Article
Food Science & Technology
Haijing Wang, Zhenzhen Zhang, Jia Song, Maosen Tian, Ren Li, Xia Cui
Summary: Phenolic compounds in tomato fruits were isolated and identified using ultrahigh performance liquid chromatography-quadrupole time-of-flight mass spectrometry. A total of 32 phenolic compounds were found, with 13 of them being previously unknown in tomato fruits. Nine out of the 13 previously unknown components were elucidated. The content difference of the 3 main and 10 previously unknown phenolic compounds led to significantly higher phenolic levels in wild tomato fruits compared to cultivated tomato.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Applied
Claudia Mariana Castillo-Fraire, Sandrine Pottier, Arnaud Bondon, Erika Salas, Stephane Bernillon, Sylvain Guyot, Pascal Poupard
Summary: During the apple juice and cider-making processes, enzymatic oxidation of phenolic compounds leads to the production of CQA dehydrodimers with structures resembling caffeic acid. A new dehydrodicaffeoyldiquinic acid molecule was also identified, displaying symmetric dicatechol skeletons.
Article
Food Science & Technology
Cristina Reche, Carmen Rossello, Esperanza Dalmau, Valeria Eim, Susana Simal
Summary: This study utilized image analysis to quantitatively assess the microstructural effect of ultrasound application during the extraction of phenolic compounds and chlorogenic acid from artichoke stem samples. The results showed that increasing the extraction temperature and ultrasound power density significantly improved the extraction yields and promoted cell shrinkage.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Physical
Monika Kalinowska, Kamila Gryko, Ewelina Golebiewska, Grzegorz Swiderski, Hanna Lewandowska, Marek Pruszynski, Malgorzata Zawadzka, Maciej Kozlowski, Justyna Sienkiewicz-Gromiuk, Wlodzimierz Lewandowski
Summary: This study synthesized complexes of chlorogenic acid (5-CQA) with copper(II) and iron(III) and analyzed their properties using various methods. The results showed the possible coordination of the complexes through the carboxylate group and the hydroxyl group from the catechol moiety. The complexes exhibited lower antioxidant properties in aqueous solution compared to 5-CQA alone, but showed higher antioxidant activity in the lipid peroxidation inhibition assay. Cu(II) 5-CQA exhibited the highest pro-oxidant activity among the studied compounds. The complexes were not toxic to HaCaT cells within the tested concentration range.
Article
Plant Sciences
Kristina Zymone, Lina Raudone, Vaidotas Zvikas, Valdas Jakstas, Valdimaras Janulis
Summary: This study determined the phenolic profiles of inflorescence extracts of 26 Sorbus species, genotypes, and cultivars, and revealed unique phytochemical profiles. Phenolic fingerprint profiles and sexangularetin derivatives could serve as markers in authenticity studies and quality control schemes.
Article
Plant Sciences
Joyce Alves Goulart da Silva, Mario Lucio Vilela de Resende, Ingridy Simone Ribeiro, Adriene Ribeiro Lima, Luiz Roberto Marques Albuquerque, Ana Cristina Andrade Monteiro, Matheus Henrique Brito Pereira, Deila Magna dos Santos Botelho
Summary: This study compared the chemical composition and antioxidant activity of leaf extracts from a partially resistant coffee cultivar and a susceptible cultivar to bacterial halo blight. The partially resistant cultivar showed higher content of phenolic compounds and flavonoids, as well as higher antioxidant activity.
Article
Chemistry, Multidisciplinary
Tatiane Luiza Cadorin Oldoni, Suelen dos Santos, Marina Leite Mitterer-Daltoe, Luiz Henrique Iaguszeski Pizone, Vanderlei Aparecido de Lima
Summary: This study evaluated the influence of seasonality, growing area, and regrowth age on the antioxidant potential and biochemical markers of Moringa oleifera leaves. The results showed that all parameters were affected by these factors. Samples cultivated in the southeast had higher phenolic compound content and antioxidant activity. Young leaves had higher antioxidant potential and phenolic content.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Applied
Shuifang Mao, Yanming Ren, Shiguo Chen, Donghong Liu, Xingqian Ye, Jinhu Tian
Summary: In this study, a sodium alginate/protocatechuic acid/iron hydrogel was prepared by rapid self-assembly of protocatechuic acid and Fe3+ under different pH conditions, without the addition of other chemical reagents. The structure of the hydrogel was characterized and the results showed significant differences in the structures prepared at different pH values. The hydrogel exhibited higher gel strength, water holding capacity, and thermal stability, and was able to control the release of bioactive substances in simulated gastrointestinal conditions.
CARBOHYDRATE POLYMERS
(2023)
Article
Plant Sciences
David Fernando dos Santos, Vandressa Alves, Edlaine Costa, Andre Martins, Alexia Flavia Franca Vieira, Gustavo Henrique Fidelis dos Santos, Catia Tavares dos Passos Francisco, Vania Zanella Pinto
Summary: Ilex paraguariensis, a native tree from South America, is known for its bioactive compounds and its leaves are consumed as hot and cold infusions after a series of processing steps including harvest, flame blanching, drying, and milling. The study investigated the impact of processing on leaf composition by extracting major compounds using different solvent ratios. The solvent ratio EW 50:50 was found to be more effective in extracting chlorogenic acids. The successful extraction of chlorogenic acids from I. paraguariensis proved its promising potential beyond traditional use.
PLANT FOODS FOR HUMAN NUTRITION
(2023)
Article
Food Science & Technology
Cristina Reche, Carmen Rossello, Monica M. Umana, Valeria Eim, Susana Simal
Summary: This study proposes valorization of artichoke by-product rich in bioactive compounds through ultrasound-assisted extraction. A mathematical model considering simultaneous diffusion and convection is used to simulate the extraction process, showing temperature and ultrasound power density effects on extraction efficiency. The model accurately predicts the extraction curves and highlights the importance of considering temperature and ultrasound power density in the extraction process.
Article
Agriculture, Multidisciplinary
Alejandra Arancibia-Diaz, Carolina Astudillo-Castro, Claudia Altamirano, Carmen Soto-Maldonado, Mauricio Vergara-Castro, Andres Cordova, Maria Elvira Zuniga-Hansen
Summary: This study evaluated the potential of using Aspergillus sp. in solid-state fermentation (SSF) to release chlorogenic acid, quinic acid, and total phenolic compounds from spent coffee grounds. The results showed that SSF significantly increased the yields of these molecules and their antioxidant capacity.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Biochemistry & Molecular Biology
Ana Rita Pereira, Carina Costa, Nuno Mateus, Victor de Freitas, Alirio Rodrigues, Joana Oliveira
Summary: Large amounts of vine shoots generated during vine pruning still contain compounds from the original plant, including phenolic compounds and structural compounds like cellulose, hemicellulose, and lignin. This study proposes the extraction of lignin from vine shoots for the production of nanoparticles, using ethanol/toluene and water/ethanol as solvents. The lignin nanoparticles showed excellent antioxidant properties and the extracts from biomass pretreatment also exhibited antioxidant activity. Overall, this work contributes to the integral reuse of vine shoot byproduct, promoting sustainability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Ashutosh Gupta, Atanas G. Atanasov, Yutong Li, Neeraj Kumar, Anupam Bishayee
Summary: Chlorogenic acid, a dietary phenolic acid produced by plants, possesses various pharmacological properties such as anticancer, antioxidant, and antidiabetic activities. It can inhibit the cell cycle, trigger apoptosis, and suppress cancer cell proliferation by modulating signaling pathways.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Plant Sciences
Liubov Skrypnik, Tatiana Styran, Tamara Savina, Nadezhda Golubkina
Summary: The application of selenium significantly increased the nutritional value of lamb's lettuce by enhancing the content of phenolic compounds, vitamin C, chlorophylls, and antioxidant activity. Additionally, lamb's lettuce harvested at different growth stages showed variations in composition and antioxidant activity.
Article
Plant Sciences
Lucia Valerga, Roxana E. Gonzalez, Maria B. Perez, Analia Concellon, Pablo F. Cavagnaro
Summary: Fresh-cut produce, including different root colors of carrots, have been studied for their response to postharvest UV-C radiation and cold storage. Results showed that purple carrots were not affected by UV-C radiation, while yellow and purple carrots could experience tissue browning after fresh-cut processing. Therefore, UV-C radiation has the potential to increase the functional value of different carrot root colors.
Review
Medicine, Research & Experimental
Sara Motyka, Karolina Jafernik, Halina Ekiert, Javad Sharifi-Rad, Daniela Calina, Basem Al-Omari, Agnieszka Szopa, William C. Cho
Summary: The use of plant secondary metabolites, particularly aryltetralin lignan-podophyllotoxin (PTOX), in preventing and treating cancer has gained significant attention. PTOX exhibits potent cytotoxic activity but cannot be used in its pure form due to toxicity and side effects. Efforts are focused on synthesizing PTOX analogs with enhanced therapeutic properties. PTOX derivatives are currently used as anticancer drugs with additional effects such as immunosuppression, antiviral activity, antioxidation, hypolipemia, and anti-inflammation. In vitro cultures of Podophyllum peltatum are highlighted as a valuable source of lignans, including PTOX. Preclinical pharmacological studies confirm the anticancer potential of PTOX and its derivatives, but clinical studies are needed for further validation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Monika Michalak, Martyna Zagorska-Dziok, Marta Klimek-Szczykutowicz, Agnieszka Szopa
Summary: In this study, various drying methods were used to analyze the phenolic profile and biological activity of methanol and water-methanol extracts of dried borage (Borago officinalis) herb. The extracts were found to contain flavonoids and phenolic acids, and the highest content of flavonoids was observed in the methanol extract from the hot-air-dried herb, while the methanol extract from the air-dried herb had the highest content of phenolic acids. In vitro tests demonstrated that the extracts have antioxidant, anti-inflammatory, and anti-ageing properties, making them a valuable source of bioactive compounds for skin cell protection.
Article
Biochemistry & Molecular Biology
Katarzyna Czarnek, Malgorzata Tatarczak-Michalewska, Piotr Dreher, Vishnu D. Rajput, Grzegorz Wojcik, Anna Gierut-Kot, Agnieszka Szopa, Eliza Blicharska
Summary: Metalloenzymes are important for regulating biological functions, and biofortification of plant materials is an effective way to prevent mineral deficiencies in human diets. This study combined biofortification of wheat sprouts with UV-C radiation treatment for seed surface sterilization and found that UV-C radiation effectively suppressed seed germination contamination by microorganisms. The sterilization process did not affect the growth and development of sprouts or nutrient bioassimilation. The results showed that wheat sprouts easily accumulate Fe, Zn, Mg, and Cr during growth, with the optimal concentrations for biofortification being 100 μg g(-1) for Fe and Zn, while the best-developed sprouts were grown in 50 μg g(-1) of Cr solution.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ewa Skala, Agnieszka Szopa
Summary: This work reviews the phytochemical profiles, ethnomedicinal uses, and biological activities of Dipsacus and Scabiosa species in the Caprifoliaceae family. These plants are rich sources of specialized metabolites with medicinal properties, and their constituents have various biological activities including anti-arthritic, anti-inflammatory, antioxidant, anticancer, and antimicrobial activities. They are also used in traditional medicine for treating bone and joint problems, liver diseases, and have potential pharmacological applications.
Editorial Material
Biochemistry & Molecular Biology
Halina Maria Ekiert, Agnieszka Szopa
Review
Biochemistry & Molecular Biology
Karolina Jafernik, Agata Ladniak, Eliza Blicharska, Katarzyna Czarnek, Halina Ekiert, Agnieszka E. Wiacek, Agnieszka Szopa
Summary: Chitosan-based nanoparticles (chitosan-based nanocomposites; chitosan nanoparticles; ChNPs) are promising materials that have attracted a lot of attention in recent decades. They have great potential as nanocarriers and can encapsulate drugs and active compounds for controlled release. This article provides an overview of the most commonly used preparation methods and their applications in medicine.
Article
Biochemistry & Molecular Biology
Sara Motyka, Barbara Kusznierewicz, Halina Ekiert, Izabela Korona-Glowniak, Agnieszka Szopa
Summary: The purpose of this study was to evaluate the phytochemical profiles of different plant raw materials obtained from Salvia hispanica, and to demonstrate their significant contribution to antioxidant and antimicrobial activities. The study used HPLC-DAD and LC-Q-Orbitrap HRMS techniques to analyze the compounds present in the plant materials. The results showed that the extracts from the leaves exhibited the strongest antibacterial and antifungal activity. This study provides valuable knowledge on the biologically active metabolites present in different parts of Salvia hispanica and their potential applications.
Review
Biochemistry & Molecular Biology
Karolina Jafernik, Halina Ekiert, Agnieszka Szopa
Summary: "A Review of Schisandra henryi: Chemical Composition and Biological Properties" provides a comprehensive review of the research conducted on this endemic plant species in Yunnan, China. The chemical composition of S. henryi is similar to the well-known medicinal plant S. chinensis, and it exhibits various pharmacological properties. The study also highlights the biotechnological potential of S. henryi in in vitro cultures as an alternative source of raw material. This article summarizes the research on the chemical profile and diverse medicinal effects of S. henryi.
Article
Biochemistry & Molecular Biology
Karolina Czech, Katarzyna Gawel-Beben, Agnieszka Szopa, Wirginia Kukula-Koch, Thomas Jakschitz, Gunther Bonn, Shah Hussain, Pawel Kubica, Halina Ekiert, Kazimierz Glowniak
Summary: This study compared the phytochemical composition and antioxidant and tyrosinase inhibitory properties of aqueous and hydroethanolic extracts from A. millefolium obtained from field conditions (AmL and AmH extracts) and in vitro cultures (AmIV extracts). The results showed that AmIV extracts had significantly different phytochemical composition compared to AmL and AmH extracts, with fewer polyphenolic compounds and higher fatty acid content. AmIV extracts had lower polyphenol content, weaker antioxidant activity, and no tyrosinase inhibitory properties. Further research is needed before microshoot cultures of A. millefolium can be used as valuable raw material in the cosmetics industry.
Review
Pharmacology & Pharmacy
Mario Sousa-Pimenta, Leticia M. Estevinho, Agnieszka Szopa, Mahnoor Basit, Khushbukhat Khan, Muhammad Armaghan, Manshuk Ibrayeva, Eda Sonmez Gurer, Daniela Calina, Christophe Hano, Javad Sharifi-Rad
Summary: Many biological and synthetic agents have been explored to stop the spread of cancer and cure it. Paclitaxel is an effective anticancer drug derived from the tree Taxus brevifolia, and its derivatives have been established as therapeutic compounds against neoplastic disorders. This review explores the mechanisms of action of paclitaxel and its derivatives, different formulations available, as well as the role of paclitaxel in hematological malignancies and potential limitations in its clinical use. The impact of paclitaxel on other oncogenic pathways and its immunomodulatory potential are also analyzed, providing insights for future chemotherapeutic approaches to cancer.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Anna Budzianowska, Monika Derda, Jaromir Budzianowski, Agnieszka Szopa, Malgorzata Kikowska
Summary: The aim of this study was to compare the potency of Plantago media L. extracts on Acanthamoeba sp. trophozoites. The extracts from leaves showed the strongest anti-amoebic effect, and the presence of phenylethanoid glycoside-acteoside was responsible for the activity. This is the first report on the amoebicidal activity of Plantago media extracts produced by biotechnological methods.
APPLIED SCIENCES-BASEL
(2023)
Review
Pharmacology & Pharmacy
Marta Sharafan, Magdalena A. Malinowska, Halina Ekiert, Beata Kwasniak, Elzbieta Sikora, Agnieszka Szopa
Summary: This review provides an overview of the botanical, ecological, and phytochemical characteristics of Vitis vinifera L., as well as its applications in the food industry, medicine, and phytocosmetology. The focus is on the cosmetic properties of V. vinifera, including its anti-ageing, anti-inflammatory, and skin-whitening effects. The review also highlights the importance of biotechnological studies on V. vinifera and discusses its safety for use.
Article
Biochemistry & Molecular Biology
Ewelina Sobstyl, Agnieszka Szopa, Malgorzata Olszowy-Tomczyk, Sebastian Gnat, Karolina Jafernik, Irena Maria Choma
Summary: HPLC and TLC profiling were conducted on leaf and fruit extracts of five species from the Schisandraceae family. Lignans and phenolic compounds were found in both fruits and leaves of all species. The highest abundance of lignans was detected in the fruit extract of Schisandra chinensis, with 15 compounds identified. The fruit extracts of S. chinensis and S. rubriflora exhibited exceptional antibacterial activity, while all fruit and leaf extracts showed enzyme-inhibiting abilities, except for the fruit extract of Kadsura japonica. Antioxidant activity was stronger in the leaf extracts compared to the fruit extracts, assessed using TLC-direct bioautography and spectrophotometric measurements.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Biochemistry & Molecular Biology
Marta Sharafan, Magdalena Anna Malinowska, Marta Kubicz, Pawel Kubica, Marin-Pierre Gemin, Cecile Abdallah, Manon Ferrier, Christophe Hano, Nathalie Giglioli-Guivarc'h, Elzbieta Sikora, Arnaud Lanoue, Agnieszka Szopa
Summary: The primary purpose of this study was to initiate and optimize shoot cultures of different Vitis vinifera L. cultivars and investigate the influence of media and genotype on metabolic content. The use of MS media variants induced the production of certain metabolites and their antioxidant and anti-tyrosinase activities were measured. The findings suggest that in vitro cultured grapes can be a potential alternative source of plant material for the cosmetic industry.
Article
Medicine, General & Internal
Agnieszka Szopa, Sara Motyka, Halina Ekeirt
Summary: Plant sprouts, including chia sprouts and microgreens, have gained attention due to their rich chemical composition and potential health benefits. This review article explores the research on chia sprouts and microgreens, highlighting their enhanced nutritional properties and potential antimicrobial effects. The study also reveals the positive impact of sprouting on antioxidant potential, increasing the production of polyphenolic compounds.
CURRENT ISSUES IN PHARMACY AND MEDICAL SCIENCES
(2023)
Article
Plant Sciences
Yi Zhu, Junlin Wang, Lu Tang, Yuxin Shang, Weiyi Zhao, Wei Zhang, Ping Hai, Yongbiao Zheng, Wenbo Li, Yanfang Su
Summary: One new iridoid glucoside and two new lignan glycosides, along with three known compounds, were isolated from the whole plants of Lancea tibetica. The structures were determined by spectroscopic methods and X-ray crystallographic analysis. One of the new iridoid glucosides and the known compounds exhibited moderate antioxidant activity.
PHYTOCHEMISTRY LETTERS
(2024)
Article
Plant Sciences
Yi Deng, Minghua Chen, Junming Yi, Yuguo Zheng
Summary: This study successfully designed and synthesized a series of quinazolinone derivatives containing purine molecules, and found that some compounds exhibited strong antiviral activity against tobacco mosaic virus. The findings have important implications for further development of antiviral drugs.
PHYTOCHEMISTRY LETTERS
(2024)
