Review
Immunology
Yang Li, Fei Sun, Tian-Tian Yue, Fa-Xi Wang, Chun-Liang Yang, Jia-Hui Luo, Shan-Jie Rong, Fei Xiong, Shu Zhang, Cong-Yi Wang
Summary: In the context of Type 1 diabetes (T1D), beta cells actively participate in the initiation of autoimmune responses by producing modified neoantigens and interacting with immune cells, leading to the activation of autoreactive T cells. This antigen-presenting function of beta cells helps explain the tissue specificity of T1D and underscores the active roles of structural cells in immune-related disorders' pathogenesis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Karla Ruiz-Cortes, Daniel N. Villageliu, Derrick R. Samuelson
Summary: Alcohol use can impact the function of both innate and adaptive immune cells, leading to immune dysfunction and organ damage. The role of innate lymphocytes, particularly liver-resident natural killer cells, in alcohol-induced pathogenesis is of increasing interest. However, the specific role of innate lymphocytes in alcohol-induced end-organ damage remains unclear.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Mireia Bachiller, Lorena Perez-Amill, Anthony Matthew Battram, Sebastian Ciro Carne, Amer Najjar, Els Verhoeyen, Manel Juan, Alvaro Urbano-Ispizua, Beatriz Martin-Antonio
Summary: This study demonstrates the important immunoregulatory role of CB-NK collaborating with CAR-T cells to enhance their antitumor activity. Combinatorial treatment based on CAR-T and CAR-NK cells or CB-NK and CAR-T cells showed that CB-NK required high doses for effectiveness, while a low number of CB-NK in the CAR-T product promoted early activation of CAR-T cells and enhanced anti-MM efficacy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Medical Laboratory Technology
Shiju Ye, Ke Lin, Gaojun Wu, Ming-Jiang Xu, Peiren Shan, Weijian Huang, Yi Wang, Guang Liang
Summary: Deficiency of TLR2 plays a role in cardiac remodeling and can alleviate cardiac hypertrophy, fibrosis, and inflammation while improving cardiac function. Preventing the formation of TLR2-MyD88 complexes may help prevent Ang II-induced cardiac remodeling and dysfunction.
TRANSLATIONAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Matthew R. Alexander, Bethany L. Dale, Charles D. Smart, Fernando Elijovich, Cara E. Wogsland, Sierra M. Lima, Jonathan M. Irish, Meena S. Madhur
Summary: Evidence from nonhuman animal models suggests that immune cells play a crucial role in hypertension, but their changes in human hypertension are unclear. Using mass cytometry, this study reveals reduced levels of CCR10+ regulatory T cells (Tregs) and PD-1+CD57-CD8+ memory T cells, indicating potential decreases in anti-inflammatory and hypofunctional T-cell populations in human hypertension.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Review
Oncology
Anneloes van Duijn, Sjoerd H. Van der Burg, Ferenc A. Scheeren
Summary: This article focuses on the interactions between myeloid immune cells and anti-tumor immune responses in the tumor microenvironment. Blocking the CD47/SIRP alpha axis can enhance adaptive immune response. The potential therapeutic role of CD47/SIRP alpha axis is discussed in tumors with acquired resistance to classic immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Medicine, Research & Experimental
Elizabeth S. Levy, Ryan Chang, Colin R. Zamecnik, Miqdad O. Dhariwala, Lawrence Fong, Tejal A. Desai
Summary: Combining immune agonists and a melanoma-specific peptide in nanoparticles significantly enhances activation of antigen-presenting cells and promotes the development and response of melanoma-sensitized T cells, leading to suppression of tumor growth and reduction of tumor burden in both solid and metastatic tumor models. This biomaterial-based approach provides insights into stimulating multiple activation pathways for promoting tumor regression and delivering combination immunotherapies effectively and safely for cancer treatment.
MOLECULAR PHARMACEUTICS
(2021)
Review
Biochemistry & Molecular Biology
Clara Chivasso, Julie Sarrand, Jason Perret, Christine Delporte, Muhammad Shahnawaz Soyfoo
Summary: Sjogren's syndrome is a chronic autoimmune disease characterized by infiltration of exocrine glands, leading to dry eyes and mouth symptoms. The pathophysiology of the disease is not well understood, but evidence suggests that different factors interact to initiate and perpetuate the disease. Immune system, both innate and adaptive, play a crucial role in the pathogenesis of SS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Jakob Einhaus, Elisa Asteriti, Ann-Christin Pecher, Hildegard Keppeler, Reinhild Klein, Corina Schneidawind, Joerg Henes, Dominik Schneidawind
Summary: The study reveals the potential of immunoregulatory invariant natural killer T (iNKT) cells in suppressing proinflammatory B cell responses in an in vitro model of inflammation. iNKT cells inhibit the production of proinflammatory interleukin-6 by B cells, and the inhibitory effect requires cell contact and CD1d interaction. B cell subsets with higher expression of CD1d are more susceptible to iNKT cell inhibition.
Review
Immunology
Trevor Ung, Nakisha S. Rutledge, Adam M. Weiss, Aaron P. Esser-Kahn, Peter Deak
Summary: This article summarizes the recent advancements in immunology and chemistry in targeted vaccine technology, including cellular targets, methods of targeting, and their effects on immune responses. The relationships between vaccine targets and subsequent adaptive immune responses are crucial for effective vaccine design, potentially leading to more effective, disease-specific vaccines.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Fisheries
Nathalie Meijerink, Daphne A. van Haarlem, Francisca C. Velkers, Arjan J. Stegeman, Victor P. M. G. Rutten, Christine A. Jansen
Summary: This study characterized various NK subsets in the intestines of broiler chickens, with differences observed between organs rather than over time. Targeting these intestinal NK subsets may be a strategy to improve immune-mediated resistance in broiler chickens.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Review
Immunology
Tianmeng Yan, Zhenying Zhang
Summary: Bullous pemphigoid (BP) is an autoimmune blistering disease primarily affecting elderly individuals. It presents with heterogeneous manifestations, typically characterized by microscopically subepidermal separation and mixed inflammatory infiltrate. The development mechanism of BP remains unclear. B cells are involved in pathogenic autoantibody production, and other immune cells such as T cells, type II inflammatory cytokines, eosinophils, mast cells, neutrophils, and keratinocytes also contribute to the pathogenesis of BP. This review focuses on the roles and crosstalk between innate and adaptive immune cells in BP.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Jack L. McMurray, Anouk von Borstel, Taher E. Taher, Eleni Syrimi, Graham S. Taylor, Maria Sharif, Jamie Rossjohn, Ester B. M. Remmerswaal, Frederike J. Bemelman, Felipe A. Vieira Braga, Xi Chen, Sarah A. Teichmann, Fiyaz Mohammed, Andrea A. Berry, Kirsten E. Lyke, Kim C. Williamson, Michael J. T. Stubbington, Martin S. Davey, Carrie R. Willcox, Benjamin E. Willcox
Summary: Gamma delta T cells are traditionally considered innate-like lymphocytes, but a new adaptive-like compartment has now been identified. This adaptive subset undergoes pathogen-driven differentiation, similar to conventional CD8(+) T cells. Expansions of specific TCRs are detected exclusively in the effector cells, indicating a specialized response to antigens.
Article
Oncology
Wenyong Huang, Dongmei Ye, Wenjing He, Xiaoshun He, Xiaomin Shi, Yifang Gao
Summary: The study found that MAIT cells in patients with HCC had lower levels in both peripheral blood and liver compared to healthy controls, with reduced IFN-γ production. While peripheral MAIT cells showed upregulation of HLA-DR and PD-1, intrasinusoidal MAIT cells did not exhibit significant differences. Additionally, MAIT cells were significantly enriched in the livers of HCC patients, showing high levels of activation and exhaustion markers.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Qi Zhang, Bingqiu Xiu, Liyi Zhang, Ming Chen, Weiru Chi, Lun Li, Rong Guo, Jingyan Xue, Benlong Yang, Xiaoyan Huang, Zhi-Ming Shao, Shenglin Huang, Yayun Chi, Jiong Wu
Summary: Despite the success of HER2-targeted therapy in treating HER2+ breast cancer (BC) patients, treatment resistance still remains a challenge. This study found that LINC00624, a long non-coding RNA, inhibited the antitumor effect of HER2-targeted therapy by blocking activation of the type I interferon (IFN) pathway. The structure of LINC00624 can be edited by the ADAR1 enzyme, which releases growth inhibition and suppresses the innate immune response triggered by the IFN response. LINC00624 also promoted ADAR1 stabilization and inhibited major histocompatibility complex class I antigen presentation, resulting in immune checkpoint blockade inhibition and anti-HER2 treatment resistance. Targeting LINC00624 through ASOs holds great therapeutic potential in future clinical applications.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
