Article
Biochemistry & Molecular Biology
Ming-Kang Yang, Xiao-Jie Zhu, Chu-Min Chen, Xu Guo, Shu-Xuan Xu, Ya-Rou Xu, Shen-Xiu Du, Shi Xiao, Bernd Mueller-Roeber, Wei Huang, Liang Chen
Summary: Autophagy exhibits circadian rhythms in plants, regulated by the LUX transcription factor. This rhythm is ubiquitous in plants and plays a role in improving plant resistance to carbon starvation.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2022)
Review
Medicine, Research & Experimental
Yi Qin, Zhong-hua Chen, Jun-Jie Wu, Zhen-Yu Zhang, Zheng-Dong Yuan, Dan-Yang Guo, Meng-Nan Chen, Xia Li, Feng-Lai Yuan
Summary: The circadian clock plays a crucial role in regulating bone metabolism, including bone loss. Clock-related genes control signaling pathways and transcription factors in osteoblasts and osteoclasts, while also regulating osteocytes and endothelial cells. Furthermore, the regulation of circadian clock genes by novel modulators presents a potential strategy for preventing and treating bone diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Endocrinology & Metabolism
Si-Ke He, Jia-Hao Wang, Tao Li, Shan Yin, Jian-Wei Cui, Yun-Fei Xiao, Yin Tang, Jia Wang, Yun-Jin Bai
Summary: This article reviews the relationship between circadian rhythm disturbance and kidney stone disease (KSD), summarizing the risk factors and treatment methods. The results indicate that KSD is associated with systemic disorders such as metabolic syndrome, inflammatory bowel disease, and microbiome dysbiosis, and some chronotherapies have been proven effective.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xiaomeng Liu, Niuben Cao, Xinchan Liu, Yu Deng, Yu Xin, Ruobing Fu, Xirui Xin, Yubo Hou, Weixian Yu
Summary: Circadian rhythms play a crucial role in regulating the body's homeostasis, and circadian rhythm disorders can have detrimental effects on metabolic and immune functions. However, the relationship between circadian rhythm disorders and periodontitis has not been well studied. This research aimed to investigate the role of the circadian rhythm control gene BMAL1 in periodontitis. The results showed that downregulation of BMAL1 in circadian rhythm disorder-induced periodontitis led to significant alveolar bone resorption, increased osteoclast differentiation, upregulation of the inflammatory signaling molecule NF-kappa B, elevated apoptosis and oxidative stress levels in periodontal tissues. This study suggests that BMAL1 is a key regulator in periodontitis exacerbated by circadian rhythm disorders, highlighting a potential avenue for periodontitis treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Sabrina Klemz, Thomas Wallach, Sandra Korge, Mechthild Rosing, Roman Klemz, Bert Maier, Nicholas C. Fiorenza, Irem Kaymak, Anna K. Fritzsche, Erik D. Herzog, Ralf Stanewsky, Achim Kramer
Summary: In organisms with circadian clocks, the post-translational modifications of clock proteins, particularly phosphorylation, play a crucial role in controlling circadian rhythms. Protein phosphatase 4 (PPP4) and its regulatory subunit PPP4R2 have been identified as critical components in mammals and Drosophila, affecting the circadian system by regulating phosphorylation and transactivation activity of CLOCK/BMAL1.
GENES & DEVELOPMENT
(2021)
Editorial Material
Cell Biology
Ueli Schibler
Summary: Mammalian body cells have cell-autonomous and self-sustained circadian oscillators relying on delayed negative feedback loops in gene expression. Transcriptional activation and repression, as well as post-translational mechanisms like phosphorylation and dephosphorylation, play crucial roles in setting the pace of these timekeepers. The study by Klemz and colleagues in Genes & Development demonstrates how dephosphorylation of BMAL1 by protein phosphatase 4 (PPP4) participates in the modulation of circadian timing.
GENES & DEVELOPMENT
(2021)
Article
Multidisciplinary Sciences
Annika F. Barber, Shi Yi Fong, Anna Kolesnik, Michael Fetchko, Amita Sehgal
Summary: Regulation of circadian behavior and physiology by the Drosophila brain clock requires communication from central clock neurons to downstream output regions. Morning and evening clock neurons have time-of-day-dependent connectivity to the pars intercerebralis, which is regulated by specific peptides and fast neurotransmitters. This study provides insights into mechanisms by which clock neurons signal to nonclock cells to drive rhythms of behavior.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Plant Sciences
Alena Patnaik, Hemasundar Alavilli, Jnanendra Rath, Kishore C. S. Panigrahi, Madhusmita Panigrahy
Summary: Circadian clock components exhibit structural variations in different plant systems, and functional variations during various abiotic stresses. These variations are crucial for plant fitness and adaptation.
Review
Cell Biology
Zainab Taleb, Phillip Karpowicz
Summary: The circadian clock is a molecular timekeeper that regulates 24-hour rhythms in animals, impacting behavior and physiology, including metabolic and digestive systems. Animal models targeting circadian clock genes have shown their role in regulating liver diseases, inflammatory bowel disease, colorectal cancer, and obesity. Thus, the circadian clock plays a crucial role in maintaining metabolic and digestive health.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maria Savino, Claudio Carmine Guida, Maria Nardella, Emanuele Murgo, Bartolomeo Augello, Giuseppe Merla, Salvatore De Cosmo, Antonio Fernando Savino, Roberto Tarquini, Francesco Cei, Filippo Aucella, Gianluigi Mazzoccoli
Summary: This article investigates the relationship between heme biosynthesis disorders and altered expression of circadian genes, finding that changes in circadian gene expression may be associated with the symptoms and signs of porphyria patients.
Review
Cell Biology
Ya Niu, Shuang Tang
Summary: The circadian system plays a crucial role in regulating physiological functions and has been found to influence cancer risk and progression. Recent studies have shown that certain nuclear receptors, which regulate the circadian clock, also play important roles in multiple cancer processes.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Min Chen, Yanke Lin, Yongkang Dang, Yifei Xiao, Fugui Zhang, Guanghui Sun, Xuejun Jiang, Li Zhang, Jianhao Du, Shuyi Duan, Xiaojian Zhang, Zifei Qin, Jing Yang, Kaisheng Liu, Baojian Wu
Summary: This study reveals that the intestinal clock plays a crucial role in regulating liver rhythmicity and metabolism. The loss of the intestinal clock leads to a large-scale reprogramming of the liver transcriptome and alters hepatic metabolism. The intestinal clock controls the rhythmicity of the hepatic transcription factor SREBP-1c, which further affects hepatic lipogenesis and gluconeogenesis. These findings suggest that targeting intestinal rhythms may be a new approach for improving metabolic health.
JOURNAL OF HEPATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Masanori Ono, Hitoshi Ando, Takiko Daikoku, Tomoko Fujiwara, Michihiro Mieda, Yasunari Mizumoto, Takashi Iizuka, Kyosuke Kagami, Takashi Hosono, Satoshi Nomura, Natsumi Toyoda, Naomi Sekizuka-Kagami, Yoshiko Maida, Naoaki Kuji, Hirotaka Nishi, Hiroshi Fujiwara
Summary: The circadian rhythm, controlled by clock genes, is crucial for reproduction. In the mouse uterus, the oscillation of circadian clock gene has been observed. CLOCK-BMAL1 heterodimer promotes the transcription of Per1/2 and Cry1/2 genes by binding to their promoters' E-box sequences. The endometrial clock plays an important role in pregnancy, and disruptions in the uterine clock can lead to complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Eleni Pitsillou, Julia Liang, Andrew Hung, Tom C. Karagiannis
Summary: Circadian rhythms are regulated by a central oscillator in the brain's suprachiasmatic nucleus, which synchronises internal clocks in peripheral organs. Disruptions in the circadian machinery can lead to changes in protein activity and gene expression, contributing to various diseases. Misalignment between internal clocks and external stimuli can result in circadian misalignment, and as research progresses, small molecules may be used to modulate proteins involved in circadian cycles.
Review
Biochemistry & Molecular Biology
Li-Ping Liu, Meng-Huan Li, Yun-Wen Zheng
Summary: Clock genes in hair follicles are regulated by both the central circadian system and external factors such as light and thyroid hormones. They play a role in regulating physiological processes of hair follicles, including hair growth and pigmentation. Hair follicles can serve as a noninvasive method for monitoring circadian-rhythm-related conditions in humans, and combining hair follicle sampling with other assays can improve their applications. Hair follicles provide insights into potential mechanisms of circadian-rhythm-related conditions and can support personalized treatment scheduling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemical Research Methods
Paulina Fuentes, Tegan Armarego-Marriott, Ralph Bock
CURRENT OPINION IN BIOTECHNOLOGY
(2018)
Article
Plant Sciences
Yanliang Wang, Erik Lysoe, Tegan Armarego-Marriott, Alexander Erban, Lisa Paruch, Andre Van Eerde, Ralph Bock, Jihong Liu-Clarke
JOURNAL OF EXPERIMENTAL BOTANY
(2018)
Article
Plant Sciences
Tegan Armarego-Marriott, Lucja Kowalewska, Asdrubal Burgos, Axel Fischer, Wolfram Thiele, Alexander Erban, Deserah Strand, Sabine Kahlau, Alexander Hertle, Joachim Kopka, Dirk Walther, Ziv Reich, Mark Aurel Schoettler, Ralph Bock
Editorial Material
Biochemistry & Molecular Biology
Tegan Armarego-Marriott
Editorial Material
Biochemistry & Molecular Biology
Tegan Armarego-Marriott
Editorial Material
Biochemistry & Molecular Biology
Tegan Armarego-Marriott
Review
Plant Sciences
Tegan Armarego-Marriott, Omar Sandoval-Ibanez, Lucja Kowalewska
JOURNAL OF EXPERIMENTAL BOTANY
(2020)
Editorial Material
Environmental Sciences
Tegan Armarego-Marriott
NATURE CLIMATE CHANGE
(2020)
Editorial Material
Environmental Sciences
Tegan Armarego-Marriott
NATURE CLIMATE CHANGE
(2020)
Editorial Material
Environmental Sciences
Alyssa Findlay
NATURE CLIMATE CHANGE
(2020)
Editorial Material
Environmental Sciences
Tegan Armarego-Marriott
NATURE CLIMATE CHANGE
(2020)
Editorial Material
Environmental Sciences
Tegan Armarego-Marriott
NATURE CLIMATE CHANGE
(2020)
Editorial Material
Environmental Sciences
Tegan Armarego-Marriott
NATURE CLIMATE CHANGE
(2020)
Editorial Material
Environmental Sciences
Tegan Armarego-Marriott
NATURE CLIMATE CHANGE
(2020)
Editorial Material
Environmental Sciences
Tegan Armarego-Marriott
NATURE CLIMATE CHANGE
(2020)
