Macrophages in vascular inflammation and atherosclerosis

MerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis

(2017) Bishuang Cai et al.   JOURNAL OF CLINICAL INVESTIGATION

Coagulation factor XII induces pro-inflammatory cytokine responses in macrophages and promotes atherosclerosis in mice

(2017) Helga D. Manthey et al.   THROMBOSIS AND HAEMOSTASIS

Blockade of Tim-1 and Tim-4 Enhances Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient MiceSignificance

(2016) Amanda C. Foks et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Jnk1Deficiency in Hematopoietic Cells Suppresses Macrophage Apoptosis and Increases Atherosclerosis in Low-Density Lipoprotein Receptor Null MiceHighlights

(2016) Vladimir R. Babaev et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hypoxia-Inducible Factor-1α Expression in Macrophages Promotes Development of AtherosclerosisHighlights

(2016) Annemarie Aarup et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Macrophage IKKα Deficiency Suppresses Akt Phosphorylation, Reduces Cell Survival, and Decreases Early AtherosclerosisSignificance

(2016) Vladimir R. Babaev et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Macrophage miRNAs in atherosclerosis

(2016) Denuja Karunakaran et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Histone acetylation and methylation significantly change with severity of atherosclerosis in human carotid plaques

(2016) Anna Greißel et al.   CARDIOVASCULAR PATHOLOGY

The clearance of dying cells: table for two

(2016) D R Green et al.   CELL DEATH AND DIFFERENTIATION

Necrotic Cell Sensor Clec4e Promotes a Proatherogenic Macrophage Phenotype Through Activation of the Unfolded Protein ResponseClinical Perspective

(2016) Marc Clément et al.   CIRCULATION

Noninvasive Molecular Imaging of Disease Activity in Atherosclerosis

(2016) Marc R. Dweck et al.   CIRCULATION RESEARCH

Macrophage Phenotype and Function in Different Stages of Atherosclerosis

(2016) Ira Tabas et al.   CIRCULATION RESEARCH

Abandoning M1/M2 for a Network Model of Macrophage Function

(2016) Matthias Nahrendorf et al.   CIRCULATION RESEARCH

Resolving Lipid Mediators Maresin 1 and Resolvin D2 Prevent Atheroprogression in Mice

(2016) Joana Viola et al.   CIRCULATION RESEARCH

Extensive Proliferation of a Subset of Differentiated, yet Plastic, Medial Vascular Smooth Muscle Cells Contributes to Neointimal Formation in Mouse Injury and Atherosclerosis ModelsNovelty and Significance

(2016) Joel Chappell et al.   CIRCULATION RESEARCH

ORP4L Facilitates Macrophage Survival via G-Protein–Coupled SignalingNovelty and Significance

(2016) Wenbin Zhong et al.   CIRCULATION RESEARCH

Interferon-β promotes macrophage foam cell formation by altering both cholesterol influx and efflux mechanisms

(2016) Marieke C.S. Boshuizen et al.   CYTOKINE

Identity Crisis: CD301b + Mononuclear Phagocytes Blur the M1-M2 Macrophage Line

(2016) Nelson H. Knudsen et al.   IMMUNITY

CD301b + Mononuclear Phagocytes Maintain Positive Energy Balance through Secretion of Resistin-like Molecule Alpha

(2016) Yosuke Kumamoto et al.   IMMUNITY

Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species

(2016) Martin Guilliams et al.   IMMUNITY

Tissue-Resident Macrophage Ontogeny and Homeostasis

(2016) Florent Ginhoux et al.   IMMUNITY

CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis

(2016) Yoko Kojima et al.   NATURE

The development and maintenance of resident macrophages

(2016) Elisa Gomez Perdiguero et al.   NATURE IMMUNOLOGY

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans

(2016) Lesca M. Holdt et al.   Nature Communications

Characterization of Proliferating Lesion‐Resident Cells During All Stages of Atherosclerotic Growth

(2016) Šárka Lhoták et al.   Journal of the American Heart Association

Divergent JAM-C Expression Accelerates Monocyte-Derived Cell Exit from Atherosclerotic Plaques

(2016) Paul F. Bradfield et al.   PLoS One

Regression of Atherosclerosis

(2015) Edward A. Fisher   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Deficiency of HIF1α in Antigen-Presenting Cells Aggravates Atherosclerosis and Type 1 T-Helper Cell Responses in MiceSignificance

(2015) Sweena M. Chaudhari et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cholesterol Loading Reprograms the MicroRNA-143/145–Myocardin Axis to Convert Aortic Smooth Muscle Cells to a Dysfunctional Macrophage-Like PhenotypeSignificance

(2015) Yuliya Vengrenyuk et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Macrophages and immune cells in atherosclerosis: recent advances and novel concepts

(2015) Clément Cochain et al.   BASIC RESEARCH IN CARDIOLOGY

Promoting macrophage survival delays progression of pre-existing atherosclerotic lesions through macrophage-derived apoE

(2015) Laura Bouchareychas et al.   CARDIOVASCULAR RESEARCH

Monocyte trafficking across the vessel wall

(2015) Teresa Gerhardt et al.   CARDIOVASCULAR RESEARCH

Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity

(2015) Jellert T. Gaublomme et al.   CELL

CD8+T Cells Regulate Monopoiesis and Circulating Ly6ChighMonocyte Levels in Atherosclerosis in MiceNovelty and Significance

(2015) Clément Cochain et al.   CIRCULATION RESEARCH

Cytokines in atherosclerosis: Key players in all stages of disease and promising therapeutic targets

(2015) Dipak P. Ramji et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Bone-Marrow-Resident NK Cells Prime Monocytes for Regulatory Function during Infection

(2015) Michael H. Askenase et al.   IMMUNITY

Self-renewing resident arterial macrophages arise from embryonic CX3CR1+ precursors and circulating monocytes immediately after birth

(2015) Sherine Ensan et al.   NATURE IMMUNOLOGY

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis

(2015) Laura S Shankman et al.   NATURE MEDICINE

Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis

(2015) A. Warnatsch et al.   SCIENCE

Interleukin-10 protects against atherosclerosis by modulating multiple atherogenic macrophage function

(2015) Xinbing Han et al.   THROMBOSIS AND HAEMOSTASIS

Maintenance of Macrophage Redox Status by ChREBP Limits Inflammation and Apoptosis and Protects against Advanced Atherosclerotic Lesion Formation

(2015) Vincent Sarrazy et al.   Cell Reports

LDL Receptor-Related Protein-1 (LRP1) Regulates Cholesterol Accumulation in Macrophages

(2015) Anna P. Lillis et al.   PLoS One

Contribution of Intimal Smooth Muscle Cells to Cholesterol Accumulation and Macrophage-Like Cells in Human Atherosclerosis

(2014) Sima Allahverdian et al.   CIRCULATION

Transdifferentiation of Vascular Smooth Muscle Cells to Macrophage-Like Cells During Atherogenesis

(2014) Susanne Feil et al.   CIRCULATION RESEARCH

Atherosclerotic Plaque Destabilization

(2014) Carlos Silvestre-Roig et al.   CIRCULATION RESEARCH

Characterization of a Resident Population of Adventitial Macrophage Progenitor Cells in Postnatal Vasculature

(2014) Peter J. Psaltis et al.   CIRCULATION RESEARCH

Hypercholesterolemia-induced priming of hematopoietic stem and progenitor cells aggravates atherosclerosis

(2014) Tom Seijkens et al.   FASEB JOURNAL

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

HIF Transcription Factors, Inflammation, and Immunity

(2014) Asis Palazon et al.   IMMUNITY

Macrophage phenotypes in atherosclerosis

(2014) Sophie Colin et al.   IMMUNOLOGICAL REVIEWS

The hemostatic system as a regulator of inflammation in atherosclerosis

(2014) Miriam Koch et al.   IUBMB LIFE

Comparative analysis of the efficiency and specificity of myeloid-Cre deleting strains using ROSA-EYFP reporter mice

(2014) Clare L. Abram et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Macrophage subsets in atherosclerosis

(2014) Giulia Chinetti-Gbaguidi et al.   Nature Reviews Cardiology

Hypoxia Induces Netrin-1 and Unc5b in Atherosclerotic Plaques

(2013) Bhama Ramkhelawon et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hyperglycemia Promotes Myelopoiesis and Impairs the Resolution of Atherosclerosis

(2013) Prabhakara R. Nagareddy et al.   Cell Metabolism

Cytotoxic and Proinflammatory CD8 + T Lymphocytes Promote Development of Vulnerable Atherosclerotic Plaques in ApoE-Deficient Mice

(2013) Tin Kyaw et al.   CIRCULATION

Role of Extracellular RNA in Atherosclerotic Plaque Formation in Mice

(2013) Sakine Simsekyilmaz et al.   CIRCULATION

Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Macrophages Increases Inflammation and Accelerates Atherosclerosis in Mice

(2013) Marit Westerterp et al.   CIRCULATION RESEARCH

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

(2013) Frederick J Sheedy et al.   NATURE IMMUNOLOGY

Fatty acid–induced mitochondrial uncoupling elicits inflammasome-independent IL-1α and sterile vascular inflammation in atherosclerosis

(2013) Stefan Freigang et al.   NATURE IMMUNOLOGY

Local proliferation dominates lesional macrophage accumulation in atherosclerosis

(2013) Clinton S Robbins et al.   NATURE MEDICINE

Apoptotic Cell Death and Efferocytosis in Atherosclerosis

(2012) Emily A. Van Vré et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses

(2012) Nathanael J. Spann et al.   CELL

Macrophage Autophagy Plays a Protective Role in Advanced Atherosclerosis

(2012) Xianghai Liao et al.   Cell Metabolism

Regulation of Hematopoietic Stem and Progenitor Cell Mobilization by Cholesterol Efflux Pathways

(2012) Marit Westerterp et al.   Cell Stem Cell

Role of Phospholipid Oxidation Products in Atherosclerosis

(2012) Sangderk Lee et al.   CIRCULATION RESEARCH

Aging and Atherosclerosis

(2012) Julie C. Wang et al.   CIRCULATION RESEARCH

Role of colony-stimulating factors in atherosclerosis

(2012) Karina Di Gregoli et al.   CURRENT OPINION IN LIPIDOLOGY

Interleukin-13 protects from atherosclerosis and modulates plaque composition by skewing the macrophage phenotype

(2012) Larissa Cardilo-Reis et al.   EMBO Molecular Medicine

Dynamic T cell–APC interactions sustain chronic inflammation in atherosclerosis

(2012) Ekaterina K. Koltsova et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques

(2012) Janine M van Gils et al.   NATURE IMMUNOLOGY

Hypercholesterolemia links hematopoiesis with atherosclerosis

(2012) Oliver Soehnlein et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Recent Advances on the Role of Cytokines in Atherosclerosis

(2011) Hafid Ait-Oufella et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cell Death, Damage-Associated Molecular Patterns, and Sterile Inflammation in Cardiovascular Disease

(2011) Yue Zheng et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Reduced atherosclerosis and inflammatory cytokines in apolipoprotein-E-deficient mice lacking bone marrow-derived interleukin-1α

(2011) Yehuda Kamari et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reversal of Hyperlipidemia With a Genetic Switch Favorably Affects the Content and Inflammatory State of Macrophages in Atherosclerotic Plaques

(2011) Jonathan E. Feig et al.   CIRCULATION

Extramedullary Hematopoiesis Generates Ly-6C high Monocytes That Infiltrate Atherosclerotic Lesions

(2011) Clinton S. Robbins et al.   CIRCULATION

Identification of a Monocyte-Predisposed Hierarchy of Hematopoietic Progenitor Cells in the Adventitia of Postnatal Murine Aorta

(2011) Peter J. Psaltis et al.   CIRCULATION

Liver X Receptors in Atherosclerosis and Inflammation

(2011) Seung-Soon Im et al.   CIRCULATION RESEARCH

Innate and adaptive immune responses to cell death

(2011) Kenneth L. Rock et al.   IMMUNOLOGICAL REVIEWS

Suppressed monocyte recruitment drives macrophage removal from atherosclerotic plaques of Apoe–/– mice during disease regression

(2011) Stephane Potteaux et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular imaging of macrophage protease activity in cardiovascular inflammation in vivo

(2011) Thibaut Quillard et al.   THROMBOSIS AND HAEMOSTASIS

Interferon-α priming promotes lipid uptake and macrophage-derived foam cell formation: A novel link between interferon-α and atherosclerosis in lupus

(2010) Jia Li et al.   ARTHRITIS AND RHEUMATISM

LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression

(2010) Jonathan E. Feig et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-33 Reduces Macrophage Foam Cell Formation

(2010) J. E. McLaren et al.   JOURNAL OF IMMUNOLOGY

p19ARFDeficiency Reduces Macrophage and Vascular Smooth Muscle Cell Apoptosis and Aggravates Atherosclerosis

(2010) Herminia González-Navarro et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Endoplasmic reticulum stress and atherosclerosis

(2010) Gökhan S Hotamisligil   NATURE MEDICINE

ATP-Binding Cassette Transporters and HDL Suppress Hematopoietic Stem Cell Proliferation

(2010) L. Yvan-Charvet et al.   SCIENCE

Role of HDL, ABCA1, and ABCG1 Transporters in Cholesterol Efflux and Immune Responses

(2009) Laurent Yvan-Charvet et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Reduced Apoptosis and Plaque Necrosis in Advanced Atherosclerotic Lesions of Apoe−/− and Ldlr−/− Mice Lacking CHOP

(2009) Edward Thorp et al.   Cell Metabolism

Resident Intimal Dendritic Cells Accumulate Lipid and Contribute to the Initiation of Atherosclerosis

(2009) Kim E. Paulson et al.   CIRCULATION RESEARCH

Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR

(2009) Noelia A-Gonzalez et al.   IMMUNITY

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites

(2009) F. K. Swirski et al.   SCIENCE

The Inflammatory Response to Cell Death

(2008) Kenneth L. Rock et al.   Annual Review of Pathology-Mechanisms of Disease

Defective Mer Receptor Tyrosine Kinase Signaling in Bone Marrow Cells Promotes Apoptotic Cell Accumulation and Accelerates Atherosclerosis

(2008) Hafid Ait-Oufella et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mertk Receptor Mutation Reduces Efferocytosis Efficiency and Promotes Apoptotic Cell Accumulation and Plaque Necrosis in Atherosclerotic Lesions of Apoe −/− Mice

(2008) Edward Thorp et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Matrix Metalloproteinase-14 Deficiency in Bone Marrow–Derived Cells Promotes Collagen Accumulation in Mouse Atherosclerotic Plaques

(2008) Fabrice Schneider et al.   CIRCULATION

Combined Inhibition of CCL2, CX3CR1, and CCR5 Abrogates Ly6C hi and Ly6C lo Monocytosis and Almost Abolishes Atherosclerosis in Hypercholesterolemic Mice

(2008) Christophe Combadière et al.   CIRCULATION

Macrophages Generate Reactive Oxygen Species in Response to Minimally Oxidized Low-Density Lipoprotein

(2008) Yun Soo Bae et al.   CIRCULATION RESEARCH

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE