Article
Cardiac & Cardiovascular Systems
Justin P. Zachariah, Yunfei Wang, Jane W. Newburger, Sarah D. deFerranti, Gary F. Mitchell, Ramachandran S. Vasan
Summary: This study found that overweight adolescents have higher aortic stiffness, which is significantly associated with BMI and low-density lipoprotein cholesterol levels. Maintaining optimal BMI and lipid levels may help mitigate aortic stiffness in adolescents.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Public, Environmental & Occupational Health
Yang Zhang, Wen-Qiang Zhang, Wei-Wei Tang, Wen-Yong Zhang, Jian-Xiong Liu, Rong-Hua Xu, Tzung-Dau Wang, Xiao-Bo Huang
Summary: This study assessed the prevalence and geographic variation of obesity-related hypertension among adults aged 45 years or older in China. The results showed a high prevalence of obesity-related hypertension, with 22.7% of the population affected, equivalent to 120 million people. The prevalence of obesity-related hypertension decreased from north to south and from east to west. Female gender, urban residence, diabetes mellitus, dyslipidemia, and hyperuricemia were positively correlated with obesity-related hypertension.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Michael Benusic, Lawrence J. Cheskin
Summary: In large US cities, median household income is inversely correlated with obesity prevalence in White and Black populations, suggesting that increasing socioeconomic status may decrease obesity rates. However, meeting physical activity guidelines does not necessarily affect obesity prevalence.
JOURNAL OF PUBLIC HEALTH
(2021)
Article
Multidisciplinary Sciences
Arielle Baskin-Sommers, Cortney Simmons, May Conley, Shou-An Chang, Suzanne Estrada, Meghan Collins, William Pelham, Emil Beckford, Haley Mitchell-Adams, Nia Berrian, Susan F. Tapert, Dylan G. Gee, B. J. Casey
Summary: Research found that adolescents are increasingly engaging with the BLM movement and experiencing positive emotions when exposed to related media. Black adolescents showed higher levels of negative emotions and more exposure to violence during in-person BLM demonstrations.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Letter
Cardiac & Cardiovascular Systems
Xiaoning Huang, Kristen Lee, Michael C. Wang, Nilay S. Shah, Sadiya S. Khan
Summary: This study examines the variations in the age of diagnosis for hypertension among adults in the US based on their race and ethnicity.
Article
Pediatrics
Godwill Azeh Engwa, Paul Chungag Anye, Nandu Goswami, Benedicta Ngwenchi Nkeh-Chungag
Summary: Obesity is strongly associated with hypertension, but the predictive ability of obesity cut-offs for hypertension screening in adolescents is controversial. This study found that using BMI percentile and WHtR as obesity cut-offs performed poorly in diagnosing hypertension in a South African adolescent population.
Article
Public, Environmental & Occupational Health
S. Strings, C. Wells, C. Bell, A. J. Tomiyama
Summary: This study examined the association between body mass index (BMI) and type 2 diabetes mellitus (T2DM) among the largest three racial/ethnic groups in the United States. Using data from the National Health and Nutrition Examination Survey from 1999 to 2018, the study found that BMI was associated with higher odds of prediabetes/T2DM for Latine and White individuals, but the association was weaker for Black individuals.
Review
Endocrinology & Metabolism
Vandana Raman, Anshu Gupta, Ambika P. Ashraf, Emily Breidbart, Evgenia Gourgari, Manmohan Kamboj, Brenda Kohn, Sowmya Krishnan, Amit Lahoti, Kristal Matlock, Shilpa Mehta, Sejal Mistry, Ryan Miller, Laura Page, Danielle Reynolds, Joan C. Han
Summary: This review focuses on recent advances in pharmacotherapy for pediatric obesity, including medications for rare monogenic forms of obesity. In addition to approved medications for weight reduction in children, off-label medications also have a broad safety margin. The review aims to provide guidance for clinicians and encourage further research into pharmacotherapy and other interventions for pediatric obesity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Multidisciplinary Sciences
Hector Gallardo-Rincon, Julieta Lomelin Gascon, Luis Alberto Martinez-Juarez, Alejandra Montoya, Rodrigo Saucedo-Martinez, Ricardo Mujica Rosales, Roberto Tapia-Conyer
Summary: MIDO, a digital strategy developed by the Carlos Slim Foundation in Mexico, facilitates screening, prevention, and management of non-communicable diseases and addresses the need for an integrated plan in primary health care during the COVID-19 pandemic.
Article
Health Care Sciences & Services
Yongze Li, Di Teng, Xiaoguang Shi, Xiaochun Teng, Weiping Teng, Zhongyan Shan, Yaxin Lai
Summary: Compared with 2007, the prevalence of hypertension and obesity among adults in mainland China significantly increased in 2017, especially for grade 1 hypertension in young adults and grade 2 hypertension in older adults.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2021)
Review
Nutrition & Dietetics
Malgorzata Wojcik, Agnieszka Koziol-Kozakowska
Summary: The relationship between obesity, arterial hypertension, and excessive salt intake has long been known, but the specific mechanism remains unclear. Recent studies indicate that obese children and adolescents are particularly vulnerable to the development of salt-sensitive arterial hypertension. Specific dietary recommendations should be developed for overweight and obese patients.
Article
Multidisciplinary Sciences
Renata Kuciene, Virginija Dulskiene
Summary: This study examined the associations between tri-ponderal mass index (TMI) and body mass index (BMI) with high blood pressure (HBP) among Lithuanian children and adolescents aged 7-18 years. The findings showed that both BMI and TMI were significantly associated with HBP, but BMI was a better predictor for HBP than TMI.
SCIENTIFIC REPORTS
(2023)
Article
Peripheral Vascular Disease
Masanobu Yamazato, Atsushi Sakima, Akio Ishida, Kentaro Kohagura, Tetsutaro Matayoshi, Takeshi Tana, Masahiro Tamashiro, Yoshio Hata, Tamayo Naka, Yoshito Nakamura, Yusuke Ohya
Summary: Reducing salt and increasing potassium intake are recommended lifestyle modifications for patients with hypertension. However, few studies have evaluated salt intake with these methods in hypertensive outpatients. In this study, urinary salt excretion value and total score on the salt check-sheet were associated with inadequate blood pressure control in hypertensive outpatients.
HYPERTENSION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Z. Xu, D. Zhang, J. Lin, X. Li, Y. Liu, J. Gao, Y. Xue, Y. Zhang, R. Ding, G. Huang, T. Zhao, H. Huang, C. Gu, W. Li
Summary: This study revealed an association between CYP2R1 variations and hypertension risk, with the rs12794714 polymorphism significantly increasing the risk. Furthermore, the interaction between rs12794714 and obesity may further elevate the susceptibility to hypertension.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Review
Peripheral Vascular Disease
Vanessa Oliveira, Anne E. Kwitek, Curt D. Sigmund, Lisa L. Morselli, Justin L. Grobe
Summary: Obesity is the major obstacle to improving cardiovascular health, involving changes in energy balance control that may lead to hypertension. Drug development targeting metabolism often leads to hypertension, but new research suggests different subtypes of AGRP neurons may have varying effects on feeding, metabolism, or blood pressure control.
Article
Surgery
Oscar A. Olavarria, Naila H. Dhanani, Karla Bernardi, Julie L. Holihan, Cynthia S. Bell, Tien C. Ko, Mike K. Liang
Summary: Prophylactic mesh reinforcement of midline laparotomy closures appears to be effective in preventing incisional hernias, but it also increases the risk of surgical site occurrences.
Article
Surgery
Naila H. Dhanani, Oscar A. Olavarria, Cynthia S. Bell, Julie L. Holihan, Mike K. Liang
Summary: In this study, 8% of the analyzed RCTs reported p-values < 0.05 that were >= 0.05 on reproduction analysis. The next steps should be to determine reasons for discordance and how to prevent this from happening.
Article
Pediatrics
Mallory Smith, Cynthia Bell, Molly Wong Vega, Naile Tufan Pekkucuksen, Laura Loftis, Mona McPherson, Jeanine Graf, Ayse Akcan Arikan
Summary: A retrospective cohort study on pediatric CKRT survivors revealed high rates of new morbidity and worse functional outcomes at PICU discharge, highlighting the necessity for targeted follow-up for this vulnerable population. Further research is needed to investigate deliberate decrease of sedation exposure as a modifiable risk factor for these patients.
PEDIATRIC NEPHROLOGY
(2022)
Article
Pediatrics
Elizabeth Black, Jason Lee, Joseph T. Flynn, Charles E. McCulloch, Joshua A. Samuels, Divya Seth, Bradley Warady, Susan Furth, Mark Mitsnefes, Elaine Ku
Summary: Adolescents with chronic kidney disease have a high prevalence of hypertension. Different definitions of hypertension in pediatric and adult populations show some variations in predicting cardiovascular and renal outcomes, with slightly better risk discrimination for left ventricular hypertrophy using pediatric definitions.
PEDIATRIC NEPHROLOGY
(2022)
Article
Pediatrics
Sameer Thadani, Thomas Fogarty, Theresa Mottes, Jack F. Price, Poyyapakkam Srivaths, Cynthia Bell, Ayse Akcan-Arikan
Summary: This study aimed to investigate the frequency of hemodynamic instability in pediatric continuous kidney replacement therapy (CKRT) and its association with patient outcomes. The study found that one in four filter connections during CKRT resulted in hypotension and one in six resulted in tachycardia. Higher severity of illness at the initiation of CKRT was independently associated with hypotension.
PEDIATRIC NEPHROLOGY
(2022)
Article
Otorhinolaryngology
David Z. Allen, Sai Challapalli, Sean McKee, Kyung Hyun Lee, Cynthia S. Bell, Soham Roy, Sarah Bowe, Karthik Balakrishnan, C. W. David Chang, Zhen Huang
Summary: The COVID-19 pandemic has resulted in a decrease in otitis media (OM) and associated procedures, but there has been an increase recently. There may be a geographic relationship, which could be influenced by mask mandates and social distancing measures.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2022)
Article
Medicine, General & Internal
Rajesh Pandey, Lydia Youmans, Chiamaka Aneji, Cynthia Bell, John Breinholt, Amir Khan
Summary: This study compared the hemodynamic stability after closing patent ductus arteriosus (PDA) in extremely premature infants using surgical ligation (SL) or cardiac catheter-based closure (CCC). The SL group had smaller and less mature infants with higher respiratory support. However, there was no significant difference in postoperative hemodynamic decompensation between the two groups.
Article
Surgery
Seyed A. Arshad, Elisa Garcia, Cynthia Bell, Elenir B. C. Avritscher, Mohineesh Kumar, Pavan Brahmamdam, James A. Fraser, Shawn D. St Peter, Arturo Aranda, Madelyn Hill, John Marquart, Kyle Van Arendonk, Leah Plumblee, Christian J. Streck, Irving J. Zamora, Muhammad O. A. Ghani, Kirk W. Reichard, Karen Sacks, Michelle Kallis, Andrew Hong, Holden Richards, Saunders Lin, Erica R. Gross, Mustafa H. Kabeer, Troy Reyna, Elizabeth A. Paton, Lauren B. Camp, Krista Stephenson, Melvin Dassinger, Kaveh Vali, Radu Filipescu, Daniel A. DeUgarte, Vikram Krishna, Bethany Slater, Saleem Islam, Grace Thompson, James T. Moore, Brian R. Englum, Stefan Scholz, Elizabeth Sharbaugh, Jeffrey W. Gander, KuoJen Tsao
Summary: This study assessed the clinical implications of cryoanalgesia for pain management in children undergoing minimally invasive repair of pectus excavatum (MIRPE). The results showed that the use of cryoanalgesia can reduce postoperative opioid requirements and length of stay without increasing complication rates.
Article
Peripheral Vascular Disease
Joyce P. Samuel, Cynthia S. Bell, Joshua A. Samuels, Celin Rajan, Adrienne K. Walton, Charles Green, Jon E. Tyson
Summary: This study aimed to assess the effect of personalized treatment choices on blood pressure control in hypertensive patients. The study found that patients whose treatment choices were informed by n-of-1 trials and ambulatory blood pressure monitoring had better blood pressure control at 6 months compared to the usual care group.
AMERICAN JOURNAL OF HYPERTENSION
(2023)
Review
Peripheral Vascular Disease
Craig Authement, Joshua Samuels, Joyce P. Samuel
Summary: The prevalence of pediatric hypertension is increasing and is associated with end organ damage. The use of n-of-1 trials to personalize antihypertensive therapy has been shown to reverse this damage.
CURRENT HYPERTENSION REPORTS
(2022)
Article
Peripheral Vascular Disease
Sunjae Bae, Joshua A. Samuels, Joseph T. Flynn, Mark M. Mitsnefes, Susan L. Furth, Bradley A. Warady, Derek K. Ng
Summary: This study aimed to develop a predictive model for masked hypertension and determine the optimal thresholds for screening. The results showed that ambulatory blood pressure monitoring (ABPM) could be selectively used in individuals with clinic systolic blood pressure (BP) <20th percentile and diastolic BP <80th percentile. However, even in this subgroup, the prevalence of masked hypertension was still relatively high, suggesting that routine ABPM remains recommended.
Article
Infectious Diseases
Peace D. Imani, Peter J. Elyanu, R. Sebastian Wanless, Sarah H. Perry, Kanyamanda Katembo, Bhekumusa Lukhele, Teresa Steffy, Tumelo Seetane, Lineo Thahane, Heather Haq, Cynthia S. Bell, Poyyapakkam Srivaths, Michael C. Braun
Summary: The study found that the prevalence of CKD among CLWHA in sub-Saharan Africa was 1.6%, and it was associated with severe immunosuppression and age, but not with ART regimen.
JOURNAL OF CLINICAL VIROLOGY PLUS
(2022)
Article
Urology & Nephrology
Sai Sudha Mannemuddhu, Ian Macumber, Joshua A. Samuels, Joseph T. Flynn, Andrew M. South
Summary: Hypertension in children is associated with an increased risk of sustained hypertension and cardiovascular disease in adulthood. Transitioning the care of adolescents and young adults with hypertension is an important unmet healthcare need that can significantly mitigate cardiovascular disease risk in adulthood. However, there is a lack of published literature on the transition process in this population, leading to considerable gaps in the field.
ADVANCES IN CHRONIC KIDNEY DISEASE
(2022)
Meeting Abstract
Obstetrics & Gynecology
Hector Mendez Figueroa, Cynthia Bell, Stephen M. Wagner, Keya Lee, Isabelle Mulder, Sean C. Blackwell, Suneet P. Chauhan, Megha Gupta
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
