Review
Pharmacology & Pharmacy
Farshad Mirzavi, Mehdi Barati, Anvar Soleimani, Roghayyeh Vakili-Ghartavol, Mahmoud Reza Jaafari, Mohammad Soukhtanloo
Summary: Liposomal delivery system has shown promising results in treating melanoma by safely and effectively delivering therapeutic agents to the tumor site. By using liposomal delivery system, the success rate of current melanoma therapies can be improved and resistance can be overcome.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Multidisciplinary Sciences
Valentin-Florian Rauca, Laura Patras, Lavinia Luput, Emilia Licarete, Vlad-Alexandru Toma, Alina Porfire, Augustin Catalin Mot, Elena Rakosy-Tican, Alina Sesarman, Manuela Banciu
Summary: The novel combination tumor-targeted treatment shows significant inhibitory effects on melanoma growth by enhancing anti-angiogenic effects and inducing apoptosis of tumor cells, with the potential to remodel the tumor microenvironment.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Wei Xiong, Zhengdong Guo, Baoyan Zeng, Teng Wang, Xiaowei Zeng, Wei Cao, Daizheng Lian
Summary: This study constructed multifunctional nanoparticles for the encapsulation of dacarbazine (DTIC) and targeted therapy of malignant melanoma (MM). In vitro and in vivo experiments showed that these nanoparticles had good release properties and exhibited strong anti-tumor effects with no side effects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Liangdi Jiang, Yongwei Gu, Yue Du, Xiaomeng Tang, Xin Wu, Jiyong Liu
Summary: The study proposes a delivery system based on TRAIL-engineered exosomes (TRAIL-Exo) for loading TPL for targeted therapy against malignant melanoma, which improves tumor targetability, enhances cellular uptake, inhibits proliferation, invasion, and migration, and induces apoptosis of A375 cells through activating the extrinsic TRAIL pathway and the intrinsic mitochondrial pathway in vitro. Intravenous injection of TRAIL-Exo/TPL significantly suppresses tumor progression and reduces the toxicity of TPL in the melanoma nude mouse model, presenting a novel strategy for high-efficiency exosome-based drug-delivery nanocarriers with synergistic therapeutic efficacy and targeting capacity for melanoma treatment.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Biochemistry & Molecular Biology
Kenta Nakamura, Ryuhei Okuyama
Summary: Immune checkpoint inhibitors (ICIs) are used for the treatment of various cancers, and understanding the mechanism of tumor immune responses can improve their efficacy. Investigating T cell receptors (TCRs) and changes in the TCR repertoire has revealed increased proliferation of T cell clones in patients responding to ICIs. This proliferation is observed in tumors as well as in the peripheral blood, suggesting that analyzing immune cell repertoire can help predict and enhance the therapeutic efficacy of ICIs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Yongwei Gu, Yue Du, Liangdi Jiang, Xiaomeng Tang, Aixue Li, Yunan Zhao, Yitian Lang, Xiaoyan Liu, Jiyong Liu
Summary: The study successfully utilized exosomes as a delivery vehicle for TP, showing promising antitumor effects against melanoma and significant inhibition of tumor growth and extension of survival time in a mouse model.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Oncology
Jason Cham, Ayal Shavit, Aren Ebrahimi, Miguel Viray, Paul Gibbs, Munveer S. Bhangoo
Summary: Melanoma can present with neuroendocrine differentiation, posing a diagnostic challenge. This case highlights the importance of broader immunohistochemical workup and genomic testing in identifying metastatic melanoma with neuroendocrine differentiation, leading to successful treatment with checkpoint inhibitors.
FRONTIERS IN ONCOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Dexuan Xiao, Yanjing Li, Taoran Tian, Tianxu Zhang, Sirong Shi, Boyao Lu, Yang Gao, Xin Qin, Mei Zhang, Wei Wei, Yunfeng Lin
Summary: siRNA combined with tFNAs and AS1411 in nanostructures showed enhanced activity and cellular uptake efficiency in gene therapy. This study provides a novel strategy for gene silencing using DNA nanomaterials.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Simeng Liu, Huimin Liu, Xiaoshuang Song, Ailing Jiang, Yuchuan Deng, Chengli Yang, Dan Sun, Kun Jiang, Fan Yang, Yu Zheng
Summary: Adoptive T cell therapy with liposomal immune regulators has been shown to effectively improve the immunosuppressive tumor microenvironment, enhance tumor immune responses, and holds potential for future clinical translation.
Article
Chemistry, Analytical
Yifan Liu, Han Zhao, Li Li, Baoyin Yang, Yongli Yue, Meng Li, Xiaowei Shi, Bo Zhang, Lei Wang, Chaochao Qi, Yibing Liu, Shuguang Ren, Kai Zhang, Juyoung Yoon
Summary: Researchers have proposed a tyrosinase-activated platinum complex for melanoma photodynamic therapy and fluorescence imaging. The complex showed high phototoxicity and induced apoptosis in melanoma cells in both in-vivo and in-vitro experiments. The study suggests that combining imaging and treatment within a single fluorophore may be useful in cancer theranostics.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Applied
Nuno M. M. Moura, Kelly A. D. F. Castro, Juliana C. Biazzotto, Juliana A. Prandini, Carlos Lodeiro, Maria A. F. Faustino, Mario M. Q. Simoes, Roberto S. da Silva, Maria G. P. M. S. Neves
Summary: This paper reports the synthesis, characterization, and efficacy of porphyrin derivatives bearing ruthenium or iridium terpyridine units as photosensitizers against resistant melanoma cells. The combination of porphyrin derivatives with ruthenium or iridium ions improves the PDT effect, leading to a decrease in cell viability due to their high singlet oxygen production and cellular uptake. The fluorescent properties of the iridium derivative were observed to be uniformly dispersed in the cells.
Article
Chemistry, Multidisciplinary
Livia Budai, Marianna Budai, Zsofia Edit Fuelopne Papay, Petra Szalkai, Noemi Anna Niczinger, Shosho Kijima, Kenji Sugibayashi, Istvan Antal, Nikolett Kallai-Szabo
Summary: Janus-faced viscoelastic gelling agents, possessing both elastic and viscous characteristics, provide materials with unique features. The viscoelasticity of various liposomal dispersions was investigated in this study, focusing on the impact of lipid concentration, the presence of cholesterol or DSPC, and the gelling agents PVA and HEC. The composition and lamellarity/size of lipid vesicles were found to influence the oscillation rheological properties of the liposomal formulations.
Article
Biochemistry & Molecular Biology
Jiaping Fang, Xuan Huang, Yun Yang, Xiaotong Wang, Xin Liang, Jianwen Liu
Summary: The study showed that BBR-PDT had significant differences in inducing apoptosis and upregulating cleaved caspase-3 protein expression in MMCs, and it also increased autophagy level and activated ER stress through ROS. Knockdown of CHOP protein expression inhibited the effects of BBR-PDT, suggesting a potential role of CHOP in apoptosis, autophagy, and ER stress in MMCs treated with BBR-PDT, demonstrating the essential impact of BBR-PDT on growth inhibition in MMCs.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Immunology
Nour el Imane Issam Salah, Farida Marnissi, Abdelhakim Lakhdar, Mehdi Karkouri, Mohamed Elbelhadji, Abdallah Badou
Summary: This study analyzed the expression of a novel immune checkpoint, VISTA, in the rare and deadly tumor UM. The results showed that VISTA expression was associated with tumor aggressiveness, T cell exhaustion, and poor overall survival. VISTA may serve as a prognostic marker and a potential target for immunotherapy in UM patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Claudia Bonechi, Fariba Fahmideh Mahdizadeh, Luigi Talarico, Simone Pepi, Gabriella Tamasi, Gemma Leone, Marco Consumi, Alessandro Donati, Agnese Magnani
Summary: Glaucoma, a group of neurodegenerative diseases, is the second leading cause of irreversible blindness worldwide. The limited penetration of drugs through the ocular barrier reduces the systemic bioavailability, leading to the need for frequent drug administration and potential toxic effects. Liposomes and other novel drug-delivery systems can enhance the therapeutic efficacy of antiglaucomatous drugs by improving drug penetration, bioavailability, sustained release, tissue targeting, and reduction in intraocular pressure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Aya Shoukry Sayed, Iman Emam Omar Gomaa, Michael Bader, Nesrine Salah El Dine El Sayed
MOLECULAR NEUROBIOLOGY
(2018)
Article
Pharmacology & Pharmacy
Mai Rady, Iman Gomaa, Nagia Afifi, Mahmoud Abdel-Kader
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2018)
Article
Biochemistry & Molecular Biology
Sara A. Abdel Gaber, Patricia Mueller, Wolfgang Zimmermann, Dirk Huettenberger, Rainer Wittig, Mahmoud H. Abdel Kader, Herbert Stepp
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2018)
Article
Oncology
Aya Ahmed Sebak, Iman Emam Omar Gomaa, Aliaa Nabil ElMeshad, Mahmoud Hashem AbdelKader
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2018)
Article
Pharmacology & Pharmacy
Soad Nasr, Mai Rady, Iman Gomaa, Tatiana Syrovets, Thomas Simmet, Walid Fayad, Mahmoud Abdel-Kader
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2019)
Article
Pharmacology & Pharmacy
Soad Nasr, Mai Rady, Aya Sebak, Iman Gomaa, Walid Fayad, Menna El Gaafary, Mahmoud Abdel-Kader, Tatiana Syrovets, Thomas Simmet
Review
Biochemistry & Molecular Biology
Aya A. Sebak, Basma M. El-Shenawy, Sara El-Safy, Mohamed El-Shazly
Summary: Nanomedicine is revolutionizing cancer treatment with unprecedented outcomes, but the heterogeneous nature of the EPR effect poses challenges. Active targeting strategies have shown limited success in enhancing therapeutic outcomes, prompting exploration of TME reengineering and the use of companion diagnostics to improve NP interactions with biological macromolecules.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Yasmeen Ezzeldeen, Shady Swidan, Aliaa ElMeshad, Aya Sebak
Summary: This study aimed to fabricate HK transfersomes for topical treatment of melanoma, which showed potential to alleviate the immunosuppressive characteristics of the tumor and reduce the expression of stem-like cell markers. The optimized formula exhibited a mean size of 190 nm and highly negative surface charge, with promising results both in vitro and in combination with other drugs.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Engineering, Biomedical
Asmaa Ramzy, Sara ElSafy, Hisham A. Elshoky, Aya Soliman, Rana Youness, Samar Mansour, Aya Sebak
Summary: This study investigated the role of hybrid nanoparticles on the immunosuppressive characteristics of triple-negative breast cancer (TNBC) cells. The results showed that hybrid nanoparticles could convert the immunosuppressive microenvironment of TNBC to an immune-active microenvironment by reducing PD-L1 expression and reversing the Warburg effect.
BIOMEDICAL MATERIALS
(2023)
Article
Instruments & Instrumentation
Asmaa Ramzy, Aya H. Soliman, Sally I. Hassanein, Aya A. Sebak
Summary: This study aimed to design a nanoparticulate system that can accumulate in the tumor and spleen to induce local and systemic immune responses and remodel the immunosuppressive tumor microenvironment. Drug-loaded PLGA nanoparticles were used to eradicate cancer cells, silence tumor-associated fibroblasts, and re-educate tumor-associated macrophages. The nanoparticles exhibited long blood circulation time and preferentially localized in the tumor and spleen. The findings suggest the potential of remodeling the tumor microenvironment for successful chemoimmunotherapy, while also highlighting the importance of careful use of combination therapies and dose-reduction strategies.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Aya Ahmed Sebak, Iman Emam Omar Gomaa, Aliaa Nabil ElMeshad, Mahmoud Hussien Farag, Ulrike Breitinger, Hans-Georg Breitinger, Mahmoud Hashem AbdelKader
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Article
Nanoscience & Nanotechnology
Aya Ahmed Sebak, Iman Emam Omar Gomaa, Aliaa Nabil ElMeshad, Mahmoud Hussien Farag, Ulrike Breitinger, Hans-Georg Breitinger, Mahmoud Hashem AbdelKader
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)