Targeting cholesterol transport in circulating melanoma cells to inhibit metastasis

Effect of lysosomotropic molecules on cellular homeostasis

(2017) Omer F. Kuzu et al.   PHARMACOLOGICAL RESEARCH

The Role of Cholesterol in Cancer

(2016) Omer F. Kuzu et al.   CANCER RESEARCH

High expression of MnSOD promotes survival of circulating breast cancer cells and increases their resistance to doxorubicin

(2016) Afu Fu et al.   Oncotarget

Mechanosensitive caveolin-1 activation-induced PI3K/Akt/mTOR signaling pathway promotes breast cancer motility, invadopodia formation and metastasis in vivo

(2016) Hong Yang et al.   Oncotarget

Pooled Analysis of Long-Term Survival Data From Phase II and Phase III Trials of Ipilimumab in Unresectable or Metastatic Melanoma

(2015) Dirk Schadendorf et al.   JOURNAL OF CLINICAL ONCOLOGY

Natural products with therapeutic potential in melanoma metastasis

(2015) A. AlQathama et al.   NATURAL PRODUCT REPORTS

Ultra-fast, label-free isolation of circulating tumor cells from blood using spiral microfluidics

(2015) Majid Ebrahimi Warkiani et al.   Nature Protocols

Novel Approaches to Treatment of Advanced Melanoma: A Review on Targeted Therapy and Immunotherapy

(2015) Anna Niezgoda et al.   Biomed Research International

Arterial Blood, Rather Than Venous Blood, is a Better Source for Circulating Melanoma Cells

(2015) Mizue Terai et al.   EBioMedicine

Circulating tumour cells as tumour biomarkers in melanoma: detection methods and clinical relevance

(2014) L. Khoja et al.   ANNALS OF ONCOLOGY

Circulating Tumor Cell Enumeration with a Combination of Epithelial Cell Adhesion Molecule- and Cell-Surface Vimentin-Based Methods for Monitoring Breast Cancer Therapeutic Response

(2014) A. Satelli et al.   CLINICAL CHEMISTRY

Safety and efficacy of vemurafenib in BRAFV600E and BRAFV600K mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study

(2014) Grant A McArthur et al.   LANCET ONCOLOGY

Nanolipolee-007, a Novel Nanoparticle-Based Drug Containing Leelamine for the Treatment of Melanoma

(2014) R. Gowda et al.   MOLECULAR CANCER THERAPEUTICS

Leelamine Mediates Cancer Cell Death through Inhibition of Intracellular Cholesterol Transport

(2014) O. F. Kuzu et al.   MOLECULAR CANCER THERAPEUTICS

Targeting Multiple Key Signaling Pathways in Melanoma Using Leelamine

(2014) R. Gowda et al.   MOLECULAR CANCER THERAPEUTICS

STAT3 in Cancer—Friend or Foe?

(2014) Hai-Feng Zhang et al.   Cancers

Studying the Role of Lipid Rafts on Protein Receptor Bindings with Cellular Automata

(2013) Fiete Haack et al.   IEEE-ACM Transactions on Computational Biology and Bioinformatics

Design and interpretation of cell trajectory assays

(2013) L. G. Bowden et al.   Journal of the Royal Society Interface

Circulating Melanoma Cells in the Diagnosis and Monitoring of Melanoma: An Appraisal of Clinical Potential

(2013) Brigid S. Mumford et al.   Molecular Diagnosis & Therapy

Computational and Experimental Models of Cancer Cell Response to Fluid Shear Stress

(2013) Michael J. Mitchell et al.   Frontiers in Oncology

Effects of cyclodextrin in two patients with Niemann–Pick Type C disease

(2012) Muneaki Matsuo et al.   MOLECULAR GENETICS AND METABOLISM

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Targeting sphingosine kinase-1 to inhibit melanoma

(2012) SubbaRao V. Madhunapantula et al.   Pigment Cell & Melanoma Research

Resistance to Fluid Shear Stress Is a Conserved Biophysical Property of Malignant Cells

(2012) J. Matthew Barnes et al.   PLoS One

Cornering metastases: therapeutic targeting of circulating tumor cells and stem cells

(2012) Bishoy Faltas   Frontiers in Oncology

Positive Feedback Loop Between PI3K-Akt-mTORC1 Signaling and the Lipogenic Pathway Boosts Akt Signaling: Induction of the Lipogenic Pathway by a Melanoma Antigen

(2011) Y. Yamauchi et al.   CANCER RESEARCH

Exosomes Released by Melanoma Cells Prepare Sentinel Lymph Nodes for Tumor Metastasis

(2011) J. L. Hood et al.   CANCER RESEARCH

Resistance to BRAF Inhibition in Melanomas

(2011) David B. Solit et al.   NEW ENGLAND JOURNAL OF MEDICINE

Transiently Entrapped Circulating Tumor Cells Interact with Neutrophils to Facilitate Lung Metastasis Development

(2010) S. J. Huh et al.   CANCER RESEARCH

Cholesterol trafficking is required for mTOR activation in endothelial cells

(2010) J. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential epidermal growth factor receptor signaling regulates anchorage-independent growth by modulation of the PI3K/AKT pathway

(2009) J O Humtsoe et al.   ONCOGENE

A Versatile Viral System for Expression and Depletion of Proteins in Mammalian Cells

(2009) Eric Campeau et al.   PLoS One

The challenge of lipid rafts

(2008) Linda J. Pike   JOURNAL OF LIPID RESEARCH

Cellular cholesterol trafficking and compartmentalization

(2008) Elina Ikonen   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular Basis of Metastasis

(2008) Anne C. Chiang et al.   NEW ENGLAND JOURNAL OF MEDICINE