Article
Biochemistry & Molecular Biology
Hueseyin Aksit, Sefa Gozcu, Ahmet Altay
Summary: Centaurium erythraea is commonly used in traditional medicine for its anthelmintic, hypotensive, antipyretic, and antidiabetic properties. This study isolated and identified several compounds from Centaurium erythraea and evaluated their cytotoxic activity against various cell lines. Erythraeaxanthone II exhibited the most potent cytotoxic activity.
Article
Plant Sciences
Jelena Bozunovic, Milica Milutinovic, Neda Anicic, Marijana Skoric, Dragana Matekalo, Suzana Zivkovic, Milan Dragicevic, Biljana Filipovic, Tijana Banjanac, Luka Petrovic, Danijela Misic
Summary: Secoiridoid glucosides (SGs) are bitter tasting monoterpenoids that play a key role in plant defense. This study found that SGs can undergo hydrolysis mediated by enzymes, leading to different metabolic pathways in plants. Transient overexpression of two beta-D-glucosidases can alter the metabolite profiles of SGs, potentially impacting the overall phytochemistry of the plant.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Enrique Maguilla, Marcial Escudero, Vania Jimenez-Lobato, Zoila Diaz-Lifante, Cristina Andres-Camacho, Juan Arroyo
Summary: The study on Centaurium plants indicates that polyploidy is a crucial factor in the diversification process, and the distribution of ploidy levels also demonstrates strong geographic correlation.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Genetics & Heredity
Ines Carvalho Leonardo, Adriana Alberti, France Denoeud, Maria Teresa Barreto Crespo, Jorge Capelo, Frederic Bustos Gaspar
Summary: This study describes the complete chloroplast genome of Centaurium erythraea subsp. majus, the first available plastome belonging to the Centaurium genus. The genome is 153,107 bp long and contains 129 genes, including tRNA, rRNA, and protein-coding genes. Phylogenetic analysis supports the placement of this subspecies under the Gentianaceae family and provides evidence for lineage divergence within the family. This study is important for conservation, phylogenetic and evolutionary studies, and DNA barcoding applications for food, feed, and supplements safety.
MITOCHONDRIAL DNA PART B-RESOURCES
(2023)
Review
Plant Sciences
Naoual El Menyiy, Fatima-Ezzahrae Guaouguaou, Aicha El Baaboua, Nasreddine El Omari, Douae Taha, Najoua Salhi, Mohammad Ali Shariati, Tarik Aanniz, Taoufiq Benali, Gokhan Zengin, Mohamed El-Shazly, Imane Chamkhi, Abdelhakim Bouyahya
Summary: Centaurium erythraea is an important medicinal plant used in traditional medicine to treat various diseases. It exhibits diverse biological properties and contains several classes of secondary metabolites, confirming the link between traditional medicinal use and scientific experiments. Further investigation using in vivo pharmacological assays, toxicological tests, and pharmacokinetic studies are recommended to validate its traditional use.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Applied
Watchara Sangsopha, Ratsami Lekphrom, Florian T. Schevenels, Brendan Byatt, Stephen G. Pyne, Nattakarn Sridadom, Kanlayanee Sawanyawisuth
Summary: This study is the first phytochemical investigation of the roots and flowers of F. fragrans, leading to the isolation of a new secoiridoid glycoside and twenty-nine other compounds. Some of these compounds showed weak to moderate cytotoxicity against cholangiocarcinoma cancer cells lines, suggesting their potential for further study as anti-cancer agents.
NATURAL PRODUCT RESEARCH
(2021)
Article
Food Science & Technology
Milos M. Dordevic, Anja Tolic, Jovana Rajic, Mirjana Mihailovic, Jelena Arambasic Jovanovic, Aleksandra Uskokovic, Nevena Grdovic, Marija B. Dordevic, Danijela Misic, Branislav Siler, Melita Vidakovic, Svetlana Dinic
Summary: This study investigated the hepato- and reno-protective effects of methanol extract of Centaurium erythraea Rafn (CEE) in STZ-diabetic rats. The results showed that CEE improved liver and kidney functionality and had antioxidant effects in diabetic rats.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Plant Sciences
Serena Fiorito, Francesco Epifano, Lucia Palumbo, Chiara Collevecchio, Fabrizio Mascioli, Roberto Spogli, Salvatore Genovese
Summary: The leaves of Gentiana lutea can serve as an additional source for extracting bitter principles, such as gentiopicroside and amarogentin, instead of solely relying on the roots. By coupling extraction of G. lutea leaves with solid-phase adsorption using differently structured solids, both secondary metabolites can be selectively isolated in high yields.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Chemistry, Applied
Xin Wang, Xiang-Jian Zhong, Na Zhou, Lin-Lin Ji, Jin-Jie Li, Ning Cai, Qing-Bo Wang, Peng-Cheng Lin, Xiao-Ya Shang
Summary: This study isolated and characterized five new secoiridoid glycosides from the fruits of Cornus officinalis. One of these compounds showed a neuroprotective effect against H2O2-induced cell damage in preliminary assays.
NATURAL PRODUCT RESEARCH
(2022)
Article
Agricultural Engineering
Biljana Filipovic, Marijana Skoric, Uros Gasic, Milan Dragicevic, Jelena Bozunovic, Dragana Matekalo, Jasmina Nestorovic Zivkovic, Tijana Banjanac, Branislav Siler, Borut Bohanec, Milica Milutinovic, Danijela Misic
Summary: Centaurium erythraea, a medicinal plant with rare bioactive compounds, was studied to understand the differences in biosynthesis and accumulation between diploid and tetraploid genotypes. Shoots were found to be the major site of compound accumulation, with varying ratios during development. Gene expression levels were found to be correlated with compound content. Differences between genotypes may be due to expression differences in key biosynthetic genes. Diploid genotypes showed higher productivity and biomass compared to tetraploid genotypes under controlled conditions.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Chemistry, Applied
Sarra Chabane, Amel Boudjelal, Souhila Bouaziz-Terrachet, Eleonora Spinozzi, Filippo Maggi, Riccardo Petrelli, Ghania Tail
Summary: The ethanolic extract of Centaurium erythraea Rafn showed analgesic activity in both peripheral and central pain models. Molecular docking studies indicated a strong binding interaction between the main bioactive compound swertiamarin and a specific protein.
NATURAL PRODUCT RESEARCH
(2023)
Article
Agricultural Engineering
Valentina G. Nikolic, Dragan Z. Troter, Ivan M. Savic, Ivana M. Savic Gajic, Jelena B. Zvezdanovic, Ina B. Konstantinovic, Sandra S. Konstantinovic
Summary: Two environmentally friendly protocols were designed for ultrasound-assisted extraction (UAE) of valuable bioactive compounds from common centaury aerial parts using aqueous mixtures of green organic solvents (ethanol and propylene glycol). Optimization of time, solvent concentration, liquid-to-solid ratio, and temperature was conducted using Box-Behnken experimental design. The liquid-to-solid ratio had the highest effect on the total polyphenolic content (TPC). The UAE/aPPG system, providing extract with more biologically functional phytochemicals and higher TPC at a lower temperature, is recommended for future eco-friendly industrial use.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Chemistry, Applied
Alejandra Bermudez-Oria, Maria Luisa Castejon, Fatima Rubio-Senent, Africa Fernandez-Prior, Guillermo Rodriguez-Gutierrez, Juan Fernandez-Bolanos
Summary: This study focused on the recovery and purification of p-Coumaroyl-6'-secologanoside (comselogoside) from olive mill waste. The extract contained a mixture of trans and cis-isomers of comselogoside, and the cis-isomer exhibited lower radical-scavenging activity compared to the trans-isomer. However, a synergistic effect was observed when the cis-isomer was supplemented by the trans-isomer.
Article
Chemistry, Organic
Atsuko Itoh, Eri Kawaguchi, Sayo Nishio, Kaori Tani, Misaki Uchigaki, Marina Nakamura, Toru Akita, Toyoyuki Nishi, Takao Tanahashi
Summary: Eleven novel secoiridoid glucosides were isolated from the dried twigs of Alstonia macrophylla, along with seventeen known compounds. The new compounds were identified as esters of secoxyloganin with a phenolic glucoside. These structures were determined based on 1D and 2D NMR spectroscopic data.
Review
Chemistry, Medicinal
Joel B. Johnson, Janice S. Mani, Daniel Broszczak, Shirtika S. Prasad, Charitha P. Ekanayake, Padraig Strappe, Peter Valeris, Mani Naiker
Summary: Phenolic and flavonoid glycosides, characterized by high polarity and strong antioxidant activity, have shown potential as therapeutic agents. Glycosylated compounds may be more bioavailable compared to their aglycone forms, and the hydrolysis of glycosides in vivo releases free aglycones, enhancing their biological activity. Further high-quality studies are needed to establish the clinical efficacy of glycosides from various plant species.
PHYTOTHERAPY RESEARCH
(2021)
Article
Chemistry, Medicinal
Abdoulaye Sissoko, Pedro Vasquez-Ocmin, Alexandre Maciuk, Daniela Barbieri, Gaelle Neveu, Laurine Rondepierre, Raphael Grougnet, Pascale Leproux, Magali Blaud, Karim Hammad, Sylvie Michel, Catherine Lavazec, Jerome Clain, Sandrine Houze, Romain Duval
ACS INFECTIOUS DISEASES
(2020)
Article
Biochemistry & Molecular Biology
Raimundo Goncalves de Oliveira-Junior, Nolwenn Marcoult-Freville, Gregoire Prunier, Laureen Beaugeard, Edilson Beserra de Alencar Filho, Eduard David Simoes Mourao, Sylvie Michel, Lucindo Jose Quintans-Junior, Jackson Roberto Guedes da Silva Almeida, Raphael Grougnet, Laurent Picot
CHEMICO-BIOLOGICAL INTERACTIONS
(2020)
Article
Immunology
Heitor G. Araujo-Filho, Erik W. M. Pereira, Luana Heimfarth, Brenda Souza Monteiro, Fabiolla Rocha Santos Passos, Pollyana Siqueira-Lima, Sathiyabama R. Gandhi, Marcio Roberto Viana dos Santos, Jackson Roberto Guedes da Silva Almeida, Laurent Picot, Raphael Grougnet, Ray S. Almeida, Henrique Douglas Melo Coutinho, Lucindo J. Quintans-Junior, Natalia Martins, Jullyana S. S. Quintans
INTERNATIONAL IMMUNOPHARMACOLOGY
(2020)
Article
Chemistry, Analytical
Julia Morais Fernandes, Sergio Ortiz, Raquel Padilha M. Tavares, Tsvetelina Mandova, Edilane Rodrigues D. Araujo, Anderson Wilbur L. Andrade, Sylvie Michel, Raphael Grougnet, Silvana Maria Zucolotto
Summary: Bryophyllum pinnatum is commonly used in traditional medicine in tropical regions for inflammation relief. This study isolated four flavonoids and established a UPLC-DAD quantification method. Compound 1 was identified as a specific marker for quality control of B. pinnatum hydroethanolic extract.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Biotechnology & Applied Microbiology
Raimundo Gonsalves de Oliveira-Junior, Raphael Grougnet, Pierre-Edouard Bodet, Antoine Bonnet, Elodie Nicolau, Ahlem Jebali, Judith Rumin, Laurent Picot
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2020)
Article
Microbiology
Renato Dantas-Medeiros, Ana Caroline Zanatta, Luanda Barbara Ferreira Canario de Souza, Julia Morais Fernandes, Bruno Amorim-Carmo, Manoela Torres-Rego, Matheus de Freitas Fernandes-Pedrosa, Wagner Vilegas, Thiago Antonio de Sousa Araujo, Sylvie Michel, Raphael Grougnet, Guilherme Maranhao Chaves, Silvana Maria Zucolotto
Summary: This study found that C. leptophloeos has antifungal and antibiofilm potential without causing toxicity in human erythrocytes. Additionally, the isolated B-type oligomeric procyanidins (BDP) demonstrated antifungal effects against Candida spp. either alone or in combination with fluconazole.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mohamed El Yaagoubi, Sergio Ortiz, Hicham Mechqoq, Carlos Cavaleiro, Marylin Lecso-Bornet, Maria Joao Rodrigues, Luisa Custodio, Abdelhamid El Mousadik, Raphael Grougnet, Noureddine El Aouad, Fouad Msanda, Marina Kritsanida
Summary: The essential oil of Chiliadenus antiatlanticus from southwest Morocco showed significant antibacterial activity against Gram-positive strains and high toxicity towards liver and melanoma tumor cell lines.
CHEMISTRY & BIODIVERSITY
(2021)
Article
Agriculture, Multidisciplinary
Julia Morais Fernandes, Aikaterini Termentzi, Tsvetelina Mandova, Karim Hammad, Kyriaki Machera, Prokopios Magiatis, Sylvie Michel, Silvana M. Zucolotto, Raphael Grougnet
Summary: Bryophyllum pinnatum is commonly used in folk medicine, with flavone glycosides as its main constituents. The nitrile glucoside sarmentosin was detected for the first time in the genus Bryophyllum/Kalanchoe, indicating a potential link to the plant's biological activities and ethnobotanical uses. Sarmentosin was also found in Kalanchoe laciniata, confirming its occurrence within the genus.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Mohamed El Yaagoubi, Hicham Mechqoq, Sergio Ortiz, Carlos Cavaleiro, Marylin Lecso-Bornet, Catarina Guerreiro Pereira, Maria Joao Rodrigues, Luisa Custodio, Abdelhamid El Mousadik, Laurent Picot, Marina Kritsanida, Fouad Msanda, Noureddine El Aouad, Raphael Grougnet
Summary: The chemical composition and biological activities of the essential oil of Micromeria macrosiphon and M. arganietorum were investigated in this study, revealing similarities with other species endemic to Macaronesia. Both oils exhibited significant toxicity towards liver HepG2 and melanoma B16 4A5 tumor cell lines, but also showed cytotoxicity towards normal cell lines. Antibacterial activity was not observed against 52 strains at 100 μg/mL.
CHEMISTRY & BIODIVERSITY
(2021)
Article
Biochemistry & Molecular Biology
Wiem Elloumi, Amina Maalej, Sergio Ortiz, Sylvie Michel, Mohamed Chamkha, Sabrina Boutefnouchet, Sami Sayadi
Summary: This study investigated the phenolic composition of P. lentiscus L. distilled leaves and its potential against key enzymes related to skin aging. The results showed that the ethyl acetate extract of PDL contained a high amount of flavonol glycoside. Transdermal diffusion study indicated that myricetin-3-O-rhamnoside had the highest transmission rate through the skin membrane barrier. The extract, along with myricetin-3-O-rhamnoside and quercetin-3-O-rhamnoside, demonstrated significant inhibitory activities against tyrosinase and elastase enzymes, without being cytotoxic. Overall, these findings suggest that they could be effective agents for treating skin pigmentation and elasticity problems.
Article
Plant Sciences
Catarina G. Pereira, Carolina Borsoi Moraes, Caio H. Franco, Clarissa Feltrin, Raphael Grougnet, Euzebio Guimaraes Barbosa, Michele Panciera, Carlos Roque D. Correia, Maria Joao Rodrigues, Luisa Custodio
Summary: Marine halophytes are a valuable source of natural products with potential anti-infectious properties, among which sea fennel flower decoction showed significant anti-Trypanosoma cruzi activity. This suggests sea fennel as a promising candidate for the treatment of Chagas disease.
Review
Chemistry, Medicinal
Antoine Grivard, Isabelle Goubet, Luiz Miranda de Souza Duarte Filho, Valerie Thiery, Sylvie Chevalier, Raimundo Goncalves de Oliveira-Junior, Noureddine El Aouad, Jackson Roberto Guedes da Silva Almeida, Przemyslaw Sitarek, Lucindo Jose Quintans-Junior, Raphael Grougnet, Helene Agogue, Laurent Picot
Summary: This article provides a comprehensive review of carotenoid metabolism in Archaea and their potential applications in biotechnology and medicine, highlighting their significance in industrial-scale production.
Review
Chemistry, Medicinal
Christiane Adrielly Alves Ferraz, Raphael Grougnet, Elodie Nicolau, Laurent Picot, Raimundo Goncalves de Oliveira Junior
Summary: Microalgal carotenoids have shown potential as adjuvant therapy for melanoma by inhibiting cell proliferation, migration, and invasion, while also enhancing the sensitivity of melanoma cells to conventional chemotherapy.
Letter
Chemistry, Multidisciplinary
Jackson Roberto Guedes da Silva Almeida, Raphael Grougnet, Lucindo Jose Quintans Junior, Sylvie Chevalier, Marc Feuilloley, Thomas Robert, Stephane Bach, Raimundo Goncalves de Oliveira Junior, Valerie Thiery, Jean-Pierre Bazureau, Florence Mongin, Marina Kritsanida, Vincent Sol, Vicente Carlos de Oliveira Costa, Nathalie Bourgougnon, Pascal Marchand, Laurent Picot
Article
Agronomy
Nabiha Benalia, Abdenour Boumechhour, Sergio Ortiz, Cristian A. Echague, Thorsten Rose, Bernd L. Fiebich, Smain Chemat, Sylvie Michel, Brigitte Deguin, Saliha Dahamna, Sabrina Boutefnouchet
Summary: Pistacia lentiscus L. is commonly found in the Mediterranean basin, and its fruit oil has been used in traditional medicine and promoted by commercial brands. This study evaluated the safety of using Pistacia lentiscus fruit oil as a cosmetic ingredient and identified the presence of alkylsalicylic acids, which call for further quantification for potential skin irritants.
OCL-OILSEEDS AND FATS CROPS AND LIPIDS
(2021)
Article
Plant Sciences
Yi Zhu, Junlin Wang, Lu Tang, Yuxin Shang, Weiyi Zhao, Wei Zhang, Ping Hai, Yongbiao Zheng, Wenbo Li, Yanfang Su
Summary: One new iridoid glucoside and two new lignan glycosides, along with three known compounds, were isolated from the whole plants of Lancea tibetica. The structures were determined by spectroscopic methods and X-ray crystallographic analysis. One of the new iridoid glucosides and the known compounds exhibited moderate antioxidant activity.
PHYTOCHEMISTRY LETTERS
(2024)
Article
Plant Sciences
Yi Deng, Minghua Chen, Junming Yi, Yuguo Zheng
Summary: This study successfully designed and synthesized a series of quinazolinone derivatives containing purine molecules, and found that some compounds exhibited strong antiviral activity against tobacco mosaic virus. The findings have important implications for further development of antiviral drugs.
PHYTOCHEMISTRY LETTERS
(2024)
