Article
Engineering, Chemical
Humaira Rizwana, Tethkar Alzahrani, Mona S. S. Alwahibi, Reem M. M. Aljowaie, Horiah A. A. Aldehaish, Noura S. S. Alsaggabi, Rasha Ramadan
Summary: Fungal plant pathogens cause significant losses in agriculture, and synthetic fungicides used to reduce these losses come with environmental and health risks. This study successfully synthesized silver nanoparticles using O. majorana leaves, which demonstrated strong inhibitory activity against various fungal pathogens.
Article
Agriculture, Multidisciplinary
Yu-Hao Zhang, Shan-Shan Yang, Qi Zhang, Tian-Tian Zhang, Tian-Yi Zhang, Bo-Hang Zhou, Le Zhou
Summary: Based on the structural features of succinate dehydrogenase inhibitors (SDHIs) and targeted covalent inhibitors, N-phenylpropiolamides with a Michael acceptor moiety were designed to find new antifungal compounds. Nineteen compounds demonstrated potent inhibition activity on nine plant pathogenic fungi. Compound 13 showed complete inhibition of Physalospora piricola infection on apples at a concentration of 200 μg/mL over 7 days and exhibited high safety to plant germination and seedling growth. It was identified as an SDH inhibitor with comparable activity to the positive drug boscalid.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Food Science & Technology
Sara Ragucci, Stefany Castaldi, Nicola Landi, Rachele Isticato, Antimo Di Maro
Summary: Ageritin from poplar mushrooms is an antifungal enzyme that inhibits the growth of various fungi affecting crops. It specifically hydrolyzes a phosphodiester bond in the large rRNA, blocking protein synthesis. The antifungal activity of ageritin was demonstrated against Botrytis cinerea, Colletotrichum truncatum, and Alternaria alternata, while no effect was observed on Trichoderma harzianum. In vitro studies revealed that ageritin can damage fungal ribosomes, and further experiments in liquid medium confirmed its concentration-dependent antifungal effect on B. cinerea and T. harzianum.
Article
Agriculture, Multidisciplinary
Ren-Xuan Wang, Sha-Sha Du, Jing-Ru Wang, Qing-Ru Chu, Chen Tang, Zhi-Jun Zhang, Cheng-Jie Yang, Ying-Hui He, Hai-Xing Li, Tian-Lin Wu, Ying-Qian Liu
Summary: The study designed, synthesized, and evaluated a series of luotonin A derivatives with potential antifungal activity, among which compound w7 exhibited excellent antifungal activity against Botrytis cinerea, possibly by disrupting the fungal cell membrane and cell wall.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Agriculture, Multidisciplinary
Li Zhang, Yunfei Shi, Xinying Duan, Wanrong He, Hongyan Si, Peng Wang, Shangxing Chen, Hai Luo, Xiaoping Rao, Zongde Wang, Shengliang Liao
Summary: By synthesizing a series of citral-thiazolyl hydrazine derivatives, it was found that these compounds exhibited good antifungal activity against a variety of phytopathogenic fungi, with compound b showing the most outstanding performance and moderate cytotoxicity.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Microbiology
Hua He, Jiao Xu, Taimin Zhou, Yang Yang, Changgui Yang, Chenghong Xiao, Chenggang Zhang, Liangyuan Li, Tao Zhou
Summary: This study investigated the changes in metabolites and microbial structure and diversity in the root of Dipsacus asper during sweating treatment using metabolomics and high-throughput sequencing technologies. The results showed significant differences in metabolites and increased microbial diversity and richness after sweating treatment. Correlation analysis revealed the association between specific microbial groups and the content of certain metabolites.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Yu-Bin Bai, Meng Zhang, Ding Li, Yu Zhao, Liang-Zhu Huang, Jin-Ming Gao
Summary: Researchers synthesized 39 diversified griseofulvin derivatives and found that compounds 5h and 5l exhibited excellent antifungal activity against two phytopathogenic fungi. Compounds 9, 10, 11, and 12 also showed potential antifungal activity.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agronomy
Giselle Hernandez, Beatriz Ramos, Haider N. Sultani, Yarelis Ortiz, Iraida Spengler, Rafael F. Castaneda, Daniel G. Rivera, Norbert Arnold, Bernhard Westermann, Yaneris Mirabal
Summary: In this study, the growth characteristics of Cladobotryum virescens on different culture media were analyzed. The fungus showed a preference for oat agar, which resulted in the highest conidia production. Additionally, C. virescens exhibited strong antifungal activity against multiple plant pathogens, and its crude ethyl acetate extract showed excellent inhibition even at low concentrations. These findings suggest that C. virescens has the potential to be a valuable biocontrol agent in agriculture.
Article
Agronomy
Yan-Yan Ding, Yu Sun, Xiong-Fei Luo, Shao-Yong Zhang, Rui Wang, Zhi-Gang Yang, Jing-Ru Wang, Bao-Qi Zhang, Zhi-Jun Zhang, Yue Ma, Jun-Xia An, Han Zhou, Ying-Qian Liu
Summary: This study extracted the essential oil and main components of Angelica sinensis and evaluated their antifungal activities. The compound 3-butylidenephthalide (3-BPH) showed the best antifungal activity against Fusarium graminearum. Mechanistic studies revealed that 3-BPH induced the generation of endogenous ROS, causing lipid peroxidation of the cell membrane and inhibiting the biosynthesis of ergosterol, leading to cell membrane damage and fungicidal activity. The study also showed that 3-BPH can reduce deoxynivalenol production.
PEST MANAGEMENT SCIENCE
(2023)
Article
Food Science & Technology
Aziz Habibi-Yangjeh, Mahdi Davari, Reza Manafi-Yeldagermani, Shervin Alikhah Asl, Samira Enaiati, Asgar Ebadollahi, Solmaz Feizpoor
Summary: TiO2/AgBr nanocomposites synthesized using ultrasonic strategy exhibit higher antifungal activities, especially against F. graminearum. The sample with 20 wt% silver bromide showed the highest inhibitory effect, degrading all fungal spores in the initial times of treatment.
FOOD SCIENCE & NUTRITION
(2021)
Review
Food Science & Technology
Frederique Reverchon, Silvia M. M. Contreras-Ramos, Akif Eskalen, Jose A. Guerrero-Analco, Evangelina E. E. Quinones-Aguilar, Claudio Rios-Velasco, Jesus B. Velazquez-Fernandez
Summary: Recent studies have been mainly focused on using entomopathogenic fungi for biocontrol of ambrosia beetles, with limited research on the potential of bacteria as biocontrol agents against ambrosia fungi. Future research should further explore the antifungal activity of bacterial strains in harsh environments, isolate more effective strains with dual biocontrol effects, and determine the best application methods of biocontrol agents in the field. Integration of microbiome studies in pest and disease management strategies may provide tools to manipulate beetle and host plant microbiomes for reduced insect fitness.
FRONTIERS IN SUSTAINABLE FOOD SYSTEMS
(2021)
Article
Agriculture, Multidisciplinary
Ruiyuan Liu, Zhuangzhuang Li, Sifan Liu, Jinshuo Zheng, PanPan Zhu, Bin Cheng, Ruijin Yu, Huiling Geng
Summary: A series of simple diarylhydrazide derivatives were designed, prepared, and screened for their antifungal activities. The most active compound, 2c, showed significant activity against various plant pathogens in vitro and in vivo. Furthermore, 2c demonstrated no toxicity towards cowpea seed germination and normal human hepatocytes.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Polymer Science
Te-Yang Huang, Mohsen Shahrousvand, Yu-Teng Hsu, Wen-Ta Su
Summary: The study aimed to evaluate the osteogenic differentiation effects of Dipsacus asper wall extracts (DAE) on periodontal ligament stem cells (PDLSCs), showing that DAE promoted cell osteogenesis and improved the physical properties of short fibers affecting the cells.
Article
Plant Sciences
Natalia Langa-Lomba, Eva Sanchez-Hernandez, Laura Buzon-Duran, Vicente Gonzalez-Garcia, Jose Casanova-Gascon, Jesus Martin-Gil, Pablo Martin-Ramos
Summary: The chemical composition of Rubia tinctorum root extract was analyzed, revealing over 50 constituents with alizarin-related anthraquinones and phenol compounds as the main phytochemicals. The extract showed strong antifungal activity, which was further enhanced when combined with chitosan oligomers or stevioside. This natural antifungal compound presents a promising alternative for sustainable control methods against grapevine trunk diseases.
Article
Plant Sciences
Zsolt Szucs, Tamas Plaszko, Eszter Bodor, Hajnalka Csoma, Lajos Acs-Szabo, Attila Kiss-Szikszai, Gabor Vasas, Sandor Gonda
Summary: The glucosinolates of Brassicaceae plants can be converted into bioactive isothiocyanates and other volatiles during stressful conditions. However, the role of weaker alternative products, such as nitriles, is not well understood.
Article
Plant Sciences
Nguyen Ngoc Tuan, Ping-Chung Kuo, Vu Dinh Hoang, Vu Thi Hien, Le Dang Quang, Tran Trung Hieu, Yue-Chiun Li, Nguyen Tan Thanh, Tian-Shung Wu, Tran Dinh Thang
Summary: Eleven chemical constituents were identified from the fruit extracts of M. azedarach, with one new limonoid trichilinin G (1) showing significant antifungal activity against Phytophthora spp. Limonoid 2 exhibited the best antifungal activity against Phytophthora species, with IC50 values indicating dose-dependent inhibition.
RECORDS OF NATURAL PRODUCTS
(2022)
Article
Chemistry, Applied
Tran Thi Minh, Ho Khanh Toan, Le Dang Quang, Vu Dinh Hoang
Summary: A new sesquiterpene glucoside, two new norsesquiterpenes, and a new homomonoterpene, along with twelve known compounds, were isolated from Myoporum bontioides. Compound 4 showed strong activity against Phytophthora capsici, demonstrating potential for further research.
NATURAL PRODUCT RESEARCH
(2022)
Article
Multidisciplinary Sciences
Min Young Kim, Jae Woo Han, Quang Le Dang, Jin-Cheol Kim, Hun Kim, Gyung Ja Choi
Summary: This study optimized the conditions for spore production and disease development of Alternaria porri and screened plant extracts for potent antifungal activity. Magnolol, identified from the methanol extract of Caryodaphnopsis baviensis, exhibited significant inhibitory activity against A. porri and showed efficacy in controlling purple blotch disease on onion plants.
Article
Chemistry, Multidisciplinary
Huong Thu Luong, Canh Xuan Nguyen, Thuong Thuong Lam, Thi-Hanh Nguyen, Quang-Le Dang, Ji-Hoon Lee, Hor-Gil Hur, Hoa Thi Nguyen, Cuong Tu Ho
Summary: This study investigated the use of copper nanoparticles to inhibit plant pathogens, Ralstonia solanacearum and Xanthomonas axonopodis. The copper nanoparticles were synthesized in a bioelectrochemical system to avoid the inhibiting effect of copper ions on bacterial cells. The results showed that the synthesized nanoparticles damaged R. solanacearum cells but did not harm X. axonopodis cells.
Article
Plant Sciences
Nguyen Ngoc Tuan, Huong Nguyen Thi, Chau Le Thi My, Tang Xuan Hai, Hieu Tran Trung, Anh Nguyen Thi Kim, Thanh Nguyen Tan, Tan Le Van, Cuong Quoc Nguyen, Quang De Tran, Ping-Chung Kuo, Quang Le Dang, Tran Dinh Thang
Summary: The phytochemical constituents from the roots of Millettia speciosa were analyzed and characterized, resulting in the identification of 10 compounds with potential pharmacological activities against inflammation and diabetes. The isolated compounds showed inhibitory effects on NO production and alpha-glucosidase, indicating their anti-inflammatory and anti-diabetic properties. Molecular docking studies revealed the better binding affinity and interactions of compounds 4, 5, and 10 with the target enzyme, suggesting their potential as lead molecules for drug development.
Article
Chemistry, Applied
Nguyen Khac Hung, Dang Ngoc Quang, Le Dang Quang, Tran Thi Minh, Ta Ngoc Dung, Pham Quang Duong, Nguyen Huu Tung, Vu Dinh Hoang
Summary: A phytochemical study on the leaves of Gardenia philastrei led to the discovery of a new compound, as well as six known compounds. These compounds exhibited anti-inflammatory activity by inhibiting nitric oxide production.
NATURAL PRODUCT RESEARCH
(2023)
Article
Plant Sciences
Cuong Bui, Quang D. Le, Anh T. K. Vo, Lam D. Tran
Summary: This study evaluated the influence of arbuscular mycorrhizal fungus on the growth and polyphenol production of two medicinal plants in Vietnam. The results showed significant effects on the growth of the plants, but the impact on polyphenol production varied between the species.
NOTULAE BOTANICAE HORTI AGROBOTANICI CLUJ-NAPOCA
(2022)
Article
Plant Sciences
Vu Dinh Hoang, Nguyen Khac Hung, Le Dang Quang, Tran Thi Minh, Ta Ngoc Dung, Pham Quang Duong, Nguyen Huu Tung, Dinh Thi Phuong Anh, Nguyen Thi Thuy My, Nguyen Quang Tung, Tran Dinh Thang, Dang Ngoc Quang
Summary: Two new acyl glycosides, angkorensides A and B, were isolated from Gardenia angkorensis Pit, along with twelve known compounds. Angkorensides A and B showed moderate anti-inflammatory effects, while the known compounds exhibited strong antioxidant activity.
PHYTOCHEMISTRY LETTERS
(2022)
Article
Plant Sciences
Gil Han, Mohamed Mannaa, Hyoseong Jeon, Hyejung Jung, Jin-Cheol Kim, Ae Ran Park, Young-Su Seo
Summary: The Korean fir, a coniferous tree species found in Jeju, South Korea, is facing population decline and has been declared endangered. This study investigated the composition of the rhizosphere microbiota of healthy and die-back-affected trees on Mount Halla. The results showed a significant reduction in microbiota richness and diversity in the rhizosphere of die-back-affected trees.
Article
Biochemistry & Molecular Biology
Hieu Nguyen-Ngoc, Trang Nguyen-Thi-Thu, Kieu-Anh Vo-Thi, Tung Nguyen-Huu, Lam Tran-Dai, Hoang Dinh Vu, Duc Trong Nghiem, Quang Le Dang
Summary: In the process of finding new antifungal compounds against plant pathogens, the methanol extract of Desmodium triflorum was investigated. Seven compounds were isolated and identified, of which six belong to flavone C-glycosides. Three major compounds showed moderate antifungal activity against three plant pathogens. In addition, the nanoemulsion of the extract displayed enhanced inhibition against the pathogens. The presence of specific compounds in the extract may contribute to its antifungal activity. These findings validate the potential of D. triflorum and its flavonoids as natural fungicides.
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
(2023)
Article
Agricultural Engineering
Quang Le Dang, Hoai Thu Thi Do, Gyung Ja Choi, Minh Van Nguyen, Hoang Dinh Vu, Gia Vu Pham, Cuong Tu Ho, Xuan Canh Nguyen, Van Hanh Vu, Thang Dinh Tran, Duc Trong Nghiem, Thi Thu Trang Nguyen
Summary: This study investigated the antimicrobial activities of Desmodium styracifolium and its metabolites against phytopathogenic fungi and bacteria. The crude extract of D. styracifolium showed potent suppression against fungal plant diseases, while n-hexane and dichloromethane-soluble extracts effectively controlled rice blast and tomato late blight. Sixteen compounds were isolated and identified, including the first report of isoflavanones and a pyrrole lactone alkaloid in D. styracifolium. Compound 9, a new isoflavone, displayed potent antifungal and antibacterial activities. Isoflavanones and isoflavones were determined as the bioactive constituents with wide-spectrum antifungal activity. The findings suggest that D. styracifolium compounds could be developed as inhibitors against phytopathogenic fungi and bacteria.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Entomology
Jehyeong Yeon, Ae Ran Park, Minkyu Kang, Van Thi Nguyen, Yookyung Lee, Ho Myeong Kim, Hae Woong Park, Panjung Ha, Yeonjong Koo, Jin-Cheol Kim
Summary: Aspergillus niger F22 and its metabolite oxalic acid can effectively control root-knot nematodes by inducing resistance in tomato plants. This study demonstrates that the A. niger F22 formulation and oxalic acid treatment can reduce root gall formation and improve the defense response of tomato plants against Meloidogyne incognita.
JOURNAL OF PEST SCIENCE
(2022)
Article
Chemistry, Applied
Hieu Nguyen-Ngoc, Bui Thi Thu Trang, Do Thi Hoai Thu, Huu Tung Nguyen, Vu Dinh Hoang, Quang De Tran, Tuan Ngoc Nguyen, Dang Ngoc Quang, Giang Nam Pham, Quang Le Dang
Summary: Four thymol derivatives (1-4) were isolated from Eupatorium fortunei and their structures were determined using NMR and mass spectrometry. One of the derivatives (1) was characterized as a new dimeric thymol derivative, and its absolute configuration was established using electronic circular dichroism quantum method. Compound 2 was also characterized for the first time using 1D and 2D NMR as well as HR-ESI mass spectrometry. The inhibitory activity of compounds 2-4 against alpha-glucosidase and acetylcholinesterase enzymes was evaluated, showing weak inhibition in both assays at concentrations ranging from 1 to 256 μg/mL.
NATURAL PRODUCT RESEARCH
(2023)
Article
Plant Sciences
Mohamed Mannaa, Gil Han, Hyejung Jung, Jungwook Park, Jin-Cheol Kim, Ae Ran Park, Young-Su Seo
Summary: This study proposes a sustainable method to enhance the drought tolerance of Korean fir trees by using a black yeast-like fungus called Aureobasidium pullulans AK10. The study investigates the impact of drought and AK10 treatment on the seedlings' rhizosphere microbiome and suggests that AK10 treatment can lead to beneficial alterations in the microbiome, improving the drought tolerance of the trees.
Article
Chemistry, Multidisciplinary
Hong Phuong Nguyen, Quang De Tran, Cuong Quoc Nguyen, Tran Phuong Hoa, Tran Duy Binh, Huynh Nhu Thao, Bui Thi Buu Hue, Nguyen Trong Tuan, Quang Le Dang, Nguyen Quoc Chau Thanh, Nguyen Van Ky, Minh Quan Pham, Su-Geun Yang
Summary: In this study, the antiproliferative activities of multiple HDAC inhibitors against myeloma cells were evaluated, and compound 7f was found to be the most bioactive with strong inhibitory activity against HDAC6. The synergistic interaction between 7f and the proteasome bortezomib inhibitor was also observed.
