dimethylallyl diphosphate/isopentenyl diphosphate ratio measured with recombinant isopentenyl diphosphate isomerase and isoprene synthase

(2013) Changfang Zhou et al.   ANALYTICAL BIOCHEMISTRY

Network Analysis of the MVA and MEP Pathways for Isoprenoid Synthesis

(2013) Eva Vranová et al.   Annual Review of Plant Biology

Simulated digestion of dried leaves of Artemisia annua consumed as a treatment (pACT) for malaria

(2013) Pamela J. Weathers et al.   JOURNAL OF ETHNOPHARMACOLOGY

Malaria and artemisinin derivatives: an updated review

(2013) Muhammad Ansari et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

High-level semi-synthetic production of the potent antimalarial artemisinin

(2013) C. J. Paddon et al.   NATURE

The metabolite chemotype ofNicotiana benthamianatransiently expressing artemisinin biosynthetic pathway genes is a function ofCYP71AV1type and relative gene dosage

(2013) Hieng-Ming Ting et al.   NEW PHYTOLOGIST

Dana G. Dalrymple, Artemisia annua, Artemisinin, ACTs and Malaria Control in Africa: Tradition, Science and Public Policy

(2013) S. Taylor   SOCIAL HISTORY OF MEDICINE

Isopentenyl diphosphate isomerase: A checkpoint to isoprenoid biosynthesis

(2012) Karine Berthelot et al.   BIOCHIMIE

Stabilizing supply of artemisinin and artemisinin-based combination therapy in an era of wide-spread scale-up

(2012) Rima Shretta et al.   MALARIA JOURNAL

Isoprenoid biosynthesis in bacterial pathogens

(2012) S. Heuston et al.   MICROBIOLOGY-SGM

Artemisinin: Discovery from the Chinese Herbal Garden

(2011) Louis H. Miller et al.   CELL

Characterization of development and artemisinin biosynthesis in self-pollinated Artemisia annua plants

(2011) Fatima Alejos-Gonzalez et al.   PLANTA

Type II Isopentenyl Diphosphate Isomerase: Probing the Mechanism with Alkyne/Allene Diphosphate Substrate Analogues

(2010) Nagendra K. Sharma et al.   BIOCHEMISTRY

The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao)

(2010) Geoffrey D. Brown   MOLECULES

Features of anthocyanin biosynthesis in pap1-D and wild-type Arabidopsis thaliana plants grown in different light intensity and culture media conditions

(2010) Ming-Zhu Shi et al.   PLANTA

The Genetic Map of Artemisia annua L. Identifies Loci Affecting Yield of the Antimalarial Drug Artemisinin

(2010) I. A. Graham et al.   SCIENCE

Molecular cloning of an aldehyde dehydrogenase implicated in artemisinin biosynthesis in Artemisia annuaThis paper is one of a selection of papers published in a Special Issue from the National Research Council of Canada – Plant Biotechnology Institute.

(2009) Keat H. Teoh et al.   Botany

Molecular cloning and characterization of Dbr1, a 2-alkenal reductase from Artemisia annuaThe nucleotide sequence reported in this article has been deposited in the GenBank database under accession No. FJ750460.This paper is one of a selection of papers published in a Special Issue from the National Research Council of Canada – Plant Biotechnology Institute.

(2009) Yansheng Zhang et al.   Botany

Isolation and Characterization of AaWRKY1, an Artemisia annua Transcription Factor that Regulates the Amorpha-4,11-diene Synthase Gene, a Key Gene of Artemisinin Biosynthesis

(2009) Dongming Ma et al.   PLANT AND CELL PHYSIOLOGY

Transient expression inNicotiana benthamianafluorescent marker lines provides enhanced definition of protein localization, movement and interactionsin planta

(2009) Kathleen Martin et al.   PLANT JOURNAL

The Molecular Cloning of Artemisinic Aldehyde Δ11(13) Reductase and Its Role in Glandular Trichome-dependent Biosynthesis of Artemisinin inArtemisia annua

(2008) Yansheng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic Evidence for the Role of Isopentenyl Diphosphate Isomerases in the Mevalonate Pathway and Plant Development in Arabidopsis

(2008) Kazunori Okada et al.   PLANT AND CELL PHYSIOLOGY

The Arabidopsis thaliana Type I Isopentenyl Diphosphate Isomerases Are Targeted to Multiple Subcellular Compartments and Have Overlapping Functions in Isoprenoid Biosynthesis

(2008) M. A. Phillips et al.   PLANT CELL

Peroxisomal Localization of Arabidopsis Isopentenyl Diphosphate Isomerases Suggests That Part of the Plant Isoprenoid Mevalonic Acid Pathway Is Compartmentalized to Peroxisomes

(2008) M. Sapir-Mir et al.   PLANT PHYSIOLOGY

Qinghaosu (Artemisinin): The Price of Success

(2008) N. J. White   SCIENCE