The Link Between Adipose Tissue Renin-Angiotensin-Aldosterone System Signaling and Obesity-Associated Hypertension

Aldosterone–Renin Ratio and Side-Selective Renal Perfusion in Essential Hypertension

(2016) Monica T.J. Schütten et al.   AMERICAN JOURNAL OF HYPERTENSION

Acute effect of mineralocorticoid receptor antagonism on vascular function in healthy older adults

(2016) Moon-Hyon Hwang et al.   EXPERIMENTAL GERONTOLOGY

Adipocytes, aldosterone and obesity-related hypertension

(2016) Aurelie Nguyen Dinh Cat et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Adipocyte-Derived Hormone Leptin Is a Direct Regulator of Aldosterone Secretion, Which Promotes Endothelial Dysfunction and Cardiac FibrosisCLINICAL PERSPECTIVE

(2015) Anne-Cécile Huby et al.   CIRCULATION

Obesity-Induced Hypertension: Interaction of Neurohumoral and Renal Mechanisms

(2015) J. E. Hall et al.   CIRCULATION RESEARCH

The Structural Factor of Hypertension: Large and Small Artery Alterations

(2015) S. Laurent et al.   CIRCULATION RESEARCH

Insulin-induced changes in skeletal muscle microvascular perfusion are dependent upon perivascular adipose tissue in women

(2015) Rick I. Meijer et al.   DIABETOLOGIA

Mineralocorticoid Receptor Antagonism Treats Obesity-Associated Cardiac Diastolic Dysfunction

(2015) S. B. Bender et al.   HYPERTENSION

Low-Dose Mineralocorticoid Receptor Blockade Prevents Western Diet–Induced Arterial Stiffening in Female MiceNovelty and Significance

(2015) Vincent G. DeMarco et al.   HYPERTENSION

Blockade of the renin–angiotensin system in small arteries and anticontractile function of perivascular adipose tissue

(2015) Claudia Agabiti Rosei et al.   JOURNAL OF HYPERTENSION

Compromised blood-brain barrier permeability: novel mechanism by which circulating angiotensin II signals to sympathoexcitatory centres during hypertension

(2015) V. C. Biancardi et al.   JOURNAL OF PHYSIOLOGY-LONDON

Vascular stiffness in insulin resistance and obesity

(2015) Guanghong Jia et al.   Frontiers in Physiology

Catheter-Based Radiorefrequency Renal Denervation Lowers Blood Pressure in Obese Hypertensive Dogs

(2014) J. R. Henegar et al.   AMERICAN JOURNAL OF HYPERTENSION

Mechanisms of Adiponectin-Associated Perivascular Function in Vascular Disease

(2014) Sarah B. Withers et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Angiotensin-(1-7) as a strategy in the treatment of hypertension?

(2014) Daan J.L. van Twist et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Mineralocorticoid Receptor Blockade Improves Coronary Microvascular Function in Individuals With Type 2 Diabetes

(2014) Rajesh Garg et al.   DIABETES

Body mass index is related to microvascular vasomotion, this is partly explained by adiponectin

(2014) Michiel P. de Boer et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Angiotensin-Converting Enzyme 2 Is a Critical Determinant of Angiotensin II–Induced Loss of Vascular Smooth Muscle Cells and Adverse Vascular Remodeling

(2014) Vaibhav B. Patel et al.   HYPERTENSION

Angiotensin-(1–7) Recruits Muscle Microvasculature and Enhances Insulin’s Metabolic Action via Mas Receptor

(2014) Zhuo Fu et al.   HYPERTENSION

Reduction of plasma aldosterone and arterial stiffness in obese pre- and stage1 hypertensive subjects after aerobic exercise

(2014) S R Collier et al.   JOURNAL OF HUMAN HYPERTENSION

Age, waist circumference, and blood pressure are associated with skin microvascular flow motion

(2014) Dennis M.J. Muris et al.   JOURNAL OF HYPERTENSION

The pathophysiology of hypertension in patients with obesity

(2014) Vincent G. DeMarco et al.   Nature Reviews Endocrinology

Mineralocorticoid-Induced Sodium Appetite and Renal Salt Retention: Evidence for Common Signaling and Effector Mechanisms

(2014) Yiling Fu et al.   NEPHRON PHYSIOLOGY

Upregulation of ERK1/2-eNOS via AT2 Receptors Decreases the Contractile Response to Angiotensin II in Resistance Mesenteric Arteries from Obese Rats

(2014) Graziela N. Hagihara et al.   PLoS One

Losartan increases muscle insulin delivery and rescues insulin's metabolic action during lipid infusion via microvascular recruitment

(2013) Nasui Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Central endogenous angiotensin-(1–7) protects against aldosterone/NaCl-induced hypertension in female rats

(2013) Baojian Xue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Angiotensin (1–7) counteracts the negative effect of angiotensin II on insulin signalling in HUVECs

(2013) Eliezer Joseph Tassone et al.   CARDIOVASCULAR RESEARCH

Randomized Trial of Perindopril, Enalapril, Losartan and Telmisartan in Overweight or Obese Patients with Hypertension

(2013) Sergey V. Nedogoda et al.   CLINICAL DRUG INVESTIGATION

Mineralocorticoid receptors modulate vascular endothelial function in human obesity

(2013) Moon-Hyon Hwang et al.   CLINICAL SCIENCE

Effect of mineralocorticoid receptor antagonist on insulin resistance and endothelial function in obese subjects

(2013) R. Garg et al.   DIABETES OBESITY & METABOLISM

Microvascular dysfunction as a link between obesity, insulin resistance and hypertension

(2013) Ü. Karaca et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Endothelial mineralocorticoid receptor activation mediates endothelial dysfunction in diet-induced obesity

(2013) Nicola Schäfer et al.   EUROPEAN HEART JOURNAL

Angiotensin-(1–7)–Induced Renal Vasodilation in Hypertensive Humans Is Attenuated by Low Sodium Intake and Angiotensin II Co-Infusion

(2013) Daan J.L. van Twist et al.   HYPERTENSION

Arterial Stiffening Precedes Systolic Hypertension in Diet-Induced Obesity

(2013) Robert M. Weisbrod et al.   HYPERTENSION

Circulating Angiotensin II Gains Access to the Hypothalamus and Brain Stem During Hypertension via Breakdown of the Blood–Brain Barrier

(2013) Vinicia Campana Biancardi et al.   HYPERTENSION

Smooth Muscle Cell Mineralocorticoid Receptors Are Mandatory for Aldosterone–Salt to Induce Vascular Stiffness

(2013) Guillaume Galmiche et al.   HYPERTENSION

Prolonged treatment with angiotensin 1–7 improves endothelial function in diet-induced obesity

(2013) Andreas M. Beyer et al.   JOURNAL OF HYPERTENSION

Retinal vascular caliber and the development of hypertension

(2013) Jie Ding et al.   JOURNAL OF HYPERTENSION

Hypertension and Vascular Dynamics in Men and Women With Metabolic Syndrome

(2013) Michel E. Safar et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Insulin's microvascular vasodilatory effects are inversely related to peripheral vascular resistance in overweight, but insulin-sensitive subjects

(2013) J.M. Hornstra et al.   Obesity

Smooth muscle cell mineralocorticoid receptors: role in vascular function and contribution to cardiovascular disease

(2013) Amy McCurley et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The role of ENaC in vascular endothelium

(2013) Kristina Kusche-Vihrog et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Hindbrain mineralocorticoid mechanisms on sodium appetite

(2012) Silmara Formenti et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Obesity-related hypertension: Epidemiology, pathophysiology, treatments, and the contribution of perivascular adipose tissue

(2012) Reza Aghamohammadzadeh et al.   ANNALS OF MEDICINE

Leptina e aldosterona na atividade simpática na hipertensão resistente, com ou sem Diabetes Tipo 2

(2012) Leandro Boer-Martins et al.   Arquivos Brasileiros de Cardiologia

Angiotensin Converting Enzyme 2 Contributes to Sex Differences in the Development of Obesity Hypertension in C57BL/6 Mice

(2012) Manisha Gupte et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Aldosterone affects blood flow and vascular tone regulated by endothelium-derived NO: therapeutic implications

(2012) Noboru Toda et al.   BRITISH JOURNAL OF PHARMACOLOGY

Aldosterone Inactivates the Endothelin-B Receptor via a Cysteinyl Thiol Redox Switch to Decrease Pulmonary Endothelial Nitric Oxide Levels and Modulate Pulmonary Arterial Hypertension

(2012) Bradley A. Maron et al.   CIRCULATION

Adipose Tissue as Regulator of Vascular Tone

(2012) Charlotte Boydens et al.   CURRENT HYPERTENSION REPORTS

Perivascular Adipose Tissue Control of Insulin-Induced Vasoreactivity in Muscle Is Impaired in db/db Mice

(2012) R. I. Meijer et al.   DIABETES

Adipocyte Deficiency of Angiotensinogen Prevents Obesity-Induced Hypertension in Male Mice

(2012) Frederique Yiannikouris et al.   HYPERTENSION

Adipocytes Produce Aldosterone Through Calcineurin-Dependent Signaling Pathways

(2012) Ana M. Briones et al.   HYPERTENSION

Spironolactone Prevents Chlorthalidone-Induced Sympathetic Activation and Insulin Resistance in Hypertensive Patients

(2012) Prafull Raheja et al.   HYPERTENSION

AT2 receptor non-peptide agonist C21 promotes natriuresis in obese Zucker rats

(2012) Quaisar Ali et al.   HYPERTENSION RESEARCH

Activation of mineralocorticoid receptors in the rostral ventrolateral medulla is involved in hypertensive mechanisms in stroke-prone spontaneously hypertensive rats

(2012) Toshiaki Nakagaki et al.   HYPERTENSION RESEARCH

Aortic Stiffness, Blood Pressure Progression, and Incident Hypertension

(2012) Bernhard M. Kaess et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Candesartan Acutely Recruits Skeletal and Cardiac Muscle Microvasculature in Healthy Humans

(2012) Matthew A. Sauder et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Angiotensin-converting enzyme 2, angiotensin-(1–7) and Mas: new players of the renin–angiotensin system

(2012) Robson A S Santos et al.   JOURNAL OF ENDOCRINOLOGY

Renal sympathetic activation from long-term low-dose angiotensin II infusion in rabbits

(2012) John-Luis Moretti et al.   JOURNAL OF HYPERTENSION

Sympathoinhibitory effects of telmisartan through the reduction of oxidative stress in the rostral ventrolateral medulla of obesity-induced hypertensive rats

(2012) Satomi Konno et al.   JOURNAL OF HYPERTENSION

Angiotensin II receptor blockers improve endothelial dysfunction associated with sympathetic hyperactivity in metabolic syndrome

(2012) Takuya Kishi et al.   JOURNAL OF HYPERTENSION

Metabolic actions of angiotensin II and insulin: A microvascular endothelial balancing act

(2012) Ranganath Muniyappa et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Superoxide anions modulate the effects of angiotensin-(1–7) in the rostral ventrolateral medulla on cardiac sympathetic afferent reflex and sympathetic activity in rats

(2012) P. Li et al.   NEUROSCIENCE

Altered regulation of the rostral ventrolateral medulla in hypertensive obese Zucker rats

(2011) Domitila A. Huber et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Adrenalectomy improves increased carotid intima-media thickness and arterial stiffness in patients with aldosterone producing adenoma

(2011) Yen-Hung Lin et al.   ATHEROSCLEROSIS

Obesity and risk of vascular disease: importance of endothelium-dependent vasoconstriction

(2011) Matthias Barton et al.   BRITISH JOURNAL OF PHARMACOLOGY

Perivascular adipose tissue from human systemic and coronary vessels: the emergence of a new pharmacotherapeutic target

(2011) Reza Aghamohammadzadeh et al.   BRITISH JOURNAL OF PHARMACOLOGY

ACE2 overexpression in the paraventricular nucleus attenuates angiotensin II-induced hypertension

(2011) Srinivas Sriramula et al.   CARDIOVASCULAR RESEARCH

Role of Angiotensin-(1-7) in Rostral Ventrolateral Medulla in Blood Pressure Regulation via Sympathetic Nerve Activity in Wistar-Kyoto and Spontaneous Hypertensive Rats

(2011) Toshiaki Nakagaki et al.   CLINICAL AND EXPERIMENTAL HYPERTENSION

Serum Aldosterone Is Associated with Inflammation and Aortic Stiffness in Normotensive Overweight and Obese Young Adults

(2011) Jennifer N. Cooper et al.   CLINICAL AND EXPERIMENTAL HYPERTENSION

Angiotensin II Receptors Modulate Muscle Microvascular and Metabolic Responses to Insulin In Vivo

(2011) Weidong Chai et al.   DIABETES

Pharmacological Modulation of Arterial Stiffness

(2011) Pierre Boutouyrie et al.   DRUGS

Alterations in perivascular adipose tissue structure and function in hypertension

(2011) Chao Lu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Angiotensin (1-7) Induces Mas Receptor Internalization

(2011) Mariela M. Gironacci et al.   HYPERTENSION

Systemic and Renal-Specific Sympathoinhibition in Obesity Hypertension

(2011) Thomas E. Lohmeier et al.   HYPERTENSION

Relations between large artery structure and function and aldosterone

(2011) Michel E. Safar et al.   JOURNAL OF HYPERTENSION

Eplerenone suppresses aldosterone/ salt-induced expression of NOX-4

(2011) Mohamed A Bayorh et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Microvascular Dysfunction: A Potential Mechanism in the Pathogenesis of Obesity-associated Insulin Resistance and Hypertension

(2011) MICHIEL P. DE BOER et al.   MICROCIRCULATION

Acute angiotensin II receptor blockade improves insulin-induced microvascular function in hypertensive individuals

(2011) Amy M. Jonk et al.   MICROVASCULAR RESEARCH

Central regulation of blood pressure by the mineralocorticoid receptor

(2011) Elise P. Gomez-Sanchez et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Mechanisms linking obesity to hypertension

(2011) J. A. N. Dorresteijn et al.   Obesity Reviews

Adipose Tissue–Specific Regulation of Angiotensinogen in Obese Humans and Mice: Impact of Nutritional Status and Adipocyte Hypertrophy

(2010) Shintaro Yasue et al.   AMERICAN JOURNAL OF HYPERTENSION

Circulating signals as critical regulators of autonomic state—central roles for the subfornical organ

(2010) Pauline M. Smith et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Effect of Losartan on Vascular Function in Fructose-Fed Rats: The Role of Perivascular Adipose Tissue

(2010) Fengyang Huang et al.   CLINICAL AND EXPERIMENTAL HYPERTENSION

Hypertension Management and Microvascular Insulin Resistance in Diabetes

(2010) Seung-Hyun Ko et al.   CURRENT HYPERTENSION REPORTS

Mechanisms for perivascular adipose tissue-mediated potentiation of vascular contraction to perivascular neuronal stimulation: The role of adipocyte-derived angiotensin II

(2010) Chao Lu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The endothelial mineralocorticoid receptor regulates vasoconstrictor tone and blood pressure

(2010) Aurelie Nguyen Dinh Cat et al.   FASEB JOURNAL

Angiotensin II Enhances Insulin-Stimulated Whole-Body Glucose Disposal but Impairs Insulin-Induced Capillary Recruitment in Healthy Volunteers

(2010) Amy M. Jonk et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Brain angiotensin peptides regulate sympathetic tone and blood pressure

(2010) Alain G Dupont et al.   JOURNAL OF HYPERTENSION

Regulated renin release from 3T3-L1 adipocytes

(2009) Jason D. Fowler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Brain-Selective Overexpression of Human Angiotensin-Converting Enzyme Type 2 Attenuates Neurogenic Hypertension

(2009) Yumei Feng et al.   CIRCULATION RESEARCH

Vascular insulin resistance in prehypertensive rats: Role of PI3-kinase/Akt/eNOS signaling

(2009) Rong Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Aldosterone Increases Oxidant Stress to Impair Guanylyl Cyclase Activity by Cysteinyl Thiol Oxidation in Vascular Smooth Muscle Cells

(2009) Bradley A. Maron et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelium-dependent relaxation factor released by perivascular adipose tissue

(2009) Robert MKW Lee et al.   JOURNAL OF HYPERTENSION

Mineralocorticoid Receptor Blockade Reverses Obesity-Related Changes in Expression of Adiponectin, Peroxisome Proliferator-Activated Receptor-γ, and Proinflammatory Adipokines

(2008) Christine Guo et al.   CIRCULATION

Impaired Tissue Perfusion

(2008) Bernard I. Levy et al.   CIRCULATION

Angiotensin-Converting Enzyme 2 Overexpression in the Subfornical Organ Prevents the Angiotensin II–Mediated Pressor and Drinking Responses and Is Associated With Angiotensin II Type 1 Receptor Downregulation

(2008) Yumei Feng et al.   CIRCULATION RESEARCH

Arterial stiffness in diabetes and the metabolic syndrome: a pathway to cardiovascular disease

(2008) C. D. A. Stehouwer et al.   DIABETOLOGIA

The angiotensin receptor type 1-Gqprotein-phosphatidyl inositol phospholipase Cβ-protein kinase C pathway is involved in activation of proximal tubule Na+-ATPase activity by angiotensin(1-7) in pig kidneys

(2008) Lucienne S. Lara et al.   EXPERIMENTAL PHYSIOLOGY

A novel adipokine CTRP1 stimulates aldosterone production

(2008) Jun Ho Jeon et al.   FASEB JOURNAL

Transgenic Angiotensin-Converting Enzyme 2 Overexpression in Vessels of SHRSP Rats Reduces Blood Pressure and Improves Endothelial Function

(2008) Brit Rentzsch et al.   HYPERTENSION

Selective Mineralocorticoid Receptor Blocker Eplerenone Reduces Resistance Artery Stiffness in Hypertensive Patients

(2008) Carmine Savoia et al.   HYPERTENSION

Body Mass Index Predicts Plasma Aldosterone Concentrations in Overweight-Obese Primary Hypertensive Patients

(2008) Gian Paolo Rossi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Comparative expression analysis of the renin–angiotensin system components between white and brown perivascular adipose tissue

(2008) B Gálvez-Prieto et al.   JOURNAL OF ENDOCRINOLOGY

Aldosterone acts centrally to increase brain renin-angiotensin system activity and oxidative stress in normal rats

(2007) Zhi-Hua Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Aldosterone Induces Superoxide Generation via Rac1 Activation in Endothelial Cells

(2007) Fumiko Iwashima et al.   ENDOCRINOLOGY