Review
Cell Biology
Katharina Held, Balazs Istvan Toth
Summary: Ion channels play a crucial role in regulating neural processes in the brain, and disruptions in their functions can lead to various neurological disorders. TRP ion channels are key players in the development and physiological functions of the central nervous system, influencing processes like neurite growth and synaptic plasticity. TRPM3, a non-selective cation channel, is emerging as a new player in the brain with potential roles in neuropathological processes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Anesthesiology
Dan Wang, Qi Gao, Ina Schaefer, Handan Moerz, Ulrich Hoheisel, Karl Rohr, Wolfgang Greffrath, Rolf-Detlef Treede
Summary: The study investigates the role of TRPM3 ion channel in nociceptive dorsal root ganglion (DRG) neurons and discovers that nerve growth factor (NGF) enhances TRPM3 function and alters mitochondrial activity. It suggests that the pulsatile superoxide production triggered by TRPM3 activation may serve as an early signaling event for pain sensitization. This finding has the potential to be a novel therapeutic strategy for chronic pain conditions.
Article
Clinical Neurology
G. Krivoshein, E. A. Tolner, A. M. J. M. van den Maagdenberg, R. A. Giniatullin
Summary: This study found that agonists of the TRPM3 channels induced nociceptive firing in mouse meninges, with a more significant response in female mice. However, no sex differences were observed for agonists of the Piezo1 channels and TRPV1 channels. These findings suggest a potential role for TRPM3 channels in the generation of migraine pain in females.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Medicine, Research & Experimental
Jiaxin Liu, Mengmeng Zhao, Zhenghao Chen, Yang Xu, Liqiang Guo, Shaoyong Wang, Yan Li, Benkang Shi, Xiulin Zhang, Xiao-Dong Jin
Summary: TRPM3 channels expressed on sensory terminals of the human ureter play a key role in inhibitory sensory neurotransmission and modulate ureter motility via the CGRP-cAMP-PKA signal pathway. Targeting TRPM3 may be a pharmacological strategy for promoting the passage of ureter stones.
Article
Neurosciences
Forrest J. Ragozzino, Rachel A. Arnold, Axel J. Fenwick, Timothy P. Riley, Jonathan E. M. Lindberg, BreeAnne Peterson, James H. Peters
Summary: TRPM3 plays a significant role in controlling spontaneous glutamate release in vagal afferents and serves as an additional temperature-sensitive calcium conductance. Its genetic deletion does not affect synchronous or asynchronous glutamate release, indicating its specific role in regulating temperature-driven neurotransmission in autonomic reflex function.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Songxue Su, Yevgen Yudin, Nawoo Kim, Yuan-Xiang Tao, Tibor Rohacs
Summary: The study showed that TRPM3 plays a role in heat hypersensitivity and spontaneous pain after nerve injury, and TRPM3 inhibitors can effectively alleviate these symptoms.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Anesthesiology
Vincenzo Davide Aloi, Silvia Joao Poseiro Coutinho Pinto, Rita Van Bree, Katrien Luyten, Thomas Voets, Joris Vriens
Summary: Chemotherapy-induced peripheral neuropathic pain (CIPNP) is a common adverse effect in cancer patients receiving cytostatic drugs. Current treatment options for CIPNP are limited and unsatisfactory. This study suggests that TRPM3 could be a potential target for the treatment of neuropathic pain in chemotherapy patients.
Article
Biochemistry & Molecular Biology
Yuefang Zhou, Thomas M. Bennett, Alan Shiels
Summary: TRPM3 gene mutation is associated with early-onset cataracts, and our study on mice with this mutation provides insights into ocular phenotypes.
Article
Neurosciences
Dan Wang, Rolf-Detlef Treede, Georg Koehr
Summary: This study demonstrates that neurosteroid pregnenolone sulfate (PregS) enhances spinal synaptic strength by activating TRPM3, which is functionally expressed in the superficial dorsal horn of adult rats. This finding provides insight into the key mechanism of chronic low back pain development and suggests a potential role of TRPM3 in mediating the interactions between neuroendocrine and nociceptive signaling.
NEUROSCIENCE LETTERS
(2023)
Article
Multidisciplinary Sciences
Linlin Sun, Chi-Kun Tong, Travis J. Morgenstern, Hang Zhou, Guang Yang, Henry M. Colecraft
Summary: Researchers have successfully achieved posttranslational functional knockdown of high-voltage-activated calcium channels in neurons, which has alleviated neuropathic pain. This study provides new insights for the development of gene therapy targeting neuropathic pain.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Makiko Kashio, Makoto Tominaga
Summary: This article focuses on thermo-transient receptor potential ion channels (thermo-TRPs) expressed in somatosensory neurons and their role in temperature sensation.
CURRENT OPINION IN NEUROBIOLOGY
(2022)
Article
Neurosciences
Ellen Lund Schaldemose, Line Raaschou-Nielsen, Rebecca Astrid Bohme, Nanna Brix Finnerup, Francesca Fardo
Summary: Paradoxical heat sensation (PHS) and the thermal grill illusion (TGI) are related to the perception of warmth or heat from innocuous cold stimuli. PHS is common in neuropathy and related to sensory loss, while TGI is more common in healthy individuals. A study of healthy participants found no overlap between PHS and TGI, suggesting that they are distinct phenomena. TGI is associated with normal thermal sensitivity, indicating that efficient thermal sensory function is important for generating the illusory sensation of pain.
NEUROSCIENCE LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Zoltan Meszar, Eva Kokai, Rita Varga, Laszlo Ducza, Tamas Papp, Monika Beresova, Marianna Nagy, Peter Szucs, Angelika Varga
Summary: This study found that Pdyn neurons in mice regulate acute thermosensation through histone H3.1 phosphorylation, without affecting mechanosensation and acute chemonociception.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Nicholas W. Villarino, Yasmeen M. F. Hamed, Britya Ghosh, Adrienne E. Dubin, Amanda H. Lewis, Max A. Odem, Meaghan C. Loud, Yu Wang, M. Rocio Servin-Vences, Ardem Patapoutian, Kara L. Marshall
Summary: Sensory neurons detect forces from the environment and internal organs to regulate physiology. PIEZO2 is a critical mechanosensory ion channel involved in touch, proprioception, and bladder stretch sensation. The use of the fluorescent dye FM 1-43 has revealed the functional role of PIEZO2-expressing neurons in detecting forces and has facilitated the study of mechanosensory processes in various organ systems.
Article
Biochemistry & Molecular Biology
Kenichi Tanaka, Takashige Kondo, Michiko Narita, Takeru Muta, Sara Yoshida, Daisuke Sato, Yukari Suda, Yusuke Hamada, Hiroyuki Tezuka, Naoko Kuzumaki, Minoru Narita
Summary: Chemogenetic activation of sensory neurons can promote tumor growth, but the underlying mechanisms are not well understood.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)