Article
Chemistry, Applied
Joaquin Gomez-Estaca, Alba Perez-Garcia, Ailen Aleman, M. Carmen Gomez-Guillen, Pilar Montero
Summary: The study evaluated the role of alginate in the drying and rehydration process of liposomal suspensions, showing that alginate can protect liposomes and provide protection at different pH levels.
FOOD HYDROCOLLOIDS
(2021)
Article
Chemistry, Physical
Ilaria Andreana, Valeria Bincoletto, Maela Manzoli, Francesca Roda, Vita Giarraputo, Paola Milla, Silvia Arpicco, Barbara Stella
Summary: Biodegradable nanocarriers are potential tools for drug delivery, but their long-term stability is a major concern influenced by water in the formulations. Freeze-drying with cryoprotectants has been proposed to address this issue. This study evaluated the influence of freeze-drying on the storage stability of PLGA nanoparticles and liposomes. It was found that only high percentages of cryoprotectants allowed stable resuspension, and HA-phospholipid conjugates maintained particle size after reconstitution. This paves the way for combining cryoprotection and active targeting using HA-phospholipids.
Article
Engineering, Chemical
Francesca Susa, Tania Limongi, Michela Millone, Valentina Cauda, Roberto Pisano
Summary: Freeze-drying, also known as lyophilization, is advantageous for biopharmaceuticals but faces challenges that can be addressed with specific excipients. Research findings indicate that certain excipients can create uniform and solid lyophilized structures at lower concentrations, showing high tolerability by cell lines.
Article
Pharmacology & Pharmacy
Marjorie Roque, Danilo Geraldes, Caroline da Silva, Monica Oliveira, Laura Nascimento
Summary: Liposomes can enhance drug stability and minimize side effects, but they often suffer from physical and chemical instabilities. Freeze-drying can immobilize liposomes and provide extended shelf life. The choice of excipients and process parameters is crucial for protecting the carrier layers.
Article
Pharmacology & Pharmacy
Khaled AboulFotouh, Haiyue Xu, Chaeho Moon, Robert O. Williams, Zhengrong Cui
Summary: The study demonstrated that thin-film freeze-drying technology can produce AS01(B) liposomal adjuvant and vaccines in freezing-insensitive, inhalable dry powder form without compromising particle size and immunogenicity.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Tobias Palle Holm, Helena Meng-Lund, Jukka Rantanen, Lene Jorgensen, Holger Grohganz
Summary: This study investigated the interactions between different proteins and excipients in freeze-dried products, revealing that the excipients sometimes have a dominant influence on critical quality attributes (CQAs), while in other cases, the CQAs are primarily dependent on the proteins themselves or the combination of both. This research provides insights into the potential impact of excipients on the stability and quality of freeze-dried products, paving the way for the use of novel excipients in the future.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Eduard Trenkenschuh, Wolfgang Friess
Summary: Lyophilization of nanoparticle suspensions is a promising technology for improving stability and providing new routes of administration in solid state. Despite being considered a gentle drying process, freeze-drying can cause stresses leading to physical instability. Nanoparticles vary in their sensitivity to lyophilization stress due to their heterogeneous physico-chemical properties, but basic concepts can still be deduced.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Engineering, Chemical
Zhe Wang, Xu Duan, Linlin Li, Guangyue Ren, Tiantian Wu, Junliang Chen, Yuan Ang, Jingfang Guo, Mengyue Zhao
Summary: This study compared the effects of freeze-drying and microwave-assisted freeze-drying on the immunological activity and structure of IgY. The results showed that MFD samples had higher activity retention than FD samples, but with a shorter drying cycle. MFD could be a potential alternative to common therapeutic protein drying methods.
Review
Food Science & Technology
Chibuzo Stanley Nwankwo, Endurance Oghogho Okpomor, Nesa Dibagar, Marta Wodecki, Wiktor Zwierz, Adam Figiel
Summary: Freeze-drying is an excellent method for dehydration, but traditional freeze-drying systems face challenges in the food industry. Upgrading or developing conventional freeze-dryers is necessary. Hybrid freeze-drying methods have the potential to achieve shorter drying durations, lower costs, and environmental friendliness while maintaining the same nutritive and sensory qualities as traditional freeze-drying in specific circumstances.
Article
Pharmacology & Pharmacy
Laurens Leys, Gust Nuytten, Pieter-Jan Van Bockstal, Thomas De Beer
Summary: Continuous spin freeze-drying allows for the implementation of several in-line process analytical technologies to control and optimize the freeze-drying process. Two methods were developed to control the freezing and drying phases at the individual vial level. Accurate control of the freezing rate and vial temperature resulted in uniform drying time between replicates.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Ji Young Yu, Piyanan Chuesiang, Gye Hwa Shin, Hyun Jin Park
Summary: Liposomes have potential as drug delivery systems, but issues such as self-aggregation, coalescence, flocculation, and precipitation may occur during formulation or storage. Post-processing techniques like freeze drying, spray drying, and spray freeze drying have been used to increase the stability of liposomes. The use of protective agents to overcome limitations of each process is also crucial.
Article
Computer Science, Interdisciplinary Applications
Prakitr Srisuma, George Barbastathis, Richard D. Braatz
Summary: Freeze drying, also known as lyophilization, is a vacuum-sublimation drying process for pharmaceutical products. Microwave-assisted freeze drying is an alternative method that utilizes microwave irradiation to dry the product, reducing drying time by 70%-80%. This article provides exact and approximate analytical solutions for conventional, microwave-assisted, and hybrid freeze drying, serving as reference solutions for validation and offering computationally efficient and accurate results.
COMPUTERS & CHEMICAL ENGINEERING
(2023)
Article
Pharmacology & Pharmacy
Laurens Leys, Gust Nuytten, Joris Lammens, Pieter-Jan Van Bockstal, Jos Corver, Chris Vervaet, Thomas De Beer
Summary: The pharmaceutical industry is moving towards more continuous manufacturing techniques and improved process control through the implementation of process analytical technology tools. Near-infrared (NIR) spectroscopy was used to study desorption kinetics during the secondary drying step of continuous spin freeze-drying, leading to the development of an inline calibration model to predict residual moisture content and evaluate the impact of different process parameters on the drying rate. The study revealed that product temperature and cooling rate during spin freezing had significant effects on the drying rate, while chamber pressure during drying had no significant impact in the tested range.
Article
Chemistry, Applied
Yinghua Nie, Jiahui Chen, Jiamin Xu, Yangyi Zhang, Mengyang Yang, Lili Yang, Xichang Wang, Jian Zhong
Summary: The study showed that vacuum freeze-drying process affects the molecular structure and emulsion stability of gelatin extracted from tilapia skin, with longer drying times leading to changes in specific secondary structures and an enhancement in emulsion stabilization.
Article
Engineering, Chemical
Aijun Di, Shengyu Zhang, Xuan Liu, Zhenbo Tong, Siping Sun, Zengchao Tang, Xiao Dong Chen, Winston Duo Wu
Summary: This study developed microparticles with improved solubility and antioxidant activity using resveratrol as a model drug. Chitosan played a key role in adjusting drug release behavior and enhancing mucoadhesion properties.
Article
Medicine, Research & Experimental
A. V. Lantsova, L. M. Borisova, G. A. Meerovich, N. D. Bunyatyan, Yu. V. Olefir, A. B. Prokof'ev, V. A. Evteev, M. M. Sapovskii, M. P. Kiseleva, E. V. Sanarova, O. L. Orlova, M. V. Dmitrieva, A. P. Polozkova, N. A. Oborotova, M. A. Ogay, Z. J. Khadzhieva, L. L. Nikolaeva
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2020)
Article
Chemistry, Medicinal
A. V. Lantsova, Yu. V. Olefir, N. D. Bunyatyan, E. V. Sanarova, O. L. Orlova, M. V. Dmitrieva, A. P. Polozkova, N. A. Oborotova, M. A. Ogai, Z. D. Khadzhieva, L. L. Nikolaeva, D. V. Kompantsev, A. M. Shevchenko, A. B. Prokof'ev
PHARMACEUTICAL CHEMISTRY JOURNAL
(2020)
Article
Chemistry, Multidisciplinary
Svitlana Shishkina, Irina S. Konovalova, Svitlana S. Kovalenko, Lyudmila L. Nikolaeva, Natalya D. Bunyatyan, Sergiy M. Kovalenko
Summary: The study on a dipharmacophore compound revealed two polymorphic forms with different molecular and crystal structures, varying in conformers and energy levels. The monoclinic form showed an abundance of interactions with close energies, while the orthorhombic form had fewer but stronger interactions. Stacking interactions differed between the two forms, with the monoclinic structure having 'head-to-head' type interactions and the orthorhombic structure having 'head-to-tail' type interactions, leading to stacked columns. Periodic calculations confirmed the lower lattice energy of the orthorhombic structure compared to the monoclinic structure.
ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Olga Konyaeva, Nataliya Kulbachevskaya, Vera Chaley, Nadezhda Ermakova, Pavel Varaksa, Anna Lantsova, Lyudmila Nikolaeva, Olga Orlova, Yuliya Rodionova, Natalia Bunyatyan
Summary: The study on Lipophtalocyan in rats showed that the drug has negative effects on male and female reproductive function, affecting fertility index, early embryonic death, but without teratogenic effects.
Review
Chemistry, Medicinal
E. Sanarova, A. Lantsova, L. L. Nikolaeva, N. A. Oborotova
Summary: Low solubility of drugs is a common problem in pharmaceutical science, and polysorbates are widely used as solubilizers to enhance drug solubility. This review highlights the properties, applications, and compatibility of polysorbates with other drugs, as well as the prospects of using them in developing dosage forms with new hydrophobic active substances.
PHARMACEUTICAL CHEMISTRY JOURNAL
(2022)
Article
Chemistry, Medicinal
L. L. Nikolaeva, A. V. Lantsova, E. V. Sanarova, O. L. Orlova, A. V. Oborotov, E. V. Ignatieva, Z. S. Shprakh, N. Yu. Kulbachevskaya, O. I. Konyaeva
Summary: The study aimed to select an excipient composition for creating an injectable dosage form (IDF) of LCS-1269 with high antitumor activity and low toxicity, and developed the technology for LCS-1269 IDF production.
PHARMACEUTICAL CHEMISTRY JOURNAL
(2023)
Article
Integrative & Complementary Medicine
Anna Lantsova, Irina Golubeva, Larisa Borisova, Lyudmila Nikolaeva, Lydia Ektova, Maria Dmitrieva, Olga Orlova
Summary: The study focused on the development and testing of a new experimental drug form LCS 1269 with antitumor properties on melanoma B-16 and Lewis lung carcinoma models in mice. Results showed high antitumor activity of LCS 1269, recommending further exploration of its sensitivity on transplantable tumors.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2021)
Article
Medicine, General & Internal
N. D. Bunyatyan, T. Vlasova, N. A. Myshkina, A. P. Vlasov, E. Polozova, N. Yu Leshchankina, A. B. Prokofiev, K. G. Gurevich
BYULLETEN SIBIRSKOY MEDITSINY
(2019)
