Animal Cryptochromes: Divergent Roles in Light Perception, Circadian Timekeeping and Beyond

Circadian Rhythm Disruption Promotes Lung Tumorigenesis

(2016) Thales Papagiannakopoulos et al.   Cell Metabolism

Cryptochrome 1 in Retinal Cone Photoreceptors Suggests a Novel Functional Role in Mammals

(2016) Christine Nießner et al.   Scientific Reports

A magnetic protein biocompass

(2015) Siying Qin et al.   NATURE MATERIALS

Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C terminus

(2015) Haiyan Xu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Melanopsin Tristability for Sustained and Broadband Phototransduction

(2015) Alan Joseph Emanuel et al.   NEURON

Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C terminus

(2015) Haiyan Xu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization

(2015) Stephanie J Papp et al.   eLife

Emerging Models for the Molecular Basis of Mammalian Circadian Timing

(2014) Chelsea L. Gustafson et al.   BIOCHEMISTRY

Interaction of Circadian Clock Proteins CRY1 and PER2 Is Modulated by Zinc Binding and Disulfide Bond Formation

(2014) Ira Schmalen et al.   CELL

Photochemistry of flavoprotein light sensors

(2014) Karen S Conrad et al.   Nature Chemical Biology

Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes

(2014) Hao A Duong et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Modulation of ATR-mediated DNA damage checkpoint response by cryptochrome 1

(2014) T.-H. Kang et al.   NUCLEIC ACIDS RESEARCH

A circadian gene expression atlas in mammals: Implications for biology and medicine

(2014) Ray Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An electromagnetic field disrupts negative geotaxis in Drosophila via a CRY-dependent pathway

(2014) Giorgio Fedele et al.   Nature Communications

Molecular assembly of the period-cryptochrome circadian transcriptional repressor complex

(2014) Shannon N Nangle et al.   eLife

Structures of Drosophila Cryptochrome and Mouse Cryptochrome1 Provide Insight into Circadian Function

(2013) Anna Czarna et al.   CELL

Competing E3 Ubiquitin Ligases Govern Circadian Periodicity by Degradation of CRY in Nucleus and Cytoplasm

(2013) Seung-Hee Yoo et al.   CELL

Crystal structure of mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligase

(2013) Shannon Nangle et al.   CELL RESEARCH

Circadian Disruption Leads to Insulin Resistance and Obesity

(2013) Shu-qun Shi et al.   CURRENT BIOLOGY

Mechanism of Photosignaling byDrosophilaCryptochrome

(2013) Nuri Ozturk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of the Cryptochrome 1 C-terminal Tail Regulates Circadian Period Length

(2013) Peng Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SCFFBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocket

(2013) Weiman Xing et al.   NATURE

Updated structure of Drosophila cryptochrome

(2013) Colin Levy et al.   NATURE

Mammalian TIMELESS Is Involved in Period Determination and DNA Damage-Dependent Phase Advancing of the Circadian Clock

(2013) Erik Engelen et al.   PLoS One

Flavin reduction activates Drosophila cryptochrome

(2013) A. T. Vaidya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ramshackle (Brwd3) promotes light-induced ubiquitylation of Drosophila Cryptochrome by DDB1-CUL4-ROC1 E3 ligase complex

(2013) N. Ozturk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a Novel Cryptochrome Differentiating Domain Required for Feedback Repression in Circadian Clock Function

(2012) Sanjoy K. Khan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Light-dependent Structural Change of Chicken Retinal Cryptochrome4

(2012) Ryuji Watari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melanopsin Is Highly Resistant to Light and Chemical Bleachingin Vivo

(2012) Timothy J. Sexton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cry1−/− Circadian Rhythmicity Depends on SCN Intercellular Coupling

(2012) Jennifer A. Evans et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Coordinated regulation of XPA stability by ATR and HERC2 during nucleotide excision repair

(2012) T-H Lee et al.   ONCOGENE

The Molecular Clockwork of the Fire Ant Solenopsis invicta

(2012) Krista K. Ingram et al.   PLoS One

Circadian clock protein cryptochrome regulates the expression of proinflammatory cytokines

(2012) R. Narasimamurthy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Small Molecule Activators of Cryptochrome

(2012) T. Hirota et al.   SCIENCE

Transcriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals

(2012) N. Koike et al.   SCIENCE

The Cryptochromes: Blue Light Photoreceptors in Plants and Animals

(2011) Inês Chaves et al.   Annual Review of Plant Biology

Delay in Feedback Repression by Cryptochrome 1 Is Required for Circadian Clock Function

(2011) Maki Ukai-Tadenuma et al.   CELL

Circadian regulation of DNA excision repair: Implications for chrono-chemotherapy

(2011) Tae-Hong Kang et al.   CELL CYCLE

Biochemical Analysis of the Canonical Model for the Mammalian Circadian Clock

(2011) Rui Ye et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melanopsin and Mechanisms of Non-visual Ocular Photoreception

(2011) Timothy Sexton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stoichiometric Relationship among Clock Proteins Determines Robustness of Circadian Rhythms

(2011) Yongjin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Light-activated Cryptochrome Reacts with Molecular Oxygen to Form a Flavin–Superoxide Radical Pair Consistent with Magnetoreception

(2011) Pavel Müller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of full-length Drosophila cryptochrome

(2011) Brian D. Zoltowski et al.   NATURE

Shift work and chronic disease: the epidemiological evidence

(2011) X.-S. Wang et al.   OCCUPATIONAL MEDICINE-OXFORD

Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis

(2011) J. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human cryptochrome exhibits light-dependent magnetosensitivity

(2011) Lauren E. Foley et al.   Nature Communications

Drosophila timeless2 Is Required for Chromosome Stability and Circadian Photoreception

(2010) Clara Benna et al.   CURRENT BIOLOGY

Circadian clock control of the cellular response to DNA damage

(2010) Aziz Sancar et al.   FEBS LETTERS

Flexible phase adjustment of circadian albumin D site-binding protein (Dbp) gene expression by CRYPTOCHROME1

(2010) M. Stratmann et al.   GENES & DEVELOPMENT

Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis

(2010) Eric E Zhang et al.   NATURE MEDICINE

Reaction mechanism of Drosophila cryptochrome

(2010) N. Ozturk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase

(2010) T.-H. Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative Photochemistry of Animal Type 1 and Type 4 Cryptochromes

(2009) Nuri Ozturk et al.   BIOCHEMISTRY

Generation of a Novel Allelic Series of Cryptochrome Mutants via Mutagenesis Reveals Residues Involved in Protein-Protein Interaction and CRY2-Specific Repression

(2009) E. V. McCarthy et al.   MOLECULAR AND CELLULAR BIOLOGY

Loss of cryptochrome reduces cancer risk inp53mutant mice

(2009) Nuri Ozturk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CONCORDANCE OF THE CIRCADIAN CLOCK WITH THE ENVIRONMENT IS NECESSARY TO MAXIMIZE FITNESS IN NATURAL POPULATIONS

(2008) Kevin J. Emerson et al.   EVOLUTION

Cryptochrome mediates light-dependent magnetosensitivity in Drosophila

(2008) Robert J. Gegear et al.   NATURE

The genetics of mammalian circadian order and disorder: implications for physiology and disease

(2008) Joseph S. Takahashi et al.   NATURE REVIEWS GENETICS

Human and Drosophila Cryptochromes Are Light Activated by Flavin Photoreduction in Living Cells

(2008) Nathalie Hoang et al.   PLOS BIOLOGY