Article
Biochemistry & Molecular Biology
Klaudia Banach, Justyna Kowalska, Zuzanna Rzepka, Artur Beberok, Jakub Rok, Dorota Wrzesniok
Summary: The study found that the combined treatment of ketoprofen and UVA radiation has significant anti-proliferative and pro-apoptotic effects on melanoma cells, while showing high selectivity for normal melanocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Plant Sciences
Yeeun Kang, Kwanuk Lee, Ken Hoshikawa, Myeongyong Kang, Seonghoe Jang
Summary: The effects of climate change, such as increased global temperatures and abnormal weather events, are causing concerns for plant vegetation and crop productivity. This review focuses on the molecular processes of plants in response to heat stress, with emphasis on the classification and functions of heat shock proteins. Developing vegetable crops with enhanced thermotolerance using genetic tools is crucial to alleviate the adverse effects of heat stress.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Oncology
Cristina Casalou, Hugo Moreiras, Jay M. Mayatra, Aurelie Fabre, Desmond J. Tobin
Summary: This article focuses on the early stages of cutaneous melanoma development, examining how melanocyte cells can be influenced by different cellular contexts and micro-environments to determine their tumor fate. It also discusses how unique features of follicular-melanin units can protect melanocytes from melanomagenesis, and explores the potential insights provided by various pigment cell diseases into immune- and non-immune-mediated outcomes for melanocytes in cutaneous melanin units.
FRONTIERS IN ONCOLOGY
(2022)
Article
Plant Sciences
Hassan Y. Sulaiman, Bin Liu, Eve Kaurilind, Ulo Niinemets
Summary: The study found that under high temperature and biotic stress, plant photosynthetic characteristics and volatile organic compound emissions are affected, but can fully recover within 48 hours.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2021)
Article
Dermatology
Emma L. Wilkinson, Lorna Ashton, Jemma G. Kerns, Sarah L. Allinson, Richard L. Mort
Summary: The study utilizes Raman spectroscopy to fingerprint and differentiate various cell types, revealing the potential of this technique in determining the differentiation status of melanocyte lineage cells. The research also describes the immediate and temporal biochemical changes in cells exposed to UV radiation, showing differing responses depending on cell type, differentiation status, and melanin synthesis capability.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Multidisciplinary Sciences
Ke-Jun Chen, Feng-Zeng Li, Qian Ye, Meng Jia, Sheng Fang
Summary: Heat shock protein 105 (HSP105) is overexpressed in cutaneous malignant melanoma (CMM) and is closely associated with different clinicopathological variables. Lesions in exposed sites, recurrent and metastatic lesions, nodular melanoma, and lentigo maligna melanoma show higher HSP105 expression, suggesting HSP105 as a potential target for the diagnosis, treatment, and prognostic prediction of CMM.
Article
Biochemistry & Molecular Biology
Tal Belity, Michal Horowitz, Jay R. Hoffman, Yoram Epstein, Yaron Bruchim, Doron Todder, Hagit Cohen
Summary: Exposure to high ambient temperature can have extensive effects on brain structure and function. This study found that preconditioning with heat stress can improve resilience to predator-scent stress and may involve the induction of heat shock protein-70. Targeting this protein could be an attractive strategy for treating stress-related psychopathology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Daniel Gonzalez-Tokman, Stephanie S. Bauerfeind, Martin A. Schafer, Richard J. Walters, David Berger, Wolf U. Blanckenhorn
Summary: The study revealed that the combination of heat and ivermectin exposure synergistically reduces offspring survival in yellow dung flies. However, there were no significant regional differences in ivermectin sensitivity among fly populations, and ivermectin sensitivity showed low heritability.
Article
Agronomy
Leonard Bonilha Piveta, Nilda Roma-Burgos, Jose Alberto Noldin, Vivian Ebeling Viana, Claudia de Oliveira, Fabiane Pinto Lamego, Luis Antonio de Avila
Summary: Rice, the staple food for many people worldwide, is affected by climatic changes impacting its yield and quality. Weedy rice, with high genetic diversity, is crucial for rice crop improvement. This study analyzed the physiological and molecular profiles of rice cultivars and weedy rice under heat and drought stress, revealing genotype-specific responses to stress conditions. Research suggests that certain genotypes perform well under stress conditions and can be used as a source of genetic diversity for rice breeding.
Article
Environmental Sciences
Chao Xing, Jinyu Li, Hongli Yuan, Jinshui Yang
Summary: This study investigated the response mechanism of microalgae under heat and cold stress. The results showed that heat stress led to a significant increase in reactive oxygen species, while cold stress initially increased and then decreased reactive oxygen species. Key elements such as superoxide dismutase and nitric oxide increased under heat stress, while proline and heat shock transcriptional factor increased under cold stress. This study provides a basis for understanding the response mechanism of microalgae to temperature stress and improving their tolerance to temperature stress.
ENVIRONMENTAL RESEARCH
(2022)
Article
Food Science & Technology
Simeng Chen, Jie Zhou, Chidimma Juliet Igbokwe, Yuqing Duan, Meihong Cai, Yuanqing He, Haihui Zhang
Summary: This study investigated the effect and potential mechanism of RDPEER, an antioxidant oligopeptide derived from watermelon seeds, on heat stress-induced liver injury and cell damage. The results showed that supplementation with RDPEER attenuated hepatocyte injury by increasing cell viability, reducing ROS production, improving antioxidant enzyme activity, and decreasing MDA content. RDPEER also inhibited HPA axis hyperactivity, transaminase activity, and inflammatory factor levels, while activating the endogenous antioxidant pathway and reducing inflammatory factor transcription and heat shock protein expression. Overall, RDPEER supplementation enhanced antioxidant capacity and alleviated liver damage caused by heat stress, suggesting its potential use in nutritional interventions.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Multidisciplinary Sciences
Naoya Hashikawa, Masanobu Ido, Yuna Morita, Narumi Hashikawa-Hobara
Summary: The induction of HSPs in different stages of atherosclerosis has shown varied effects, with early induction beneficial in inhibiting disease progression while later induction promotes the hardening process. Therefore, the induction and inhibition of HSPs should be considered for prevention and treatment of atherosclerosis.
SCIENTIFIC REPORTS
(2021)
Article
Fisheries
Yeyu Chen, Xiaoyun Wu, Pengcheng Li, Ya Liu, Mingjiang Song, Feiyang Li, Jun Ou, Jiansheng Lai
Summary: This study conducted an integrated analysis of the transcriptome and metabolism of Triplophysa siluroides under heat stress conditions. The results revealed that heat stress strongly upregulated genes in the Hsp family and affected specific pathways, while also causing differential abundance of metabolites. The combined analysis of transcriptome and metabolism results showed enhanced ubiquitin-dependent proteolysis and purine metabolism pathways under heat stress conditions to protect cells from damage.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Oncology
Zeynep Eroglu, Y. Ann Chen, Inna Smalley, Jiannong Li, Joseph K. Markowitz, Andrew S. Brohl, Leticia Tetteh, Hayley Taylor, Vernon K. Sondak, Nikhil I. Khushalani, Keiran S. M. Smalley
Summary: In this study, the efficacy and safety of vemurafenib and cobimetinib in combination with different doses of the HSP90 inhibitor XL888 for the treatment of advanced melanoma were explored. The study found that this combination therapy showed activity in some patients, but also had significant toxicity.
Article
Agriculture, Dairy & Animal Science
Tingting Li, Wengang He, Xiudong Liao, Xi Lin, Liyang Zhang, Lin Lu, Yanli Guo, Zongping Liu, Xugang Luo
Summary: The study found that zinc can alleviate heat stress on broiler hepatocytes by enhancing their antioxidant ability and attenuating heat shock responses.
Article
Nutrition & Dietetics
Marina Colom-Pellicer, Romina M. Rodriguez, Jorge R. Soliz-Rueda, Leonardo Vinicius Monteiro de Assis, Elia Navarro-Masip, Sergio Quesada-Vazquez, Xavier Escote, Henrik Oster, Miquel Mulero, Gerard Aragones
Summary: Consumption of grape seed proanthocyanidin extract (GSPE) can restore the diurnal rhythm of white adipose tissue (WAT) and provide an innovative time-dependent strategy for the treatment of obesity and metabolic diseases.
Article
Oncology
Hendrik Ungefroren, Isabel Thuerling, Benedikt Faerber, Tanja Kowalke, Tanja Fischer, Leonardo Vinicius Monteiro De Assis, Ruediger Braun, Darko Castven, Henrik Oster, Bjoern Konukiewitz, Ulrich Friedrich Wellner, Hendrik Lehnert, Jens-Uwe Marquardt
Summary: Intratumoral heterogeneity is an intrinsic feature of malignant tumors that can lead to treatment failure or relapse. Epithelial-mesenchymal transition and its reverse process, MET, drive cellular plasticity and tumor progression. In pancreatic ductal adenocarcinoma, single cell-derived clonal cultures with different EMT phenotypes were generated, which were associated with tumorigenic potential and circadian clock function.
Article
Biology
Leonardo Vinicius Monteiro de Assis, Jose Thalles Lacerda, Maria Nathalia Moraes, Omar Alberto Dominguez-Amorocho, Gabriela Sarti Kinker, Davi Mendes, Matheus Molina Silva, Carlos Frederico Martins Menck, Niels Olsen Saraiva Camara, Ana Maria de Lauro Castrucci
Summary: Our study shows that the absence of Opsin 4 (Opn4) can slow down cell proliferation and tumor progression in cutaneous melanoma. Furthermore, Opn4(KO) tumors exhibit a higher immune system response. The evaluation of TCGA database confirms these findings in human melanoma.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jose Thalles Lacerda, Patricia R. L. Gomes, Giovanna Zanetti, Nathana Mezzalira, Otoniel G. Lima, Leonardo V. M. de Assis, Ali Guler, Ana Maria Castrucci, Maria Nathalia Moraes
Summary: The transient receptor potential channel vanilloid type 1 (TRPV1) plays an important role in hepatic glucose metabolism, and its loss is associated with increased gluconeogenesis through the PKA signaling pathway. The study provides clues related to TRPV1-associated proteins and metabolic regulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Leonardo Vinicius Monteiro de Assis, Lisbeth Harder, Jose Thalles Lacerda, Rex Parsons, Meike Kaehler, Ingolf Cascorbi, Inga Nagel, Oliver Rawashdeh, Jens Mittag, Henrik Oster, Matthew A. Quinn
Summary: This study demonstrates that fluctuations in thyroid hormone (TH) levels restructuring the diurnal liver metabolic transcriptome independent of local molecular circadian clocks, which affects energy metabolism processes in the liver.
Article
Physiology
Daniela Dantas David, Leonardo Vinicius Monteiro de Assis, Maria Nathalia Moraes, Flavia Pinheiro Zanotto, Ana Maria de Lauro Castrucci
Summary: This study investigated the diurnal rhythm of hormone and gene expression in the molt cycle of Callinectes sapidus and found that melatonin had a remarkable influence on the molt cycle of the crabs.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Physiology
Leonardo Vinicius Monteiro de Assis, Muenevver Demir, Henrik Oster
Summary: This review focuses on the role of circadian rhythms in the liver and their impact on the development of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). The disruption of circadian rhythms and its potential consequences are discussed, as well as the potential use of the clock system in prevention and treatment of NAFLD/NASH. Attention to circadian timing may provide new avenues for optimizing therapies and targeting these prevalent disorders.
Review
Biochemistry & Molecular Biology
Ana Beatriz Rezende Paula, Leticia Teresinha Resende, Isabela Alcantara Barretto Araujo Jardim, Bianca Iara Campos Coelho, Denise de Coutinho Miranda, Alexandre Martins Oliveira Portes, Maria Cecilia Teles, Ana Maria de Lauro Castrucci, Mauro Cesar Isoldi
Summary: This systematic review discusses the impact of diet on the heart clock in animal models and examines the relationship between chronodisruption of the clock and the development of cardiovascular disorders over the past 15 years. The review finds that a healthy circadian system is linked to cardiovascular health and that maintaining a robust circadian system may reduce the risks of cardiometabolic and cardiovascular diseases. The timing of eating has a notable effect on the modulation of circadian rhythms of the cardiac clock and energy homeostasis, with detrimental effects observed during the sleep phase and/or at the end of the active phase.
Article
Endocrinology & Metabolism
Luis Felipe Galvao Valdivia, Erique Castro, Rosangela Aparecida dos Santos Eichler, Mayara Franzoi Moreno, Erica de Sousa, Giovanna Freitas Rodrigues Jardim, Albert Souza Peixoto, Maria Nathalia Moraes, Ana Maria de Lauro Castrucci, Jan Nedergaard, Natasa Petrovic, William T. Festuccia, Patricia Reckziegel
Summary: This study found that cold acclimation and PPARγ agonism combined have additive effects in increasing UCP1 content and thermogenic capacity in brown and beige adipocytes, but do not increase basal energy expenditure.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Cristhian Sua-Cespedes, Jose Thalles Lacerda, Giovanna Zanetti, Daniela Dantas David, Maria Nathalia Moraes, Leonardo V. M. de Assis, Ana Maria L. Castrucci
Summary: The presence of Opn4 in melanocytes has been associated with UVA reception. This study demonstrates the protective role of Opn4 in skin physiology and the increased UVA-induced damage in its absence. Proteomics analyses reveal molecular signatures and gene expression changes associated with proteolysis, DNA damage response, immune response, oxidative stress, and antioxidant responses in the absence of Opn4.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Leonardo Vinicius Monteiro de Assis, Muenevver Demir, Henrik Oster
Summary: Circadian profiling improves the detection of target genes and characterization of pathways in mouse models of nonalcoholic steatohepatitis. Fatty livers show a 3-hour advance in metabolic and clock gene transcript rhythms. Circadian profiling reveals temporal changes in lipid, carbohydrate, and cholesterol metabolic transcripts.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)