Article
Medicine, General & Internal
Anat Yaskolka Meir, Wanyu Huang, Tingyi Cao, Xiumei Hong, Guoying Wang, Colleen Pearson, William G. Adams, Xiaobin Wang, Liming Liang
Summary: This study used data from a US birth cohort and found four distinct growth trajectories of body-mass-index in children from birth to age 18. These trajectories were associated with changes in DNA methylation. If further validated, these findings may help identify high-risk children and obesity issues in early stages.
Article
Multidisciplinary Sciences
Shirin Faraji Azad, Akbar Biglarian, Maryam Rostami, Razieh Bidhendi-Yarandi
Summary: Using the smoothing mixture model (SMM), this study aimed to identify the latent longitudinal trajectories of maternal weight associated with adverse pregnancy outcomes. Data from 877 pregnant women were analyzed, and three trajectories (low, medium, and high weight) were identified. Results showed that the low weight trajectory had significantly higher risks for certain adverse neonatal events compared to the high weight trajectory.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Teodora Z. Markova, Claire J. Ciampa, Jourdan H. Parent, Molly R. LaPoint, Mark D'Esposito, William J. Jagust, Anne S. Berry
Summary: The study used [F-18]Fluoro-m-tyrosine ([F-18]FMT) PET imaging to measure serotonin synthesis capacity in the brains of healthy adults, and found that serotonin synthesis capacity increases with age. This is associated with longitudinal changes in cortical thickness, self-reported depression symptoms, AD-related tau and β-amyloid pathology, and sex differences.
MOLECULAR PSYCHIATRY
(2023)
Article
Hematology
Ellen-Sofie Hansen, Fridtjof B. Rinde, Magnus S. Edvardsen, Kristian Hindberg, Nadezhda Latysheva, Pal Aukrust, Thor Ueland, Annika E. Michelsen, John-Bjarne Hansen, Sigrid K. Braekkan, Vania M. Morelli
Summary: The results of the study suggest that elevated plasma D-dimer levels are associated with an increased risk of incident VTE. However, the risk estimates were slightly attenuated after adjusting for body mass index and C-reactive protein, indicating that D-dimer may partly reflect underlying conditions related to obesity and inflammation.
THROMBOSIS RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Xiaolin Yang, Tuomas Kukko, Irinja Lounassalo, Janne Kulmala, Harto Hakonen, Suvi P. Rovio, Katja Pahkala, Mirja Hirvensalo, Sanna H. Palomaki, Nina Hutri-Kahonen, Olli T. Raitakari, Tuija H. Tammelin, Kasper Salin
Summary: This study identified the trajectories of organized youth sports over a 9-year period in youths aged 9-18 years and examined whether these trajectories predicted physical activity, sedentary behavior, and obesity in midlife. The results showed that sustained participation in organized youth sports is independently predictive of physical activity patterns, sedentary time, and obesity in midlife, especially among girls.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jia Liu, Huiying Pan, Yue Liu, Mengying Guan, Xia Li, Shuo Chen, Xingyao Tong, Yanxia Luo, Xiaonan Wang, Xinghua Yang, Xiuhua Guo, Jingbo Zhang, Lixin Tao
Summary: This study examines the association between hyperuricemia trajectories and diabetes risk in middle-aged adults. The high-increasing hyperuricemia pattern is significantly associated with an increased risk of diabetes, and obesity, dyslipidemia, and hypertension mediate this relationship.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Endocrinology & Metabolism
Nasra N. Alam, Alison K. Wright, Martin K. Rutter, Iain Buchan, Darren M. Ashcroft, Matthew Sperrin, Andrew G. Renehan
Summary: This study evaluated the relationship between body mass index (BMI) and cancer mortality in patients with type 2 diabetes. Positive associations were found between BMI and endometrial cancer mortality in women who never smoked, while associations between BMI and obesity-related cancer mortality in men were inverse but attenuated towards null among never smokers. The proportion of cardiovascular disease (CVD) deaths increased with higher BMI categories in men.
DIABETES OBESITY & METABOLISM
(2022)
Letter
Medicine, General & Internal
Nirvik Pal, Vishal Yajnik
Summary: This article discusses the issue of prone positioning during ventilation for critically ill patients with high BMI in the ICU, and emphasizes the importance of preventing ophthalmologic injuries in any situation involving prone position ventilation.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Endocrinology & Metabolism
Ming Ying, Xiangming Hu, Qiang Li, Haojian Dong, Yingling Zhou, Zhujun Chen
Summary: This study examined the relationship between BMI trajectories and MetS, revealing that long-term BMI measurements are associated with cumulative incident MetS. Different BMI trajectories have varying impacts on the risk of MetS, providing important guidance for the prevention and management of MetS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Hematology
Tobias Frischmuth, Kristian Hindberg, Pal Aukrust, Thor Ueland, Sigrid K. Braekkan, John-Bjarne Hansen, Vania M. Morelli
Summary: This study aimed to investigate the association between plasma PAI-1 levels and the risk of future incident VTE, as well as to explore the potential mediation of PAI-1 on the VTE risk in obesity.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Multidisciplinary Sciences
Qing-Xiang Zheng, Hai-Wei Wang, Xiu-Min Jiang, Yan Lin, Gui-Hua Liu, Mian Pan, Li Ge, Xiao-Qian Chen, Jing-Ling Wu, Xiao-Yun Zhang, Yu-Qing Pan, Hong-Gu He
Summary: This study aimed to determine the ranges of gestational weight gain (GWG) in Chinese women with gestational diabetes mellitus (GDM) and investigate the associations between prepregnancy body mass index (BMI), GWG, and maternal-infant adverse outcomes. The findings revealed that the ranges of GWG in Chinese women with GDM were different from the National Academy of Medicine's recommendation, and GDM women with high prepregnancy BMI and excessive GWG were associated with higher risks of adverse outcomes for both the mother and the infant.
SCIENTIFIC REPORTS
(2022)
Article
Medical Laboratory Technology
Maura Ravera, Thomas Nickolas, Mario Plebani, Giorgio Iervasi, Andrea Aghi, Pascale Khairallah, Maurizio Gallieni, Maria Cristina Mereu, Sandro Giannini, Stefania Sella, Martina Zaninotto, Ernesto Paoletti, Elisabetta Bussalino, Luca Di Lullo, Antonio Bellasi, Laura Cosmai, Marina Foramitti, Fabio Malberti, Maria Luisa Brandi, Serge Ferrari, Giovanni Tripepi, Maria Fusaro
Summary: The study found an inverse relationship between Vitamin K2 levels and BMI in hemodialysis patients, with lower Bone Gla protein levels in overweight and obese patients. The increase in body mass index was associated with lower MK7/triglycerides levels.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Article
Endocrinology & Metabolism
Conghui Liu, Jing Tian, Matthew D. Jose, Terence Dwyer, Alison J. Venn
Summary: This study found that participants with increasing BMI trajectories from childhood had an increased risk of subclinical kidney damage (SKD) in midlife.
Article
Oncology
James M. Foran, Zhuoxin Sun, Catherine Lai, Hugo F. Fernandez, Larry D. Cripe, Rhett P. Ketterling, Janis Racevskis, Selina M. Luger, Elisabeth Paietta, Hillard M. Lazarus, Yanming Zhang, John M. Bennett, Ross L. Levine, Jacob M. Rowe, Mark R. Litzow, Martin S. Tallman
Summary: This study examined the association of obesity with AML and its impact on clinical outcomes. The results showed that obesity was associated with certain clinical and genetic features of AML, but did not affect patient survival.
Article
Multidisciplinary Sciences
Yun Jeong Lee, Sooyoung Yoo, Soyoung Yi, Seok Kim, Chunggak Lee, Jihoon Cho, Soyeon Ahn, Sunkyu Choi, Hee Hwang, Young Ah Lee, Choong Ho Shin, Hyung-Jin Yoon, Kwangsoo Kim, Eunhye Song, Jin Ho Choi, Han Wook Yoo, Young-Hak Kim, Ji Seon Oh, Eun-Ae Kang, Ga Kyoung Baek, Jae Hyun Kim
Summary: This study evaluated trajectories of HbA1c levels and BMIz for 5 years after diagnosis among Korean children and adolescents with type 1 or type 2 diabetes using a common data model. It found that T1D patients had lower BMIz and higher HbA1c levels at diagnosis compared to T2D patients. After treatment, T1D patients showed consistent increases in BMIz, while T2D patients showed no significant change in BMIz during follow-up. Achieving optimal glycemic control and preventing obesity should be emphasized in pediatric diabetes care.
SCIENTIFIC REPORTS
(2021)
Article
Geriatrics & Gerontology
Laura Kananen, Mikko Hurme, Alexander Buerkle, Maria Moreno-Villanueva, Jurgen Bernhardt, Florence Debacq-Chainiaux, Beatrix Grubeck-Loebenstein, Marco Malavolta, Andrea Basso, Francesco Piacenza, Sebastiano Collino, Efstathios S. Gonos, Ewa Sikora, Daniela Gradinaru, Eugene H. J. M. Jansen, Martijn E. T. Dolle, Michel Salmon, Wolfgang Stuetz, Daniela Weber, Tilman Grune, Nicolle Breusing, Andreas Simm, Miriam Capri, Claudio Franceschi, Eline Slagboom, Duncan Talbot, Claude Libert, Jani Raitanen, Seppo Koskinen, Tommi Harkanen, Sari Stenholm, Mika Ala-Korpela, Terho Lehtimaki, Olli T. Raitakari, Olavi Ukkola, Mika Kahonen, Marja Jylha, Juulia Jylhava
Summary: Circulating cell-free DNA (cf-DNA) levels are associated with age, sex, smoking, physical activity, vegetable consumption, ageing phenotypes, and various biomarkers. Higher cf-DNA levels were found in men, especially middle-aged men and women who smoke, and older frail individuals. Inflammatory markers, metabolites, and antioxidant levels were correlated with cf-DNA levels. These findings have implications for future studies on the epidemiology and biological mechanisms of cf-DNA and its potential as a clinical marker.
Article
Psychology, Clinical
Amanda Nurmi, Laura Pulkki-Raback, Pia Salo, Katja Pahkala, Markus Juonala, Nina Hutri-Kahonen, Mika Kahonen, Terho Lehtimaki, Eero Jokinen, Liisa Keltikangas-Jarvinen, Tomi P. Laitinen, Paivi Tossavainen, Leena Taittonen, Jorma S. A. Viikari, Olli T. Raitakari, Suvi P. Rovio
Summary: The study found that adverse childhood psychosocial factors are associated with midlife learning ability and memory. Specifically, poor self-regulatory behavior and social adjustment in childhood are related to poorer learning ability and memory 30 years later.
Article
Psychology, Clinical
Laila Ketvel, Liisa Keltikangas-Jarvinen, Katja Pahkala, Markus Juonala, Ari Ahola-Olli, Terho Lehtimaki, Jorma Viikari, Olli Raitakari, Suvi Rovio, Aino Saarinen
Summary: This study aimed to investigate the relationship between stress-related exhaustion (chronic or short-term, and co-occurring with depression or not) and cognitive performance, and whether polygenic cognitive potential modifies these associations. The study found that high stress-related exhaustion, especially chronic, was associated with slower reaction time. Clinical levels of depression were only related to slower reaction time. Polygenic cognitive potential did not modify these associations. There were no differences in cognitive performance between individuals with co-occurring exhaustion and depression vs. those with only either condition.
COGNITIVE THERAPY AND RESEARCH
(2023)
Article
Genetics & Heredity
Tiit Ord, Tapio Lonnberg, Valtteri Nurminen, Aarthi Ravindran, Henri Niskanen, Miika Kiema, Kadri Ounap, Maleeha Maria, Pierre R. Moreau, Pashupati P. Mishra, Senthil Palani, Jenni Virta, Heidi Liljenback, Einari Aavik, Anne Roivainen, Seppo Yla-Herttuala, Johanna P. Laakkonen, Terho Lehtimaki, Minna U. Kaikkonen
Summary: Coronary artery disease (CAD) is a global disease with significant genetic factors. By using single-cell and bulk RNA sequencing, this study explores the biological diversity of atherosclerosis-associated cell states and their contribution to CAD risk. The researchers identified disease-associated cell states, with Vcam1 thorn smooth muscle cells showing the highest contribution to CAD heritability. The findings provide insights into CAD risk mechanisms and have implications for precision medicine and tailored therapeutic interventions.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Peripheral Vascular Disease
Erika Kahonen, Satu Korpimaki, Markus Juonala, Mika Kahonen, Terho Lehtimaki, Nina Hutri-Kahonen, Olli T. Raitakari, Mika Kivimaki, Jussi Vahtera
Summary: Limited data is available on the association between neighbourhood deprivation and arterial stiffening. This study found that neighbourhood deprivation in childhood and adulthood predicts arterial stiffness indicated by pulse wave velocity (PWV). These findings suggest that neighbourhood deprivation and low adulthood socioeconomic status are independent risk factors for increased arterial stiffness in adulthood.
Article
Biochemistry & Molecular Biology
Amen Keshawarz, Roby Joehanes, Jiantao Ma, Gha Young Lee, Ricardo Costeira, Pei-Chien Tsai, Olatz M. Masachs, Jordana T. Bell, Rory Wilson, Barbara Thorand, Juliane Winkelmann, Annette Peters, Jakob Linseisen, Melanie Waldenberger, Terho Lehtimaeki, Pashupati P. Mishra, Mika Kahonen, Olli Raitakari, Mika Helminen, Carol A. Wang, Phillip E. Melton, Rae-Chi Huang, Craig E. Pennell, Therese A. O'Sullivan, Carolina Ochoa-Rosales, Trudy Voortman, Joyce B. J. van Meurs, Kristin L. Young, Misa Graff, Yujie Wang, Douglas P. Kiel, Caren E. Smith, Paul F. Jacques, Daniel Levy
Summary: Through meta-analysis of epigenome-wide association studies, we found significant associations between dietary and supplemental intake of vitamins C and E with DNA methylation. Vitamin C intake was associated with 4,656 CpG sites, while vitamin E intake was associated with 160 CpG sites. Vitamin C intake was found to be related to systems development and the immune response, while no significant associations were found for vitamin E intake with any biological pathways investigated.
Article
Multidisciplinary Sciences
Miikael Lehtimaki, Binisha H. H. Mishra, Coral Del-Val, Leo-Pekka Lyytikainen, Mika Kahonen, C. Robert Cloninger, Olli T. T. Raitakari, Reijo Laaksonen, Igor Zwir, Terho Lehtimaki, Pashupati P. P. Mishra
Summary: This study used an unsupervised machine learning method called PGMRA to discover the genotype-lipidome relations in a Finnish population. The researchers found 93 statistically significant lipidome-genotype relations, which contained a total of 5977 SNPs across 3164 genes. Twenty nine of these relations represented distinct subgroups with unique SNPs and participants. Pathway enrichment analysis identified 30 significantly enriched biological processes related to plasma lipid metabolism. These findings have implications for precision medicine research.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Juhani S. Koskinen, Ville Kyto, Markus Juonala, Jorma S. A. Viikari, Jaakko Nevalainen, Mika Kahonen, Terho Lehtimaki, Nina Hutri-Kahonen, Tomi P. Laitinen, Paivi Tossavainen, Eero Jokinen, Costan G. Magnussen, Olli T. Raitakari
Summary: This study examines the association between childhood and adult dyslipidemia and adult carotid atherosclerotic plaques, and found that childhood dyslipidemia, even if resolved by adulthood, is still a risk factor for adult carotid plaques.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Public, Environmental & Occupational Health
Chuanwei Ma, Yayang Huang, Sixuan Li, Min Zhao, Xinying Zeng, Xinbo Di, Costan G. Magnussen, Bo Xi, Shiwei Liu
Summary: It is well-known that secondhand smoke exposure among adolescents in China is associated with increased morbidity and mortality. This study found that while prevalence of secondhand smoke exposure decreased from 2013-2014 to 2019, it still remains unacceptably high. More effective strategies and stronger action are needed in China to further reduce secondhand smoke exposure among adolescents.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Article
Medicine, General & Internal
Jiahong Sun, Xue Liu, Min Zhao, Costan G. Magnussen, Bo Xi
Summary: This study found a dose-response association between maternal cigarette use during each trimester of pregnancy and infant all-cause and cause-specific death. Maternal smoking during the entire pregnancy was associated with increased risks of infant death due to various causes. However, mothers who smoked only during the first trimester and then quit smoking had a reduced risk of infant death compared to those who smoked throughout the pregnancy.
Article
Neurosciences
Simo-Pekko Salminen, Anssi Solismaa, Leo-Pekka Lyytikainen, Vesa Paavonen, Nina Mononen, Terho Lehtimaki, Esa Leinonen, Olli Kampman
Summary: This study examined the clustering of Cloninger's temperament dimensions and their association with single nucleotide polymorphisms (SNPs). The results showed that multiple SNPs from different genes were associated with different temperament clusters. Genetic risk scores (GRSs) were also found to be associated with individuals' temperament profiles. However, further research is needed to explore the clinical applicability of these clusters.
ACTA NEUROPSYCHIATRICA
(2023)
Article
Pediatrics
Jia Guo, Brooklyn J. Fraser, Leigh Blizzard, Michael D. Schmidt, Terence Dwyer, Alison J. Venn, Costan G. Magnussen
Summary: There is a correlation between childhood and adulthood cardiorespiratory fitness.
JOURNAL OF PEDIATRICS
(2024)
Article
Multidisciplinary Sciences
Yordi van de Vegte, Ruben P. Eppinga, M. Yldau van der Ende, Yanick Hagemeijer, Yuvaraj V. Mahendran, Elias Y. Salfati, Albert E. Smith, Vanessa Tan, Dan V. Arking, Ioanna Ntalla, Emil A. Appel, Claudia Schurmann, Jennifer Brody, Rico Rueedi, Ozren Polasek, Gardar Sveinbjornsson, Cecile Lecoeur, Claes Ladenvall, Jing Hua Zhao, Aaron Isaacs, Lihua Wang, Jian'an Luan, Shih-Jen Hwang, Nina U. Mononen, Kirsi F. Auro, Anne Jackson, Lawrence Bielak, Linyao Zeng, Nabi Shah, Maria Nethander, Archie Campbell, Tuomo Rankinen, Sonali Pechlivanis, Lu Qi, Wei Zhao, Federica Rizzi, Toshiko Tanaka, Antonietta Robino, Massimiliano Cocca, Leslie Lange, Martina Mueller-Nurasyid, Carolina E. Roselli, Weihua Zhang, Marcus J. Kleber, Xiuqing Guo, Henry E. Lin, Francesca Pavani, Tessel Galesloot, Raymond E. Noordam, Yuri Milaneschi, Katharina Schraut, Marcel den Hoed, Frauke E. Degenhardt, Stella Trompet, Marten van den Berg, Giorgio Pistis, Yih-Chung S. Tham, Stefan L. Weiss, Xueling J. Sim, Hengtong M. Li, Peter van der Most, Ilja Nolte, Leo-Pekka R. Lyytikaeinen, M. Abdullah Said, Daniel Witte, Carlos M. Iribarren, Lenore S. Launer, Susan Ring, Paul de Vries, Peter P. Sever, Allan Linneberg, Erwin M. Bottinger, Sandosh Padmanabhan, Bruce Psaty, Nona Sotoodehnia, Ivana Kolcic, Delnaz D. Roshandel, Andrew O. Paterson, David F. Arnar, Daniel Gudbjartsson, Hilma Holm, Beverley T. Balkau, Claudia H. Silva, Christopher Newton-Cheh, Kjell Nikus, Perttu L. Salo, Karen A. Mohlke, Patricia Peyser, Heribert Schunkert, Mattias Lorentzon, Jari C. Lahti, Dabeeru C. Rao, Marilyn D. Cornelis, Jessica A. Faul, Jennifer Smith, Katarzyna Stolarz-Skrzypek, Stefania Bandinelli, Maria Pina Concas, Gianfranco Sinagra, Thomas Meitinger, Melanie F. Waldenberger, Moritz Sinner, Konstantin E. Strauch, Graciela D. Delgado, Kent Taylor, Jie Yao, Luisa Foco, Olle Melander, Jacqueline de Graaf, Renee de Mutsert, Eco J. C. de Geus, Asa K. Johansson, Peter K. Joshi, Lars Lind, Andre W. Franke, Peter V. Macfarlane, Kirill Tarasov, Nicholas B. Tan, Stephan Felix, E-Shyong Q. Tai, Debra Quek, Harold Snieder, Johan Ormel, Martin Ingelsson, Cecilia P. Lindgren, Andrew T. Morris, Olli Raitakari, Torben Hansen, Themistocles Assimes, Vilmundur J. Gudnason, Nicholas C. Timpson, Alanna B. Morrison, Patricia P. Munroe, David Strachan, Niels Grarup, Ruth J. F. R. Loos, Susan Heckbert, Peter Vollenweider, Caroline Hayward, Kari Stefansson, Philippe Froguel, Leif J. Groop, Nicholas M. Wareham, Cornelia F. van Duijn, Mary J. Feitosa, Christopher O'Donnell, Mika Kaehoenen, Markus Perola, Michael Boehnke, Sharon L. R. Kardia, Jeanette Erdmann, Colin N. A. Palmer, Claes J. Ohlsson, David G. Porteous, Johan Eriksson, Claude Bouchard, Susanne Moebus, Peter R. Kraft, David Weir, Daniele Cusi, Luigi Ferrucci, Sheila Ulivi, Giorgia Girotto, Adolfo Correa, Stefan Kaeaeb, Annette C. Peters, John S. Chambers, Jaspal Kooner, Winfried I. Maerz, Jerome A. Rotter, Andrew Hicks, J. Gustav Smith, Lambertus A. L. M. O. Kiemeney, Dennis Mook-Kanamori, Brenda W. J. H. Penninx, Ulf F. Gyllensten, James Wilson, Stephen Burgess, Johan Sundstroem, Wolfgang Lieb, J. Wouter Jukema, Mark Eijgelsheim, Edward L. M. Lakatta, Ching-Yu Cheng, Marcus Doerr, Tien-Yin Wong, Charumathi J. Sabanayagam, Albertine Oldehinkel, Harriette Riese, Terho Lehtimaeki, Niek Verweij, Pim van der Harst
Summary: This study identifies new genetic variants associated with resting heart rate (RHR) and demonstrates that higher genetically predicted RHR is associated with a decreased risk of atrial fibrillation and ischemic stroke. Genome-wide analysis reveals multiple genetic variants in cardiomyocyte-related genes and provides insights into their electrocardiogram (ECG) signature. Mendelian randomization analyses indicate that higher genetically predicted RHR increases the risk of dilated cardiomyopathy, but reduces the risk of atrial fibrillation, ischemic stroke, and cardio-embolic stroke.
NATURE COMMUNICATIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Matilda Hurskainen, Juho Tynkkynen, Markku Eskola, Terho Lehtimaki, Jussi Hernesniemi
Summary: This study aimed to investigate the risk factors for ischemic stroke (IS) after acute coronary syndromes (ACS). Based on a retrospective registry study of 8049 ACS patients, it was found that previous stroke, atrial fibrillation or flutter, and heart failure indicated by the Killip classification were the most significant risk factors for both early-onset and late-onset IS. Left ventricular ejection fraction and coronary artery disease severity were important risk factors for early-onset IS, while age and peripheral artery disease were important risk factors for late-onset IS. The CHA(2)DS(2)-VASc score and its components were strong predictors for both early-onset and late-onset IS.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Biotechnology & Applied Microbiology
Pashupati P. Mishra, Binisha H. Mishra, Emma Raitoharju, Nina Mononen, Jorma Viikari, Markus Juonala, Nina Hutri-Kahonen, Mika Kahonen, Olli T. Raitakari, Terho Lehtimaki
Summary: Advanced integrative analysis of DNA methylation and transcriptomics data reveals the effects of smoke-induced epigenetic alterations on gene expression and biological processes, linking smoking and related diseases.
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2023)