An Efficient and Rapid Method to Monitor the Oxidative Degradation of Protein Pharmaceuticals: Probing Tyrosine Oxidation with Fluorogenic Derivatization

Metal-Catalyzed Oxidation of Protein Methionine Residues in Human Parathyroid Hormone (1-34): Formation of Homocysteine and a Novel Methionine-Dependent Hydrolysis Reaction

(2013) Olivier Mozziconacci et al.   MOLECULAR PHARMACEUTICS

Fluorogenic Tagging Methodology Applied to Characterize Oxidized Tyrosine and Phenylalanine in an Immunoglobulin Monoclonal Antibody

(2013) Shuxia Zhou et al.   PHARMACEUTICAL RESEARCH

Oxidation of Therapeutic Proteins and Peptides: Structural and Biological Consequences

(2013) Riccardo Torosantucci et al.   PHARMACEUTICAL RESEARCH

Oxidation of Human Growth Hormone by Oxygen-Centered Radicals: Formation of Leu-101 Hydroperoxide and Tyr-103 Oxidation Products

(2012) Daniel Steinmann et al.   MOLECULAR PHARMACEUTICS

Advances and challenges in analytical characterization of biotechnology products: Mass spectrometry-based approaches to study properties and behavior of protein therapeutics

(2011) Igor A. Kaltashov et al.   BIOTECHNOLOGY ADVANCES

Analysis of 2,2’-Azobis (2-Amidinopropane) Dihydrochloride Degradation and Hydrolysis in Aqueous Solutions

(2011) Jay Werber et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Forced Degradation of Therapeutic Proteins

(2011) Andrea Hawe et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Impact of methionine oxidation in human IgG1 Fc on serum half-life of monoclonal antibodies

(2011) Weirong Wang et al.   MOLECULAR IMMUNOLOGY

The Degradation of Polysorbates 20 and 80 and its Potential Impact on the Stability of Biotherapeutics

(2011) Ravuri S. K. Kishore et al.   PHARMACEUTICAL RESEARCH

Characterization of protein therapeutics by mass spectrometry: recent developments and future directions

(2010) Guodong Chen et al.   DRUG DISCOVERY TODAY

Stability of Protein Pharmaceuticals: An Update

(2010) Mark Cornell Manning et al.   PHARMACEUTICAL RESEARCH

Fluorogenic Tagging of Peptide and Protein 3-Nitrotyrosine with 4-(Aminomethyl)benzenesulfonic Acid for Quantitative Analysis of Protein Tyrosine Nitration

(2009) Victor S. Sharov et al.   CHROMATOGRAPHIA

Application of LC/MS to proteomics studies: current status and future prospects

(2009) Guodong Chen et al.   DRUG DISCOVERY TODAY

Methionine, tryptophan, and histidine oxidation in a model protein, PTH: Mechanisms and stabilization

(2009) Junyan A. Ji et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

MassMatrix: A database search program for rapid characterization of proteins and peptides from tandem mass spectrometry data

(2009) Hua Xu et al.   PROTEOMICS

Effect of methionine oxidation of a recombinant monoclonal antibody on the binding affinity to protein A and protein G

(2008) Georgeen Gaza-Bulseco et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Polysorbates 20 and 80 Used in the Formulation of Protein Biotherapeutics: Structure and Degradation Pathways

(2007) Bruce A. Kerwin   JOURNAL OF PHARMACEUTICAL SCIENCES

Protein therapeutics: a summary and pharmacological classification

(2007) Benjamin Leader et al.   NATURE REVIEWS DRUG DISCOVERY